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Memorial Lecture (memorial + lecture)
Selected Abstracts"THE FARTHER REACHES OF HUMAN TIME": RETROSPECT ON CARL SAUER AS PREHISTORIAN,GEOGRAPHICAL REVIEW, Issue 4 2002DAVID R. HARRIS ABSTRACT. Carl Ortwin Sauer (1889,1975) is widely regarded as one of the most influential geographers of the twentieth century, admired particularly for his studies in cultural and historical geography. His contribution to the study of prehistory is less widely acknowledged, but, between 1944 and 1962, he published a series of speculative yet scholarly papers that contain many prescient insights into humanity's remote past and the relationships of our ancestors to the environments they occupied,and modified. In this essay, based on the Carl O. Sauer Memorial Lecture given at the University of California, Berkeley, in October 2001, I reflect on Sauer's contribution to the science of prehistory by examining, in the light of recent advances in knowledge, two major themes of Sauer's work: the early dispersal of Homo sapiens in the Old World, and the origins and prehistoric spread of agriculture. [source] Berend Houwen Memorial Lecture: ISLH Las Vegas May 2009INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, Issue 3 2009The pathogenesis, management of thrombotic microangiopathies Summary Thrombotic microangiopathies are a relatively rare group of congenital and inherited disorders caused by defects in processing the ultra large forms of von Willibrand factor which pathologically give rise to platelet rich microthrombi in the micro arterial circulation leading to end organ damage particularly in the brain, heart and kidneys. Identification of the ADAMTS 13 gene has led to the definition of congenital deficiency of its activity or failure of activity due to the development of an inhibitory IgG antibody. The idiopathic autoimmune form of the disease is the most common. There are various subgroups of acquired TTP associated with HIV infection, pregnancy, pancreatitis, associated with bone marrow transplantation, various disseminated malignancies and certain drugs, particularly Clopidogrel. Diagnostic assays are now becoming widely available to identify ADAMTS 13 activity and also acquired antibodies to the enzyme. Mainline treatment is associated with daily plasma exchange with associated other immunosuppressant treatments particularly steroids and recently the use of Rituximab, a monoclonal anti-CD20 antibody. Despite improvement in treatment modalities there is still significant mortality of 10,20%, particularly if there is a delay in initiating plasma exchange. Relapse also occurs in 20,50% of patients although this may be improved by Rituximab therapy. [source] Allen Denver Russell Memorial Lecture, 2006JOURNAL OF APPLIED MICROBIOLOGY, Issue 4 2006The use of microbiocides in infection control: a critical look at safety, applications, testing Abstract Microbial pathogens continue as major threats to health. Indeed, many ongoing societal changes are enhancing our vulnerability and exposure to several frank and opportunistic pathogens. This, together with rampant antimicrobial resistance and reduced prospects for newer drugs and vaccines, is forcing a higher reliance on microbiocides in infection prevention and control. That this reliance may not be well-founded becomes apparent from a closer look at current ways of testing and registering microbiocides, their label claims as well as human and environmental safety of certain widely used microbicidal chemicals. Many methods to test microbiocides for registration are flawed and/or entail test conditions irrelevant to field use. Pathogens listed on product labels may not be among those amenable to interruption through microbiocide use. The wide variations and discrepancies in existing national/regional regulations for registering microbiocides for sale stifle innovation. This is a critical look at the above-mentioned issues with emphasis on chemicals meant for use on environmental surfaces and medical devices. It highlights better ways to test microbiocides and to attain global harmonization of testing and product registration. It also details the known and potential dangers of microbiocide use and what to consider in choosing such formulations for optimal safety and effectiveness. End users are advised to be more critical and prudent in the selection and application of microbicidal chemicals, manufacturers are encouraged to explore infection control products and technologies that are safer in the workplace and for the environment, and regulators are urged to review and update the requirements and procedures for premarket review of microbiocide efficacy data and label claims. Independent investigations are also urgently needed to document the proportion of nosocomial infections that would be amenable to prevention through chemical disinfection of environmental surfaces. [source] Third S. S. Ratnam Memorial Lecture 2007.JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH (ELECTRONIC), Issue 3 2009Ovarian cancer: Is there hope for women? Abstract Ovarian cancer is today the most lethal female cancer with an overall survival of only 49.9%. The currently available screening modalities are disappointing in detecting highly curable early stage ovarian cancer. Natural history of ovarian cancer is unknown; it appears it can develop quickly from normal looking ovaries. Timely referral of women with non-specific symptoms (such as abdominal bloating, pelvic pain) for an ultrasound scan or blood CA125 assessments may help in the early diagnosis. Patients with Stage IA or IB disease with grade 1 tumors have a cure rate of >90%; this is likely to be compromised by laparoscopic surgery. In selected patients fertility preservation with good obstetric outcome is possible. However, the relapse rate in ,high risk' early stage ovarian cancers is 40,45%; adjuvant chemotherapy is needed. Only 20,25% of those with stage III and IV disease are cured. Despite a high primary response (70%) majority (70,75%) will relapse and all are likely to succumb. Optimal debulking surgery followed by adjuvant chemotherapy are needed for stages III and IV disease; the outcome is superior if managed by gynecologic oncologists. Where cost of drugs is an important consideration, an alternative is carboplatin (an affordable and equally effective drug). The role of vaccines needs further study. When relapses occur palliation will be the aim in most instances. Oral contraceptives, breast feeding, tubal sterilization and hysterectomy also have a protective effect. Risk-reducing salpingo-oopherectomy has been suggested in women with BRCA mutations. [source] New frontiers of assisted reproductive technology (Chien Tien Hsu Memorial Lecture 2007)JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH (ELECTRONIC), Issue 1 2009P. C. Ho Abstract Many significant advances have been made in assisted reproductive technology since the birth of the first baby conceived with in vitro fertilization and embryo transfer. The development of recombinant gonadotropins and gonadotropin releasing hormone antagonists helps to simplify the ovarian stimulation. Excessive ovarian stimulation should be avoided because of the risks of ovarian hyperstimulation syndrome and reduction in endometrial receptivity. Maturation of oocytes in vitro has been developed in some centers. It is still uncertain whether techniques such as assisted hatching, blastocyst transfer and pre-implantation aneuploidy screening can improve the live birth rates in assisted reproduction. The introduction of pre-implantation genetic diagnosis for selection of human lymphocyte antigens (HLA) compatible embryos for treatment of siblings has raised ethical concerns. There is a higher risk of obstetric complications and congenital abnormalities even in singleton pregnancies achieved with assisted reproduction. Because of the risks of multiple pregnancies, elective single embryo transfer is increasingly used in good-prognosis patients. With a good freezing program, the cumulative pregnancy rate (including the pregnancies from subsequent replacement of frozen-thawed embryos) is not adversely affected. Improvement in cryopreservation techniques has made it possible to cryopreserve slices of ovarian tissue or oocytes, thus helping women who have to receive sterilizing forms of anti-cancer treatment to preserve their fertility. It is important that the development of the new techniques should be based on good scientific evidence. Ethical, legal and social implications should also be considered before the introduction of new techniques. [source] A brief history of the Human Biology Association: 1974,2004AMERICAN JOURNAL OF HUMAN BIOLOGY, Issue 2 2005Michael A. Little Originally incorporated as the Human Biology Council in 1974, the Human Biology Association, as it has been known since 1994, has matured in the intervening 30 years to become a society that represents broadly the interests of human biologists in the U.S. and throughout the world. The purpose of this paper is to trace the development of the Association from its foundation to the present in the context of changes in the organization of the Association and in its By-Laws, officers, committees, and membership; the history of the two journals that served as the Association's official organs (Human Biology and American Journal of Human Biology); and how the annual meetings have evolved from a modest one-day plenary session to meetings that last more than two days and include a variety of scientific contributions. Highlights of the national meetings include the Raymond Pearl Memorial Lecture, the Franz Boas Distinguished Achievement Award, and the Edward E. Hunt, Jr. Student Prize. Am. J. Hum. Biol. 17:141,154, 2005. © 2005 Wiley-Liss, Inc. [source] IPOS Sutherland Memorial Lecture: psycho-oncology and health care researchPSYCHO-ONCOLOGY, Issue 6 2008Uwe KochArticle first published online: 2 MAY 200 Abstract Remarkable changes of health-care systems, increasing costs of health care and