Home About us Contact
|
Home About us Contact | ||
|
|
||
Multiple Purposes (multiple + purpose)
Selected AbstractsSurveying Recent Literature on the Arabic and Persian Mirrors for Princes GenreHISTORY COMPASS (ELECTRONIC), Issue 2 2009L. Marlow The study of the medieval Arabic and Persian ,mirror for princes' literatures in many respects resembles that of the similarly abundant literatures produced in Byzantium and the Latin West. In earlier scholarship, the predominant approach was that of the history of ideas, and scholars tended to focus on depictions of the ideal ruler and other aspects of the ,political thought' expressed in the mirror literatures. A secondary area of interest concerned textual transmission within and across these literatures. More recent scholarship has continued to develop and refine these established approaches, and has also developed new directions of research. Notably, several scholars have explored the Sitz im Leben of individual mirrors, and have studied their meaning and significance in the historical settings in and for which they were composed. Certain recent publications have highlighted the flexibility of mirrors, the multiple purposes they often served, the range of perspectives represented by their authors, and the importance of authors' choices of language and genre in shaping the composition and reception of their works. [source] Cancellous Bone Remodeling Occurs in Specialized Compartments Lined by Cells Expressing Osteoblastic MarkersJOURNAL OF BONE AND MINERAL RESEARCH, Issue 9 2001Ellen M. Hauge Abstract We describe a sinus, referred to as a bone remodeling compartment (BRC), which is intimately associated with cancellous bone remodeling. The compartment is lined on its marrow side by flattened cells and on its osseous side by the remodeling bone surface, resembling a roof of flattened cells covering the bone surface. The flat marrow lining cells are in continuity with the bone lining cells at the margins of the BRC. We examined a large number of diagnostic bone biopsy specimens received during recent years in the department. Furthermore, 10 patients (8 women and 2 men, median age 56 [40,69] years) with the high turnover disease of primary hyperparathyroidism who were treated with parathyroidectomy and followed for 3 years were included in the histomorphometric study. Bone samples for the immuno-enzyme staining were obtained from an amputated extremity of child. The total cancellous bone surface covered by BRC decreases by 50% (p < 0.05) following normalization of turnover and is paralleled by a similar 50% decrease in remodeling surface (p < 0.05). The entire eroded surface and two-thirds of the osteoid surface are covered by a BRC. BRC-covered uncompleted walls are 30% (p < 0.05) thinner than those without a BRC. This indicates that the BRC is invariably associated with the early phases of bone remodeling, that is, bone resorption, whereas it closes during the late part of bone formation. Immuno-enzyme staining shows that the flat marrow lining cells are positive for alkaline phosphatase, osteocalcin, and osteonectin, suggesting that they are bone cells. The first step in cancellous bone remodeling is thought to be the lining cells digesting the unmineralized matrix membrane followed by their disappearance and the arrival of the bone multicellular unit (BMU). We suggest that the lining cell barrier persists during bone remodeling; that the old lining cells become the marrow lining cells, allowing bone resorption and bone formation to proceed under a common roof of lining cells; that, at the end of bone formation, new bone lining cells derived from the flattened osteoblasts replace the marrow lining cells thereby closing the BRC; and that the two layers of lining cells eventually becomes a single layer. The integrity of the osteocyte-lining cell system is reestablished by the new generation of lining cells. The BRC most likely serves multiple purposes, including efficient exchange of matrix constituents and minerals, routing, monitoring, or modulating bone cell recruitment, and possibly the anatomical basis for the coupling of bone remodeling. [source] Evaluating the inter-respondent (consumer vs. staff) reliability and construct validity (SIS vs.JOURNAL OF INTELLECTUAL DISABILITY RESEARCH, Issue 4 2009Vineland) of the Supports Intensity Scale on a Dutch sample Abstract Background Despite various reliability studies on the Supports Intensity Scale (SIS), to date there has not been an evaluation of the reliability of client vs. staff judgments. Such determination is important, given the increasing consumer-driven approach to services. Additionally, there has not been an evaluation of the instrument's construct validity on a non-English speaking sample. This is important as the SIS is currently translated into 13 languages. Method Data were collected in two different samples, using the Dutch translation of the SIS and the Vineland-Z. Results There was a significant correlation between ratings of staff and consumers on the SIS; however, the relationship between the mean scores of consumer and staff responses indicated significant differences in staff and consumer scores. All correlations between the Vineland-Z domains and the SIS subscales were significant and negative, ranging from ,0.37 to ,0.89. Conclusions Analyses of the inter-respondent reliability suggest that one needs to consider the source of information regarding needed supports carefully. The significant negative correlations between SIS and Vineland-Z reflect that the SIS is measuring a different construct (needed support) than the Vineland-Z (adaptive behaviour). The results of the two studies provide additional support for the etic (universal) properties of the SIS, as both hypotheses were confirmed. In conclusion, SIS users are provided with a wealth of information that can be used for multiple purposes. [source] Modulation of inflammation in brain: a matter of fatJOURNAL OF NEUROCHEMISTRY, Issue 3 2007Akhlaq A. Farooqui Abstract Neuroinflammation is a host defense mechanism associated with neutralization of an insult and restoration of normal structure and function of brain. Neuroinflammation is a hallmark of all major CNS diseases. The main mediators of neuroinflammation are microglial cells. These cells are activated during a CNS injury. Microglial cells initiate a rapid response that involves cell migration, proliferation, release of cytokines/chemokines and trophic and/or toxic effects. Cytokines/chemokines stimulate phospholipases A2 and cyclooxygenases. This results in breakdown of membrane glycerophospholipids with the release of arachidonic acid (AA) and docosahexaenoic acid (DHA). Oxidation of AA produces pro-inflammatory