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Meaningful
Terms modified by Meaningful Selected AbstractsMaking Experiences , MeaningfulDESIGN MANAGEMENT REVIEW, Issue 4 2009Thomas Lockwood [source] Is Postmodernism Meaningful in Yoruba?JOURNAL OF SOCIAL PHILOSOPHY, Issue 2 2008Adeshina Afolayan First page of article [source] To Commit or Not to Commit: Modeling Agent Conversations for ActionCOMPUTATIONAL INTELLIGENCE, Issue 2 2002Roberto A. Flores Conversations are sequences of messages exchanged among interacting agents. For conversations to be meaningful, agents ought to follow commonly known specifications limiting the types of messages that can be exchanged at any point in the conversation. These specifications are usually implemented using conversation policies (which are rules of inference) or conversation protocols (which are predefined conversation templates). In this article we present a semantic model for specifying conversations using conversation policies. This model is based on the principles that the negotiation and uptake of shared social commitments entail the adoption of obligations to action, which indicate the actions that agents have agreed to perform. In the same way, obligations are retracted based on the negotiation to discharge their corresponding shared social commitments. Based on these principles, conversations are specified as interaction specifications that model the ideal sequencing of agent participations negotiating the execution of actions in a joint activity. These specifications not only specify the adoption and discharge of shared commitments and obligations during an activity, but also indicate the commitments and obligations that are required (as preconditions) or that outlive a joint activity (as postconditions). We model the Contract Net Protocol as an example of the specification of conversations in a joint activity. [source] Rapid (partial) prescreening of cervical smears: the quality control method of choice?CYTOPATHOLOGY, Issue 4 2002D. BROOKE Rapid rescreening of all negative and inadequate smears is the quality control method of choice in the UK. The sensitivity of primary screening of laboratory and individual screeners are major indicators of screening quality and are dependent on the number of false negative smears found by rapid screening for their calculation. High sensitivity may indicate good quality primary screening or poor quality rapid review. Quantifiably high quality rapid rescreening is essential if these sensitivity figures are to be meaningful. A 12-month study was undertaken in routine practice using the prescreening mode to ascertain the sensitivity of rapid (partial) screening in our department . The final results of smears were compared with those of rapid prescreening. The calculated sensitivity ranged from 92,54% for high-grade abnormalities and 75,33% for all grades, revealing a wide range of performance between individual prescreeners. Rapid prescreening can identify individuals best suited to rapid screening in routine practice. By using these prescreeners only, the sensitivity of cervical screening could be raised. Rapid (partial) prescreening should be considered as the quality control method of choice. [source] Channel Coordination for a Supply Chain with a Risk-Neutral Manufacturer and a Loss-Averse Retailer,DECISION SCIENCES, Issue 3 2007Charles X. Wang ABSTRACT This articles considers a decentralized supply chain in which a single manufacturer is selling a perishable product to a single retailer facing uncertain demand. It differs from traditional supply chain contract models in two ways. First, while traditional supply chain models are based on risk neutrality, this article takes the viewpoint of behavioral principal,agency theory and assumes the manufacturer is risk neutral and the retailer is loss averse. Second, while gain/loss (GL) sharing is common in practice, there is a lack of analysis of GL-sharing contracts in the supply chain contract literature. This article investigates the role of a GL-sharing provision for mitigating the loss-aversion effect, which drives down the retailer order quantity and total supply chain profit. We analyze contracts that include GL-sharing-and-buyback (GLB) credit provisions as well as the special cases of GL contracts and buyback contracts. Our analytical and numerical results lend insight into how a manufacturer can design a contract to improve total supply chain, manufacturer, and retailer performance. In particular, we show that there exists a special class of distribution-free GLB contracts that can coordinate the supply chain and arbitrarily allocate the expected supply chain profit between the manufacturer and retailer; in contrast with other contracts, the parameter values for contracts in this class do not depend on the probability distribution of market demand. This feature is meaningful in practice because (i) the probability distribution of demand faced by a retailer is typically unknown by the manufacturer and (ii) a manufacturer can offer the same contract to multiple noncompeting retailers that differ by demand distribution and still coordinate the supply chains. [source] Measurement and reporting of the duration of untreated psychosisEARLY INTERVENTION IN PSYCHIATRY, Issue 4 2008Matthew Large Abstract