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Metallic Taste (metallic + taste)

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Medical Sciences100%

Selected Abstracts

Metallic Taste: An Unusual Reaction to Botulinum Toxin A

DERMATOLOGIC SURGERY, Issue 5 2003
Christian Murray MD
BACKGROUND Botulinum neurotoxin formulations are safe and effective agents for the treatment of facial rhytides. OBJECTIVES A patient is described who complained of metallic taste after each treatment with botulinum toxin A (BTX-A). RESULTS The sensation of metallic taste diminished after successive treatments with BTX-A, despite adequate dosing for cosmetic purposes. CONCLUSION Metallic taste is associated with the use of numerous medications; however, the pathogenesis remains unclear. Alteration in zinc metabolism, which may occur with BTX-A administration, has been suggested as a possible mechanism. Although this is the first known report of dysgeusia after BTX-A, physicians and patients may be reassured that the taste alteration was self-limited and was not significantly problematic for the patient in our case. [source]

Excess of symptoms among radiographers,

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, Issue 2 2003
Helen Dimich-Ward PhD
Abstract Background The prevalence and occupational determinants of miscellaneous symptoms referred to as "Darkroom disease" was compared between radiographers and physiotherapists working in British Columbia, Canada. Methods The participation rate for the mailout questionnaire survey was 66.1%. A small subset underwent spirometry and methacholine challenge testing. Results Radiographers had a higher prevalence of most symptoms, with an extreme odds ratio of 11.4 for chemical/metallic taste. The percentage of radiographers with non-specific bronchial hyperresponsiveness (NSBHR) was 3 times higher than that of physiotherapists, although the comparison was not statistically significant. Reporting inadequate ventilation, frequently detecting the odor of X-ray processing chemicals and cleaning up spills within the past 12 months were highly associated with most of the symptoms. Conclusions Our results suggest that differences in the prevalence of symptoms represent a complex process, both in exposure and response to the many constituents found in radiographic processing chemicals. Objective testing of health outcomes and more refined exposure measurements are recommended to further investigate occupational health problems of radiographers. Am. J. Ind. Med. 43: 132,141, 2003. © 2003 Wiley-Liss, Inc. [source]

Metallic Taste: An Unusual Reaction to Botulinum Toxin A

DERMATOLOGIC SURGERY, Issue 5 2003
Christian Murray MD
BACKGROUND Botulinum neurotoxin formulations are safe and effective agents for the treatment of facial rhytides. OBJECTIVES A patient is described who complained of metallic taste after each treatment with botulinum toxin A (BTX-A). RESULTS The sensation of metallic taste diminished after successive treatments with BTX-A, despite adequate dosing for cosmetic purposes. CONCLUSION Metallic taste is associated with the use of numerous medications; however, the pathogenesis remains unclear. Alteration in zinc metabolism, which may occur with BTX-A administration, has been suggested as a possible mechanism. Although this is the first known report of dysgeusia after BTX-A, physicians and patients may be reassured that the taste alteration was self-limited and was not significantly problematic for the patient in our case. [source]

High Efficacy of Ranitidine Bismuth Citrate, Amoxicillin, Clarithromycin and Metronidazole Twice Daily for Only Five Days in Helicobacter pylori Eradication

HELICOBACTER, Issue 2 2001
Javier P. Gisbert
ABSTRACT Aim. The combination of a proton pump inhibitor (PPI) or ranitidine-bismuth-citrate (Rbc) and two antibiotics for 7,10 days are, at present, the preferred treatments in Helicobacter pylori eradication. However, therapies for fewer than 7 days have been scarcely evaluated and it is unknown whether the length of treatment can be shortened, without a lost of efficacy, if three instead of two antibiotics are used. The aim of our study was to evaluate the efficacy of Rbc plus three antibiotics for only 5 days in H. pylori eradication. Methods. We prospectively studied 80 patients (34% duodenal ulcer, 66% functional dyspepsia) infected by H. pylori. At endoscopy, biopsies were obtained for histological study and rapid urease test, and a 13C-urea breath test was carried out. Urea breath test was repeated 4 weeks after completing eradication treatment with Rbc [400 mg twice a day (bid)], amoxicillin (1 g bid), clarithromycin (500 mg bid) and metronidazole (500 mg bid). All drugs were administered together after breakfast and dinner for 5 days only, and no treatment was administered thereafter. Compliance with therapy was determined from the interrogatory and the recovery of empty envelopes of medications. Results. In 79 out of the 80 patients, H. pylori eradication success or failure was assessed after therapy (one patient was lost from follow-up). All but one of these 79 patients took all the medications (one patient stopped treatment on the day 3 due to nausea/vomiting). Per protocol eradication was achieved in 72/78 (92%; 95% CI, 84,96%) and in 72/80 (90%; 81,95%) by intention-to-treat. Therapy was more effective in patients with duodenal ulcer than in those with functional dyspepsia [100% (87,100%) vs. 85% (73,92%) by intention-to-treat; p < .05]. Adverse effects were described in ten patients (12%), and included the perception of a metallic taste (eight patients), nausea/vomiting (two patients, one of them abandoned the treatment due to this), and diarrhea (two patients). Conclusion. The combination of Rbc, amoxicillin, clarithromycin and metronidazole for only 5 days represents a promising therapy for H. pylori infection, due to its high efficacy, simple posology, low cost and excellent tolerance. [source]

Exposure, health complaints and cognitive performance among employees of an MRI scanners manufacturing department

JOURNAL OF MAGNETIC RESONANCE IMAGING, Issue 2 2006
Frank de Vocht MSc
Abstract Purpose To assess sensory effects and other health complaints that are reported by system testers working near magnetic resonance imaging (MRI) magnets, realizing that it is believed that exposure up to 8 T is safe for humans. Materials and Methods Levels of exposure to static magnetic fields (SMFs), movement speed during exposure, health complaints, and cognitive performance among employees in an MRI-manufacturing department and at a reference department have been analyzed. Mercury concentrations in urine samples were determined to analyze whether they depend on exposure to SMFs. Results Average exposure of system testers was 25.9 mT/8 hours at a 1.0-T system and 40.4 mT/8 hours at a 1.5-T system. Vertigo, metallic taste, and concentration problems were more reported among workers of MRI-fabrication than in the reference department. Cognitive performance was tested outside the SMF, and no significant changes were detected. Conclusion This study suggests that any effects on cognitive functions are acute and transient and disappear rapidly after exposure has ended. All complaints, except for headaches, were more frequently reported by "fast movers" than by "slow movers," and depended on field strength and duration of exposure. Mercury-levels in urine were not affected. J. Magn. Reson. Imaging 2006. © 2005 Wiley-Liss, Inc. [source]