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Muscle Enzymes (muscle + enzyme)
Selected AbstractsThe clinical presentation of mitochondrial diseases in children with progressive intellectual and neurological deterioration: a national, prospective, population-based studyDEVELOPMENTAL MEDICINE & CHILD NEUROLOGY, Issue 5 2010CHRISTOPHER M VERITY Aim, Our aim was to study the clinical presentation, mode of diagnosis, and epidemiology of mitochondrial disorders in children from the UK who have progressive intellectual and neurological deterioration (PIND). Method, Since April 1997, we have identified patients aged 16 years or younger with suspected PIND through the monthly notification card sent to all UK consultant paediatricians by the British Paediatric Surveillance Unit. Clinical details obtained from reporting paediatricians are classified by an Expert Group. Results, By July 2008, 2493 cases of PIND had been reported, among which there were 112 children (69 males, 43 females) with mitochondrial diseases presenting between birth and 14 years 7 months (median 12mo), divided into 13 subgroups. In some instances, clinical features were characteristic of mitochondrial disease, but many children presented non-specifically with combinations of developmental delay, hypotonia, failure to thrive, and seizures; 16 children had multisystem disease at presentation. Mortality was high: 40 children had died. Blood and/or cerebrospinal fluid lactate measurements were abnormal in 87 children, and 47 of 78 brain magnetic resonance images showed increased basal ganglia signal. Definite diagnoses were usually made by muscle enzyme or genetic studies. Interpretation, This is a unique population-based study of the mitochondrial disorders that cause childhood neurodegenerative disease. It provides detailed information about the clinical presentation and investigation of these complex cases. [source] Bilateral degenerative suspensory desmitis with acute rupture in a Standardbred coltEQUINE VETERINARY EDUCATION, Issue 6 2010K. D. Miller Summary A 3-month-old Standardbred colt was examined for acute, bilateral hindlimb swelling and lameness. Serum chemistry demonstrated elevated muscle enzymes (AST, ALT, LDH and CK). Radiographs of the hindlimbs demonstrated intact proximal sesamoid bones that were displaced distally and subluxation of the pastern joints. Ultrasonography of the affected areas revealed large, diffuse hypoechoic areas in the bodies of both hind suspensory ligaments consistent with bilateral rupture. Histology of the lesions was consistent with degenerative suspensory desmitis with acute rupture. [source] Analysis of the factors related with mate choice and reproductive success in male three-spined sticklebacksJOURNAL OF FISH BIOLOGY, Issue 5 2000E. R. Cubillos Territorial three-spined sticklebacks moved 5·3 times as far as non-territorial males in 2 min (P < 0·001) and spent 11·1 times longer in aggression in the pools (P< 0·001). Territorial males had slightly higher condition factors than non-territorial males. Condition factor was correlated positively with the gonad mass (P< 0·006), carotenoid concentration (P< 0·006) and the activity of CS in the axial muscle (P< 0·05) and lactate dehydrogenase (LDH) in pectoral muscle (P < 0·003). The male traits best correlated positively with female mate choice were courtship effort (P< 0·001), coloration (P< 0·003) and initial condition (P< 0·025). Courtship behaviour was related to intestine mass (P< 0·018), axial (P< 0·028) and pectoral muscle citrate synthase (CS) activity (P< 0·047); coloration was related to gonad mass (P< 0·037). These muscle enzymes may be involved in ATP generation for sustained activities or in recuperation between bouts of burst activity. Females that choose to mate with assiduously courting males which bear higher CS levels may be choosing individuals that show honestly their good condition and capacity to accomplish reproductive tasks. [source] A case of benign acute childhood myositis associated with influenza A (H1N1) virus infectionCLINICAL MICROBIOLOGY AND INFECTION, Issue 2 2010M. Koliou Clin Microbiol Infect 2010; 16: 193,195 Abstract Benign acute childhood myositis (BACM) is a rare transient condition usually occurring at the early convalescent phase of a viral upper respiratory tract illness, normally influenza A, and, more frequently, influenza B infection. It is characterized by acute-onset difficulty in walking as a result of severe bilateral calf pain and by elevated muscle enzymes including creatinine kinase. It is self-limiting because there is rapid full recovery usually within 1 week. We describe the first case of BACM in association with the new pandemic influenza A (H1N1) virus infection in an 11-year-old boy from Cyprus. The child had the typical clinical and laboratory characteristics of this clinical syndrome. Prompt diagnosis of this clinical entity is essential to prevent unnecessary investigations and therapeutic interventions and to reassure the patient and parents of the excellent prognosis. [source] | ||||||||||