Aim: The aim of this study was to investigate the demographic, illness and methodological factors associated with mean and median duration of untreated psychosis (DUP). Methods: A systematic review and meta-analysis of the published studies of DUP and an examination of available DUP distributions. Results: DUP was longer in samples with a higher proportion of patients with schizophrenia and was shorter in samples that included affective psychosis. Sex, age, and the methods of measuring the onset and end-point of DUP and the type of service in which the studies were performed did not contribute to the heterogeneity of the mean or median DUP values. Mean DUP is significantly prolonged by a small number of patients, and the median DUP is a poor indicator of the rate at which patients present. Conclusions: The DUP of patients with affective and non-affective psychosis should be examined separately in order to make measures of DUP more meaningful and comparable, and DUP should be reported using more comprehensive measures. We suggest a method of reporting DUP based on the rate of presentation of first-episode psychosis patients rather than the length of DUP. [source] Critical damping of structures with elastically supported visco-elastic dampersEARTHQUAKE ENGINEERING AND STRUCTURAL DYNAMICS, Issue 2 2002Yujin Lee Abstract This paper presents a new formulation for critical damping of structures with elastically supported visco-elastic dampers.Owing to the great dependence of damper performance on the support stiffness, this model is inevitable for reliable modelling of structures with visco-elastic dampers. It is shown that the governing equation of free vibration of this model is reduced to a third-order differential equation and the conventional method for defining the critical damping for second-order differential equations cannot be applied to the present model. It is demonstrated that the region of overdamped vibration is finite in contrast to that (semi-infinite) for second-order differential equations and multiple critical damping coefficients exist. However, it turns out that the smaller one is practically meaningful. Copyright © 2001 John Wiley & Sons, Ltd. [source] Representing Preferences with a Unique Subjective State SpaceECONOMETRICA, Issue 4 2001Eddie Dekel We extend Kreps' (1979) analysis of preference for flexibility, reinterpreted by Kreps (1992) as a model of unforeseen contingencies. We enrich the choice set, consequently obtaining uniqueness results that were not possible in Kreps' model. We consider several representations and allow the agent to prefer commitment in some contingencies. In the representations, the agent acts as if she had coherent beliefs about a set of possible future (ex post) preferences, each of which is an expected-utility preference. We show that this set of ex post preferences, called the subjective state space, is essentially unique given the restriction that all ex post preferences are expected-utility preferences and is minimal even without this restriction. Because the subjective state space is identified, the way ex post utilities are aggregated into an ex ante ranking is also essentially unique. Hence when a representation that is additive across states exists, the additivity is meaningful in the sense that all representations are intrinsically additive. Uniqueness enables us to show that the size of the subjective state space provides a measure of the agent's uncertainty about future contingencies and that the way the states are aggregated indicates whether these contingencies lead to a desire for flexibility or commitment. [source] Some Notes on Institutions in Evolutionary Economic GeographyECONOMIC GEOGRAPHY, Issue 2 2009Ron Boschma abstract Within the evolutionary economic geography framework, the role of institutions deserves more explicit attention. We argue that territorial institutions are to be viewed as orthogonal to organizational routines since each territory is characterized by a variety of routines and a single firm can apply its routines in different territorial contexts. It is therefore meaningful to distinguish between institutional economic geography and evolutionary economic geography as their explanans is different. Yet the two approaches can be combined in a dynamic framework in which institutions coevolve with organizational routines, particularly in emerging industries. Furthermore, integrating the evolutionary and institutional approach allows one to analyze the spatial diffusion of organizational routines that mediate conflicts among social groups, in particular, those between employers and employees. An evolutionary economic geography advocates an empirical research program, both qualitative and quantitative, that can address the relative importance of organizational routines and territorial institutions for regional development. [source] Hepatitis C virus infection among drug injectors in St Petersburg, Russia: social and molecular epidemiology of an endemic infectionADDICTION, Issue 11 2009Elijah Paintsil ABSTRACT Aims To understand the epidemiology and transmission patterns of hepatitis C virus (HCV), the predominant blood borne-pathogen infecting injection drug users (IDUs), in a part of the former Soviet Union. Design Cross-sectional respondent-driven sample