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Many Contributions (many + contribution)

Distribution by Scientific Domains
Medical Sciences50%

Selected Abstracts

Addiction Research Centres and the Nurturing of Creativity The Chinese National Institute on Drug Dependence, Peking University: past, present and future

ADDICTION, Issue 9 2010
Xi Wang
ABSTRACT In the 25 years since drug abuse re-emerged in China in the 1980s, the National Institute of Drug Dependence (NIDD) has made many contributions to China's antidrug campaign. This present paper offers an account of the history, current status and future of drug dependence research at NIDD. NIDD was originally a research centre at Beijing Medical University, founded by the Chinese Ministry of Health to address the rapid spread of drug abuse in China. Originally, the main task of NIDD was to complete the commissions assigned by the government and university. Further developments transformed NIDD into a national research institute in the field of drug addiction that began to conduct its own research. NIDD has now created a professional team spread across several independent departments involved in neurobiological mechanisms, epidemiological surveys and monitoring, pre-clinical and clinical evaluation of new drugs (mainly analgesic drugs and detoxification drugs) and informatics and data analysis. As a university-based research institute, NIDD's funding derives mainly from grants provided by the government and financial support from international organizations. Its past and present research has a gained NIDD a reputation with both practitioners and policy makers in the field of drug addiction. In the future, NIDD will continue to engage in various aspects of drug addiction research and will enter the field of brain function. [source]

A multi-angular mass spectrometric view at cyclic nucleotide dependent protein kinases: In vivo characterization and structure/function relationships

MASS SPECTROMETRY REVIEWS, Issue 4 2008
Arjen Scholten
Abstract Mass spectrometry has evolved in recent years to a well-accepted and increasingly important complementary technique in molecular and structural biology. Here we review the many contributions mass spectrometry based studies have made in recent years in our understanding of the important cyclic nucleotide activated protein kinase A (PKA) and protein kinase G (PKG). We both describe the characterization of kinase isozymes, substrate phosphorylation, binding partners and post-translational modifications by proteomics based methodologies as well as their structural and functional properties as revealed by native mass spectrometry, H/D exchange MS and ion mobility. Combining all these mass spectrometry based data with other biophysical and biochemical data has been of great help to unravel the intricate regulation of kinase function in the cell in all its magnificent complexity. © 2008 Wiley Periodicals, Inc. Mass Spec Rev 27: 331,353, 2008 [source]

Edna Dell Weinel, Champion of Public Health Nursing, Excerpts from an Oral History

PUBLIC HEALTH NURSING, Issue 2 2008
Irene Kalnins
ABSTRACT Edna Dell Weinel is a former executive director (1980,1991) of the Family Care Center, a federally funded neighborhood health center in St. Louis, Missouri; this position capped her career as a county public health nurse, state maternal-child nursing consultant, and educator. In all her positions, Weinel lived her values: working at one's highest level of skill, social justice, and teamwork, and used political skills to build alliances for the improvement of community health. Her many contributions to public health and public health nursing were recognized by the Public Health Nursing Section of the American Public Health Association in 1993 with the Ruth B. Freeman Distinguished Career award. In interviews conducted early in 2007, Weinel spoke of her pride in being a public health nurse, her unchanging belief that health care can best be delivered by teams, and that public health nurses are an essential part of any effective team. [source]

From Gauß to Biermann: Highlights from the first 117 years of publications in Astronomische Nachrichten/Astronomical Notes

ASTRONOMISCHE NACHRICHTEN, Issue 6 2009
R. von Berlepsch
Abstract We present facsimiles of some of the scientifically and historically most relevant papers published in Astronomische Nachrichten/Astronomical Notes (AN) between 1821 and 1938. Almost all of these papers were written and printed in German and it is sometimes not completely straightforward to find these original works and then to cite the historically correct version, e.g. in case of a series of articles or editorial letters. It was common during the early years that many contributions were made in form of letters to the editor. We present a summary for these original works with an English translation of their titles. Among the highlights are the originals of the discovery of stellar parallaxes by FriedrichWilhelm Bessel, the discovery of the solar cycle by Heinrich Schwabe, the discovery of the planet Neptune by Johann Gottfried Galle, the first ever measured stellar radial velocity by Hermann Vogel, the discovery of radio emission from the Sun by Wilsing and Scheiner, the first ever conducted photoelectric photometry of stars by Paul Guthnick and up to the pioneering work by Karl Schwarzschild, Ejnar Hertzsprung, Erwin Finlay Freundlich and others. As a particular gimmick we present the still world record holding shortest paper ever published; by Johannes Hartmann in AN 226, 63 (1926) on Nova Pictoris. Our focus is on contributions in the early years and published until 1938 near the verge of the second world war (© 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source]