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Appropriate Approach (appropriate + approach)
Selected AbstractsA pedagogical Web service-based interactive learning environment for a digital filter design course: An evolutionary approachCOMPUTER APPLICATIONS IN ENGINEERING EDUCATION, Issue 3 2010Wen-Hsiung Wu Abstract The course of digital filter design in electronic/electrical engineering involves complicated mathematical equations and dynamic waveform variations. It is a consensus among educators that using simulation tools assist in improving students' learning experiences. Previous studies on system simulation seemed to lack an appropriate approach to design such a course. Few emphasized the design of an interactive learning environment by using an evolutionary approach. This study integrated the design concept of an evolutionary approach and Web service-based technology into a simulation system entitled Pedagogical Web Service-Based Interactive Learning Environment (PEWSILE) was introduced. The PEWSILE system contained two interactive learning environments,a simple system and an advanced system. It offered a total of six pedagogical Web services. The simple interactive learning environment included text/color-based services, and text/color/diagram-based services. The advanced interactive learning environment included batch-based, interval change-based, comparison-based, and scroll bar-based services. The study also assessed the students' performance in six pedagogical Web services covering interaction and overall use, usefulness, and intention to use through a questionnaire survey and subsequent interviews. Three significant findings were reported. For example, in the advanced interactive learning environment, the designs of interval change-based and comparison-based services make it easier to observe differences in the outcome of parameter change, while batch-based services lacks the element of waveform comparison. In sum, the findings in this study provide helpful implications in designing engineering educational software. © 2010 Wiley Periodicals, Inc. Comput Appl Eng Educ 18: 423,433, 2010; View this article online at wileyonlinelibrary.com; DOI 10.1002/cae.20163 [source] At-risk mental state (ARMS) detection in a community service center for early attention to psychosis in BarcelonaEARLY INTERVENTION IN PSYCHIATRY, Issue 3 2010Yanet Quijada Abstract Aim: To describe the strategy and some results in at-risk mental state (ARMS) patient detection as well as some of the ARMS clinical and socio-demographical characteristics. The subjects were selected among the patients visited by an Early Care Equipment for patients at high risk of psychoses, in Barcelona (Spain) during its first year in operation. Methods: Descriptive study of the community,team relations, selection criteria and intervention procedure. Description of patient's socio-demographic and symptomatic characteristics according to the different instruments used in detection and diagnoses, taking account of four principal origins of referrals: mental health services, primary care services, education services and social services. Results: Twenty of 55 referred people fulfilled the at-risk mental state criteria, showing an incidence of 2.4 cases per 10 000 inhabitants. They were mainly adolescent males referred from health, education and social services. Overall, negative symptoms were predominant symptoms and the more frequent specific symptoms were decrease of motivation and poor work and school performance, decreased ability to maintain or initiate social relationships, depressed mood and withdrawal. Conclusions: It is possible to detect and to provide early treatment to patients with prodromal symptoms if the whole matrix of the community , including the social services , contributes to the process. The utilization of a screening instrument and a two-phase strategy , the second carried out by the specialized team , seems to be an appropriate approach for early psychosis and ARMS detection. [source] Mouse lymphoma thymidine kinase gene mutation assay: Follow-up meeting of the international workshop on Genotoxicity testing,Aberdeen, Scotland, 2003,Assay acceptance criteria, positive controls, and data evaluation,ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, Issue 1 2006Martha M. Moore Abstract The Mouse Lymphoma Assay (MLA) Workgroup of the International Workshop on Genotoxicity Testing (IWGT), comprised of experts from Japan, Europe, and the United States, met on August 29, 2003, in Aberdeen, Scotland, United Kingdom. This meeting of the MLA Workgroup was devoted to reaching a consensus on the appropriate approach to data evaluation and on acceptance criteria for both the positive and negative/vehicle controls. The Workgroup reached consensus on the acceptance criteria for both the agar and microwell versions of the MLA. Recommendations include acceptable ranges for mutant frequency, cloning efficiency, and suspension growth of the negative/vehicle controls and on criteria to define an acceptable positive control response. The