of IDUs. Setting St Petersburg, Russia. Participants A total of 387 IDUs were recruited in late 2005 and throughout 2006. Measurements Participants were surveyed to collect demographic, medical and both general and dyad-specific drug injection and sexual behaviors. A blood sample was collected to detect antibodies to hepatitis C and to amplify viral RNA for molecular analysis. The molecular data, including genotypes, were analyzed spatially and linkage patterns were compared to the social linkages obtained by respondent-driven sampling (RDS) for chains of respondents and among the injection dyads. Findings HCV infection was all but ubiquitous: 94.6% of IDUs were HCV-seropositive. Among the 209 viral sequences amplified, genotype 3a predominated (n = 119, 56.9%), followed by 1b (n = 61, 29.2%) and 1a (n = 25, 11.9%). There was no significant clustering of genotypes spatially. Neither genotypes nor closely related sequences were clustered within RDS chains. Analysis of HCV sequences from dyads failed to find associations of genotype or sequence homology within pairs. Conclusions Genotyping reveals that there have been at least five unique introductions of HCV genotypes into the IDU community in St Petersburg. Analysis of prevalent infections does not appear to correlate with the social networks of IDUs, suggesting that simple approaches to link these networks to prevalent infections, rather than incident transmission, will not prove meaningful. On a more positive note, the majority of IDUs are infected with 3a genotype that is associated with sustained virological response to antiviral therapy. [source] Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessmentENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 3 2010Gerald T. Ankley Abstract Ecological risk assessors face increasing demands to assess more chemicals, with greater speed and accuracy, and to do so using fewer resources and experimental animals. New approaches in biological and computational sciences may be able to generate mechanistic information that could help in meeting these challenges. However, to use mechanistic data to support chemical assessments, there is a need for effective translation of this information into endpoints meaningful to ecological risk,effects on survival, development, and reproduction in individual organisms and, by extension, impacts on populations. Here we discuss a framework designed for this purpose, the adverse outcome pathway (AOP). An AOP is a conceptual construct that portrays existing knowledge concerning the linkage between a direct molecular initiating event and an adverse outcome at a biological level of organization relevant to risk assessment. The practical utility of AOPs for ecological risk assessment of chemicals is illustrated using five case examples. The examples demonstrate how the AOP concept can focus toxicity testing in terms of species and endpoint selection, enhance across-chemical extrapolation, and support prediction of mixture effects. The examples also show how AOPs facilitate use of molecular or biochemical endpoints (sometimes referred to as biomarkers) for forecasting chemical impacts on individuals and populations. In the concluding sections of the paper, we discuss how AOPs can help to guide research that supports chemical risk assessments and advocate for the incorporation of this approach into a broader systems biology framework. Environ. Toxicol. Chem. 2010;29:730,741. © 2009 SETAC [source] Changes in the Frequency Structure of a Mating Call Decrease Its Attractiveness to Females in the Cricket Frog Acris crepitans blanchardiETHOLOGY, Issue 8 2001Klaudia Witte In many species, females often prefer male signals that are more complex than in nature or beyond the range of calls naturally produced by conspecific males in spectral, temporal and amplitude features. In this study we examined both the ability of females to recognize signals outside the normal range of spectral frequency variation seen in male advertisement calls, and the influence of increasing call complexity by adding spectral components to enhance the attractiveness of a male advertisement call in the cricket frog Acris crepitans blanchardi, while keeping its amplitude constant. We used two different natural male call groups and created the following synthetic call groups: with a dominant frequency at 3500 Hz, i.e. at the normal dominant frequency with a frequency band within the sensitivity range of the inner ear basilar papilla; with a dominant frequency at 700 Hz, i.e. outside the normal range of variation and with a frequency band outside the sensitivity range of the basilar papilla but within the range of the amphibian papilla; with two dominant frequencies, one at 700 Hz and another at 3500 Hz, stimulating the basilar and amphibian papilla simultaneously. In double choice experiments we tested all combinations of the three call groups, and we tested the 3500 Hz call groups against the same natural call groups. Additionally, we tested the 700 Hz call groups against white noise to see whether these signals are meaningful in mate choice. Females preferred 3500 Hz call groups over all other call groups. The synthetic call group was as attractive to females as the same natural call group. The 700 Hz call group was not meaningful in mate