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Terms modified by Many Selected AbstractsTwins and cerebral palsyACTA PAEDIATRICA, Issue 2001POD Pharoah In a national follow-up study of twin births, monozygous compared with dizygous twins were at significantly increased for both to die in utero, one to die in utero and the co-twin to die in infancy, or both to be livebirths but both die in infancy. The prevalence of cerebral palsy among survivors of a co-twin fetal death was 80.2 and other cerebral impairment was 107.0 per 1000. Many apparently singleton cases of cerebral palsy and impairment may be due to fetal death of a twin that has not been recognized or has been recognized but not registered. [source] Visualizing massively multithreaded applications with ThreadScopeCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 1 2010Kyle B. Wheeler Abstract As highly parallel multicore machines become commonplace, programs must exhibit more concurrency to exploit the available hardware. Many multithreaded programming models already encourage programmers to create hundreds or thousands of short-lived threads that interact in complex ways. Programmers need to be able to analyze, tune, and troubleshoot these large-scale multithreaded programs. To address this problem, we present ThreadScope: a tool for tracing, visualizing, and analyzing massively multithreaded programs. ThreadScope extracts the machine-independent program structure from execution trace data from a variety of tracing tools and displays it as a graph of dependent execution blocks and memory objects, enabling identification of synchronization and structural problems, even if they did not occur in the traced run. It also uses graph-based analysis to identify potential problems. We demonstrate the use of ThreadScope to view program structure, memory access patterns, and synchronization problems in three programming environments and seven applications. Copyright © 2009 John Wiley & Sons, Ltd. [source] Death Rides the Forest: Perceptions of Fire, Land Use, and Ecological Restoration of Western ForestsCONSERVATION BIOLOGY, Issue 4 2004J. BOONE KAUFFMAN fuego prescrito; incendios catastróficos; incendios en áreas silvestres; incendios no controlados; reducción de riesgo de combustible; restauración de bosques; tala de bosques Abstract:,Large wild fires occurring in forests, grasslands, and chaparral in the last few years have aroused much public concern. Many have described these events as "catastrophes" that must be prevented through aggressive increases in forest thinning. Yet the real catastrophes are not the fires themselves but those land uses, in concert with fire-suppression policies that have resulted in dramatic alterations to ecosystem structure and composition. The first step in the restoration of biological diversity (forest health) of western landscapes must be to implement changes in those factors that have caused degradation or are preventing recovery. This includes changes in policies and practices that have resulted in the current state of wildland ecosystems. Restoration entails much more than simple structural modifications achieved though mechanical means. Restoration should be undertaken at landscape scales and must allow for the occurrence of dominant ecosystem processes, such as the natural fire regimes achieved through natural and/or prescribed fires at appropriate temporal and spatial scales. Resumen:,En años recientes, grandes incendios en bosques, pastizales y chaparrales han causado bastante preocupación en la opinión pública. Muchos han descrito estos eventos como "catástrofes" que deben ser prevenidas mediante incrementos agresivos en la tala de bosques. Pero los incendios mismos no son las verdaderas catástrofes, sino los usos del suelo en conjunto con políticas de supresión de fuego que han resultado en alteraciones dramáticas de la estructura y composición de ecosistemas. El primer paso en la restauración de la diversidad biológica (salud del bosque) en paisajes occidentales debe ser la implementación de cambios en los factores que causaron la degradación o que están impidiendo la recuperación. Esto incluye cambios en políticas y prácticas que han resultado en el estado actual de ecosistemas en áreas silvestres. La restauración implica mucho más que simples modificaciones estructurales obtenidas mediante medios mecánicos. La restauración debe llevarse a cabo a nivel de paisaje y debe permitir que ocurrencia de procesos ecológicos dominantes (por ejemplo, regímenes de incendios