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Minor Changes (minor + change)
Kinds of Minor Changes Selected AbstractsDeltas in the Abisko area, northern Sweden: the Abiskojokka delta in lake TorneträskGEOGRAFISKA ANNALER SERIES A: PHYSICAL GEOGRAPHY, Issue 3-4 2002Hans Andrén Several small river deltas are found within the Abisko area. This study deals with the Abiskojokka delta in Lake Torneträsk. The aim is to describe the recent delta and its morphological development since the middle 1960s. In the apex of the delta, bars consist of boulders and cobbles while the mouth,bars are built by pebbles, gravel and to some extent sand. Birch vegetation is found on the sandy levées while willows and sedges dominate the interlevée basins. Mouth bars close to the lake generally lack vegetation. A comparison of the map in the present study with a map from 1965 shows comparatively small changes since 1964. Similar results are achieved when comparing aerial photographs from 1959 and 2000. Thus, the growth of the Abiskojokka delta is rather small compared to several other deltas in the Scandinavian mountains. This low growth rate is a result of upstream lakes trapping the major part of the fluvial sediments. Therefore, most of the delta sediment is redistributed old glaciofluvial material from the terraces within the Abiskojokka valley. Some material might also emanate from the Abiskojokka canyon. Formation of the main part of the delta is probably associated with the lowering of the Torneträsk ice,lakes, during and after the deglaciation of the region. Although some extreme rainstorm events have occurred in the area during recent decades, the effects of these on the delta are small. The result of such events is, however, visible as deposition of sand and silt on the levées after flooding. On the other hand, the shoreline and the mouth bars are continuously changing due to rather high wave energy especially during northerly winds. Along several mouth bars, spits are formed and reformed due to wave action. Minor changes of, and within, the two main distributaries have also been noticed, especially as bank erosion and redistribution of bars. The project will continue with a survey of the distal slope (foreset slope) of the delta as well as a study (including X,ray radiography) of the bottom sediments in Lake Torneträsk close to the delta front. The upstream deltas within this drainage basin as well as other deltas within the Torneträsk region will be studied. [source] A spectroscopic investigation into the interactions of 3,- O -carboxy esters of thymidine with bovine serum albuminBIOPOLYMERS, Issue 9 2009Kalyan Sundar Ghosh Abstract Binding studies of 3,-O-carboxy esters of thymidine, reported inhibitors of ribonucleases, with bovine serum albumin (BSA) have been explored in this report. Fluorescence spectroscopy in combination with Fourier transform infrared (FTIR) and circular dichroism (CD) spectroscopy have been used to determine the nature and mode of binding. The binding and quenching parameters were determined from tryptophan fluorescence quenching by Scatchard plots and modified Stern,Volmer plots. The association constants are of the order of 104 M,1 for both the ligands. Thermodynamic parameters suggest that apart from an initial hydrophobic association, hydrogen bonding and van der Waals interactions play a decisive role during protein-ligand complex formation. Minor changes were observed in the secondary structures of human serum albumin (HSA) as revealed by FTIR and CD. Docking studies suggest that the ligands are close to Trp 213, which causes fluorescence quenching. © 2009 Wiley Periodicals, Inc. Biopolymers 91: 737,744, 2009. This article was originally published online as an accepted preprint. The "Published Online" date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com [source] One-Stage Operative Procedure Using Two Different Implant Systems: A Prospective Study on Implant Overdentures in the Edentulous MandibleCLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, Issue 4 2001Andrew Tawse-Smith DDS, Cert Perio (Göteborg) ABSTRACT Background: Evidence-based reports are needed to support the application of a one-stage surgical protocol for unsplinted implants supporting mandibular overdentures. Purpose: To examine the feasibility and success of using two different dental implant systems (originally designed for two-stage operative technique) using a one-stage operative procedure in patients being rehabilitated with implant mandibular overdentures. Materials and Methods: The study sample involved 24 edentulous subjects (aged 55,80 yr) randomly allocated to two different implant systems, one with a machined titanium implant surface (Steri-Oss, Nobel Biocare, Göteborg, Sweden) and the other with a roughened titanium surface (Southern Implants, Ltd., Irene, South Africa). Two unsplinted implants to support implant overdentures were placed in the anterior mandible of all patients, using a standardized one-stage surgical and prosthodontic procedure. Primary stability and bicortical anchorage of the implants was mandatory before healing abutments were connected at the time of implant placement. Implant overdentures and their respective matrices were inserted following a standard 12-week healing period. Data relating to mobility tests, radiographs, and peri-implant parameters were documented at 12, 16, and 52 weeks after surgery. Results: A success rate of 95.8% for the Steri-Oss and 100% for the Southern Implants was found, without any statistically significant differences in the marginal bone loss. Significant changes in Periotest values were observed for both types between 12 and 52 weeks (p <.001). Minor changes were observed in the peri-implant parameters evaluated. Conclusions: These preliminary findings show a successful application of this one-stage approach for unsplinted implants supporting mandibular overdentures with Steri-Oss and Southern Implant Systems. [source] Implant Stability during Initiation and Resolution of Experimental Periimplantitis: An Experimental Study in the DogCLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, Issue 3 2005Lars Sennerby DDS ABSTRACT Background: Histologic studies have demonstrated the possibility to reestablish direct bone-implant contacts after ligature-induced periimplantitis. The influence of the reosseointegration on the stability of implants is not known. Purpose: The aim of the present investigation was to study bone tissue and associated implant stability alterations that occurred during induction and resolution of periimplantitis using resonance frequency analysis (RFA), radiography, and histology. Materials and Methods: Three implants with smooth (turned) or roughened (SLA®) surfaces were placed in each side of the edentulous