choice. The combined (700 Hz + 3500 Hz) call group was significantly less attractive to females than the 3500 Hz call group. Thus, making a call more spectrally complex without increasing its overall amplitude decreases its attractiveness to cricket frog females. [source] Dental students' motivation and the context of learningEUROPEAN JOURNAL OF DENTAL EDUCATION, Issue 1 2009Bettina Tjagvad Kristensen Abstract This qualitative study shows dental students' motives for choosing the dental education and how the motives influence their motivation at the first semester of study. Further the study demonstrates the relevance of the context of learning. This issue is of importance when planning a curriculum for the dental education. The material consists of interviews with eight dental students. The results show that dental students were focused on their future professional role, its practical dimensions and their future working conditions. Their motivation for choosing the dental education was found to influence their motivation for studying and their experience of the relevance of the first semester. The dental students who had co-education with the medical students at the first year of study missed a dental context and courses with clinically relevant contents. In conclusion, our data signify the importance of the context of learning. It is recommended that a future curriculum for the dental school should be designed in a way where basic science subjects are taught with both theoretically as well as practically oriented subjects and in a context which is meaningful for the students. [source] REVIEW: Understanding the construct of impulsivity and its relationship to alcohol use disordersADDICTION BIOLOGY, Issue 2 2010Danielle M. Dick ABSTRACT There are well-established links between impulsivity and alcohol use in humans and other model organisms; however, the etiological nature of these associations remains unclear. This is likely due, in part, to the heterogeneous nature of the construct of impulsivity. Many different measures of impulsivity have been employed in human studies, using both questionnaire and laboratory-based tasks. Animal studies also use multiple tasks to assess the construct of impulsivity. In both human and animal studies, different measures of impulsivity often show little correlation and are differentially related to outcome, suggesting that the impulsivity construct may actually consist of a number of more homogeneous (and potentially more meaningful) subfacets. Here, we provide an overview of the different measures of impulsivity used across human and animal studies, evidence that the construct of impulsivity may be better studied in the context of more meaningful subfacets, and recommendations for how research in this direction may provide for better consilience between human and animal studies of the connection between impulsivity and alcohol use. [source] Dissecting cytotoxic T,cell responses towards the NY-ESO-1 protein by peptide/MHC-specific antibody fragmentsEUROPEAN JOURNAL OF IMMUNOLOGY, Issue 10 2004Gerhard Held Abstract NY-ESO-1 is a germ cell antigen aberrantly expressed by different tumor types that elicits strong humoral and cellular immune responses, representing one of the most promising candidates for vaccination of cancer patients. A detailed analysis of CD8+ T,cells generated in vaccine trials using NY-ESO-1-derived peptides (157,165 and 157,167) revealed that the dominant immune response was directed against a cryptic epitope (159,167) diverting the immune response from tumor recognition. Only CTL reactivity to the NY-ESO-1157,165 peptide appeared to be capable of lysing NY-ESO-1/HLA-A0201-expressing tumor cells. To study the process of NY-ESO-1 peptide presentation by tumor cells in more detail we generated a high-affinity (KD=60,nM) antibody fragment that specifically recognizes the NY-ESO-1157,165 peptide/HLA-A0201 complex. Peptide variants such as the NY-ESO-1157,167 peptide or the cryptic NY-ESO-1159,167 peptide were not recognized. The antibody fragment blocked in a dose-dependent fashion the recognition of NY-ESO-1/HLA-A2-positive tumor cells by NY-ESO-1157,165 peptide-specific CD8+ T,cells. This antibody fragment is a novel reagent that binds with TCR-like specificity to the NY-ESO-1157,165/HLA-A2 complex thus distinguishing between CTL responses against immunological meaningful or cryptic NY-ESO-1-derived peptides. It may therefore become a useful monitoring tool for the development of NY-ESO-1-based cancer vaccines. [source] Effect of a 1-month vs. a 12-month reference period on responses to the 14-item Oral Health Impact ProfileEUROPEAN JOURNAL OF ORAL SCIENCES, Issue 3 2007Saila Sutinen The length of the reference period used in surveys of subjective oral health may have a marked influence on the responses obtained. We aimed to evaluate the effect of a 1-month (RP-1) vs. a 12-month (RP-12) reference period in the Oral Health Impact Profile (OHIP-14) questionnaire. Using a randomized cross-over design, RP-1 and RP-12 OHIP-14 questionnaires were administered, 1 month apart, to two samples of Finnish adults, namely people awaiting orthognathic surgery (n = 104) and non-patient workers (n = 111). The effect of the reference period was computed by subtracting RP-1 OHIP-14 severity scores from