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Many Hundreds (many + hundred)
Selected AbstractsClassification of abused inhalantsADDICTION, Issue 6 2009Robert L. Balster ABSTRACT Many hundreds of household and industrial products can be volatilized readily and are subject to abuse. Inhalant abuse research has been hampered by a lack of consensus on whether or not there are subclassifications of abused inhalants based on chemical structure, form or intended use of the product or pharmacological properties. This paper discusses strengths and weaknesses of various approaches to classification of inhalants and suggests areas for future research in this area. It is concluded that classification of inhalants by form or product types is not useful for scientific purposes; rather, subclassification of inhalants should be based on a yet-to-be-determined combination of chemical and pharmacological similarity and shared patterns of abuse. One of the ways in which we can improve our understanding of inhalant abuse is to obtain more detailed information on individual products and chemicals, their patterns of use and the geographical distribution of their use. [source] Refined Geographic Distribution of the Oriental ALDH2*504Lys (nee 487Lys) VariantANNALS OF HUMAN GENETICS, Issue 3 2009Hui Li Summary Mitochondrial aldehyde dehydrogenase (ALDH2) is one of the most important enzymes in human alcohol metabolism. The oriental ALDH2*504Lys variant functions as a dominant negative, greatly reducing activity in heterozygotes and abolishing activity in homozygotes. This allele is associated with serious disorders such as alcohol liver disease, late onset Alzheimer disease, colorectal cancer, and esophageal cancer, and is best known for protection against alcoholism. Many hundreds of papers in various languages have been published on this variant, providing allele frequency data for many different populations. To develop a highly refined global geographic distribution of ALDH2*504Lys, we have collected new data on 4,091 individuals from 86 population samples and assembled published data on a total of 80,691 individuals from 366 population samples. The allele is essentially absent in all parts of the world except East Asia. The ALDH2*504Lys allele has its highest frequency in Southeast China, and occurs in most areas of China, Japan, Korea, Mongolia, and Indochina with frequencies gradually declining radially from Southeast China. As the indigenous populations in South China have much lower frequencies than the southern Han migrants from Central China, we conclude that ALDH2*504Lys was carried by Han Chinese as they spread throughout East Asia. Esophageal cancer, with its highest incidence in East Asia, may be associated with ALDH2*504Lys because of a toxic effect of increased acetaldehyde in the tissue where ingested ethanol has its highest concentration. While the distributions of esophageal cancer and ALDH2*504Lys do not precisely correlate, that does not disprove the hypothesis. In general the study of fine scale geographic distributions of ALDH2*504Lys and diseases may help in understanding the multiple relationships among genes, diseases, environments, and cultures. [source] Reproduction in three species of rainbowfish (Melanotaeniidae) from rainforest streams in northern Queensland, AustraliaECOLOGY OF FRESHWATER FISH, Issue 2 2001B. J. Pusey Abstract , The reproductive biology of three species of rainbowfish (Melanotaeniidae) in northeastern Australian rainforest streams was investigated. Two species, Melanotaenia eachamensis and Cairnsichthys rhombosomoides are endemic to the area, whereas the third, M. splendida splendida, is more widespread. The species were all highly fecund, producing many hundreds of eggs between 1.10 and 1.24 mm in diameter. Melanotaenia eachamensis was the most fecund, produced the largest eggs of the three species, and consequently exhibited the greatest maternal investment (as measured by gonadosomatic index). The majority of reproductive effort occurred during the dry season, although reproductively active fish were present year-round for each of the species, but particularly so for M. s. splendida and C. rhombosomoides. No evidence for a role by temperature or photoperiod as environmental cues for reproduction was found, and it was suggested that gonad development was strongly tied to somatic growth. The concentration of reproduction to the dry season ensures that larvae are produced during a period of relatively stable and benign physical conditions. Comparison of temporal changes in gonadosomatic index values suggest that the spawning season of M. eachamensis, which occurs in high-elevation streams, is more restricted and commences about 1 month earlier than either other species. A similar phenology was observed for the M. s. splendida population found at high elevation and highlights the potential for spatial differences in stream productivity to influence life history., [source] Developments in research concerning Mesozoic,Tertiary Tethys and neotectonics in the Isparta Angle, SW TurkeyGEOLOGICAL JOURNAL, Issue 3-4 2003Alastair H. F. Robertson Abstract The Isparta Angle has played a critical role in the development of concepts concerning the tectonic evolution of the Mesozoic,Tertiary Neotethys in the Eastern Mediterranean region. Following early regional studies, mainly by the Mineral Research and Exploration Institute of Turkey (MTA), during the 1960s and 1970s, a French team mapped the area and confirmed a regional tectonostratigraphy of three great allochthonous systems of mainly Mesozoic,Early Tertiary age, termed the Antalya, Lycian and Hoyran-Bey,ehir-Had,m nappes. During the 1970s and 1980s a British group studied the Neotethyan evolution of what they termed the Antalya Complex, utilizing knowledge of plate tectonic processes. Throughout the 1970s and 1980s MTA systematically remapped the area at 1:25,000 scale. The root zone of the Antalya allochthon was either a southerly Neotethys, within and to the south of the Isparta Angle, or a northerly Neotethys, many hundreds of kilometres to the north. The southerly origin is nowadays favoured but some questions remain. Attention focused in the 1990s until present to the post-collisional, neotectonic evolution of the Isparta Angle and its links with the neighbouring Mediterranean