mandible of four dogs. Experimental periimplantitis was induced for 3 months. Five weeks later, the animals were treated with antibiotics and surgical therapy and were followed for another 6 months. Periapical radiographs and RFA were used to evaluate marginal bone levels and implant stability throughout the study period. After termination, the tissue-implant interface was evaluated by light microscopy in ground sections. Results: There was a linear relationship between radiographic and RFA findings because continuous loss of marginal bone and a decrease in implant stability were observed for both implant surfaces during the periimplantitis period. Antibiotic treatment and surgical therapy resulted in some reosseointegration, which was more marked for the SLA surface. The resonance frequency values corresponded well to the histometric measurements because reosseointegration resulted in an increase in implant stability. Conclusions: The findings from the present study indicate a linear relationship between marginal bone level and resonance frequency value. It is suggested that the RFA technique is sensitive and may be used to detect even a minor change in the level of bone-implant contact. [source] Effects of short-term metformin treatment on insulin sensitivity of blood glucose and free fatty acidsDIABETES OBESITY & METABOLISM, Issue 1 2004S. Iannello Aim:, Based on the known effect of metformin (MET) in improving insulin sensitivity in type 2 diabetes, with the scope to focus the effects on glycaemic and free fatty acids (FFA) levels, we studied the effects of a short-term treatment with this drug in obese subjects and obese patients with diabetes or family history of diabetes (FHD). We used a method to allow us to evaluate the possible difference of insulin sensibility with regard to the insulin action on glycaemia and blood FFA, both in the basal state and during oral glucose tolerance test (OGTT). Methods:, Insulin sensitivity was investigated before and after MET treatment (850 mg bid for 10 days) in seven obese subjects with normal glucose tolerance and without FHD and 13 obese patients with diabetes (n = 7) or FHD (n = 6). By using specifically designed formulae, we calculated four insulin-sensitivity indices (ISI) from basal level (b) and area values (a) (during OGTT) of insulinaemia, glycaemia (gly) or FFA (ffa), namely: ISI (gly)-b, ISI (gly)-a, ISI (ffa)-b and ISI (ffa)-a. Results:, In patients with diabetes or FHD, MET improved ISI (gly)-b (0.79 ± 0.06 vs. 0.59 ± 0.07, p < 0.001) and ISI (gly)-a (0.69 ± 0.09 vs. 0.51 ± 0.07, p < 0.05), whereas only minor changes occurred for ISI (ffa)-b and ISI (ffa)-a. In contrast, in simple obese subjects, MET induced further deterioration of both ISI (gly)-a (0.47 ± 0.07 vs. 0.64 ± 0.10, p < 0.01) and ISI (ffa)-a (0.43 ± 0.07 vs. 0.55 ± 0.08, p < 0.05). Fasting level and total area of lactate were high in the obese patients and were not affected by MET. A statistically significant increase (p < 0.01), however, was observed for the ,decremental' area of lactate in obese subjects with diabetes or FHD, which might probably contribute to the reduction of insulin resistance induced by the drug in these patients. Conclusions:, Although the low number of subjects studied precludes absolute conclusions, data would suggest that MET improved ISI towards glucose but not towards FFA, in the diabetic and ,prediabetic' obese patients, whereas worsened it in the obese subjects without FHD. Therefore, the effects of MET would not be secondary to changes of FFA but rather to a primary action of MET on glucose metabolism. Thus, utilization of MET to treat the insulin resistance in obesity is indicated only in the presence of alterations of glucose metabolism or FHD. [source] GAD65 autoantibody epitopes in adult patients with latent autoimmune diabetes following GAD65 vaccinationDIABETIC MEDICINE, Issue 5 2007L. M. Bekris Abstract Aims Subcutaneous injection of recombinant human GAD65 (rhGAD65) in patients with latent autoimmune diabetes in adults (LADA) correlates with an increase in C-peptide levels. In this study we analysed the effect of rhGAD65 administration on the GAD65-specific autoimmune response. Methods Longitudinal serum samples obtained from LADA patients (n = 47) who received 4, 20, 100 or 500 µg alum-formulated rhGAD65 or placebo by subcutaneous injection twice (4 weeks apart) were analysed for their epitope recognition using GAD65-specific recombinant Fab and GAD65/67 fusion proteins. Results Overall, minor changes in the epitope pattern were observed using either approach. Only in the 500-µg dosage group was an increase in GAD65Ab level associated with a significant increase in the binding to a conformational epitope located at the middle part of GAD65. Conclusions Our data suggest that the apparent beneficial effects of 20 µg alum-formulated recombinant human GAD65 is not explained by changes in the GAD65Ab epitope pattern. [source] Bootstrap simulations for evaluating the uncertainty associated with peaks-over-threshold estimates of extreme wind velocityENVIRONMETRICS, Issue 1 2003M. D. Pandey Abstract In the peaks-over-threshold (POT) method of extreme quantile estimation, the selection of a suitable threshold is critical to estimation accuracy. In practical applications, however, the threshold selection is not so obvious due to erratic variation of quantile estimates with minor changes in threshold. To address this issue, the article investigates the variation of quantile uncertainty (bias and variance) as a function of threshold using a semi-parametric bootstrap algorithm. Furthermore, the article compares the performance of L-moment and de Haan methods that are used for fitting the Pareto distribution to peak data. The analysis of simulated and actual U.S. wind speed data illustrates that the L-moment method can lead to almost unbiased quantile estimates for certain thresholds. A threshold corresponding to minimum standard error appears to provide reasonable estimates of wind speed extremes. It is concluded that the quantification of uncertainty associated with a quantile estimate is necessary for selecting a suitable threshold and estimating the design wind speed. For this purpose, semi-parametric bootstrap method has proved to be a simple, practical and effective tool. Copyright © 2003 John Wiley & Sons, Ltd. [source] Complexes of Yb3+ with EDTA and CDTA , Molecular and Electronic StructureEUROPEAN JOURNAL OF INORGANIC CHEMISTRY, Issue 19 2008Janicki Abstract Two Yb3+ compounds, [C(NH2)3]2[Yb(EDTA)(H2O)2]ClO4·6H2O and [C(NH2)3][Yb(CDTA)(H2O)2]·4H2O, where EDTA is the ethylenediaminetetraacetate anion and CDTA is the trans -1,2-diaminecyclohexane- N,N,N,,N, -tetraacetate anion, were obtained and their crystal structures and spectroscopic properties were determined. In both compounds, the coordination geometries of the eight-coordinate Yb3+ ion are very similar. In each case, the inner sphere of the metal ion consists of four carboxyl oxygen atoms, two nitrogen atoms and two water molecules. The complexes were characterized by UV/Vis/NIR absorption at different temperatures and IR spectroscopy. The spectroscopic results revealed high sensitivity of the electronic 4f13 configuration upon minor changes in the coordination geometry around the Yb3+ ion. These data also demonstrate that species present in solutions of Yb3+,EDTA are similar to those found in the crystal, whereas in solutions of Yb3+,CDTA an equilibrium between at least two different forms exists. For the Yb3+,EDTA complex in solution and in the crystalline state, a charge-transfer transition was detected. Theoretical calculations revealed its complicated (Yb , ligand and ligand , Yb) character.