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Appropriate Species (appropriate + species)

Distribution by Scientific Domains

Life Sciences	40%

Selected Abstracts

REVIEW: Consilient research approaches in studying gene × environment interactions in alcohol research

ADDICTION BIOLOGY, Issue 2 2010
Kenneth J. Sher
ABSTRACT This review article discusses the importance of identifying gene-environment interactions for understanding the etiology and course of alcohol use disorders and related conditions. A number of critical challenges are discussed, including the fact that there is no organizing typology for classifying different types of environmental exposures, many key human environmental risk factors for alcohol dependence have no clear equivalents in other species, much of the genetic variance of alcohol dependence in human is not ,alcohol specific', and the potential range of gene-environment interactions that could be considered is so vast that maintaining statistical control of Type 1 errors is a daunting task. Despite these and other challenges, there appears to be a number of promising approaches that could be taken in order to achieve consilience and ecologically valid translation between human alcohol dependence and animal models. Foremost among these is to distinguish environmental exposures that are thought to have enduring effects on alcohol use motivation (and self-regulation) from situational environmental exposures that facilitate the expression of such motivations but do not, by themselves, have enduring effects. In order to enhance consilience, various domains of human approach motivation should be considered so that relevant environmental exposures can be sampled, as well as the appropriate species to study them in (i.e. where such motivations are ecologically relevant). Foremost among these are social environments, which are central to the initiation and escalation of human alcohol consumption. The value of twin studies, human laboratory studies and pharmacogenetic studies is also highlighted. [source]

Identification of crucial residues for the antibacterial activity of the proline-rich peptide, pyrrhocoricin

FEBS JOURNAL, Issue 17 2002
Goran Kragol
Members of the proline-rich antibacterial peptide family, pyrrhocoricin, apidaecin and drosocin appear to kill responsive bacterial species by binding to the multihelical lid region of the bacterial DnaK protein. Pyrrhocoricin, the most potent among these peptides, is nontoxic to healthy mice, and can protect these animals from bacterial challenge. A structure,antibacterial activity study of pyrrhocoricin against Escherichia coli and Agrobacterium tumefaciens identified the N-terminal half, residues 2,10, the region responsible for inhibition of the ATPase activity, as the fragment that contains the active segment. While fluorescein-labeled versions of the native peptides entered E. coli cells, deletion of the C-terminal half of pyrrhocoricin significantly reduced the peptide's ability to enter bacterial or mammalian cells. These findings highlighted pyrrhocoricin's suitability for combating intracellular pathogens and raised the possibility that the proline-rich antibacterial peptides can deliver drug leads into mammalian cells. By observing strong relationships between the binding to a synthetic fragment of the target protein and antibacterial activities of pyrrhocoricin analogs modified at strategic positions, we further verified that DnaK was the bacterial target macromolecule. Inaddition, the antimicrobial activity spectrum of native pyrrhocoricin against 11 bacterial and fungal strains and the binding of labeled pyrrhocoricin to synthetic DnaK D-E helix fragments of the appropriate species could be correlated. Mutational analysis on a synthetic E. coli DnaK fragment identified a possible binding surface for pyrrhocoricin. [source]

The conservation management of upland hay meadows in Britain: a review

GRASS & FORAGE SCIENCE, Issue 4 2005
R. G. Jefferson
Abstract Upland hay meadows conforming to MG3 in the National Vegetation Classification of the UK are a rare habitat in Britain and are largely confined to upland valleys in northern England. Agricultural intensification, particularly ploughing and reseeding and a shift from hay-making to silage production over the last 50 years, has resulted in large losses of species-rich upland hay meadows. Remaining species-rich meadows have been the focus of much nature conservation effort resulting in many of the species-rich sites being protected by statutory designations or through voluntary agri-environment scheme agreements. Research and monitoring has tended to confirm that species richness is maximized by management involving spring and autumn grazing, a mid-July hay cut, no inorganic fertilizer and possibly low levels of farmyard manure. Deviations from this regime result in a loss of species richness. Restoration of semi-improved grassland to swards resembling species-rich MG3 also requires a similar regime but is also dependent on the introduction of seed of appropriate species. The role of Rhinanthus minor as a tool for manipulating meadow biodiversity during restoration management is discussed. Suggestions for future research are outlined. [source]

