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Migration Reaction (migration + reaction)

Distribution by Scientific Domains
Chemistry100%

Selected Abstracts

ChemInform Abstract: PtCl2 -Catalyzed Tandem Triple Migration Reaction Toward (Z)-1,5-Dien-2-yl Esters.

CHEMINFORM, Issue 2 2009
Ke-Gong Ji
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

Au-Catalyzed Tandem Cyclization/[1,2]-Alkyl Migration Reaction of Epoxy Alkynes: Synthesis of Spiropyranones

CHEMISTRY - A EUROPEAN JOURNAL, Issue 17 2008
Xing-Zhong Shu Dr.
Abstract A novel gold-catalyzed tandem cyclization/[1,2]-alkyl migration process of epoxy alkynes to spiropyranones has been discovered. From this process, the construction of adjacent multiple stereocenters with a new quaternary carbon atom is achieved. The gold-catalyzed domino process is stereospecific with respect to the migrating carbon atom. A type of unusual CC bond cleavage of epoxide systems has also been discovered, which can lead to the formation of two Z,alkenes and a carbonyl functional group in one step with excellent stereoselectivity. Furthermore, this efficient domino process could be achieved in the presence of the simplest and least expensive gold catalyst [NaAuCl4],2,H2O with a low catalyst loading. [source]

ChemInform Abstract: Atroposelective Radical Aryl Migration Reactions from Sulfur to Carbon.

CHEMINFORM, Issue 20 2009
Birte Schulte
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

Synthesis of 2,4-difuryl-4H -3,1-benzothiazines via a furan ring migration reaction

JOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 2 2008
Vladimir T. Abaev
A new simple synthetic approach to 2,4-difuryl-4H -3,1-benzothiazines from 2-isothiocyanoaryldifuryl-methanes in the presence of acidic catalyst is described. This rearrangement is a new example of furan ring migration reaction resulting from intramolecular attack with electrophilic carbon. [source]

"Click Peptides",Chemical Biology-Oriented Synthesis of Alzheimer's Disease-Related Amyloid , Peptide (A,) Analogues Based on the "O- Acyl Isopeptide Method"

CHEMBIOCHEM, Issue 10 2006
Youhei Sohma
Abstract A clear understanding of the pathological mechanism of amyloid , peptide (A,) 1,42, a currently unexplained process, would be of great significance for the discovery of novel drug targets for Alzheimer's disease (AD) therapy. To date, though, the elucidation of these A,1,42 dynamic events has been a difficult issue because of uncontrolled polymerization, which also poses a significant obstacle in establishing experimental systems with which to clarify the pathological function of A,1,42. We have recently developed chemical biology-oriented pH- or phototriggered "click peptide" isoform precursors of A,1,42, based on the "O -acyl isopeptide method", in which a native amide bond at a hydroxyamino acid residue, such as Ser, is isomerized to an ester bond, the target peptide subsequently being generated by an O,N intramolecular acyl migration reaction. These click peptide precursors did not exhibit any self-assembling character under physiological conditions, thanks to the presence of the one single ester bond, and were able to undergo migration to give the target A,1,42 in a quick and easy, one-way (so-called "click")conversion reaction. The use of click peptides could be a useful strategy to investigate the biological functions of A,1,42 in AD through inducible activation of A,1,42 self-assembly. [source]

ChemInform Abstract: Catalytic Asymmetric Synthesis of R207910.

CHEMINFORM, Issue 39 2010
Yutaka Saga
Abstract The first asymmetric synthesis of the potent anti-tuberculosis drug (VI) involves two key catalytic transformations: an enantioselective proton migration reaction of dihydroquinolinone (I) using an in situ generated yttrium catalyst, and a CuF-catalyzed highly diastereoselective allylation of the resulting quinolinone (II). [source]