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008) [source] DIVERGENCE WITH GENE FLOW IN THE ROCK-DWELLING CICHLIDS OF LAKE MALAWIEVOLUTION, Issue 5 2000Patrick D. Danley Abstract Within the past two million years, more than 450 species of haplochromine cichlids have diverged from a single common ancestor in Lake Malawi. Several factors have been implicated in the diversification of this monophyletic clade, including changes in lake level and low levels of gene flow across limited geographic scales. The objectives of this study were to determine the effect of recent lake-level fluctuations on patterns of allelic diversity in the genus Metriaclima, to describe the patterns of population structure within this genus, and to identify barriers to migration. This was accomplished through an analysis of allele frequencies at four microsatellite loci. Twelve populations spanning four species within Metriaclima were surveyed. The effect of lake-level fluctuations can be seen in the reduced genetic diversity of the most recently colonized sites; however, genetic diversity is not depressed at the species level. Low levels of population structure exist among populations, yet some gene flow persists across long stretches of inhospitable habitat. No general barrier to migration was identified. The results of this study are interpreted with respect to several speciation models. Divergence via population bottlenecks is unlikely due to the large allelic diversity observed within each species. Genetic drift and microallopatric divergence are also rejected because some gene flow does occur between adjacent populations. However, the reduced levels of gene flow between populations does suggest that minor changes in the selective environment could cause the divergence of populations. [source] Robustness of a 3 min all-out cycling test to manipulations of power profile and cadence in humansEXPERIMENTAL PHYSIOLOGY, Issue 3 2008Anni Vanhatalo The purpose of this study was to assess whether end-test power output (EP, synonymous with ,critical power') and the work done above EP (WEP) during a 3 min all-out cycling test against a fixed resistance were affected by the manipulation of cadence or pacing. Nine subjects performed a ramp test followed, in random order, by three cadence trials (in which flywheel resistance was manipulated to achieve end-test cadences which varied by ,20 r.p.m.) and two pacing trials (30 s at 100 or 130% of maximal ramp test power, followed by 2.5 min all-out effort against standard resistance). End-test power output was calculated as the mean power output over the final 30 s and the WEP as the power,time integral over 180 s for each trial. End-test power output was unaffected by reducing cadence below that of the ,standard test' but was reduced by ,10 W on the adoption of a higher cadence [244 ± 41 W for high cadence (at an end-test cadence of 95 ± 7 r.p.m.), 254 ± 40 W for the standard test (at 88 ± 6 r.p.m.) and 251 ± 38 W for low cadence (at 77 ± 5 r.p.m.)]. Pacing over the initial 30 s of the test had no effect on the EP or WEP estimates in comparison with the standard trial. The WEP was significantly higher in the low cadence trial (16.2 ± 4.4 kJ) and lower in the high cadence trial (12.9 ± 3.6 kJ) than in the standard test (14.2 ± 3.7 kJ). Thus, EP is robust to the manipulation of power profile but is reduced by adopting cadences higher than ,standard'. While the WEP is robust to initial pacing applied, it is sensitive to even relatively minor changes in cadence. [source] Differences in Local Environment Determine the Site of Physiological Angiogenesis in Rat Skeletal MuscleEXPERIMENTAL PHYSIOLOGY, Issue 5 2003I. Badr The specificity in location of angiogenesis to either glycolytic or oxidative fibre types, or muscle regions, was examined in the tibialis anterior (TA) and extensor digitorum longus (EDL) muscles of rat. Angiogenesis was induced by mechanical means either with (chronic muscle stimulation) or without (muscle stretch by overload) changes in blood flow, treatments which invoked only minor changes in fibre type and fibre size. Proliferation estimated by PCNA labelling of cells co-localised with capillaries was very rare in control muscles, where it occurred mainly in the glycolytic regions, but was increased in both models of angiogenesis. However, when labelled capillaries were scored according to the type of surrounding fibres, only muscle stimulation significantly accentuated proliferation of capillaries surrounded by glycolytic fibres. We conclude that while mechanical stimuli are important for proliferation in glycolytic regions in both models, capillary growth occurs specifically around glycolytic fibres in that region when the angiogenic stimulus includes increased blood flow and/or increased metabolic demand. [source] The crystal structure of phenylpyruvate decarboxylase from Azospirillum brasilense at 1.5 Å resolutionFEBS JOURNAL, Issue 9 2007Implications for its catalytic, regulatory mechanism Phenylpyruvate decarboxylase (PPDC) of Azospirillum brasilense, involved in the biosynthesis of the plant hormone indole-3-acetic acid and the antimicrobial compound phenylacetic acid, is a thiamine diphosphate-dependent enzyme that catalyses the nonoxidative decarboxylation of indole- and phenylpyruvate. Analogous to yeast pyruvate decarboxylases, PPDC is subject to allosteric substrate activation, showing sigmoidal v versus [S] plots. The present paper reports the crystal structure of this enzyme determined at 1.5 Å resolution. The subunit architecture of PPDC is characteristic for other members of the pyruvate oxidase family, with each subunit consisting of three domains with an open ,/, topology. An active site loop, bearing the catalytic residues His112 and His113, could not be modelled due to flexibility. The biological tetramer is best described as an asymmetric dimer of