recommendation for the determination of a positive/negative test chemical response includes both the requirement that the response exceeds a defined value [the global evaluation factor (GEF)] and that there also be a positive dose,response (evaluated by an appropriate statistical method). Environ. Mol. Mutagen., 2006. Published 2005 Wiley-Liss, Inc. [source] Agronomic performance and nutritive value of common and alternative grass and legume species in the Peruvian highlandsGRASS & FORAGE SCIENCE, Issue 2 2009K. Bartl Abstract The agronomic performance and nutritive value of twelve annual and perennial grasses and legumes were analysed in order to define alternatives to local forages for dry-season feeding of ruminants in the Peruvian Andes. There were twelve species and two fertilizer treatments (no fertilizer and a N;P;K fertilizer mainly applied at sowing) in an experiment with a randomized complete block design with three replicates at each of two sites. Plant height, soil cover by forage and weed species, frost damage, dry matter (DM) yield and nutritive value of herbage were evaluated in 2005 and 2006. Among the annual species, Hordeum vulgare L. cv. UNA 80 and ×Triticosecale Wittm. had the highest DM yields when fertilized (8226 and 6934 kg ha,1 respectively). Without fertilizer the alternative cultivars had similar DM yields to that of the local forages. Cultivars of Avena sativa L. had lower concentrations of neutral-detergent fibre (NDF) (557 g kg,1 DM) and higher concentrations of predicted net energy for lactation (5·86 MJ kg,1 DM) than the other annual grass species (625 g kg,1 DM and 5·01 MJ kg,1 DM respectively), while the legumes were superior in concentrations of crude protein (277 g kg,1 DM) and NDF (362 g kg,1 DM). Considering the low agronomic performance of the perennial forages, a mixture of fertilized annual grasses and legumes appears the most appropriate approach to meeting the demand for forage of high nutritive value in the Peruvian highlands. [source] Iterative modal perturbation and reanalysis of eigenvalue problemINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING, Issue 4 2003X. L. Liu Abstract This paper presents an examination of the methods for the iterative modal perturbation and the application of these methods to the reanalysis of the eigenvalue problem. The iteration is based on the first-order modal perturbation. In two examples, it is shown that the iterative analysis has the advantage of accuracy over the addition of higher-order perturbations and it is an appropriate approach for the reanalysis of the eigenvalue problem in terms of accuracy and computational efficiency. Copyright © 2003 John Wiley & Sons, Ltd. [source] Optimal setpoint chasing in dynamic positioning of deep-water drilling and intervention vesselsINTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONTROL, Issue 13 2001Asgeir J. Sørensen Abstract Conventional controller designs for dynamic positioning of ships and floating marine structures have so far been based on the principle on automatic positioning in the horizontal-plane about desired position and heading co-ordinates defined by the operator. A three degrees-of-freedom multivariable controller either of linear or nonlinear type, normally with feedback signals from surge, sway and yaw position and velocities, has been regarded as adequate for the control objective. For floating structures with small waterplane area such as semi-submersibles, feedback from roll and pitch angular rotation velocity may also be included to avoid thrust-induced roll and pitch motions that are caused by the hydrodynamic and the geometrical couplings between the horizontal and vertical planes. However, for certain marine operations this control philosophy may not be the most appropriate approach ensuring safety and cost effectiveness. For drilling and work-over operations the main positioning objective is to minimize the bending stresses along the riser and the riser angle magnitudes at the well head on the subsea structure, and at the top joint as well. A positioning control strategy solely based on manual setting of the desired position co-ordinates may not be the most optimal solution for these applications. In this paper a new hybrid dynamic positioning controller, that also accounts for riser angle offsets and bending stresses is proposed. It is shown that a significant reduction in riser angle magnitude can be achieved. Simulations with a drilling semi-submersible demonstrate the effect of the proposed control strategy. Copyright © 2001 John Wiley & Sons, Ltd. [source] Aid, Relief, and Containment: The First Asylum Country and BeyondINTERNATIONAL MIGRATION, Issue 5 2002B.S. Chimni A fundamental problem that confronts the European Union today is how it can maintain its commitment to the institution of asylum while checking irregular migration and the abuse of its asylum system. In order to explore a response to this dilemma the paper addresses the following questions: what role can relief and aid policies play in influencing migration patterns? What should be the