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Maternal Environment (maternal + environment)
Selected AbstractsMaternal environment affects endogenous virus induction in the offspring of type 1 diabetes model non-obese diabetic miceCONGENITAL ANOMALIES, Issue 3 2005Yukiko Kagohashi ABSTRACT Type 1 diabetes results from the destruction of pancreatic b-cells (insulitis). It is a multifactorial disease involving genetic and environmental factors, including the maternal environment. Viruses have also been implicated in the pathogenesis of human type 1 diabetes as well as in its model non-obese diabetic (NOD) mice during the perinatal period, as endogenous viruses and/or as infectious agents vertically transmitted from mothers. However, the role of virus as genetic or environmental factor and its interaction with other maternal factors remain unclear. In a series of experiments, we transplanted preimplantation-stage NOD embryos into the uterus of recipient Institute of Cancer Research (ICR) mice, which are without diabetic genetic predisposition, and NOD mice, which did not exhibit overt diabetes during the experiment, and designated offspring as NOD/ICR and NOD/NOD, respectively. We previously observed that NOD/ICR offspring developed insulitis significantly earlier than NOD/NOD offspring. To assess the role of viruses in the development of insulitis, we examined the appearance of viral particles and expression of retroviruses between NOD/ICR and NOD/NOD. NOD/ICR showed earlier expression of env region of the xenotropic type C retrovirus by polymerase chain reaction analysis than NOD/NOD, while the retrovirus-like particles were observed in the islet b-cells similarly in both groups by electron microscopy. Serum corticosterone level, which is suggested to enhance retroviral induction, was significantly higher in the ICR than in the NOD surrogate mothers. These findings suggest that the observed virus is endogenous and that maternal environmental factors, including hormone levels, affect the induction of endogenous viruses and cause the earlier onset of insulitis. [source] Motherless rats show deficits in maternal behavior towards fostered pupsDEVELOPMENTAL PSYCHOBIOLOGY, Issue 2 2010Daniela J. Palombo Abstract Complete maternal deprivation in rats, through artificial rearing (AR), produces deficits in subsequent maternal behavior of the offspring. These deficits are partially reversed when isolated pups are provided with additional tactile stimulation designed to simulate maternal licking (e.g., Gonzalez et al. [2001] Developmental Psychobiology, 38, 11,32). These findings highlight the importance of the early maternal environment in subsequent development. However, given the possibility that prenatal environments may differ between AR and maternally reared (MR) offspring, the deficits in the behavior of AR mothers may be driven by the characteristics of their pups derived from the effects of an altered prenatal environment. Hence differences in the neonatal pups of AR mothers may produce the alterations in the AR maternal behavior. To rule out this possibility, we employed a fostering paradigm where AR and MR mothers received cross-fostered mother-reared pups. AR mothers showed the same level of deficits in maternal behavior towards MR foster pups as they do with their own pups and these deficits were partially reversed with additional tactile stimulation. Hence, maternal behavior deficits reported in mothers who had been reared in isolation are due primarily to the direct effects of the earlier experience on mechanisms regulating their maternal behavior and not to the effects on their offspring. © 2010 Wiley Periodicals, Inc. Dev Psychobiol 52:142,148, 2010 [source] Intermediate metabolism in normal pregnancy and in gestational diabetesDIABETES/METABOLISM: RESEARCH AND REVIEWS, Issue 4 2003G. Di Cianni Abstract Complex though integrated hormonal and metabolic changes characterize pregnancy. In the face of progressive decline in insulin action, glucose homeostasis is maintained through a compensatory increase in insulin secretion. This switches energy production from carbohydrates to lipids, making glucose readily available to the fetus. This precise and entangled hormonal and metabolic condition can, however, be disrupted and diabetic hyperglycemia can develop (gestational diabetes). The increase in plasma glucose level is believed to confer significant risk of complications to both the mother and the fetus and the newborn. Moreover, exposition of fetal tissues to the diabetic maternal environment can translate into an increased risk for development of diabetes and/or the metabolic syndrome in the adult life. In women with previous gestational diabetes, the risk of developing type 2 diabetes is greatly enhanced, to the point that GDM represents an early stage in the natural history of type 2 diabetes. In these women, accurate follow-up and prevention strategies are needed to reduce the subsequent development of overt diabetes. This paper will review current knowledge on the modifications occurring in normal pregnancy, while outlining the mechanisms. In this paper, we will review the changes of intermediary metabolism occurring during pregnancy. In