dimers. A cysteine residue that has been suggested as the site for regulatory substrate binding in yeast pyruvate decarboxylase is not conserved, requiring a different mechanism for allosteric substrate activation in PPDC. Only minor changes occur in the interactions with the cofactors, thiamine diphosphate and Mg2+, compared to pyruvate decarboxylase. A greater diversity is observed in the substrate binding pocket accounting for the difference in substrate specificity. Moreover, a catalytically important glutamate residue conserved in nearly all decarboxylases is replaced by a leucine in PPDC. The consequences of these differences in terms of the catalytic and regulatory mechanism of PPDC are discussed. [source] Seasonal response of nutrients to reduced phosphorus loading in 12 Danish lakesFRESHWATER BIOLOGY, Issue 10 2005MARTIN SØNDERGAARD Summary 1.,Concentrations of phosphorus, nitrogen and silica and alkalinity were monitored in eight shallow and four deep Danish lakes for 13 years following a phosphorus loading reduction. The aim was to elucidate the seasonal changes in nutrient concentrations during recovery. Samples were taken biweekly during summer and monthly during winter. 2.,Overall, the most substantive changes in lake water concentrations were seen in the early phase of recovery. However, phosphorus continued to decline during summer as long as 10 years after the loading reduction, indicating a significant, albeit slow, decline in internal loading. 3.,Shallow and deep lakes responded differently to reduced loading. In shallow lakes the internal phosphorus release declined significantly in spring, early summer and autumn, and only non-significantly so in July and August. In contrast, in deep lakes the largest reduction occurred from May to August. This difference may reflect the much stronger benthic pelagic-coupling and the lack of stratification in shallow lakes. 4.,Nitrogen only showed minor changes during the recovery period, while alkalinity increased in late summer, probably conditioned by the reduced primary production, as also indicated by the lower pH. Silica tended to decline in winter and spring during the study period, probably reflecting a reduced release of silica from the sediment because of enhanced uptake by benthic diatoms following the improved water transparency. 5.,These results clearly indicate that internal loading of phosphorus can delay lake recovery for many years after phosphorus loading reduction, and that lake morphometry (i.e. deep versus shallow basins) influences the patterns of change in nutrient concentrations on both a seasonal and interannual basis. [source] MEGX disposition in critically-ill trauma patients: subsequent assessments during the first week following traumaFUNDAMENTAL & CLINICAL PHARMACOLOGY, Issue 6 2002Federico Pea ABSTRACT The objective of this study was to evaluate MEGX disposition as a surrogate marker in assessing the influence that injury may exert on liver function during the first week after the traumatic event in young vs. elderly patients. The MEGX exposure over time was assessed at 0.25, 0.5, 1, 2, 4 and 6 h after the intravenous administration of a 1 mg/kg lidocaine test dose in 12 young and 7 elderly trauma patients on days1, 4 and 7 after a severe injury (Apache II score > 10). MEGX plasma concentration,time profiles were consistently different on day 1 in the elderly vs. young, consistent with a statistically significant lower rate of both lidocaine clearance and MEGX formation, and with a considerably longer MEGX elimination in the elderly than in the young. This suggests an impairment of liver blood flow as a result of splanchnic vasoconstriction occurring mainly in elderly trauma patients. A significant improvement in MEGX disposition occurred on days 4 and 7 vs. the day of trauma in most elderly, whereas minor changes were observed in the young. Multiple factors may account for these major changes in the elderly: the more severe status, the major sensitivity to the pathophysiologic changes induced by trauma, and also at least partially the ageing processes. Although referring to a limited number of observations, our findings on MEGX disposition suggest that liver function may be affected by the severity of injury, even if the influence of age should not be underestimated in these patients. [source] Hemodynamic and Volume Changes during HemodialysisHEMODIALYSIS INTERNATIONAL, Issue 3 2003Robert M. Lindsay Background:,Volume overload is a factor in the hypertension of hemodialysis (HD) patients. Fluid removal is therefore integral to the hemodialysis treatment. Fluid removal by hemodialysis ultrafiltration (UF) may cause intradialytic hypotension and leg cramps. Understanding blood pressure (BP) and volume changes during UF may eliminate intradialytic hypotension and cramps. Studies (S1, S2, and S3) were carried out to determine the amount and direction of changes in body fluid compartments following UF and to determine the relationships between BP, changes in blood volume (,BV), central blood volume (CBV), cardiac output (CO), peripheral vascular resistance (PVR) plus total body water (TBW), and intra- and extracellular fluid volumes (ICF, ECF) in both the whole body and body segments (arms, legs, trunk). Methods:,Indicator dilution technology (Transonic) was used for CBV, CO, and PVR; hematocrit monitoring (Crit-Line) was used for ,BV segmental bioimpedance (Xitron) for TBW, ICF, and ECF. Results:,S1 (n = 21) showed UF sufficient to cause ,BV of ,7% and lead to minor changes (same direction) in CBV and CO, and with cessation of UF, vascular refilling was preferential to CBV. S2 (n = 20) showed that predialysis HD patients are ECF-expanded (ECF/ICF ratio = 0.96, controls = 0.74 [P < 0.0001]) and BP correlates with ECF (r = 0.47, P = 0.35). UF to cause ,BV of ,7% was associated with a decrease in ECF (P < 0.0001) and BP directly (r = 0.46, P = 0.04) plus ,BV indirectly (r = ,0.5, P = 0.024) correlated with PVR, while CBV and CO were maintained. S3 (n = 11) showed that following UF, total-body ECF changes were correlated with leg ECF (r = 0.94) and arm ECF (r = 0.72) but not trunk ECF. Absolute ECF reduction was greatest from the legs. Conclusions:,Predialysis ECF influences BP and UF reduces ,BV and ECF, but CBV and BP are conserved by increasing PVR. ECF reduction is mainly from the legs, hence may cause cramps. Intradialytic hypotension is caused by failure of PVR response. [source] Definitions of hypotension after spinal anaesthesia for caesarean section: literature search and application to parturientsACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 8 2010S. KlÖHR Background: Spinal anaesthesia for caesarean section may cause hypotension, jeopardizing the foetus and its mother. We aimed to identify the spectrum of