of social inequality in modern societies, an aging population and the increase of chronic illnesses such as cancer implicate various future challenges for the provision of health care. Health-care research aims to improve the effectiveness and efficiency of patient-oriented services involving the evaluation of innovative treatment approaches and settings. It deals with the patients' path through different areas of health-care systems in order to identify significant factors for the provision of quality assurance of structures and resources concerning treatments, processes and health outcomes. Health-care research focusses on three main topics that play an important role for quality management: (1) the admission to health-care services and assessment strategies including indication, utilization and specificity of settings and target groups; (2) the treatment process including the implementation, standardization and flexibility of services and dose-effect relationship of interventions; (3) health-care outcome including effectiveness and efficiency of interventions and services, the cost-benefit relationship and the transfer from research to health-care practice. Given the objectives of health-care research, the topics of health-care research in psychosocial care for cancer patients include the study of structural conditions of psycho-oncological services, the epidemiology of distress and mental disorders and the subjective need of psycho-oncological support in cancer patients, the improvement of psycho-oncological measures and assessment strategies in daily treatment, the study of psycho-oncological interventions under routine conditions, and quality assurance. Requirements of future health-care research and developments of psycho-oncology including aspects of orientation, strategies, health-care equity, and resources are discussed. Copyright © 2008 John Wiley & Sons, Ltd. [source] Sir Gordon Bell Memorial Lecture 2008: Academic surgery: a turning tide?ANZ JOURNAL OF SURGERY, Issue 6 2009John A. Windsor First page of article [source] Strategy of the reviewAUSTRALASIAN JOURNAL ON AGEING, Issue 2 2005Warren P Hogan This offering is about the ways in which the work of the recent review into aged care was conducted. The account is not exhaustive but is illustrative of some of the major issues experienced. Some of the policy themes and outcomes were explored in the recent Shann Memorial Lecture [1]. The circumstances with which the review was confronted are treated in the second part of the paper. This comes in two segments with the first explaining the measures in place and the second exploring some of the important questions arising from initial considerations of those measures. The onerous nature of the queries should be acknowledged. The following part is about the activities of the review in an effort to cast light on questions raised by the measures in place in relation to the Terms of Reference. The dual task of the review reflected the very substantial lack of empirical work on the aged care industry as well as evidence on the efforts of boards and managements of entities providing aged care services. This coverage is taken further in the final segment which deals with some of the major issues which the review was seeking to address. Some are of the greatest strategic moment. [source] Jack Tizard Memorial Lecture: Educational Reform and the Mental Health of Vulnerable Children and Young PeopleCHILD AND ADOLESCENT MENTAL HEALTH, Issue 4 2001David Galloway Although research has demonstrated the differential influence of schools on children's psychosocial adjustment, the influence of radical legislative changes since 1979 is less clear. Evidence of a sharp rise in exclusions and in referral for special educational needs is contrasted with evidence that behaviour in most schools is good, and with data showing a steep reduction in the number of pupils leaving school with no qualifications. It is argued that these reforms have improved overall standards and may thereby have contributed positively to the mental health of many vulnerable children. However, the way they have been implemented has undermined teachers in some schools and, as a result, pupils there experience education as an additional source of stress rather than of stability and support. [source] The Michiyoshi Harasawa and Ann J Woolcock Memorial LecturesRESPIROLOGY, Issue 2 2003Wah-Kit Lam President No abstract is available for this article. [source] 10th international symposium on the synthesis and applications of isotopes and isotopically labelled compounds,Professor John R. Jones memorial lectures, Monday, June 15, 2009JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, Issue 5-6 2010David Hesk Session Chair Abstract The first Session of the Conference was dedicated to the memory of Professor John R. Jones. Labelling with Deuterium and Tritium was the common theme. William J.S. Lockley, Frank Tang and Shuiyu Lu gave presentations. Copyright © 2010 John Wiley & Sons, Ltd. [source] | |||||||||||||