naturales logrados mediante incendios naturales y/o prescritos en escalas temporales y espaciales apropiadas). [source] Dental trauma in Turkish children, ,stanbulDENTAL TRAUMATOLOGY, Issue 2 2003Betul Kargul Abstract,,, Numerous studies focus on visits to dental clinics for emergent dental problems. Many are all-inclusive, studying traumatic injuries as well as visits for infection and other causes. Epidemiologic studies have focused on the investigation of the prevalence or incidence of dental injury. The patients were evaluated at Pediatric Dentistry, Marmara University Dental School, ,stanbul over a 2-year period. For these 300 patients (446 teeth), specific diagnoses were evaluated. Dental injuries that presented most frequently in permanent dentition were crown fractures of enamel only and crown fractures of enamel and dentin. The most frequently presented dental injury in primary dentition were avulsions and crown fractures of enamel. The more frequent treatments for primary teeth were examination only. Bandage restoration, space maintainer were common procedures for permanent teeth. [source] Perioperative Management of Medications for Psoriasis and Psoriatic Arthritis: A Review for the DermasurgeonDERMATOLOGIC SURGERY, Issue 4 2008CLAUDIA HERNANDEZ MD BACKGROUND Psoriasis affects an estimated 3% of the world's population. Many are on chronic immunosuppressive therapy for the cutaneous and joint manifestations of this disorder. The management of these medications in the perioperative period is controversial. Psoriasis and psoriatic arthritis medications can affect wound healing, hemostasis, and infection risk during cutaneous surgery. OBJECTIVES The objective of this article is to provide a critical review of various medications used for care of the psoriatic patient and their potential effect on cutaneous surgical procedures. CONCLUSIONS This review summarizes current understanding of wound healing, hemostatic effects, and infectious risks regarding many psoriasis medications including nonsteroidal anti-inflammatory drugs, cyclooxygenase inhibitors, corticosteroids, various immunosuppressants, and biologic response modifiers. Recommendations vary depending on the agent in question, type of procedure, and comorbid conditions in the patient. Caution is advised when using many of the medications reviewed due to lack of human data of their effects in the perioperative period. [source] Findings from a multidisciplinary clinical case series of females with Rett syndromeDEVELOPMENTAL MEDICINE & CHILD NEUROLOGY, Issue 5 2003Hilary Cass BSc FRCPCH Systematic data from a multidisciplinary clinical assessment of a large series of females with Rett syndrome (RS; n=87) is presented. Participants' ages ranged from 2 years 1 month to 44 years 10 months. Areas assessed included oromotor skills, feeding problems, growth, breathing abnormalities, mobility, postural abnormalities and joint deformities, epilepsy, hand use and stereotypies, self-care, and cognitive and communication skills. Many previously reported trends in the presentation of RS over time were confirmed, notably the increasingly poor growth and near pervasiveness of fixed joint deformities and scoliosis in adulthood. In contrast, there was a slight trend towards improved autonomic function in adulthood, whereas feeding difficulties increased into middle childhood and then reached a plateau. Improvements in mobility into adolescence were followed by a decline in those skills in adulthood. Levels of dependency were high, confirming findings from previous studies. Despite the presence of repetitive hand movements, a range of hand-use skills was seen in individuals of all ages. Cognitive and communication skills were limited, but there was little evidence of deterioration of these abilities with age. These findings confirm that RS is not a degenerative condition and indicate that intervention and support to maintain and increase motor skills, daily living skills, and cognitive and communicative functioning are appropriate targets for individuals with RS. [source] C-peptide makes a comebackDIABETES/METABOLISM: RESEARCH AND REVIEWS, Issue 5 2003John Wahren Proinsulin C-peptide was for long considered to be without biological activity of its own. New findings demonstrate, however, that it is capable of eliciting both molecular and physiological effects, suggesting that C-peptide is in fact a bioactive peptide. When administered in replacement doses to animal models or to patients with type 1 diabetes, C-peptide ameliorates