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Mild Primary Hyperparathyroidism (mild + primary_hyperparathyroidism)

Distribution by Scientific Domains

Medical Sciences	100%

Selected Abstracts

Role of surgery in mild primary hyperparathyroidism in the elderly, Letter 2 (Br J Surg 2001; 88: 595)

BRITISH JOURNAL OF SURGERY (NOW INCLUDES EUROPEAN JOURNAL OF SURGERY), Issue 8 2001
N. Roche
No abstract is available for this article. [source]

Morbidity and mortality in mild primary hyperparathyroidism

CLINICAL ENDOCRINOLOGY, Issue 5 2010
Andrew Grey
No abstract is available for this article. [source]

Morbidity and mortality in mild primary hyperparathyroidism

CLINICAL ENDOCRINOLOGY, Issue 5 2010
Graham Leese
No abstract is available for this article. [source]

Increased mortality and morbidity in mild primary hyperparathyroid patients.

CLINICAL ENDOCRINOLOGY, Issue 1 2010
Audit Research Study (PEARS), The Parathyroid Epidemiology
Summary Objective, To describe mortality and disease-specific morbidities in patients with mild primary hyperparathyroidism (PHPT). Design, Retrospective population-based observational study. Setting, Tayside, Scotland, from 1997 to 2006. Participants, Patients with mild PHPT were selected from a predefined PHPT cohort between 1997 and 2006. Main outcome measures, Standardised mortality ratios (SMRs) were examined for all-cause mortality, as well as cardiovascular and cancer mortality. Standardised morbidity ratios and standardised incidence ratios were also calculated for eleven observed co-morbidities. Results, In total, there were 1683 (69·1% female) patients identified with mild PHPT in Tayside. Patients were found to have an increased risk of all-cause mortality and cardiovascular mortality (SMR-all cause 2·62, 95% CI 2·39,2·86; SMR-cardiovascular 2·68, 95% CI 2·34,3·05). Patients with mild PHPT had a significantly increased risk of developing cardiovascular and cerebrovascular disease, renal dysfunction and fractures compared to the age- and sex-adjusted general population. Conclusions, Mortality and morbidity were increased for patients with mild untreated PHPT, which is similar to more severe PHPT. [source]

Increased plasma concentrations of N-terminal pro-B-type natriuretic peptide in patients with mild primary hyperparathyroidism

CLINICAL ENDOCRINOLOGY, Issue 6 2006
Erik G. Almqvist
Summary Objective, Primary hyperparathyroidism (PHPT) is associated with heart disease. The aims of the present study were to evaluate how cardiac function and secretion of N-terminal pro-B-type natriuretic peptide (NT-proBNP) correlate in patients with mild PHPT, and how the plasma level of NT-proBNP is influenced by cure of the parathyroid disease. Design and patients, Forty-two patients with PHPT without symptoms of heart disease were examined before and 1 year after curative parathyroidectomy. Measurements, Plasma or serum concentrations of NT-proBNP, calcium, PTH, creatinine, oestradiol, testosterone and SHBG were measured. Cardiac function was evaluated by equilibrium radionuclide angiography (ERNA). Results, At baseline, NT-proBNP levels correlated negatively with systolic function [left ventricular ejection fraction (LVEF), P < 0·001]. Twelve per cent of the patients had NT-proBNP levels above normal reference values preoperatively. One year postoperatively, the corresponding proportion was 21%. The mean plasma concentration of NT-proBNP increased after parathyroidectomy (P < 0·01) in parallel with a dip in diastolic function (peak filling rate, P < 0·05) and a falling trend in systolic function (LVEF, P = 0·08). The postoperative percentage changes in circulating NT-proBNP and total oestradiol correlated positively (P < 0·05). Conclusions, Patients with mild PHPT and normal renal function may have high levels of circulating NT-proBNP despite the absence of symptomatic heart disease. Cure of the parathyroid disease is followed by a further increase in NT-proBNP secretion in parallel with ERNA measures, indicating subclinical changes in heart function. These results are in line with data indicating an association between PHPT and increased risk of premature death. [source]