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Medicinal Interest (medicinal + interest)
Selected AbstractsChiral separation of the plant lignan matairesinol by capillary electrophoresis,ELECTROPHORESIS, Issue 17 2008Ulrike Müller Abstract Lignans are dimeric phenylpropanoid compounds in plants that enjoy increasing medicinal interest because of their phytoestrogen activity. Lignans are chiral compounds and for most natural occurring lignans, chirality is not known. Separation of racemic matairesinol by CE in a non-coated silica capillary with carboxymethyl-,-cyclodextrin as chiral selector in phosphate buffer was successful. Electrolyte and selector concentrations and pH were systematically optimized in order to obtain baseline separation and short analysis times. Matairesinol from safflower fruit was determined as (,)-enantiomer. Quantitation results for matairesinol with the optimized method after calibration with authentic lignan were very similar to those by HPLC. The limit of detection is 2,,g/mL sample by DAD detection. [source] 4-Hydroxynonenal: A membrane lipid oxidation product of medicinal interestMEDICINAL RESEARCH REVIEWS, Issue 4 2008G. Poli Abstract A comprehensive focus on 4-hydroxynonenal (HNE) as candidate molecule in a variety of pathophysiological conditions occurring in humans is here provided. Despite an active, now well characterized, metabolism in most cells and tissues, HNE can be easily detected and quantified by means of several methods, although with different sensitivity. Measurements of HNE and/or stable metabolites in biological fluids are already applied as lipid peroxidation/oxidative stress markers in a huge number of human disease processes, often sustained by inflammatory reactions. A primary involvement of this aldehydic product of membrane lipid oxidation in inflammation-related events, as well as in regulation of cell proliferation and growth, in necrotic or apoptotic cell death, appears supported by its marked ability to modulate several major pathways of cell signaling and, consequently, gene expression. The actual knowledge of HNE reactivity, metabolism, signaling and modulatory effect in the various human organs should provide a solid background to the investigation of the aldehyde's contribution to the pathogenesis of human major chronic diseases and would likely promote advanced and oriented applications not only in diagnosis and prevention but also in molecular treatment of human diseases. © 2007 Wiley Periodicals, Inc. Med Res Rev, 28, No. 4, 569,631, 2008 [source] The relationship between the electrospray ionization behaviour and biological activity of some phosphino Cu(I) complexesRAPID COMMUNICATIONS IN MASS SPECTROMETRY, Issue 11 2010Francesco Tisato Electrospray ionization mass spectrometry was usefully employed for the characterization of three phosphino copper(I) complexes of medicinal interest. This technique revealed that the original [CuL4]+ pro-drugs (L,=,hydrophilic tertiary phosphine) underwent dissociation with production of coordinative unsaturated [CuL3]+ and [CuL2]+ species, which represented key intermediates for the activation of potential biological properties. The more favoured was the displacement of the ligands from the [CuL4]+ parent complex, the more favoured was in turn the possibility for the metal ion to directly interact with biological substrates, including pharmacological targets related to cancer proliferation. An inverse correlation between the stability and the cytotoxic activity of the three copper(I) complexes investigated has been clearly established. Copyright © 2010 John Wiley & Sons, Ltd. [source] Four Generations of Water-Soluble Dendrimers with 9 to 243 Benzoate Tethers: Synthesis and Dendritic Effects on Their Ion Pairing with Acetylcholine, Benzyltriethylammonium, and Dopamine in WaterCHEMISTRY - A EUROPEAN JOURNAL, Issue 18 2008Elodie Boisselier Abstract Water-soluble benzoate-terminated dendrimers of four generations (from G0 with 9 branches to G3 with 243 branches) were synthesized and fully characterized. They form water-soluble assemblies by ion-pairing interactions with three cations of medicinal interest (acetylcoline, benzyltriethylammonium, and dopamine), which were characterized and investigated by 1H,NMR spectroscopy, whereas such interactions do not provoke any significant shift of 1H,NMR signals with the monomeric benzoate anion. The calculated association constants confirm that the dendritic carboxylate termini reversibly form ion pairs and aggregates. Diffusion coefficients and hydrodynamic diameters of the dendrimers, as well as changes thereof on interaction with the cations, were evaluated by DOSY experiments. The lack of increase of dendrimer size on addition of the cations and the upfield shifts of the 1H,NMR signals of the cation indicate encapsulation within the hydrophobic dendrimer interiors together with probable backfolding of the benzoate termini. [source] | ||||||||||