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Multiple Challenges (multiple + challenge)

Distribution by Scientific Domains

Life Sciences	60%

Selected Abstracts

The First-Episode Psychosis Outcome Study: premorbid and baseline characteristics of an epidemiological cohort of 661 first-episode psychosis patients

EARLY INTERVENTION IN PSYCHIATRY, Issue 2 2007
Philippe Conus
Abstract Aims:, Studies conducted in first-episode psychosis (FEP) samples avoid many biases. However, very few studies are based on epidemiological cohorts treated in specialized FEP services. The aim of this file audit study was to examine premorbid and baseline characteristics of a large epidemiological sample of FEP. Methods:, File audit study of all patients admitted to the Early Psychosis Prevention and Intervention Centre between 1998 and 2000 using a specialized questionnaire. Results:, There were 661 patient files included in the study. Premorbid evaluation revealed high rates of substance use disorder (74.1%), history of psychiatric disorder (47.5%), past traumatic events (82.7%) suicide attempts (14.3%) and family history of psychiatric illness (55.6%). Baseline characteristics revealed high intensity of illness (mean CGI 5.5), high prevalence of lack of insight (62%) and high rate of comorbidity (70%). Conclusion:, High rates of traumatic events or episodes of mental illness before treatment for FEP must be considered when designing treatment approaches because a too narrow focus on positive psychotic symptoms will inevitably lead to incomplete treatment. Additionally, early intervention programmes need sufficient range of resources to address the multiple challenges presented by FEP patients such as high severity of illness, comorbidities and functional impairment. Finally, observation of an important degree of functional impairment despite short duration of untreated psychosis suggests that while early detection of FEP is a necessary step in early intervention, it may not be sufficient to improve functional recovery in psychosis and that efforts aimed at identifying people during the prodromal phase of psychotic disorders should be pursued. [source]

Liquid chromatography on chip

ELECTROPHORESIS, Issue 15 2010
Karine Faure
Abstract LC is one of the most powerful separation techniques as illustrated by its leading role in analytical sciences through both academic and industrial communities. Its implementation in microsystems appears to be crucial in the development of ,-Total Analysis System. If electrophoretic techniques have been widely used in miniaturized devices, LC has faced multiple challenges in the downsizing process. During the past 5 years, significant breakthroughs have been achieved in this research area, in both conception and use of LC on chip. This review emphasizes the development of novel stationary phases and their implementation in microchannels. Recent instrumental advances are also presented, highlighting the various driving forces (pressure, electrical field) that have been selected and their respective ranges of applications. [source]

China's South-to-North Water Transfer Project: Is it Needed?

GEOGRAPHY COMPASS (ELECTRONIC), Issue 9 2010
Chansheng He
China has started the construction of the South-to-North Water Transfer Project (SNWTP; its magnitude is even greater than the Three Gorges Dam Project), to deliver about 45 billion m3 of water from the Yangtze River to the water starving North China Plain. Is the project needed given the multiple socioeconomic, engineering, and environmental challenges and controversies it is facing and the effects of demand management programs China has been implementing in recent years? This article, through the analysis of the water shortage problems in the North China Plain and the Yellow River basin, demonstrates that considering China's current economic base, technological capacity, and income levels, the SNWTP, while facing multiple challenges, is still needed to relieve the water deficit problems in the North China Plain. However, the SNWTP is only a partial solution to North China's chronic water shortage problem. China should continue to actively implement and enforce its demand management programs nationwide to ensure that its limited fresh water resources are used to meet the multiple needs of human societies and ecosystems in a socially responsible, economically viable, and environmentally sustainable way. [source]

Relevance of genetically modified crops in light of future environmental and legislative challenges to the agri-environment

ANNALS OF APPLIED BIOLOGY, Issue 3 2009
M. O'Brien
Abstract A key challenge for countries like Ireland up to 2030 is to produce sufficient supplies of food, feed and fuel, without compromising on public health or negatively impacting the environment. As we progress through the technology era, certain agricultural technologies [e.g. genetically modified (GM) crops] have been championed to maximise production while minimising environmental impact. Yet, multiple arguments have been made to counter such a claim, which has led to a polarisation of opinions and a plethora of generic commentaries being made in regard to the impact of this technology. Yet, few studies within the European Union (EU) have conducted a critical needs analysis to assess the potential of specific GM traits in light of issues, such as climate change, increased environmental legislation (e.g. EU Water Framework, Nitrates Directive, proposed reform to the Pesticide Directive and Common Agricultural Policy reform), mitigating biodiversity loss and sustainable biofuel production. The goal of this study is to collate a register of GM traits such that a list of potential GM crops could be prioritised against the backdrop of the challenges facing the tillage sector. Clearly, the crops with the most significant potential for genetic modification are those that are grown widely and/or receive high applications of pesticides and fertilisers (e.g. potato, wheat, barley and maize). GM traits with significant agronomic potential include late blight resistant potato, Fusarium head blight resistant wheat and Septoria resistant wheat and herbicide-tolerant winter oilseed rape and maize. Following on from these, crops with enhanced nitrogen-use efficiency could provide significant input to the tillage sector in light of EU-based restrictions on nitrogen usage, crops with elevated protein content could offset the costs of imported animal feed and crops with modified oil content/lignocellulose composition could assist in biodiesel/bioenergy production at a regional level. This study is relevant to other European countries that cultivate similar crops and like Ireland, are facing multiple challenges to their tillage sector in the near future. [source]

Hypothesis: Could Epstein-Barr virus play a role in the development of gastroschisis?

BIRTH DEFECTS RESEARCH, Issue 2 2010
Martha M. Werler
BACKGROUND: The strong inverse association between maternal age and risk of gastroschisis in offspring has spurred many investigators to hypothesize that behaviors among younger females are the cause. Examples include cigarette smoking, illicit drugs, genitourinary infections, and sexually transmitted diseases, each of which has been reported to be associated with gastroschisis. Although these exposures are more common in young women, recent studies have shown that cigarette smoking, genitourinary infections, and sexually transmitted diseases are most strongly associated with gastroschisis in older women. There is both anecdotal and published evidence showing that gastroschisis sometimes (but not always) occurs in clusters, raising the possibility that an infectious agent might be involved in its pathogenesis. RESULTS: One such agent whose epidemiologic characteristics parallel those of gastroschisis is Epstein-Barr virus (EBV). Primary EBV infection in early childhood has been decreasing over time, leaving a greater proportion of adolescents at risk, as reflected by increased rates of infectious mononucleosis over time. During the childbearing years, risk of primary EBV infection decreases dramatically, as does risk of gastroschisis. The stronger risks of gastroschisis associated with cigarette smoking, genitourinary infections, and sexually transmitted diseases in older women might be explained by EBV reactivation resulting from multiple challenges to immune response such as pregnancy, age, toxic exposures, and genitourinary and sexually transmitted infections. CONCLUSION: EBV and other herpes viruses should be added to the research agenda for gastroschisis. Birth Defects Research (Part A) 2010. © 2009 Wiley-Liss, Inc. [source]