Home About us Contact
|
Home About us Contact | ||
|
|
||
Marine Toxins (marine + toxin)
Selected AbstractsEnantioselective Total Synthesis of the Marine Toxin (,)-Gymnodimine Employing a Barbier-Type Macrocyclization,ANGEWANDTE CHEMIE, Issue 40 2009Ke Kong Exoten des Meeres: tert -Butyllithium vermittelt bei Umgebungstemperatur eine Barbier-Makrocyclisierung in der ersten Totalsynthese von (,)-Gymnodimin (Ts: Toluol-4-sulfonyl; TBS: tert -Butyldimethylsilyl), einem marinen Toxin aus der Familie der spirocyclischen Imine. Die Synthese enthält außerdem eine vinyloge Mukaiyama-Aldolreaktion zur Kupplung der labilen Butenolidgruppe an eine makrocyclische Keton-Zwischenstufe. [source] Biosynthetic studies of the DSP toxin skeletonTHE CHEMICAL RECORD, Issue 1 2004Antonio H. Daranas Abstract Marine toxins have drawn wide interest because their economical impact and disastrous effect upon the shellfish industry and public health in many parts of the world. One of the most interesting group of substances of marine toxins, from structural and pharmacological points of view are polyether compounds, which generally present a great diversity in size and potent biological activities. The subject of this work was about to biosynthesis of okadaic acid skeleton as leader as DSP toxins. Its biosynthesis attracts considerable attention since the carbon skeleton has been shown to be synthesised via an unusual route. In this paper we report on stable isotope incorporation experiments on DSP toxin in artificial cultures of dinoflagellate. The comparison of the degrees of incorporation in these samples measured by different methods led to contradictory results. This implies that further experimental data is needed in order to propose a logical biogenetic scheme. © 2004 The Japan Chemical Journal Forum and Wiley Periodicals, Inc. Chem Rec 4: 1,9; 2004: Published online in Wiley InterScience (www.interscience.wiley.com ) DOI 10.1002/tcr.10072 [source] Detection of ciguatoxin in fish tissue using sandwich ELISA and neuroblastoma cell bioassayJOURNAL OF CLINICAL LABORATORY ANALYSIS, Issue 4 2008Cara Empey Campora Abstract The applicability of a new enzyme-linked immunoassay (ELISA) for detecting ciguatoxin (CTX) in fish tissue was evaluated by testing three fish species commonly implicated in ciguatera fish poisoning in Hawaii. A total of 164 individual almaco jack (Seriola rivoliana) and greater amberjack (S. dumerili) and a total of 175 individuals of the blue-spotted grouper (Cephalopholis argus) were caught at various locations in the Hawaiian Islands. Muscle tissue from each individual was assessed for the presence of CTX using two methods: a semi-quantitative ELISA that was recently developed for detecting picogram levels of CTX in fish extract and a neuroblastoma (NB) cell assay commonly used to screen for marine toxins in fish. Results of the tests were highly correlated, with the ELISA indicating the presence of CTX in 9.4% of all fish samples, and the NB assay indicating toxicity in 6.8% of the fish samples. We conclude that the ELISA produces reliable and accurate results that are consistent with those provided by the accepted NB assay and that the ELISA has potential for future applications in screening fish populations for CTX. J. Clin. Lab. Anal. 22:246,253, 2008. © 2008 Wiley-Liss, Inc. [source] Biosynthetic studies of the DSP toxin skeletonTHE CHEMICAL RECORD, Issue 1 2004Antonio H. Daranas Abstract Marine toxins have drawn wide interest because their economical impact and disastrous effect upon the shellfish industry and public health in many parts of the world. One of the most interesting group of substances of marine toxins, from structural and pharmacological points of view are polyether compounds, which generally present a great diversity in size and potent biological activities. The subject of this work was about to biosynthesis of okadaic acid skeleton as leader as DSP toxins. Its biosynthesis attracts considerable attention since the carbon skeleton has been shown to be synthesised via an unusual route. In this paper we report on stable isotope incorporation experiments on DSP toxin in artificial cultures of dinoflagellate. The comparison of the degrees of incorporation in these samples measured by different methods led to contradictory results. This implies that further experimental data is needed in order to propose a logical biogenetic scheme. © 2004 The Japan Chemical Journal Forum and Wiley Periodicals, Inc. Chem Rec 4: 1,9; 2004: Published online in Wiley InterScience (www.interscience.wiley.com ) DOI 10.1002/tcr.10072 [source] | ||||||||||