definitions of hypotension used in the scientific literature. In a second part, we applied these definitions to a prospective cohort in order to evaluate the effect of different definitions on the incidence of hypotension. Methods: A systematic literature search in PubMed was performed from 1999 to 2009 with the search terms ,hypotension' and ,caesarean section'. Consecutive parturients undergoing caesarean section under spinal anaesthesia were included in a prospective study. Results: Sixty-three eligible publications (7120 patients) were retrieved, revealing 15 different definitions of hypotension. A decrease below 80% baseline and the combined definition of a blood pressure below 100 mmHg or a decrease below 80% baseline were the two most frequent definitions, found in 25.4% and 20.6% of the papers, respectively. When applying the spectrum of definitions to a prospective cohort, the incidences of hypotension varied between 7.4% and 74.1%. The incidence increased from 26.7% to 38.5% when using a value below 75% of baseline instead of below 70% of baseline. Conclusion: There is not one accepted definition of hypotension in the scientific literature. The incidence of hypotension varies depending on the chosen definition. Even minor changes of the definition cause major differences in the frequency of hypotension. This makes it difficult to compare studies on interventions to treat/prevent hypotension and probably hampers progress in this area of research. [source] Physicochemical, textural, sensory characteristics and storage stability of goat meat patties extended with full-fat soy paste and soy granulesINTERNATIONAL JOURNAL OF FOOD SCIENCE & TECHNOLOGY, Issue 3 2008Arun K. Das Summary The performance of full-fat soy paste (FFSP) with reduced beany flavour made by simple processing technology was compared with the commercially available textured soy granules in goat meat patties. Addition of soy proteins (soy paste and soy granules) did not significantly affect the emulsion stability and product yield. Shrinkage of patties with soy paste was comparable with control. A significant (P < 0.05) reduction in redness and increase in yellowness of patties was due to addition of soy proteins than in control. Patties with soy paste had comparable but slightly higher total lipid and cholesterol content with that of control but significantly (P < 0.05) higher than patties with soy granules. Lower force was required to compress or shear the sample, as hardness decreased in soy-added patties. Flavour and overall acceptability scores between control and patties with soy paste did not differ significantly, whereas patties with soy granules were rated significantly lower. The patties remained stable with minor changes in physicochemical, microbiological and sensory quality during refrigerated storage (4 ± 1 °C) for 20 days. It is concluded from this study that FFSP had potential application similar to commercially available textured soy granules in comminuted meat products. [source] Comparative theoretical study of small Rhn nanoparticles (2 , n , 8) using DFT methodsINTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, Issue 6 2010V. Bertin Abstract This work is aimed at identifying some key characteristics (energy, geometry, and spin) concerning Rhn particles (2 = n , 8) to perform further studies on adsorption and coadsorption sites of pollutants (CO and NO). The DFT methods of the Gaussian 03 program with the LANL2DZ basis set and the LANL2 potential are used. With the purpose to obtain a better nanoparticles definition, five different functionals were tested: B3LYP, O3LYP, BPW91, BP86, and HCTH; and the corresponding results are used to determine which of them best describes distances, spin, and gives acceptable highest vibration frequency and binding energy values, by comparing these results with values measured or calculated by many other authors. For the structure optimization process of the particles, the initial geometric shape was taken mainly from the literature, using the Rh,Rh distance: 2.67 Å, known for the bulk; and doing a complete optimization. We also considered flat nanoparticles structures, which most of them display three-dimensional structures after the optimization process. The few flat shapes are mainly higher in energy than those of three-dimensional structure. For some Rhn particles for different n values, the spin of the ground state present degeneration. In some cases, the optimization process changes the initial geometry, but in most cases, there are only minor changes in bonds and geometry. © 2009 Wiley Periodicals, Inc. Int J Quantum Chem, 2010 [source] Health Financing in Singapore: A Case for Systemic ReformsINTERNATIONAL SOCIAL SECURITY REVIEW, Issue 1 2006Mukul G. Asher This paper assesses Singapore's healthcare financing arrangements in terms of their efficiency, fairness, and adequacy. Singapore represents an interesting case study because it is perhaps the only high-income, rapidly ageing country to rely on mandatory savings to finance healthcare, thus eschewing extensive risk-pooling arrangements, generally regarded as efficient and equitable. The paper argues that parametric reforms, i.e. relatively minor changes in the parameters of current schemes which preserve the existing philosophy and system design, will not be sufficient to meet healthcare financing objectives. Systemic reforms, which will bring Singapore into the mainstream of health financing arrangements found in the OECD countries, are urgently needed. Their design and timing should be based on good quality, timely and relevant data, and an environment conducive to vigorous debate. [source] Eclogites from the Chinese continental scientific drilling borehole, their petrology and different P-T evolutionsISLAND ARC, Issue 4 2007Yong-Feng Zhu Abstract Four phengite-bearing eclogites, taken from different depths of the Chinese continental scientific drilling (CCSD) borehole in the Sulu ultrahigh pressure terrane, eastern China, were studied with the electron microprobe. The compositional zonations of garnet and omphacite are moderate, whereas phengite compositions generally vary significantly in a single sample from core to rim by decrease of the Si content. Various geothermobarometric methods were applied to constrain the P-T conditions of these eclogites on the basis of the compositional variability of the above minerals. The constrained P-T path for sample B218 is characterized by pressure decrease from ca 3.0 GPa (ca 600°C) to 1.3 GPa (ca 550°C). Eclogite B310 yielded P-T conditions of 3.0 GPa and 750°C. The path for eclogite B1008 starts at about 650°C and 3.6,3.9 GPa (stage I) followed by a pressure decrease to 2.8,3.0 GPa and a significant temperature rise (stages II and IIIa, 750,810°C). Afterwards, this rock