diabetes-induced functional and structural changes in both the kidneys and the peripheral nerves. It augments blood flow in a number of tissues, notably skeletal muscle, myocardium, skin and nerve. These effects are thought to be mediated via a stimulatory influence on Na+,K+ -ATPase and on endothelial nitric oxide synthase. Specific binding of C-peptide to cell membranes of intact cells and to detergent-solubilized cellular components has been demonstrated, indicating the existence of cell-surface binding sites for C-peptide. A number of intracellular responses are elicited by C-peptide, including a rise in Ca2+ concentration and activation of MAP-kinase signaling pathways. Many but not all of C-peptide's intracellular effects can be inhibited by pertussis toxin, supporting the notion that C-peptide may interact via a G-protein-coupled receptor. Additional data suggest that C-peptide may interact synergistically also in the insulin signaling pathway. Combined, the available observations show conclusively that C-peptide is biologically active, even though its molecular mechanism of action is not as yet fully understood. The possibility that replacement of C-peptide in patients with type 1 diabetes may serve to retard or prevent the development of long-term complications should be evaluated. Copyright © 2003 John Wiley & Sons, Ltd. [source] Maternal transmission of diabetesDIABETIC MEDICINE, Issue 2 2002J. C. Alcolado Abstract Type 2 diabetes mellitus represents a heterogeneous group of conditions characterized by impaired glucose homeostasis. The disorder runs in families but the mechanism underlying this is unknown. Many, but not all, studies have suggested that mothers are excessively implicated in the transmission of the disorder. A number of possible genetic phenomena could explain this observation, including the exclusively maternal transmission of mitochondrial DNA (mtDNA). It is now apparent that mutations in mtDNA can indeed result in maternally inherited diabetes. Although several mutations have been implicated, the strongest evidence relates to a point substitution at nucleotide position 3243 (A to G) in the mitochondrial tRNAleu(UUR) gene. Mitochondrial diabetes is commonly associated with nerve deafness and often presents with progressive non-autoimmune ,-cell failure. Specific treatment with Coenzyme Q10 or L-carnitine may be beneficial. Several rodent models of mitochondrial diabetes have been developed, including one in which mtDNA is specifically depleted in the pancreatic islets. Apart from severe, pathogenic mtDNA mutations, common polymorphisms in mtDNA may contribute to variations of insulin secretory capacity in normal individuals. Mitochondrial diabetes accounts for less than 1% of all diabetes and other mechanisms must underlie the maternal transmission of Type 2 diabetes. Possibilities include the role of maternally controlled environments, imprinted genes and epigenetic phenomena. [source] Female Adolescents and Their Sexuality: Notions of Honour, Shame, Purity and Pollution during the FloodsDISASTERS, Issue 1 2000Sabina Faiz Rashid This paper explores the experiences of female adolescents during the 1998 floods in Bangladesh, focusing on the implications of socio-cultural norms related to notions of honour, shame, purity and pollution. These cultural notions are reinforced with greater emphasis as girls enter their adolescence, regulating their sexuality and gender relationships. In Bangladeshi society, adolescent girls are expected to maintain their virginity until marriage. Contact is limited to one's families and extended relations. Particularly among poorer families, adolescent girls tend to have limited mobility to safeguard their ,purity'. This is to ensure that the girl's reputation does not suffer, thus making it difficult for the girl to get married. For female adolescents in Bangladesh, a disaster situation is a uniquely vulnerable time. Exposure to the unfamiliar environment of flood shelters and relief camps, and unable to maintain their ,space' and privacy from male strangers, a number of the girls were vulnerable to sexual and mental harassment. With the floods, it became difficult for most of the girls to be appropriately `secluded'. Many were unable to sleep, bathe or get access to latrines in privacy because so many houses and latrines were underwater. Some of the girls who had begun menstruation were distressed at not being able to keep themselves clean. Strong social taboos associated with menstruation and the dirty water that surrounded