RP-12 OHIP-14 severity scores (,RP). Potential order effects were assessed by comparing ,RP between groups completing the RP-1 vs. the RP-12 questionnaire first. Mean OHIP-14 severity scores were slightly higher when the RP-12 questionnaire was administered first, but mean ,RP values were below the value of 2.5 considered clinically meaningful, and all 95% confidence intervals for ,RP included zero. No order effects in the OHIP-14 severity scores were observed. Therefore, although a standardized reference period of 12 months is recommended, in population surveys the use of a shorter reference period does not appear to influence responses. [source] Sacred Practices in Highly Religious Families: Christian, Jewish, Mormon, and Muslim Perspectives,FAMILY PROCESS, Issue 2 2004Loren Marks Ph.D. Quantitative research examining linkages between family relationships and religious experience has increased substantially in recent years. However, related qualitative research, including research that examines the processes and meanings behind recurring religion-family correlations, remains scant. To address this paucity, a racially diverse sample (N=24) of married, highly religious Christian, Jewish, Mormon, and Muslim parents of school-aged children were interviewed regarding the importance of religious family interactions, rituals, and practices in their families. Mothers and fathers discussed several religious practices that were meaningful to them and explained why these practices were meaningful. Parents also identified costs and challenges associated with these practices. Interview data are presented in connection with three themes: (1) "practicing [and parenting] what you preach," (2) religious practices, family connection, and family communion, and (3) costs of family religious practices. The importance of family clinicians and researchers attending to the influence of religious practice in the lives of highly religious individuals and families is discussed. [source] Family Resiliency in Childhood Cancer,FAMILY RELATIONS, Issue 2 2002Marilyn McCubbin Based on in-depth interviews with 42 parents (25 mothers, 17 fathers) in 26 families who had had a child treated for cancer within the previous 3 years, resiliency factors that helped the family recover were identified. The resiliency factors included internal family rapid mobilization and reorganization; social support from the health care team, extended family, the community, and the workplace; and changes in appraisal to make the situation more comprehensible, manageable, and meaningful. [source] Life-history strategies in freshwater macroinvertebratesFRESHWATER BIOLOGY, Issue 9 2008WILCO C. E. P. VERBERK Summary 1Explaining spatial and temporal differences in species assemblages is a central aim of ecology. It requires a sound understanding of the causal mechanisms underlying the relationship of species with their environment. A species trait is widely acknowledged to be the key that links pattern and process, although the enormous variety of traits hampers generalization about which combination of traits are adaptive in a particular environment. 2In three steps, we used species traits to match species and environment, and chose lentic freshwater ecosystems to illustrate our approach. We first identified key environmental factors and selected the species traits that enable the organism to deal with them. Secondly, we investigated how investments in these traits are related (e.g. through trade-offs). Thirdly, we outlined 13 life-history strategies, based on biological species traits, their interrelations known from life-history theory and their functional implications. 3Species traits and environmental conditions are connected through life-history strategies, with different strategies representing different solutions to particular ecological problems. In addition, strategies may present an integrated response to the environment as they are based on many different traits and their interrelationships. The presence and abundance of (species exhibiting) different life-history strategies in a location may therefore give direct information about how a particular environment is experienced by the species present. 4Life-history strategies can be used to (i) explain differences in species assemblages either between locations or in different periods; (ii) compare waterbodies separated by large geographical distances, which may comprise different regional species pools or span species distribution areas and (iii) reduce often very complex, biodiverse assemblages into a few meaningful, easily interpretable relationships. [source] ,The unforgettable forgotten': The Traces of Trauma in Herta Müller's Reisende auf einem BeinGERMAN LIFE AND LETTERS, Issue 3 2002Brigid Haines Trauma can be read as a metaphor of the (post)modern condition, particularly in a German context. This is because it is associated with aporias in memory and understanding which are nevertheless meaningful because they arise from and speak of specific historical circumstances. This article places Herta Müller's 1989 Berlin novel Reisende auf einem Bein within the context of twentieth-century trauma literature. I read the protagonist, Irene, as a traumatised individual, whose experience (in Ceau,escu's Romania, then as an ethnic German