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Methodological Analysis (methodological + analysis)

Distribution by Scientific Domains

Humanities and Social Sciences	50%

Selected Abstracts

Methodological Analysis of Diagnostic Dobutamine Stress Echocardiography Studies

ECHOCARDIOGRAPHY, Issue 8 2004
Boudewijn J. Krenning M.D.
Background: Dobutamine stress echocardiography (DSE) is an accepted test for the diagnosis of coronary artery disease (CAD), despite its wide diagnostic accuracy. Aim: Which factors cause test variability of DSE for the diagnosis of CAD. Methods: In a retrospective analysis of 46 studies in 5,353 patients, the potential causes of diagnostic variability were systematically analyzed, including patient selection, definition of CAD, chest pain characteristics, confounding factors for DSE (left ventricular hypertrophy, left bundle branch block, female gender), work-up bias (present when patient's chance to undergo coronary angiography is influenced by the result of DSE), review bias (present when DSE is interpreted in relation to CAG), DSE protocol and definition of a positive DSE. Results: Diagnostic variability was related to definition of a positive test, but not related to the definition of CAD or DSE protocol. However, only three of eight methodological standards for research design found general compliance. Differences in the selection of the study population (quality of echocardiographic window, angina pectoris), handling of confounding factors and analysis of disease in individual coronary arteries were observed. Lack of data on analysis of relevant chest pain syndromes and handling of nondiagnostic test results hampered further evaluation of these standards. Conclusion: Methodological problems may explain the wide range in diagnostic variability of DSE. An improvement of clinical relevance of DSE testing is possible by stronger adherence to common and new methodological standards. [source]

Methodological analysis for determination of enzymatic digestibility of cellulosic materials

BIOTECHNOLOGY & BIOENGINEERING, Issue 1 2007
Y.-H. Percival Zhang
Abstract Accurate measurement of enzymatic cellulose digestibility (X) is important in evaluating the efficiency of lignocellulose pretreatment technologies, assessing the performance of reconstituted cellulase mixtures, and conducting economic analysis for biorefinery processes. We analyzed the effect of sugars contained in enzymes solutions, usually added as a preservative, and random measurement errors on the accuracy of X calculated by various methods. The analysis suggests that exogenous sugars at levels measured in several commercial enzyme preparations significantly bias the results and that this error should be minimized by accounting for these sugars in the calculation of X. Additionally, a method of calculating X equating the ratio of the soluble glucose equivalent in the liquid phase after hydrolysis to the sum of the soluble glucose equivalent in the liquid phase and the insoluble glucose equivalent in the residual solid after hydrolysis was found to be the most accurate, particularly at high conversion levels (>ca. 50%). Biotechnol. Bioeng. 2007;96: 188,194. © 2006 Wiley Periodicals, Inc. [source]

What can the Social Sciences Contribute to the Study of Ethics?

BIOETHICS, Issue 2 2002
Empirical, Substantive Considerations, Theoretical
This article seeks to establish that the social sciences have an important contribution to make to the study of ethics. The discussion is framed around three questions: (i) what theoretical work can the social sciences contribute to the understanding of ethics? (ii) what empirical work can the social sciences contribute to the understanding of ethics? And (iii) how does this theoretical and empirical work combine, to enhance the understanding of how ethics, as a field of analysis and debate, is socially constituted and situated? Through these questions the argument goes beyond the now commonly cited objection to the over-simplistic division between normative and descriptive ethics (that assigns the social sciences the ,handmaiden' role of simply providing the ,facts'). In extending this argument, this article seeks to establish, more firmly and in more detail, that: (a) the social sciences have a longstanding theoretical interest analysing the role that a concern with ethics plays in explanations of social change, social organisation and social action; (b) the explanations that are based on the empirical investigations conducted by social scientists exemplify the interplay of epistemological and methodological analyses so that our understanding of particular substantive issues is extended beyond the conventional questions raised by ethicists, and (c) through this combination of theoretical and empirical work, social scientists go beyond the specific ethical questions of particular practices to enquire further into the social processes that lie behind the very designation of certain matters as being ,ethical issues'. [source]

Theorizing in Family Gerontology: New Opportunities for Research and Practice

FAMILY RELATIONS, Issue 5 2006
Karen A. Roberto
Abstract: We examine the extent to which theory has been used in empirical studies of families in later life, identify prevalent types of theoretical frameworks, and assess connections between theory and both focal topics and analytic methods in the family gerontology literature. The paper is based on content and methodological analysis of 838 empirical articles with a family-level focus published in 13 social science journals during the 1990s. Approximately one half of the articles included theory, with micro-interpretive (social psychological) theories being used most often to guide and inform research and practice. To advance the field and understand better the intricacies of family life among older adults, we suggest that investigators and practitioners explicitly incorporate theoretical frameworks into their endeavors. [source]