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Meticillin-resistant Staphylococcus Aureus (meticillin-resistant + staphylococcus_aureu)
Selected AbstractsMeticillin-resistant Staphylococcus aureus in a veterinary orthopaedic referral hospital: staff nasal colonisation and incidence of clinical casesJOURNAL OF SMALL ANIMAL PRACTICE, Issue 4 2008C. L. McLean Objectives: To evaluate staff nasal colonisation with meticillin-resistant Staphylococcus aureus in a veterinary orthopaedic referral hospital, and its effect on the occurrence of meticillin-resistant Staphylococcus aureus -associated postoperative wound complications in orthopaedic and spinal surgical patients. Methods: Nasal bacterial swabs were collected from veterinary staff and environmental surfaces swabbed at six monthly intervals for meticillin-resistant Staphylococcus aureus monitoring over an 18 month period. The incidence of meticillin-resistant Staphylococcus aureus -associated postoperative wound complications of two veterinary orthopaedic surgeons was reviewed for a period when one was positive for nasal meticillin-resistant Staphylococcus aureus. Results: Meticillin-resistant Staphylococcus aureus was isolated from a maximum of two out of 10 staff on each occasion. The persistently infected clinician was primary surgeon in 180 cases, of which four developed meticillin-resistant Staphylococcus aureus -associated wound complications. None of 141 operations led by the other surgeon developed meticillin-resistant Staphylococcus aureus -associated complications. This difference is not statistically significant (P=0·0974). The 95 per cent confidence interval for this odds ratio was 0·83 to 44·0. Meticillin-resistant Staphylococcus aureus resistance patterns of the human nasal isolates and three of four wound-associated isolates were similar. Clinical Significance: Veterinary workers are at increased risk for meticillin-resistant Staphylococcus aureus colonisation, so it is likely that many veterinary patients are treated by meticillin-resistant Staphylococcus aureus -positive staff. Nasal colonisation of veterinary surgeons with meticillin-resistant Staphylococcus aureus appears to present only a small risk to their patients when appropriate infection control procedures are followed. [source] Impact of rapid molecular screening for meticillin-resistant Staphylococcus aureus in surgical wards,BRITISH JOURNAL OF SURGERY (NOW INCLUDES EUROPEAN JOURNAL OF SURGERY), Issue 3 2008M. R. S. Keshtgar Background: This study aimed to establish the feasibility and cost-effectiveness of rapid molecular screening for hospital-acquired meticillin-resistant Staphylococcus aureus (MRSA) in surgical patients within a teaching hospital. Methods: In 2006, nasal swabs were obtained before surgery from all patients undergoing elective and emergency procedures, and screened for MRSA using a rapid molecular technique. MRSA-positive patients were started on suppression therapy of mupirocin nasal ointment (2 per cent) and undiluted chlorhexidine gluconate bodywash. Results: A total of 18 810 samples were processed, of which 850 (4·5 per cent) were MRSA positive. In comparison to the annual mean for the preceding 6 years, MRSA bacteraemia fell by 38·5 per cent (P < 0·001), and MRSA wound isolates fell by 12·7 per cent (P = 0·031). The reduction in MRSA bacteraemia and wound infection was equivalent to a saving of 3·78 beds per year (£276 220), compared with the annual mean for the preceding 6 years. The cost of screening was £302 500, making a net loss of £26 280. Compared with 2005, however, there was a net saving of £545 486. Conclusion: Rapid MRSA screening of all surgical admissions resulted in a significant reduction in staphylococcal bacteraemia during the screening period, although a causal link cannot be established. Copyright © 2007 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. [source] Strain relatedness of meticillin-resistant Staphylococcus aureus isolates recovered from patients with repeated bacteraemiaCLINICAL MICROBIOLOGY AND INFECTION, Issue 5 2010C-H. Liao Clin Microbiol Infect 2010; 16: 463,469 Abstract Information on the relatedness of isolates causing repeated meticillin-resistant Staphylococcus aureus (MRSA) bacteraemia is limited. An observational study of 177 patients with MRSA bacteraemia, admitted to the emergency department of National Taiwan University Hospital, was conducted from January 2001 to June 2006. Among these patients, 28 had a previous episode of MRSA bacteraemia and 59 died during the index episode of bacteraemia. Until December 2007, among the 118 patients who survived the index episode (101 without previous bacteraemia and 17 with previous bacteraemia), 24 (20.3%) had repeated MRSA bacteraemia. The duration from discontinuation of antimicrobial therapy to repeat episodes was in the range 35,854 days (median 86 days). Eight patients (33.3%) died as a result of the second bacteraemic episode. Clinical characteristics associated with repeated bacteraemia included the diagnosis of infective endocarditis and active malignancy. Pulsed-field gel electrophoresis and multilocus sequence typing analysis were performed for 32 pairs of available isolates recovered from patients with repeated bacteraemia and revealed that 29 of them (90.6%) were genetically closely-related strains. The majority of patients with repeated MRSA bacteraemia had recurrent infections and a high mortality rate. [source] | ||||||||||