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Monolithic Integration (monolithic + integration)
Selected AbstractsSDS-CGE of proteins in microchannels made of SU-8 filmsELECTROPHORESIS, Issue 18 2006Maria Agirregabiria Abstract This work describes the SDS-CGE of proteins carried out in microchannels made of the negative photoresist EPON SU-8. Embedded electrophoretic microchannels have been fabricated with a multilayer technology based on bonding and releasing steps of stacked SU-8 films. This technology allows the monolithic integration of the electrodes in the device. A high wafer fabrication yield and mass production compatibility guarantees low costs and high reliability. A poly(methyl methacrylate) (PMMA) packaging allows an easy setup and replacement of the device for electrophoresis experiments. In addition, the wire-bonding step is avoided. The electrophoretic mobilities of four proteins have been measured in microchannels filled with polyacrylamide. Different pore sizes have been tested obtaining their Ferguson plots. Finally, a separation of two proteins (20 and 36,kDa) has been carried out confirming that this novel device is suitable for protein separation. A resolution of 2.75 is obtained. This is the first time that this SU-8 microfluidic technology has been validated for SDS-CGE of proteins. This technology offers better separation performance than glass channels, at lower costs and with an easy packaging procedure. [source] Integrated on-chip derivatization and electrophoresis for the rapid analysis of biogenic aminesELECTROPHORESIS, Issue 14 2004Nigel P. Beard Abstract We demonstrate the monolithic integration of a chemical reactor with a capillary electrophoresis device for the rapid and sensitive analysis of biogenic amines. Fluorescein isothiocyanate (FITC) is widely employed for the analysis of amino-group containing analytes. However, the slow reaction kinetics hinders the use of this dye for on-chip labeling applications. Other alternatives are available such as o -phthaldehyde (OPA), however, the inferior photophysical properties and the UV ,max present difficulties when using common excitation sources leading to a disparity in sensitivity. Consequently, we present for the first time the use of dichlorotriazine fluorescein (DTAF) as a superior in situ derivatizing agent for biogenic amines in microfluidic devices. The developed microdevice employs both hydrodynamic and electroosmotic flow, facilitating the creation of a polymeric microchip to perform both precolumn derivatization and electrophoretic analysis. The favorable photophysical properties of the DTAF and its fast reaction kinetics provide detection limits down to 1 nM and total analysis times (including on-chip mixing and reaction) of <60 s. The detection limits are two orders of magnitude lower than current limits obtained with both FITC and OPA. The optimized microdevice is also employed to probe biogenic amines in real samples. [source] Structural Characterization of Multi-Quantum Wells in Electroabsorption-Modulated Lasers by using Synchrotron Radiation Micrometer-BeamsADVANCED MATERIALS, Issue 18 2010Lorenzo Mino Advanced optoelectronic devices require monolithic integration of different functions at chip level. This is the case of multi-quantum well (MQW) electro absorption modulated lasers (EMLs) realized by using the selective area growth (SAG) technique, and which can be employed in long-distance, high-frequency optical fiber communication applications. We demonstrate that a micrometer-resolved X-ray beam available at third-generation synchrotron radiation sources allows direct measurement of determinant structural parameters of MQW EML structures. [source] From lumped-element circuits to monolithic integrated circuits: A contribution to RF and microwave mixer designINTERNATIONAL JOURNAL OF RF AND MICROWAVE COMPUTER-AIDED ENGINEERING, Issue 4 2005Peter Waldow Abstract This article deals with the mixer design for UHF-, microwave- and millimeter-wave applications. Thereby, several aspects such as the chosen technology (lumped elements, hybrid- or monolithic integration) and the applied transmission line (printed circuits, strip-, slot- or coplanar line) are considered. During the course of this contribution, the authors point out the developments in mixer design from lumped-element circuits to monolithic integrated circuits on the example of research activities in Duisburg and Kamp-Lintfort, Germany. The results of these scientific investigations, regarding both the theoretical and experimental aspects, show the feasibility of the proposed techniques. © 2005 Wiley Periodicals, Inc. Int J RF and Microwave CAE, 2005. [source] 60 GHz SoC/SoP radio system for high data-rate transmissionMICROWAVE AND OPTICAL TECHNOLOGY LETTERS, Issue 3 2010K. C. Eun Abstract We present the 60 GHz CMOS and system-on-package (SoP) research activities in Korea Advanced Institute of Science and Technology for high data-rate and short-range wireless communication. A low-power single-chip resonant frequency CMOS receiver for 60 GHz mobile terminals consists of four-stage current reuse LNA, resistive mixer, Ka-band low-phase noise VCO, high-suppression frequency doubler, and two-stage current reuse drive amplifiers. The receiver conversion gain and input P1dB are ,9.5 dB and ,12.5 dBm, respectively, with a size of 2.67 × 0.75 mm2 and power consumption of 21.9 mW. The integration and communication tests of a transmitter/receiver (Tx/Rx) radio have been demonstrated at a data rate of 3 Gbps for short-range transmission and with a communication distance of over 3.5 m at 650 Mbps data rate. The design and fabrication of mmW subcircuits, such as low-loss transmission lines and transitions with noble air cavity structures, a high-Q resonator using zigzagged dual-row via posts and a ,/4 short stub, and the monolithic integration of band-pass filter and antennas, have been performed for low-temperature cofired ceramic SoP integration with a size of 37 × 11 mm2 for the whole Tx or Rx radio. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 667,673, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25024 [source] Integrated fluorescence sensor based on ring-shaped organic photodiodesPHYSICA STATUS SOLIDI - RAPID RESEARCH LETTERS, Issue 7 2010Bernhard Lamprecht Abstract We demonstrate a novel sensor type, which is based on the monolithic integration of luminescent optical sensor spots together with ring-shaped thin-film organic photodiodes on one substrate. The organic photodiodes serve as integrated fluorescence detectors, simplifying the detection system by minimizing the number of required optical components. The proposed concept enables filter-less discrimination between excitation light and generated fluorescence light. The functionality of the concept is demonstrated by an integrated oxygen sensor, exhibiting excellent performance. The sensor spots are excited by an assembled organic light emitting diode. The integrated optical sensor platform is suitable for the parallel detection of multiple parameters. Sensor schemes for the analytical parameters carbon dioxide, temperature and ammonia, are proposed. (© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Low-Creep Metallic Thin Films and Reflective Coatings for Optical MicrosystemsPLASMA PROCESSES AND POLYMERS, Issue S1 2007Jan U. Schmidt Abstract The large-scale integration of analog operable MEMS micromirrors onto active CMOS address circuitry involves several challenges. Mirror actuators must be fabricated using CMOS compatible technology, exhibit highly reflecting planar optical surfaces, and stable analog deflection-voltage characteristics not compromised by drift or creep effects. CMOS integration imposes strict limits depending on the range of available materials and the restricted temperature budget. Highly elastic materials such as single-crystalline Si or poly-SiGe have been integrated by layer transfer bonding or PECVD deposition, respectively. In this paper, a novel approach, i.e., the low-temperature monolithic integration of creep-resistant all-sputtered glassy TiAl mirror actuators with Al reflective coating is presented. [source] | |||||||||||||