immigrant in West Berlin) is locatable, but the causes of whose trauma elude representation because they are not synthesisable into frameworks of understanding. Irene comes to accommodate her trauma by inhabiting her surroundings and renouncing control , while reasserting agency. Thus the structure of trauma provides a way out of the perceived paralysis of postmodern constructions of subjectivity. Finally the novel bears witness to ,the unforgettable forgotten'. ,Das Überleben ist kein Leben mehr und dennoch das einzig mögliche Leben.' (Alexander García Düttmann) ,Whenever one represents, one inscribes in memory, and this might seem a good defense against forgetting. It is, I believe, just the opposite.' (Jean-François Lyotard) ,Nicht Sprache ist Heimat, sondern das, was gesprochen wird.' (Jorge Semprun) [source] Global evidence that deforestation amplifies flood risk and severity in the developing worldGLOBAL CHANGE BIOLOGY, Issue 11 2007COREY J. A. BRADSHAW Abstract With the wide acceptance of forest-protection policies in the developing world comes a requirement for clear demonstrations of how deforestation may erode human well-being and economies. For centuries, it has been believed that forests provide protection against flooding. However, such claims have given rise to a heated polemic, and broad-scale quantitative evidence of the possible role of forests in flood protection has not been forthcoming. Using data collected from 1990 to 2000 from 56 developing countries, we show using generalized linear and mixed-effects models contrasted with information-theoretic measures of parsimony that flood frequency is negatively correlated with the amount of remaining natural forest and positively correlated with natural forest area loss (after controlling for rainfall, slope and degraded landscape area). The most parsimonious models accounted for over 65% of the variation in flood frequency, of which nearly 14% was due to forest cover variables alone. During the decade investigated, nearly 100 000 people were killed and 320 million people were displaced by floods, with total reported economic damages exceeding US$1151 billion. Extracted measures of flood severity (flood duration, people killed and displaced, and total damage) showed some weaker, albeit detectable correlations to natural forest cover and loss. Based on an arbitrary decrease in natural forest area of 10%, the model-averaged prediction of flood frequency increased between 4% and 28% among the countries modeled. Using the same hypothetical decline in natural forest area resulted in a 4,8% increase in total flood duration. These correlations suggest that global-scale patterns in mean forest trends across countries are meaningful with respect to flood dynamics. Unabated loss of forests may increase or exacerbate the number of flood-related disasters, negatively impact millions of poor people, and inflict trillions of dollars in damage in disadvantaged economies over the coming decades. This first global-scale empirical demonstration that forests are correlated with flood risk and severity in developing countries reinforces the imperative for large-scale forest protection to protect human welfare, and suggests that reforestation may help to reduce the frequency and severity of flood-related catastrophes. [source] Linking return visits and return migration among Commonwealth Eastern Caribbean migrants in TorontoGLOBAL NETWORKS, Issue 1 2004David Timothy Duval Return visits are periodic but temporary sojourns made by members of migrant communities to their external homeland or another location where strong social ties exist. As a result, the conceptual framework in this article revolves around transnationalism as the return visit is shown to be a transnational exercise that may facilitate return. Using data from ethnographic fieldwork, three themes highlight the link between return visits and return migration: (1) the need to facilitate ties such that relationships are meaningful upon permanent return; (2) the functional nature of the return visit, such that changes are measured and benchmarked against what is remembered and internalized by the migration after the migration episode; and (3) the knowledge that return visits aid in reintegration. [source] Markers of ,Authentic Place'?HIGHER EDUCATION QUARTERLY, Issue 2 2001Awards, Qualifications in the Analysis of Higher Education Systems, The Significance of Degrees Although the power to award degrees lies at the heart of the concept of a university, neither it nor degrees themselves have attracted much scholarly attention. The paper contends that award-conferment provides an interface of major importance between higher education and its environment; and that the awards themselves can serve as rich and informative (yet often coded) indicators of the relationship between the two. For awards to be seen in this way, the paper argues, two conditions are required: the conceptual independence of awards in their own right has to be recognised as entities distinct from courses of study; and instrumentalist views have to be sufficiently prevalent to make it meaningful to treat an award as specifying a set of purposes and intended outcomes (that is to say, as an ,end'potentially achievable by various ,means'). These conditions, it is suggested, only