cooled down to 620,660°C at still high pressures (2.5,2.7 GPa, stage IIIb). Retrograde conditions were about 670°C and 1.3 GPa (stage IV). Eclogite B1039 yielded a P-T path starting at ca 600°C and 3.3,3.9 GPa (stage I). A pressure decrease to about 3.0 GPa (stage II, 590,610°C) and then a moderate isobaric temperature increase to ca 630°C (stage III) followed. Stage IV is characterized by temperatures of 650°C at pressures close to 1.3 GPa. During and after this stage (hydrous) fluids partially rich in potassium penetrated the rocks causing minor changes. Relatively high oxygen fugacities led to andradite and magnetite among the newly formed minerals. We think that the above findings can be best explained by mass flow in a subduction channel. Thus, we conclude that the assembly of UHP rocks of the CCSD site, eclogites, quartzofeldspathic rocks, and peridotites, cannot represent a crustal section that was already coherent at UHP conditions as it is the common belief currently. The coherency was attained after significant exhumation of these UHP rocks. [source] Effect of bile on the lipid composition and surface properties of bifidobacteriaJOURNAL OF APPLIED MICROBIOLOGY, Issue 5 2002A. Gómez Zavaglia Aim: The changes produced on the bacterial surface of Bifidobacteria cells when they are grown in bile were compared with those provoked by bile added to bacteria grown in the absence of bile. Methods and Results: The adhesive properties, the zeta potential and the lipid composition of Bifidobacterial strains, isolated from human faeces and grown in MRS medium, were determined. Bacteria grown in MRS with bile showed a loss of adherence and autoaggregation in correlation with a decrease in the surface hydrophobicity in comparison to those grown in MRS without bile, concomitant with the absence of two glycolipids, the increase of sugar content and minor changes in fatty acid composition. The surface changes caused by bile shock on bacteria grown in bile-free medium were much less pronounced and, in addition, no effect on the lipid composition was apparent. Conclusions: The comparison of the results indicates that bile action on surface properties is related to metabolic changes. Significance and Impact of the Study: Long-term exposure of bacteria to bile may cause metabolic changes affecting their adhesive properties irreversibly. This may be taken as a criterion to define the probiotic properties of different strains. [source] Relative effectiveness of powered and manual toothbrushes in elderly patients with implant-supported mandibular overdenturesJOURNAL OF CLINICAL PERIODONTOLOGY, Issue 4 2002A. Tawse-Smith Abstract Aim: The aim of this study was to compare the clinical effectiveness of a powered toothbrush (Braun Oral-B Plaque Remover 3-D) and a manual soft toothbrush (Oral-B Squish-grip brush) for the control of supragingival plaque and soft tissue inflammation around implants supporting mandibular overdentures. Material and methods: The study sample involved 40 edentulous subjects, aged 55,80 years, having 2 unsplinted mandibular implants supporting a complete removable overdenture opposed by a maxillary complete denture. In this single-blinded, randomised, cross-over clinical trial, two 6-week experimental phases were separated by a 2-week wash-out period. 2 weeks prior to each experimental phase (pre-entry visits), implant abutments were polished to remove all plaque and a standardised instruction in the use of the toothbrush was given. Modified plaque and bleeding indices were recorded at the start and end of each experimental period. Mean index scores at each phase were analysed using paired t -test, and the mean number of sites showing a change in plaque or mucositis were compared using the Mann-Whitney U -test. Combined data from 2 different implant systems were considered after controlling for implant type. Results: Only minor changes in plaque and bleeding scores were observed following the two test periods. There were no statistically significant differences between the manual and powered toothbrushes. Conclusion: Manual and powered brushes were found to be of comparable efficacy with regard to improvement in peri-implant bleeding and plaque indices. Zusammenfassung Zielsetzung: Untersuchung der klinischen Effektivität einer elektrischen Zahnbürste (Braun Oral-B Plaque Remover 3-D) im Vergleich zu einer weichen Handzahnbürste (Oral-B Squish-grip brush) zur Kontrolle supragingivaler Plaque und Weichgewebsentzündung an Implantaten, die Unterkiefer-Totalprothesen tragen. Material und Methoden: Das Untersuchungskollektiv bestand aus 40 zahnlosen Patienten im Alter zwischen 55 und 80 Jahren, die 2 unverblockte Unterkiefer-Implantate zur Unterstützung einer Totalprothese aufwiesen. Der Oberkiefer war jeweils mit einer total schleimhautgetragenen Prothese versorgt. In dieser einfach verblindeten, randomisierten klinischen Cross-over-Studie wurden 2 6-wöchige experimentelle Phasen von einer 2-wöchigen Auswaschperiode unterbrochen. 2 Wochen vor jeder experimentellen Phase wurden die supragingivalen Implantatflächen von sämtlicher Plaque gereinigt und die Patienten erhielten eine Instruktion im Gebrauch der Zahnbürsten. Modifizierte Plaque- und Blutungsindizes wurden zu Beginn und am Ende jeder experimentellen Phase erhoben. Die Mittelwerte für die Indizes wurden mittels des paarigen t -Tests und die Zahl der Stellen, die eine Veränderung in Plaque und Mucositis aufwiesen, wurden durch den Mann-Whitney U -Test verglichen. Die Daten für 2 Implantatsysteme wurden zusammengefasst, nachdem der Einfluss des Implantatsystems überprüft worden war. Ergebnisse: Es wurden nur geringe Veränderungen der Plaque- und Blutungsindizes am Ende beider Testphasen beobachtet. Ein statistisch signifikanter Unterschied zwischen elektrischer und Handzahnbürste konnte nicht gezeigt werden. Schlussfolgerungen: Hand- und elektrische Zahnbürsten erwiesen sich als gleich effektiv für die Verbesserung periimplantärer Plaque- und Blutungsindizes. Résumé But: Le but de cette étude était de comparer l'efficacité clinique d'une brosse à dent électrique (Plaque remover 3D de Braun Oral B) et une brosse souple manuelle (squish grip d'oral B) pour le contrôle de la plaque supra-gingivale et l'inflammation des tissus mous autour d'implants supportant des overdentures mandibulaires. Matériaux et méthodes: L'échantillon étudié comprenait 40 sujets édentés, âgés de 55 à 80 ans, ayant 2 implants mandibulaires non reliés supportant une overdenture amovible complète et une prothèse maxillaire antagoniste complète. Dans cet essai clinique croisé en aveugle simple, randomisée, 2 phases expérimentales de 6 semaines encadraient une période d'arrêt de 2 semaines. 