them made it difficult for the girls to wash their menstrual cloths or change them frequently enough. Many of them became separated from their social network of relations, which caused them a great deal of anxiety and stress. Their difficulty in trying to follow social norms have had far-reaching implications on their health, identity, family and community relations. [source] Gene diversity of CYP153A and AlkB alkane hydroxylases in oil-degrading bacteria isolated from the Atlantic OceanENVIRONMENTAL MICROBIOLOGY, Issue 5 2010Liping Wang Summary Alkane hydroxylases, including the integral-membrane non-haem iron monooxygenase (AlkB) and cytochrome P450 CYP153 family, are key enzymes in bacterial alkane oxidation. Although both genes have been detected in a number of bacteria and environments, knowledge about the diversity of these genes in marine alkane-degrading bacteria is still limited, especially in pelagic areas. In this report, 177 bacterial isolates, comprising 43 genera, were obtained from 18 oil-degrading consortia enriched from surface seawater samples collected from the Atlantic Ocean. Many isolates were confirmed to be the first oil-degraders in their affiliated genera including Brachybacterium, Idiomarina, Leifsonia, Martelella, Kordiimonas, Parvibaculum and Tistrella. Using degenerate PCR primers, alkB and CYP153A P450 genes were surveyed in these bacteria. In total, 82 P450 and 52 alkB gene fragments were obtained from 80 of the isolates. These isolates mainly belonged to Alcanivorax, Bacillus, Erythrobacter, Martelella, Parvibaculum and Salinisphaera, some of which were reported, for the first time, to encode alkane hydroxylases. Phylogenetic analysis showed that both genes were quite diverse and formed several clusters, most of which were generated from various Alcanivorax bacteria. Noticeably, some sequences, such as those from the Salinisphaera genus, were grouped into a distantly related novel cluster. Inspection of the linkage between gene and host revealed that alkB and P450 tend to coexist in Alcanivorax and Salinisphaera, while in all isolates of Parvibaculum, only P450 genes were found, but of multiple homologues. Multiple homologues of alkB mostly cooccurred in Alcanivorax isolates. Conversely, distantly related isolates contained similar or even identical sequences. In summary, various oil-degrading bacteria, which harboured diverse P450 and alkB genes, were found in the surface water of Atlantic Ocean. Our results help to show the diversity of P450 and alkB genes in prokaryotes, and to portray the geographic distribution of oil-degrading bacteria in marine environments. [source] Tracing salmon-derived nutrients and contaminants in freshwater food webs across a pronounced spawner density gradientENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 6 2007Irene Gregory-Eaves Abstract Many have demonstrated that anadromous Pacific salmon are significant vectors of nutrients from the ocean to freshwaters. Recently, however, it has been recognized that salmon spawners also input significant quantities of contaminants. The objectives of this paper are to delineate the extent to which salmon-derived nutrients are integrated into the freshwater food web using ,15N and ,13C and to assess the influence of the salmon pathway in the accumulation of contaminants in rainbow trout (Oncorhynchus mykiss). We found that the ,15N and ,13C of food web components were related positively and significantly to sockeye salmon (Oncorhynchus nerka) spawner density. Contaminant concentrations in rainbow trout also positively and significantly were related to sockeye salmon spawner density. These data suggest that the anadromous salmon nutrient and contaminant pathways are related and significantly impact the contaminant burden of resident fish. [source] Many zeros does not mean zero inflation: comparing the goodness-of-fit of parametric models to multivariate abundance dataENVIRONMETRICS, Issue 3 2005David I. Warton Abstract An important step in studying the ecology of a species is choosing a statistical model of abundance; however, there has been little general consideration of which statistical model to use. In particular, abundance data have many zeros (often 50,80 per cent of all values), and zero-inflated count distributions are often used to specifically model the high frequency of zeros in abundance data. However, in such cases it is often taken for granted that a zero-inflated model is required, and the goodness-of-fit to count distributions with and without