prostaglandins, leukotrienes, and thromboxanes. One of the lyso-glycerophospholipids, the other products of reactions catalyzed by phospholipase A2, is used for the synthesis of pro-inflammatory platelet-activating factor. These pro-inflammatory mediators intensify neuroinflammation. Lipoxin, an oxidized product of AA through 5-lipoxygenase, is involved in the resolution of inflammation and is anti-inflammatory. Docosahexaenoic acid is metabolized to resolvins and neuroprotectins. These lipid mediators inhibit the generation of prostaglandins, leukotrienes, and thromboxanes. Levels of prostaglandins, leukotrienes, and thromboxanes are markedly increased in acute neural trauma and neurodegenerative diseases. Docosahexaenoic acid and its lipid mediators prevent neuroinflammation by inhibiting transcription factor NF,B, preventing cytokine secretion, blocking the synthesis of prostaglandins, leukotrienes, and thromboxanes, and modulating leukocyte trafficking. Depending on its timing and magnitude in brain tissue, inflammation serves multiple purposes. It is involved in the protection of uninjured neurons and removal of degenerating neuronal debris and also in assisting repair and recovery processes. The dietary ratio of AA to DHA may affect neurodegeneration associated with acute neural trauma and neurodegenerative diseases. The dietary intake of docosahexaenoic acid offers the possibility of counter-balancing the harmful effects of high levels of AA-derived pro-inflammatory lipid mediators. [source] IMPACTS OF CLIMATE CHANGE ON MISSOURI RWER BASIN WATER YIELD,JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION, Issue 5 2001Mark C. Stone ABSTRACT: Water from the Missouri River Basin is used for multiple purposes. The climatic change of doubling the atmospheric carbon dioxide may produce dramatic water yield changes across the basin. Estimated changes in basin water yield from doubled CO2 climate were simulated using a Regional Climate Model (RegCM) and a physically based rainfall-runoff model. RegCM output from a five-year, equilibrium climate simulation at twice present CO2 levels was compared to a similar present-day climate run to extract monthly changes in meteorologic variables needed by the hydrologic model. These changes, simulated on a 50-km grid, were matched at a commensurate scale to the 310 subbasin in the rainfall-runoff model climate change impact analysis. The Soil and Water Assessment Tool (SWAT) rainfall-runoff model was used in this study. The climate changes were applied to the 1965 to 1989 historic period. Overall water yield at the mouth of the Basin decreased by 10 to 20 percent during spring and summer months, but increased during fall and winter. Yields generally decreased in the southern portions of the basin but increased in the northern reaches. Northern subbasin yields increased up to 80 percent: equivalent to 1.3 cm of runoff on an annual basis. [source] Wiki a la carte: Understanding participation behaviorsPROCEEDINGS OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE & TECHNOLOGY (ELECTRONIC), Issue 1 2007Pnina Shachaf Organizer This panel focuses on trends in research on Wikis. Wikis have become prevalent in our society and are used for multiple purposes, such as education, knowledge sharing, collaboration, and coordination. Similar to other popular social computing tools, they raise new research questions and have attracted the attention of researchers in information science. While some focus on the semantic web, the automatic processing of data accumulated by users, and tool improvements, others discuss social implications of Wikis. This panel presents five studies that address the social uses of Wikis that support information sharing. In their studies, the panelists use a variety of novel applications of research methods, such as action research, and online ethnography, site observation, survey, and interviews. The panelists will present their findings: Shachaf and Hara will discuss Wikipedians' norms and behaviors; Bonk will present collaborative writing on Wikibook; Mackey will discuss authorship and collaboration in PBwiki.com; Hemminger will share results from the early use of wikis for conference communications; and Stvilia will outline the community mechanism of information quality assurance in Wikipedia. [source] Rethinking groundwater monitoring at the Hanford SiteREMEDIATION, Issue 2 2000Daniel Michael Groundwater monitoring at Department of Energy's (DOE's) Hanford Site is a large, expensive undertaking serving multiple purposes, including compliance with regulations and DOE orders, remediation efforts under CERCLA, and sitewide risk evaluations. Like most large Federal facilities, the monitoring program currently in place has evolved and grown overtime as new requirements were established and groups were assigned to address them. DOE and its regulators simultaneously awakened to the fact that there was a need to reevaluate the monitoring activities at Hanford, to better integrate the program, to avoid duplicative sampling, to improve everyone's understanding of the performance of the network, and to evaluate whether adequate data could be collected for lower cost. This paper describes the approch that was developed to guide the rethinking effort with direct and extensive involvement of DOE, EPA, Washington Department of Ecology, Indian Tribes, and DOE Contractors, and how this approach was applied to a large portion of the site. Both the human element of the process (cultural change), as well as some of the technical details associated with the effort, including a flexible application of EPA's data quality objectives process, are discussed. [source] Bridging the educational research-teaching practice gapBIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION, Issue 1 2010Tools for evaluating the quality of assessment instruments Abstract Student assessment is central to the educational process and can be used for multiple purposes including, to promote student learning, to grade student performance and to evaluate the educational quality of qualifications. It is, therefore, of utmost importance that assessment instruments are of a high quality. In this article, we present various tools that instructors could use, both to improve instrument design and validity before presentation to students and, to evaluate the reliability and quality of the assessment after students have answered the questions. In keeping with our goals of the Bridging-the-Gap series, we also present various ideas from the educational literature regarding the evaluation of assessment quality and end with a list of criteria that instructors could use to guide their evaluation process. [source] | |||||||||||||