tend to arise in particular social circumstances, specifically those of mass higher education. Having illustrated these points by considering certain changes of usage in the terms used for higher education awards (degree, qualification, etc), the paper concludes with a tentative sketch of a framework by which to analyse the various ways in which awards might contribute to the workings of HE as a system. [source] Definitions of antiretroviral treatment failure for measuring quality outcomesHIV MEDICINE, Issue 7 2010A Samaranayake Objectives Our aim was to compare three different definitions of treatment failure and discuss their use as quality outcome measures for a clinical service. Methods Data for treatment-naïve patients who attended the Melbourne Sexual Health Centre (MSHC) between 1 January 2000 and 31 December 2008 were analysed. Definition 1 was the strict Food and Drug Administration (FDA) definition of treatment failure as determined using the time to loss of virological response (TLOVR) algorithm. Definition 2 defined treatment failure as occurring in those whose viral load never fell to <400 HIV-1 RNA copies/mL or who developed two consecutive viral loads ,400 copies/mL on any treatment (switching or stopping treatment with a viral load <400 copies/mL was permitted). Definition 3 was the same as definition 2 except that individuals were also deemed to have failed if they stopped treatment for 6 months or longer. Results There were 310 antiretroviral-naïve patients who started treatment in the study period. Of these, 156 [50.3%; 95% confidence interval (CI) 42.1,53.3%] experienced treatment failure under definition 1, 10 (3.2%; 95% CI 1.5,5.8%) experienced treatment failure under definition 2, and 16 (4.5%; 95% CI 2.5,7.4%) experienced treatment failure under definition 3 over the 108 months of follow-up. The probability of failing definition 1 was statistically different from the probability of failing definition 2 or 3 (P=0.01). Conclusion There were significant differences in treatment failure for the three definitions. If definition 1 were used, the outcomes would be sufficiently common to enable clinics to be compared but would be less meaningful. If definition 2 or 3 were used, the events would be too rare to enable clinics to be compared, but it would be possible to set a benchmark level of success that clinics could aim to reach. [source] A forward application of age associated gray and white matter networks,HUMAN BRAIN MAPPING, Issue 10 2008Adam M. Brickman Abstract To capture patterns of normal age-associated atrophy, we previously used a multivariate statistical approach applied to voxel based morphometry that identified age-associated gray and white matter covariance networks (Brickman et al. [2007]: Neurobiol Aging 28:284,295). The current study sought to examine the stability of these patterns by forward applying the identified networks to an independent sample of neurologically healthy younger and older adults. Forty-two younger and 35 older adults were imaged with standard high-resolution structural magnetic resonance imaging. Individual images were spatially normalized and segmented into gray and white matter. Covariance patterns that were previously identified with scaled subprofile model analyses were prospectively applied to the current sample to identify to what degree the age-associated patterns were manifested. Older individuals were also assessed with a modified version of the Mini Mental State Examination (mMMSE). Gray matter covariance pattern expression discriminated between younger and older participants with high optimal sensitivity (100%) and specificity (90.5%). While the two groups differed in the degree of white matter pattern expression (t (75) = 5.26, P < 0.001), classification based on white matter expression was relatively low (sensitivity = 80% and specificity = 61.9%). Among older adults, chronological age was significantly associated with increased gray matter pattern expression (r (32) = 0.591, P < 0.001) but not with performance on the mMMSE (r (31) = ,0.314, P = 0.085). However, gray matter pattern expression was significantly associated with performance on the mMMSE (r (31) = ,0.405, P = 0.024). The findings suggest that the previously derived age-associated covariance pattern for gray matter is reliable and may provide information that is more functionally meaningful than chronological age. Hum Brain Mapp 2008. © 2007 Wiley-Liss, Inc. [source] Human genome variation and pharmacogenetics,HUMAN MUTATION, Issue 4 2008Bruce Gottlieb Abstract A recent HGVS-sponsored symposium has examined, for the first time, the possible effects of the discovery of very large and widespread amounts of human genome variation on the emerging fields of pharmacogenetics and pharmacogenomics. This article discusses the effects of the resultant paradigm shifts and raises a number of important questions that need to be considered in order to truly advance the field in a meaningful and significant way. Hum Mutat 29(4):453,455, 2008. © 2008 Wiley-Liss, Inc. [source] Supporting a diverse workforce: What type of support is most meaningful for lesbian and gay employees?HUMAN RESOURCE MANAGEMENT, Issue 2 2008Ann H. Huffman We examine differences in type of support (i.e., supervisor, coworker, organizational) received