zero inflation is not often compared for abundance data. In this article, the goodness-of-fit was compared for several marginal models of abundance in 20 multivariate datasets (a total of 1672 variables across all datasets) from different sources. Multivariate abundance data are quite commonly collected in applied ecology, and the properties of these data may differ from abundances collected in autecological studies. Goodness-of-fit was assessed using AIC values, graphs of observed vs expected proportion of zeros in a dataset, and graphs of the sample mean,variance relationship. The negative binomial model was the best fitting of the count distributions, without zero-inflation. The high frequency of zeros was well described by the systematic component of the model (i.e. at some places predicted abundance was high, while at others it was zero) and so it was rarely necessary to modify the random component of the model (i.e. fitting a zero-inflated distribution). A Gaussian model based on transformed abundances fitted data surprisingly well, and rescaled per cent cover was usually poorly fitted by a count distribution. In conclusion, results suggest that the high frequency of zeros commonly seen in multivariate abundance data is best considered to come from distributions where mean abundance is often very low (hence there are many zeros), as opposed to claiming that there are an unusually high number of zeros compared to common parametric distributions. Copyright © 2005 John Wiley & Sons, Ltd. [source] Febrile Seizures: Treatment and PrognosisEPILEPSIA, Issue 1 2000Finn Ursin Knudsen Summary: Recent epidemiologic data indicate that the vast majority of children with febrile seizures have a normal long-term outcome. A precise knowledge of the short- and long-term outcome with or without treatment, and short- and long-term side effects is an important prerequisite for assessing the various treatment strategies. We focus on the impact of short-term or prophylactic treatment on the short- and long-term outcome of various types of febrile seizures. There is universal agreement that daily prophylaxis with antiepileptic agents should never be used routinely in simple febrile seizures, but only in highly selected cases, if at all. Intermittent diazepam (DZP) prophylaxis at times of fever may or may not reduce the recurrence rate, but it does not appear to improve the long-term outcome as compared with short-term seizure control. The treatment may be used to reduce the recurrence rate for a small arbitrarily defined group with multiple simple febrile seizures, complex febrile seizures, especially focal, prolonged or both, febrile status, and when parental anxiety is severe. However, there is no evidence that treatment of simple febrile seizures can prevent the rare cases of later epilepsy, and many children with complex febrile seizures have a benign long-term outcome, even without treatment. Many prefer a "wait and see" policy. An attractive alternative is to treat new febrile seizures with rectal DZP in solution at seizure onset, given by the parents at home to prevent febrile status. Newer, less well documented short-term strategies include nasal, oral, or rectal administration of other benzodiazepines. Short-term seizure control of febrile status and careful parental counseling are the two most important targets of treatment. [source] Risk Assessment and Withdrawal Behavior by Two Species of Aposematic Poison Frogs, Dendrobates auratus and Oophaga pumilio, on Forest TrailsETHOLOGY, Issue 4 2009William E. Cooper Jr Many chemically defended prey advertize toxicity to predators by aposematic coloration. When aposematic prey are approached, they often move slowly or not at all, allowing predators to evaluate their unprofitability. Poison frogs (Dendrobatidae) are toxic, aposematically colored, forage openly and diurnally, and are much easier to capture than many palatable frogs. Although protected against diverse predators, they are sometimes attacked and are subjected to injury by large animals without predatory intent. We predicted that they have limited escape behavior, but retain ability to assess and respond to risk. When we approached Dendrobates auratus and Oophaga pumilio on forest trails, both species hopped by the shortest route to the nearer forest edge and stopped there. When approached, D. auratus moved after shorter latency at an angle closer to perpendicular to the forest edge, were more likely to leave the trail, and left the trail sooner with fewer changes in direction