2 semaines avant chaque phase expérimentale, (visite de pré-entrée), les piliers implantaires étaient polis afin d'éliminer toute la plaque et des instructions standardisées d'utilisation de la brosse étaient données. On notait les indices, de saignement et de plaque modifié, au début et à la fin de chaque période expérimentale. Les notes d'indices moyens à chaque phase étaient analysées par le test t apparié et le nombre moyen de sites présentant une modification de la plaque ou de la mucosite était comparé par le test U de Mann Whitney. Les données combinées des 2 systèmes implantaires étaient considérées après cotrôle pour chaque type d'implant Résultats: De minimes modifications des notes de plaque et de saignement étaient observées après les deux périodes de test. Il n'y avait pas de différences statistiques significatives entre les brosses manuelles et électriques. Conclusion: Les brosses manuelles et électriques ont une efficacité comparable du point de vue de l'amélioration des indices de saignement et de plaque peri-implantaires. [source] Novel computer program for fast exact calculation of accessible and molecular surface areas and average surface curvatureJOURNAL OF COMPUTATIONAL CHEMISTRY, Issue 6 2002Oleg V. Tsodikov Abstract New computer programs, SurfRace and FastSurf, perform fast calculations of the solvent accessible and molecular (solvent excluded) surface areas of macromolecules. Program SurfRace also calculates the areas of cavities inaccessible from the outside. We introduce the definition of average curvature of molecular surface and calculate average molecular surface curvatures for each atom in a structure. All surface area and curvature calculations are analytic and therefore yield exact values of these quantities. High calculation speed of this software is achieved primarily by avoiding computationally expensive mathematical procedures wherever possible and by efficient handling of surface data structures. The programs are written initially in the language C for PCs running Windows 2000/98/NT, but their code is portable to other platforms with only minor changes in input-output procedures. The algorithm is robust and does not ignore either multiplicity or degeneracy of atomic overlaps. Fast, memory-efficient and robust execution make this software attractive for applications both in computationally expensive energy minimization algorithms, such as docking or molecular dynamics simulations, and in stand-alone surface area and curvature calculations. © 2002 Wiley Periodicals, Inc. J Comput Chem 23: 600,609, 2002 [source] Analgesia for labour: a survey of Norwegian practice , with a focus on parenteral opioidsACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 6 2009T. O. TVEIT Background: During the last two decades, epidural analgesia has become ,a gold standard' for labour pain in most Western countries. Newer short-acting opioids given systemically represent an alternative for adequate pain relief without using regional techniques. With this survey, we wish to explore how Norwegian hospitals practice labour analgesia, especially their use of systemic opioids. Methods: A questionnaire was sent to the head of all 46 registered Norwegian labour units in 2005. The questionnaire focused on epidural and the use of systemic opioids. In 2008, the same questionnaire was sent to the 19 largest units reporting >1000 births a year, seeking updated information. Results: Forty-three of the 46 original questionnaires were returned. An epidural frequency of 25.9% was registered. For epidural treatment, bupivacaine was the preferred local anaesthetic, while sufentanil was the opioid of choice for the majority of units. Pethidine was the most commonly used opioid for systemic administration (77%). All units reported nurse administration of systemic opioids. The intramuscular route was most commonly used, either alone (58%) or in combination with an intravenous (i.v.) administration (34%). Only one unit used i.v. fentanyl. There were only minor changes with the repeated survey, except for one large unit, which reported over a 50% increase in the epidural frequency. Conclusion: In Norway, the frequency of epidural for labour analgesia is still relatively low, but seems to be increasing. Systemic opioids are often used instead of or as a supplement. Clinical practice seems to be conservative, and newer short-acting opioids are seldom used systemically. [source] Nondestructive Measurement of Oxygen in Modified Atmosphere Packaged Hams Using a Phase-Fluorimetric Sensor SystemJOURNAL OF FOOD SCIENCE, Issue 8 2002D.B. Papkovsky ABSTRACT: The phase-fluorimetric oxygen sensing system recently developed by our team was used for nondestructive measurement of oxygen content in the heasdspace of 4 types of ham slice products. The system allowed accurate measurement of oxygen levels in all types of ham packs in a contact-less nondestructive fashion; it worked satisfactorily under ambient light and in conditions of direct contact with packaged cooked ham slices and variation of sample temperature. A primary screening for oxygen content of the modified atmosphere packs revealed that a significant proportion of packs contained elevated levels of oxygen. The sensor demonstrated minor changes in calibration as a result of direct physical contact with food and prolonged exposure. [source] Properties of Arrowroot Starch Treated with Aqueous HCl at Ambient TemperatureJOURNAL OF FOOD SCIENCE, Issue 1 2002J.K. John Arrowroot starch was acid-treated using 2.2 M HCl at 29 to 30° C for durations of 0 to 72 h, and properties of the control and modified samples were compared. Increasing length of acid treatment produced a progressive decline in amylose blue value, intrinsic viscosity, and swelling power, as well as an increase in free sugars and solubility. Differential scanning calorimetry (DSC) studies highlighted changes effected by acid-treatment in the gelatinization behavior of the starch samples. Gel permeation chromatography (GPC) studies on 32- and 72-h acid-treated samples indicated a greater proportion of dextrins with a higher percentage of reducing sugars, compared to the control. While X-ray diffraction data suggested minor changes in the crystal phase impacted by acid-treatment, in vitro digestibility of both control and acid-treated samples did not show any appreciable change in overall patterns. [source] Microtopography of metal surfaces influence fibroblast growth by modifying cell shape, cytoskeleton, and adhesionJOURNAL OF ORTHOPAEDIC RESEARCH, Issue 11 2007David O. Meredith Abstract Stainless Steel (SS), titanium (cpTi), and Ti-6Al-7Nb (TAN) are frequently used metals in fracture fixation, which contact not only bone, but also soft tissue. In previous soft tissue cytocompatibility studies, TAN was demonstrated to inhibit cell growth in its "standard" micro-roughened state. To