Sea. Here, we trace the development of research and the ongoing debates concerning alternative tectonic concepts used to explain the evolution of the Isparta Angle from Mesozoic to Recent time. We conclude by outlining several tectonic models for the evolution of the Antalya allochthon within a southerly Neotethys that require to be tested by future field studies. Copyright © 2003 John Wiley & Sons, Ltd. [source] Integration of DNA barcoding into an ongoing inventory of complex tropical biodiversityMOLECULAR ECOLOGY RESOURCES, Issue 2009DANIEL H. JANZEN Abstract Inventory of the caterpillars, their food plants and parasitoids began in 1978 for today's Area de Conservacion Guanacaste (ACG), in northwestern Costa Rica. This complex mosaic of 120 000 ha of conserved and regenerating dry, cloud and rain forest over 0,2000 m elevation contains at least 10 000 species of non-leaf-mining caterpillars used by more than 5000 species of parasitoids. Several hundred thousand specimens of ACG-reared adult Lepidoptera and parasitoids have been intensively and extensively studied morphologically by many taxonomists, including most of the co-authors. DNA barcoding , the use of a standardized short mitochondrial DNA sequence to identify specimens and flush out undisclosed species , was added to the taxonomic identification process in 2003. Barcoding has been found to be extremely accurate during the identification of about 100 000 specimens of about 3500 morphologically defined species of adult moths, butterflies, tachinid flies, and parasitoid wasps. Less than 1% of the species have such similar barcodes that a molecularly based taxonomic identification is impossible. No specimen with a full barcode was misidentified when its barcode was compared with the barcode library. Also as expected from early trials, barcoding a series from all morphologically defined species, and correlating the morphological, ecological and barcode traits, has revealed many hundreds of overlooked presumptive species. Many but not all of these cryptic species can now be distinguished by subtle morphological and/or ecological traits previously ascribed to ,variation' or thought to be insignificant for species-level recognition. Adding DNA barcoding to the inventory has substantially improved the quality and depth of the inventory, and greatly multiplied the number of situations requiring further taxonomic work for resolution. [source] Front and Back Covers, Volume 22, Number 5.ANTHROPOLOGY TODAY, Issue 5 2006October 200 Front and back cover caption, volume 22 issue 5 Front cover Kayapo men of Brazilian Amazonia dance at a meeting of all Kayapo villages held in March 2006 with the aim of forging a united movement against the encroachment of agribusiness and large-scale development projects into the Xingú river valley. Up to the time of this meeting the widely dispersed Kayapo communities had never joined together as a single political organization under a common leadership. That they were able to do so at this meeting owed much to their ability to draw upon their shared tradition of collective ritual dance performances, which serve as the principal means of reproducing the social and political structures of their separate villages. At the meeting, held at the Kayapo village of Piaraçu on the Xingú, members of rival communities with mutually suspicious leaders joined in dances such as this one, drawn from the ritual for war, that expressed their solidarity in opposition to the common external threat. For the general audience, periodic interludes of dancing also provided a dramatic way of showing solidarity with one another and jointly expressing support for the orators, who were mostly leaders of the different communities. The meeting closed with a new ritual created for the occasion that began with a collective dance and culminated in a rite symbolizing the new level of common chiefly authority and leadership, encompassing Kayapo society as a whole, that had been created at the meeting. Back cover COMPETITIVE HUMANITARIANISM The back cover of this issue shows a detail from a map of ,Humanitarian actors involved in tsunami-related activities in Sri Lanka'. This excerpt lists but a few dozen of the many hundreds of agencies competing to provide relief in the wake of the tsunami that hit Sri Lanka in December 2004. In most disasters, a major problem facing relief agencies is a lack of resources. In the case of the 2004 tsunami, however, agencies were forced into competition with each other for effective distribution of an embarrassment of riches. Yet this distribution had to be in line with international standards, and needed to meet the requirements of those who had donated to the various appeals in other parts of the world and had specific ideas of what constituted relief. The result was an over-concentration on the visible and the photogenic rather than the arguably more important work of rebuilding institutions and social networks. As well as needing to meet international standards, relief agencies were subject to the bureaucratic requirements that they should expend their resources in an accountable fashion. Their slow reaction opened the way for a plethora of small and inexperienced organizations (and individuals) to enter the relief business. The aid they dispensed was often poorly directed and technically inferior, but the visibility of their operations prompted an easy criticism of the more ponderous activities of the larger relief organisations. While ready availability of resources marked out the tsunami relief effort from most other disasters, what seems to characterize aid operations in the wake of such disasters is a high degree of competition between relief agencies, and a continual call for a greater degree of co-ordination between relief organizations. Yet competitive pressures mean that co-ordination is unlikely to be attainable over more than the short term. From an anthropological point of view the following paradox is worthy of study: while philanthropy can be seen as the antithesis of self-interest, philanthropic organisations are inherently part of a self-interested, market-orientated social order. What starts out as a ,free gift' from the public of Europe, Asia or elsewhere ends up as a commodity in the marketplace of competitive humanitarianism. [source] | ||||||||||