after moving a shorter distance than when not approached. In agreement with predictions of optimal escape theory based on risk, flight initiation distance by D. auratus was greater when approached directly than indirectly and rapidly than slowly, and was greater when frogs were in the open than partially concealed. Frogs neither attempted rapid escape nor entered refuges. Both species hopped leisurely and remained visible after stopping. They exhibit the diminished escape behavior of aposematic prey, yet retain the capacity to assess risk and adjust behavior accordingly. Their behavior demonstrates continued need for escape behavior by highly toxic aposematic prey. [source] Who is Looking for Nutritional Food Labels?: Wer sucht nach Nährwertangaben auf Lebensmitteln?: Mais qui donc s'occupe du contenu nutritionnel sur les étiquettes?EUROCHOICES, Issue 1 2005Andreas C. Drichoutis Summary Who is Looking for Nutritional Food Labels? Obesity amongst the population in Europe is increasing at an alarming rate. Consequently, nutritional and lifestyle factors are implicated in the huge increase in several chronic diseases in Europe. The Southern Europeans tend to be amongst the worst, mth Greece being first in adult obesity mainly due to the replacement of the Mediterranean diet with ready-made and fast foods. People want to see change towards an environment that makes it easier to make healthy choices. The EU, in order to assist consumers make healthy food choices, tried to make nutritional information available to consumers through a food labelling law framework, which currently works on a voluntary basis with the perspective to change towards a mandatory system. We conducted a study in Greece in order to assess consumer use of nutritional food labels and determine which consumers use certain types of nutrient content information. We found that almost a third of consumers often use food labels and these are the more educated, who are more nutritionally knowledgeable. Many others do not, and to increase their chances of reading the labels one should improve their knowledge of nutrition havlng in mind that they are not big users of the media but get their information from informd sources. Mais qui donc s'occupe du contenu nutritionnel sur les etiquettes? La prevalence de I'obesitk augmente a un t a u toujours plus preoccupant en Europe. Les facteurs nutritionnels et les styles de vie sont par consequent impliquks dans l'Cnorme accroissement constati: de diverses pathologies chroniques. La situation est specialement mauvaise en Europe du sud, ou la Grece detient le record du taux d'obesite dans la population adulte, en particulier du fait du remplacement du fameux ,regime mediterraneen' par les plats prepares et la restauration rapide. Les gens souhaitent un environnement susceptible de leur faciliter le choix d'une alimentation saine. C'est pour cela que l'Union europkenne a tente de mettre des informations nutritionnelles a la disposition des consommateurs, en instituant un cadre legal pour l'etiquetage alimentaire Il fonctionne actuellement sur la base du volontariat, mais il a pour vocation d'evoluer vers un systeme obligatoire. Il est rendu compte ici d'une enquOte effectuee en Grkce pour determiner quels types de consommateurs utilisent quels genres dindications de contenu nutritionnel portees sur les etiquettes alimentaires, et dans quelle mesure. Environ un tiers des consommateurs utilisent souvent les contenus nutritionnels. Ce sont les plus eduques et les mieux informks. La plupart des autres negligent les etiquettes. Pour accroitre les chances que ces dernieres soient lues, il faudrait donc arneliorer les connaissances nutritionnelles, en gardant a l'esprit que les personnes concernkes utilisent peu les mkdias et tirent leurs informations de sources informelles. Wer sucht nach Nährwertangaben auf Die Fettleibigkeit in der europaischen Bevolkerung nimmt alarmierend schnell zu. Folglich spiegeln sich Ernahrung und Lebensstil in dem hohen Anstieg zahlreicher chronischer Erkrankungen in Europa wider. Fur die Sudeuropaer ergeben sich einige der schlechtesten Werte, wobei in Griechenland die Erwachsenenfettleibigkeit am ausgepriigtesten ist. Dies liegt hauptsachlich daran, dass die mediterrane Erniihrung von Fertiggerichten und Fast-Food abgelost wurde. Die Bevolkerung wiinscht sich eine Veriinderung hin zu einer Umgebung, die sie darin unterstutzt, der Gesundheit zutr;dgliche Entscheidungen zu treffen. Die EU wollte den Verbrauchern gesundheitlich relevante Informationen durch