particular, we will outline the mechanisms responsible for gestational diabetes; the link between these alterations and associated maternal and neonatal morbidity will be examined. Copyright © 2003 John Wiley & Sons, Ltd. [source] PARENTAL EFFECTS AND GENDER SPECIALIZATION IN A TROPICAL HETEROSTYLOUS SHRUBEVOLUTION, Issue 3 2000Germá;n Avila-Sakar Abstract., Male sterility in hermaphroditic species may represent the first step in the evolution toward dioecy. However, gender specialization will not proceed unless the male-sterile individuals compensate for fitness lost through the male function with an increase in fitness through the female function. In the distylous shrub Erythroxylum havanense, thrum plants are partially male-sterile. Using data collected throughout eight years, we investigated whether thrum individuals have an increased performance as female parents, thereby compensating for their loss of male fitness. We found that thrum plants outperformed pins in the probabilities of seed maturation and germination and long-term growth of the seedlings. In turn, pollen from pin plants achieved greater pollen tube growth rates. Our results suggest that the superior performance of the progeny of thrum maternal plants is a consequence of better seed provisioning via effects of the maternal environment, cytotype or nuclear genes. Overall, our results suggest that E. havanense is evolving toward a dioecious state through a gynodioecious intermediate stage. This evolutionary pathway is characterized by an unusual pattern of gender dimorphism with thrums becoming females and pins becoming males. We propose that this pattern may be better explained by the interaction between male-sterility cytoplasmic genes and the heterostyly supergene. [source] An experimental test for effects of the maternal environment on delayed germinationJOURNAL OF ECOLOGY, Issue 5 2010Katja Tielbörger Summary 1.,Recent models on bet-hedging germination in annual plants assume a negative relationship between the proportion of offspring that germinate and the quality of the maternal environment. An increase in the proportion of seeds remaining dormant in the next year, when produced in seasons with high reproduction may result from selection that avoids overcrowding in the following year. 2.,We present the first empirical test of this prediction by utilizing a field experiment in Israel which manipulated the entire maternal environment. We subjected semi-arid and Mediterranean annual plant communities to different rainfall treatments: control, reduced and increased rainfall. We then related maternal environment quality to offspring germination fractions for three focal species in two consecutive seasons. 3.,There was a negative relationship between the quality of the maternal environment and offspring germination fraction in four out of twelve cases. The negative relationship was stronger for the least competitive species and in the environment with high competition intensity, supporting the role of competition for the observed pattern. 4.,Our results suggest that competition with all neighbours is more likely to explain the pattern than sib competition. 5.,Synthesis. Our findings provide the first experimental evidence of a highly reliable cue (productivity of maternal environment) that allows for plants to respond to their future biotic environment. There is an urgent need for testing predictions of theoretical models in natural populations and for incorporating the role of density dependence in studies of bet-hedging germination. [source] An explicit test for the contribution of environmental maternal effects to rapid clinal differentiation in an invasive plantJOURNAL OF EVOLUTIONARY BIOLOGY, Issue 5 2009A. MONTY Abstract Population differentiation of alien invasive plants within their non-native range has received increasingly more attention. Common gardens are typically used to assess the levels of genotypic differentiation among populations. However, in such experiments, environmental maternal effects can influence phenotypic variation among individuals if seed sources are collected from field populations under variable environmental regimes. In the present study, we investigated the causes of an altitudinal cline in an invasive plant. Seeds were collected from Senecio inaequidens (Asteraceae) populations along an altitudinal gradient in southern France. In addition, seeds from the same populations were generated by intra-population crossings in a climatic chamber. The two seed lots were grown in a common garden in Central Belgium to identify any evidence of environmentally induced maternal effects and/or an altitudinal cline in a suite of life-history traits. Results failed to detect any environmental maternal effects. However, an altitudinal cline in plant height and above-ground biomass was found to be independent of the maternal environment. [source] A test of three hypotheses for ovariole number determination in the grasshopper Romalea micropteraPHYSIOLOGICAL ENTOMOLOGY, Issue 3 2010BENJAMIN J. TAYLOR Ovariole number in insects determines potential fecundity and can be influenced by genes, environmental conditions during development and parental effects. In the present