Aboveground biomass estimation of the shrubs, Echiochilon fruticosum (Desf.) and Helianthemum kahiricum (Del.) in the arid zone rangelands of Tunisia

AFRICAN JOURNAL OF ECOLOGY, Issue 1 2010
Abdelkader Idi
Abstract The knowledge of the plant biomass is very important for the assessment of the rangeland productivity. It could help to select the appropriate species for the improvement of natural ecosystems (rehabilitation, restoration and seedling). By examining different correlations between the biomass production and the volume parameters of two North African shrub species of high range value (Echiochilon fruticosum Desf. and Helianthemum kahiricum Del.), we aimed to establish the appropriate regression models, which could be useful for the prediction of the productivity of these species. The data showed a significant relationship between the total biomass (TB) production and the mean diameter (MD) of the studied species (R2 = 0.65 for Echiochilon and R2 = 0.75 for Helianthemum). Likewise, annual fresh production (leaves and current-year shoots) was well correlated with MD of Helianthemum (R2 = 0.82). However, the correlation between these two parameters was relatively low for Echiochilon (R2 = 0.42). Résumé Il est très important de connaître la biomasse végétale pour évaluer la productivité d'un territoire. Il peut être utile de sélectionner les espèces appropriées pour l'amélioration d'écosystèmes naturels (restauration, réhabilitation, plantations). En analysant différentes corrélations entre les paramètres de production de biomasse et de volume de deux espèces d'arbustes nord-africains de grande distribution (Echiochilon fruticosum Desf. et Helianthemum kahiricum Del.), nous avons voulu établir les modèles de régression appropriés qui pourraient servir pour prédire la productivité de ces espèces. Les données ont montré un lien significatif entre la production totale de biomasse et le diamètre moyen des espèces étudiées (R2 = 0.65 pour Echiochilon, et R2 = 0.75 pour Helianthemum). De même, la production annuelle de matière fraîche (feuilles et rameaux de l'année) était bien liée au diamètre moyen pour Helianthemum (R2 = 0.82). Cependant, la corrélation entre ces deux paramètres était relativement faible pour Echiochilon (R2 = 0.42). [source]

Checkpoints and pitfalls in the experimental neuropathology of circulatory disturbance

NEUROPATHOLOGY, Issue 1 2003
Toshihiko Kuroiwa
In neural tissue injury many pathological processes are common to different neurological disorders, including cerebral ischemia. Because ischemia has a fundamentally simple impact on neural tissue, good laboratory modeling can help improve the general understanding of the neuropathological processes involved. Summarized here are some basic principles that should be followed to ensure that cerebral ischemia studies are reproducible and informative: (i) selection of an appropriate model of cerebral ischemia in an appropriate species (although rodents are widely used for genomic studies, the use of larger animals, with brain structures macroscopically similar to those of humans, is appropriate for many studies, e.g. of white matter lesions or the pathophysiology of cerebral edema); (ii) correct maintenance of physiological parameters, including body temperature, systemic blood pressure, and blood gas tensions, under appropriate general anesthesia; (iii) selection of an appropriate method of cerebral blood flow (CBF) monitoring (decisions include whether or not the experiment requires real-time monitoring, in vivo measurement, and CBF mapping); (iv) appropriate timing of drug application in therapeutic studies (many drugs that are effective when given immediately after a short period of ischemi are ineffective in clinical trials, probably because of longer periods of ischemia and delayed drug delivery in clinical settings); and (v) multiparametric evaluation of therapeutic effect (with the recent increase in diagnosis of cases of mild stroke, measurement of mortality and infarct size have proven to be insufficient for the evaluation of therapeutic effect). Use of mild ischemia models and batteries of neurological tests for individual neurological functions, such as motor, somatosensory, and visual function, are becoming important in experimental ischemia research. In histological evaluation, assessment of the extent of both selective neuronal loss and the infarct will become mandatory. Regional analysis of each brain structure and coordination of the results with the apparent neurological dysfunction is a promising approach. [source]