eine Kennzeichnung der Inhaltsstoffe der Lebensmittel verschaffen. Dieses System sieht gegenwartig lediglich eine freiwillige Kennzeichnung vor, ist aber als obligatorisch geplant. Wir fiihrten in Griechenland eine Studie durch, um zu beurteilen, inwiefern Nahrwertangaben auf Lebensmitteln den Verbrauchern nutzen, und um festzustellen, welche Verbraucher auf bestimmte Nahrwertangaben achten. Wir fanden heraus, dass beinahe ein Drittel aller Verbraucher auf die Lebensmittelkennzeich nung achten. Diese Verbraucher verfiigen uber eine hohere Bildung und kennen sich in Erniihrungsfragen relativ gut aus. Ein großer Anted der Verbraucher verfiigt uber keinerlei gesundheitliche Grundkenntnisse; um diesen Verbrauchern das Lesen der Etiketten zu ermoglichen, sollte man ihre Kenntnisse in Sachen Ernahrung verbessern und sich dabei vor Augen fiihren, dass diese Verbraucher die Medien nicht allzu intensiv nutzen, sondern ihre Informationen aus informellen Quellen beziehen. [source] Hippocampal gene expression profiling across eight mouse inbred strains: towards understanding the molecular basis for behaviourEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 9 2004Cathy Fernandes Abstract Mouse inbred strains differ in many aspects of their phenotypes, and it is known that gene expression does so too. This gives us an opportunity to isolate the genetic aspect of variation in expression and compare it to other phenotypic variables. We have investigated these issues using an eight-strain expression profile comparison with four replicates per strain on Affymetrix MGU74av2 GeneChips focusing on one well-defined brain tissue (the hippocampus). We identified substantial strain-specific variation in hippocampal gene expression, with more than two hundred genes showing strain differences by a very conservative criterion. Many such genetically driven differences in gene expression are likely to result in functional differences including differences in behaviour. A large panel of inbred strains could be used to identify genes functionally involved in particular phenotypes, similar to genetic correlation. The genetic correlation between expression profiles and function is potentially very powerful, especially given the current large-scale generation of phenotypic data on multiple strains (the Mouse Phenome Project). As an example, the strongest genetic correlation between more than 200 probe sets showing significant differences among our eight inbred strains and a ranking of these strains by aggression phenotype was found for Comt, a gene known to be involved in aggression. [source] PROMISCUITY DRIVES SEXUAL SELECTION IN A SOCIALLY MONOGAMOUS BIRDEVOLUTION, Issue 9 2007Michael S. Webster Many socially monogamous species paradoxically show signs of strong sexual selection, suggesting cryptic sources of sexual competition among males. Darwin argued that sexual selection could operate in monogamous systems if breeding sex ratios are biased or if some males attract highly fecund females. Alternatively, sexual selection might result from promiscuous copulations outside the pair bond, although several recent studies have cast doubt on this possibility, in particular by showing that variance in apparent male reproductive success (number of social young) differs little from variance in actual male reproductive success (number of young sired). Our results from a long-term study of the socially monogamous splendid fairy-wren (Malurus splendens) demonstrate that such comparisons are misleading and do not adequately assess the effects of extra-pair paternity (EPP). By partitioning the opportunity for selection and calculating Bateman gradients, we show that EPP has a strong effect on male annual and lifetime fitness, whereas other proposed mechanisms of sexual selection do not. Thus, EPP drives sexual selection in this, and possibly other, socially monogamous species. [source] SUMMIT ON UNIFIED FAMILY COURTS: SERVING CHILDREN AND FAMILIES EFFICIENTLY, EFFECTIVELY, AND RESPONSIBLYFAMILY COURT REVIEW, Issue 2 2008Karen J. Mathis As president of the American Bar Association when the "Summit on Unified Family Courts" convened in May 2007, Karen J. Mathis welcomed summit attendees. Recounting the many reasons children wind up in court, Mathis observed that society is lucky if these problems even come before the courts. Too often, she said, the underlying problems of destructive behavior among youth are lost in the shuffle of too many lawyers, case workers, and judges. "Many times they're ignored by the