appropriate approach to the granting of relief and aid to developing countries of first asylum? Should it be viewed as a part of the larger problem of development or be treated as a distinct issue? What kind of a relief/aid model will help refugees return to post,conflict societies and stop the conflict from reproducing itself? The paper examines two different approaches to address these questions: the alliance,containment approach and the distributive,developmental approach. It also looks at some empirical evidence, which reveals that at present it is a conservative alliance,containment approach that informs EU relief and aid practices. This approach, however, does not help achieve the stated objective of checking abuse of asylum and migration procedures while sustaining a commitment to a liberal asylum regime. The paper goes on to identify the gaps in EU policy and the lessons that can be drawn. It concludes by looking at different policy alternatives and suggesting the adoption of a reformist distributive,developmental model. The implementation of this model holds out the hope of reverting to a more liberal asylum regime while controlling irregular migration and "bogus" asylum seekers, for the reformist distributive developmental model takes a more long,term view of migration trends and also seeks to address the growing North,South divide. [source] An approach for post-market monitoring of potential environmental effects of Bt -maize expressing Cry1Ab on natural enemiesJOURNAL OF APPLIED ENTOMOLOGY, Issue 4 2009O. Sanvido Abstract Post-market monitoring (PMM) consistent with Swiss and European Union legislation should ensure the detection and prevention of adverse effects on the environment possibly deriving from commercial cultivation of genetically modified (GM) crops. Insect-resistant GM crops (such as Bt -maize) raise particular questions regarding disturbances of biological control functions provided by beneficial insects such as predators and parasitoids (so-called natural enemies). Consensus among regulators, scientists and the agricultural biotech industry on appropriate PMM plans allowing the detection and possibly prevention of such adverse effects is still lacking. The aims of this study were to identify the necessity for PMM of Bt -maize expressing Cry1Ab on natural enemies and to develop an appropriate PMM plan. The approach chosen consisted in determining what type of monitoring is most appropriate to address potential effects of Bt -maize on natural enemies during commercial cultivation. This included identifying whether there remain substantial scientific uncertainties that would support case-specific monitoring. Existing pre-market risk assessment data indicate that Bt -maize (Cry1Ab) comprises a negligible risk for disturbances in biological control functions of natural enemies. As a consequence, a faunistic monitoring of specific groups of natural enemies is not considered an appropriate approach to detect failures in biological control functions. Alternatively, an approach is proposed that consists in indirectly analysing biological control functions by surveying outbreaks of maize herbivores. Unusual herbivore outbreaks could indicate failures in biological control functions of natural enemies. Data could be collected via questionnaires addressed to farmers growing Bt -maize. Significant correlations between unusual occurrences of specific maize herbivores and the cultivation of Bt -maize would subsequently need specific studies to determine possible causalities in more detail. The here proposed approach has the advantage of covering different natural enemy groups. It represents a cost-effective strategy to obtain scientifically sound data as a basis for regulatory decision-making. [source] Failure of xenoimplantation using porcine synovium-derived stem cell-based cartilage tissue constructs for the repair of rabbit osteochondral defectsJOURNAL OF ORTHOPAEDIC RESEARCH, Issue 8 2010Ming Pei Abstract The use of xenogeneic tissues offers many advantages with respect to availability, quality control, and timing of tissue harvest. Our previous study indicated that implantation of premature tissue constructs from allogeneic synovium-derived stem cells (SDSCs) facilitated cartilage tissue regeneration. The present study investigated the feasibility of xenoimplantation of SDSC-based premature tissue constructs for the repair of osteochondral defects. Porcine SDSCs were mixed with fibrin gel, seeded in polyglycolic acid (PGA) scaffolds, and cultured in a rotating bioreactor system supplemented for 1 month with growth factor cocktails. The engineered porcine premature tissues were implanted to repair surgically induced osteochondral defects in the medial femoral condyles of 12 rabbits. Three weeks after surgery, the xenoimplantation group exhibited a smooth, whitish surface while the untreated control remained empty. Surprisingly, 6 months after surgery, the xenoimplantation group displayed some tissue loss while the untreated control group was overgrown with fibrocartilage tissue. In the xenoimplantation group, chronic inflammation was observed in synovial tissue where porcine major histocompatibility complex (MHC) class II antigen positively stained in the engulfed foreign bodies. In addition, porcine source cells also migrated from the implantation site and may have been responsible for the observed loss of glycosaminoglycans (GAGs) underneath surrounding articular cartilage. The histological score was much worse in the xenoimplanted group than in the untreated control. Our study suggested that SDSC-based xenogeneic tissue constructs might cause delayed immune rejection. Xenotransplantation may not be an appropriate approach to repair osteochondral defects. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:1064,1070, 2010 [source] Psychogeriatrics in the New Century,Issues and Challenge ,PSYCHOGERIATRICS, Issue 3 2001Kazuo Hasegawa Abstract: Many huge changes have taken place in our own field of psychogeriatrics and psychogeriatric care at the beginning of the new century. The speed of these changes has been extremely rapid, and increasingly difficult problems have emerged. We, thus, must at this juncture gather together our collective wisdom, devise an appropriate approach to the new century, and aggressively tackle those areas that need to be addressed. While predicting the future is by no means an easy task, I would like to discuss the following three points: educational issues, research activities and the psychogeriatric service. I sincerely pray for the future of our psychogeriatric society with a famous religious philosopher Dr. Reinhold Neibuhr "God, grant me the serenity to accept the things I cannot change, the coursjge to change the things I can, and the wisdom to know the difference." [source] Towards a universal product ion mass spectral library , reproducibility of product ion spectra across eleven different mass spectrometersRAPID COMMUNICATIONS IN MASS SPECTROMETRY, Issue 12 2008Chris Hopley Product ion spectra produced by collision-induced dissociation (CID) in tandem mass spectrometry experiments can differ markedly between instruments. There have been a number of attempts to standardise the production of product ion spectra; however, a consensus on the most appropriate approach to the reproducible production of spectra has yet to be reached. We have previously reported the comparison of product ion spectra on a number of different types of instruments , a triple quadrupole, two ion traps and a Fourier transform ion cyclotron resonance mass spectrometer (Bristow AWT, Webb KS, Lubben AT, Halket JM. Rapid Commun. Mass Spectrom. 2004; 18: 1). The study showed that a high degree of reproducibility was achievable. The goal of this study was to improve the comparability and reproducibility of CID product ion mass spectra produced in different laboratories and using different instruments. This was carried out experimentally by defining a spectral calibration point on each mass spectrometer for product ion formation. The long-term goal is the development of a universal (instrument independent) product ion mass spectral library for the identification of unknowns. The spectra of 48 compounds have been recorded on eleven mass spectrometers: six ion traps, two triple quadrupoles, a hybrid triple quadrupole, and two quadrupole time-of-flight instruments. Initially, 4371 spectral comparisons were carried out using the data from eleven instruments and the degree of reproducibility was evaluated. A blind trial has also been carried out to assess the reproducibility of spectra obtained during LC/MS/MS. The results suggest a degree of reproducibility across all instrument types using the tuning point technique. The reproducibility of the product ion spectra is increased when comparing the tandem in time type instruments and the tandem in space instruments as two separate groups. This may allow the production of a more limited, yet useful, screening library for LC/MS/MS identification using instruments of the same type from different manufacturers. Copyright © 2008 John Wiley & Sons, Ltd. [source] Treatment of Laryngeal Carcinomas by Laser Endoscopic Microsurgery ,THE LARYNGOSCOPE, Issue 6 2000Pierre R. Moreau MD Abstract Objectives To determine if laser endoscopic microsurgery is a reliable and appropriate approach in the treatment of laryngeal cancers. Study Design Retrospective study of 160 patients treated from 1988 to 1996 at Liège. Analysis of indication, technique, and oncologic results. Methods Glottic tumors were treated with either type I, type II, or type III cordectomy, with or without conservation of an inferior muscular band, and extended if necessary to all or part of the contralateral cord. For supraglottic cancers, an excision limited to a part of the vestibule, a trans-preepiglottic resection, or a radical supraglottic resection was carried out. Results Our corrected actuarial survival at 5 years was 97% for the 98 infiltrative glottic tumors and 100% for the 18 infiltrative supraglottic and 27 in situ carcinomas. No local recurrences were noted, in either the group of 118 infiltrating