study, three hypotheses are tested for ovariole number determination in the grasshopper Romalea microptera (Beauvois), which exhibits both intra- and interpopulation variation in ovariole number. In hypothesis 1, variation in ovariole number is a result of genetic variation. In hypothesis 2, ovariole number is influenced by nutrition during development. In hypothesis 3, ovariole number is influenced by maternal nutritional status. Females from four treatments are compared: low-food, high-food, daughters of low-food, and daughters of high-food. There is a relationship between parent and offspring ovariole number despite different environments, supporting hypothesis 1. Also, ovariole numbers are slightly, but significantly lower in individuals fed a low-food diet compared with a high-food diet, supporting hypothesis 2. Hypothesis 3 is not supported: starved and well-fed females produce eggs of similar mass, as well as offspring with similar numbers of ovarioles, suggesting that the nutritional status of mothers does not influence offspring mass or offspring ovariole number. The results imply that genetic variation and developmental conditions determine ovariole number in this species but maternal environment does not. These results conflict with previous studies of ovariole determination in grasshoppers and locusts. [source] OUTBREEDING DEPRESSION VARIES AMONG COHORTS OF IPOMOPSIS AGGREGATA PLANTED IN NATUREEVOLUTION, Issue 2 2000Nickolas M. Waser Abstract., Outbreeding depression in progeny fitness may arise from disruption of local adaptation, disruption of allelic coadaptation, or a combination of these "environmental" and "physiological" mechanisms. Thus the minimum spatial scale over which outbreeding depression arises should depend on the spatial scale of gene dispersal and (with an environmental mechanism) of change in selection regimes. We previously reported substantial outbreeding depression in lifetime fitness of progeny resulting from crosses among parents separated by 100 m in natural populations of the herbaceous plant Ipomopsis aggregata. In this paper we explore the effect of crossing distance on fitness in two additional experiments begun in 1987 and 1990. We planted seed progeny derived from partial diallel crossing designs in randomized blocks in maternal environments and scored emergence of seedlings, survival, and eventual flowering of individuals over the subsequent six to eight years. Nested within each diallel design were crossing distances of 1 m, 10 m, and 100 m. Compared to 1-m and 10-m progeny, 100-m progeny of the 1987 diallel suffered a significant reduction in seedling emergence, and both 1-m and 100-m progeny that survived to flower achieved lower ,-values on average than 10-m progeny. Total outbreeding depression suffered by 100-m relative to 10-m progeny was approximately 10%, compared to approximately 30% in our earlier study of I. aggregata. Progeny of 10-m crosses also outperformed 1-m and 100-m progeny of the 1990 diallel by approximately 5%, but no difference among crossing distance treatments was significant. Thus, the magnitude of outbreeding depression in 100-m crosses varied among experiments. This is not surprising given likely spatial and temporal variation in gene flow and selection regimes, different population histories, and different parental and progeny environments. Characterizing outbreeding depression on the shortest spatial scales over which it is expressed, as well as its variation and causes, is worthwhile because it promises to shed light on the earliest stages of angiosperm speciation. [source] Contribution of direct and maternal genetic effects to life-history evolutionNEW PHYTOLOGIST, Issue 3 2009Laura F. Galloway Summary ,,Maternal effects are ubiquitous in nature. In plants, most work has focused on the effects of maternal environments on offspring trait expression. Less is known about the prevalence of genetic maternal effects and how they influence adaptive evolution. Here, we used multivariate genetic models to estimate the contributions of maternal and direct genetic (co)variance, the cross-generation direct-maternal covariance, and M, the matrix of maternal effect coefficients, for life-history traits in Campanulastrum americanum, a monocarpic herb. ,,Following a three-generation breeding design, we grew paternal half-sib families with full-sib relatives of each parent and measured juvenile and adult traits. ,,Seed size was influenced exclusively by maternal environmental effects, whereas maternal genetic effects influenced traits throughout the life cycle, including strong direct and maternal additive genetic correlations within and between generations for phenological and size traits. Examination of M suggested that both juvenile and adult traits in maternal plants influenced the expression of offspring traits. ,,This study reveals substantial potential for genetic maternal effects to contribute to adaptive evolution including cross-generation direct-maternal correlations that may slow selection response, maternal effects on phenology that reinforce genetic correlations, and within- and between-generation genetic correlations that may influence life-history polymorphism. [source] | ||||||||||