by lesbian, gay, and bisexual (LGB) employees and the relationship between type of support and relevant outcomes (job and life satisfaction, outness of sexual orientation). Surveys were administered to 99 LGB individuals, and results indicate that support is best viewed as a multi-dimensional construct composed of supervisor, coworker, and organizational support for LGB employees. Overall, supervisor support was related to job satisfaction, coworker support was related to life satisfaction, and organizational support for LGB employees was related to outness.Thus, support for LGB employees isrelated to important outcomes. Practical suggestions for increasing organizational support for LGB employees are offered. © 2008 Wiley Periodicals, Inc. [source] What aspects of the job have most effect on nurses?HUMAN RESOURCE MANAGEMENT JOURNAL, Issue 1 2003Abraham Sagie The study reported here compared the influences of psychological constructs (job demands and scheduling control) and objective work characteristics (shiftwork, night-work and hospital department type) on job satisfaction, organisational commitment, burnout and withdrawal intentions. Our hypothesis was that psychological constructs have a higher influence on work-related attitudes than objective characteristics of work schedules. In addition to the main effects, we proposed an interactive hypothesis: poor attitudes would result from high demands and low control rather than from other combinations of both psychological variables. Using a sample of 153 hospital nurses in Israel, the hypotheses were generally supported. As night-work, shiftwork and working in intensive care units are unavoidable characteristics of the modern medical environment, these findings are meaningful for improving the personal adjustment of hospital nurses. [source] Getting Hired: Sex and RaceINDUSTRIAL RELATIONS, Issue 3 2005TROND PETERSEN The hiring process is currently probably the least understood aspect of the employment relationship. It may very well be the most important for understanding the broad processes of stratification with allocation by sex and race to jobs and firms. A central reason for the lack of knowledge is that it is very difficult to assemble extensive data on the processes that occur at the point of hiring. We analyzed data on all applicants to a large service organization in the U.S. in a 16-month period in 1993,1994. We investigated the rating at the time of application, the probability of getting hired, and the ratings achieved one, three, and six months after hire. Overall differences between men and women were (a) negligible in rating received at the time of application, (b) small but slightly in favor of women in probability of getting hired, and (c) clearly in favor of women for ratings after hire. The evidence points unambiguously in one direction: Women do not come out worse than men in the hiring process in this organization. To the extent there is a difference, it is to the advantage of women. However, if the posthire performance ratings are free of sex bias, then women should have been hired at an even higher rate. When analyses were done separately by occupation, there are few differences between men and women in getting hired in the three occupations accounting for 94 percent of hires. In the other two, only 8 and 15 hires were made, making statistical analysis less meaningful. However, there is evidence that blacks face a disadvantage in getting hired, and also receive lower ratings after hire. Hispanic men are especially disadvantaged in getting hired. [source] Executive functioning by 18-24-month-old children: effects of inhibition, working memory demands and narrative in a novel detour-reaching taskINFANT AND CHILD DEVELOPMENT, Issue 5 2006Nicola McGuigan Abstract Infants can inhibit a prepotent but wrong action towards a goal in order to perform a causal means-action. It is not clear, however, whether infants can perform an arbitrary means-action while inhibiting a prepotent response. In four experiments, we explore this executive functioning in 18,24-month-old children. The working memory and inhibition demands in a novel means-end problem were systematically varied in terms of the type and combination of means-action(s) (causal or arbitrary) contained within the task, the number of means-actions (1 or 2), the goal visual availability and whether the task was accompanied by a narrative. Experiments 1 and 2 showed that children performed tasks that contained causal as opposed to arbitrary information more accurately; accuracy was also higher in tasks containing only one step. Experiment 2 also demonstrated that performance in the arbitrary task improved significantly when all sources of prepotency were removed. In Experiment 3, task performance improved when the two means-actions were intelligibly linked to the task goal. Experiment 4 demonstrated that the use of a narrative that provided a meaningful (non-causal) link between the two means-actions also improved children's performance by assisting their working memory in the generation of a rationale. Findings provide an initial account of executive functioning in the months that bring the end of infancy. Copyright © 2006 John Wiley & Sons, Ltd. [source] | ||||||||||||||||||||||||||||||||||||||||||||||||||||