cancers (in whom two precancerous lesions were treated with a further laser excision), or in the 27 in situ carcinomas. Local control was thus 100%. One patient died of his cancer, with lung metastases after neck recurrence. Conclusions Like Steiner and Rudert, this series demonstrates the oncologic validity of this surgical approach to the treatment of unadvanced glottic tumors. Unlike these authors' study, however, strict case selection, as in cases with significant involvement of the anterior commissure, has allowed us to avoid local recurrences and consequently to avoid salvage total laryngectomies. Our experience with supraglottic cancers is too small to confirm the oncologic validity of this type of surgery but seems promising. [source] Integration of Ranked Lists via Cross Entropy Monte Carlo with Applications to mRNA and microRNA StudiesBIOMETRICS, Issue 1 2009Shili Lin Summary One of the major challenges facing researchers studying complex biological systems is integration of data from -omics platforms. Omic-scale data include DNA variations, transcriptom profiles, and RAomics. Selection of an appropriate approach for a data-integration task is problem dependent, primarily dictated by the information contained in the data. In situations where modeling of multiple raw datasets jointly might be extremely challenging due to their vast differences, rankings from each dataset would provide a commonality based on which results could be integrated. Aggregation of microRNA targets predicted from different computational algorithms is such a problem. Integration of results from multiple mRNA studies based on different platforms is another example that will be discussed. Formulating the problem of integrating ranked lists as minimizing an objective criterion, we explore the usage of a cross entropy Monte Carlo method for solving such a combinatorial problem. Instead of placing a discrete uniform distribution on all the potential solutions, an iterative importance sampling technique is utilized "to slowly tighten the net" to place most distributional mass on the optimal solution and its neighbors. Extensive simulation studies were performed to assess the performance of the method. With satisfactory simulation results, the method was applied to the microRNA and mRNA problems to illustrate its utility. [source] Recent Progress in Exploring Magnetocaloric MaterialsADVANCED MATERIALS, Issue 45 2009B. G. Shen Abstract The magnetic refrigeration technique based on the magnetocaloric effect (MCE) has attracted increasing interest because of its high efficiency and environment friendliness. In this article, our recent progress in exploring effective MCE materials is reviewed with emphasis on the MCE in the LaFe13,xSixbased alloys discovered by us. These alloys show large entropy changes over a wide temperature range near room temperature. The effects of magnetic rare-earth doping, interstitial atoms and high pressure on the MCE have been systematically studied. Special issues, such as appropriate approaches to determining the MCE associated with the first-order magnetic transition, the depression of magnetic and thermal hysteresis, and the key factors determining the magnetic exchange in alloys of this kind, are discussed. The applicability of giant MCE materials to magnetic refrigeration near ambient temperature is evaluated. A brief review of other materials with significant MCE is also presented. [source] Regulation of Technology Transfer to Developing Countries: The Relevance of Institutional Capacity,LAW & POLICY, Issue 1 2005KEVIN E. DAVIS This article revisits the debate over appropriate approaches to the regulation of technology transfer to developing countries. It begins by contrasting two stylized approaches, labeled for convenience the "New International Economic Order" model and the "Globalization" model, which have historically struggled for acceptance. It then explores the implications for the choice between these or alternative models of the fact that many developing countries presently lack the institutional capacity required to provide optimal regulation of technology transfer. Existing discussions appear either to assume that developing countries possess sufficient institutional capacity to design and implement sophisticated regulatory regimes, or to take the opposite approach and assume a drastic shortage of institutional capacity. Both approaches ignore the intermediate category of countries that do face constraints upon institutional capacity but are striving to overcome them. The analysis here is intended to demonstrate the general point that a country's present and future institutional capacity ought to be considered highly relevant to the design of central aspects of the regime that it uses to regulate technology transfer. The analysis is also designed to highlight the specific need for attention to the distinctive questions of regulatory design which arise in countries that are in the process of enhancing their institutional capacity in this and other regulatory contexts. [source] | ||||||||||||||||