elucidate a possible mechanism for this inhibition, cell area, shape, adhesion, and cytoskeletal integrity was studied. Only minor changes in spreading were observed for cells on electropolished SS, cpTi, and TAN. Cells on "standard" cpTi were similarly spread in comparison with electropolished cpTi and TAN, although the topography influenced the cell periphery and also resulted in lower numbers and shorter length of focal adhesions. On "standard" microrough TAN, cell spreading was significantly lower than all other surfaces, and cell morphology differed by being more elongated. In addition, focal adhesion numbers and mean length were significantly lower on standard TAN than on all other surfaces, with 80% of the measured adhesions below a 2-µm threshold. Focal adhesion site location and maturation and microtubule integrity were compromised by the presence of protruding ,-phase microspikes found solely on the surface of standard TAN. This led us to propose that the impairment of focal adhesion numbers, maturation (length), and cell spreading to a possibly sufficient threshold observed on standard TAN blocks cell cycle progress and eventually cell growth on the surface. We believe, as demonstrated with standard cpTi and TAN, that a difference in surface morphology is influential for controlling cell behavior on implant surfaces. © 2007 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 25:1523,1533, 2007 [source] Assessing Cost-Effectiveness of Sealant Placement in ChildrenJOURNAL OF PUBLIC HEALTH DENTISTRY, Issue 2 2005Rocio B. Quiñonez DMD Abstract Objective: The lack of cost-effectiveness information regarding sealant placement strategies is thought to have influenced reimbursement policies and subsequent sealant utilization in dental practice. This study compared three strategies for managing the occlusal surfaces of first permanent molars: seal all (SA), risk-based (RBS), and seal none (SN). Methods: A decision tree was developed for various possible outcomes following each of the above strategies. Due to the complexity of the decision tree, a Markov model was used to allow for the construction of a chain of events representing the natural history of sealant retention, caries formation, and their associated health states. The outcome measures were the incremental cost per month gained in a cavity-free state over a ten-year period. Results: Our theoretical model showed that RBS strategy improved clinical outcomes, in the form of cavity-free months, and saved money over SN. The strategy of sealing both high and low risk teeth (SA) further improved outcomes but at an additional cost compared to RBS. However, the cost was small, $08 for each additional cavity-free month gained per tooth. Further, minor changes in the baseline assumptions resulted in the SA strategy being the dominant strategy. Conclusion: This study provides evidence that sealing children's first permanent molars can improve outcomes and save money by delaying or avoiding invasive treatment and the destructive cycle of caries. In a time of limited funds for dental services, these results can assist payers in establishing more rational sealant reimbursement policies. [source] Effects of hyperoncotic or hypertonic,hyperoncotic solutions on polymorphonuclear neutrophil count, elastase- and superoxide-anion production: a randomized controlled clinical trial in patients undergoing elective coronary artery bypass graftingACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 7 2007G. P. Molter Background:, Hypertonic,hyperoncotic solutions may be an effective treatment for systemic inflammatory response syndrome (SIRS). With regard to the immunomodulatory effects of these drugs, previous studies demonstrated controversial results. Therefore, the present study investigated the influence of different hyperoncotic and hypertonic,hyperoncotic solutions on polymorphonuclear neutrophil leukocyte (PMNL) count, elastase and superoxide-anion production in patients undergoing elective coronary artery bypass grafting (CABG) with cardiopulmonary bypass. Methods:, Fifty patients scheduled for elective CABG with cardiopulmonary bypass were randomly assigned to five groups: (i) NaCl 0.9%, 750 ml/m2 body surface area (BSA); (ii) hydroxyethylic starch 10%, 250 ml/m2 BSA and NaCl 0.9%, 400 ml/m2 BSA; (iii) dextran 10%, 250 ml/m2 BSA and NaCl 0.9%, 300 ml/m2 BSA; (iv) hypertonic sodium chloride 7.2%/hyperoncotic hydroxyethylic starch 10%, 150 ml/m2 BSA; and (v) hypertonic sodium chloride 7.2%/hyperoncotic dextran 10%, 150 ml/m2 BSA. Blood samples were drawn from arterial, central venous and coronary artery sinus catheters peri-operatively. PMNL count, superoxide-anion production and elastase were recorded. Results:, PMNL counts and elastase activity increased in all groups after reperfusion. Superoxide-anion production showed only minor changes. Between groups, no significant differences were demonstrated. Conclusions:, Infusion of clinically relevant doses of hypertonic,hyperoncotic solution did not affect PMNL count, elastase- or superoxide-anion production during elective CABG with cardiopulmonary bypass. [source] Temperature controlled burn generation system based on a CO2 laser and a silver halide fiber optic radiometerLASERS IN SURGERY AND MEDICINE, Issue 5 2003Meir Cohen MD Abstract Background and Objectives Experimental animal study of burns is dependent on a reliable burn generation system. Most of the experimental systems used today are unable to produce precise partial thickness burns. This limits the ability to study minor changes associated with burn care. The aim of the study was to develop a method for generating burns with a fixed depth using a CO2 laser burn generation system. Materials and Methods The burn generation system was composed of two components: a burn generation device and a temperature sensing and control system. These components were designed to operate together in order to keep a constant, predetermined skin surface temperature during prolonged burn generation. One hundred thirty-eight spot burns were generated on the back of five shaved 450 g male Wistar rats. The rat skin was exposed to a 70°C for 5,60 seconds. The burned areas were excised and underwent evaluation by hematoxylin-eosin-stained slide microscopy. Results A linear correlation was found between the duration of exposure and the average burn depth (r,=,0.93). This correlation is represented by the equation: burn depth in millimeters,=,0.012×,(duration in seconds of skin exposure at 70°C). Conclusions The fiber-optic-controlled laser burn generation system studied is a reliable tool for creating partial thickness as well as full thickness skin burns in rats. Lasers Surg. Med. 32:413,416, 2003. © 2003 Wiley-Liss, Inc. [source] | ||||||||||||||||||||||||||||||||||||||||