professionals among us who are not trained to be aware that the problems even exist," she said. The solution to this fragmented approach is unified family courts, she concluded. [source] Learning Styles,How Making Too Many "Wrong Mistakes" Is the Right Thing to Do: A Response to SparksFOREIGN LANGUAGE ANNALS, Issue 3 2006Obdulia Castro First page of article [source] Origin of post-Minoan caves and volcaniclastic cave fill, Thera (Santorini), GreeceGEOARCHAEOLOGY: AN INTERNATIONAL JOURNAL, Issue 5 2003Joan M. Ramage The Aegean island of Thera (Santorini) was covered by tephra from its cataclysmic Late Bronze Age (ca. 3600 yr B.P.) eruption. Vertical exposures of the eruptive sequence show secondary, nonvolcanic, circular (in cross section) features composed of stratified sediment. Many are inaccessible from the floors of modern quarries and appear to be caves filled with younger sediment, but show no connection to the land surface. A filled cave was found in the wall of a modern gully outside the modern quarries, and a filled cave was found in a terrace scarp, well above the modern gully. Natural (and probably rapid) incision by gullies into the thick tephra deposit left many locations with lateral access to tephra. Inhabitants from post-Minoan to recent times excavated tephra for materials and buildings, and caves were subsequently filled by sporadic (possibly seasonal) flood events that deposited sediment. These gullies may have provided access for modern tephra removal that isolated the filled caves high on the modern quarry walls. © 2003 Wiley Periodicals, Inc. [source] Caribbean Transnational Return Migrants as Agents of ChangeGEOGRAPHY COMPASS (ELECTRONIC), Issue 1 2007Dennis Conway This article challenges several of the firmly held convictions drawn from extant research on return migration to the Caribbean. For many contemporary small island societies undergoing rapid change and transformation, modernization and integration into the wider global economy, today's younger and more youthful return migrants are no longer an ineffective demographic cohort. Despite their numerically small size, many are demonstrating they can be influential "agents of change." No longer merely returning retirees, they are more diverse, in terms of age, life-course transitions, class and gendered social positions, family networks, and migration histories. Multiple identities are the rule, rather than the exception, as returnees of different ages choose to live, work (and play) in island society, to give something back to the island home of their parents or of their youth. Many embrace transnational strategies to live in and between two worlds, or more if their family network's reach is multilocal. [source] Smoking after the age of 65 years: a qualitative exploration of older current and former smokers' views on smoking, stopping smoking, and smoking cessation resources and servicesHEALTH & SOCIAL CARE IN THE COMMUNITY, Issue 6 2006Susan Kerr BA MSc PhD RN HV Abstract The aim of this study was to explore older current/former smokers' views on smoking, stopping smoking, and smoking cessation resources and services. Despite the fact that older smokers have been identified as a priority group, there is currently a dearth of age-related smoking cessation research to guide practice. The study adopted a qualitative approach and used the health belief model as a conceptual framework. Twenty current and former smokers aged , 65 years were recruited through general practices and a forum for older adults in the West of Scotland. Data were collected using a semistructured interview schedule. The audio-taped interviews were transcribed and then analysed using content analysis procedures. Current smokers reported many positive associations with smoking, which often prevented a smoking cessation attempt. The majority were aware that smoking had damaged their health; however, some were not convinced of the association. A common view was that ,the damage was done', and therefore, there was little point in attempting to stop smoking. When suggesting a cessation attempt, while some health professionals provided good levels of support, others were reported as providing very little. Some of the participants reported that they had never been advised to stop smoking. Knowledge of local smoking cessation services was generally poor. Finally, concern was voiced regarding the perceived health risks of using nicotine replacement therapy. The main reasons why the former smokers had stopped smoking were health-related. Many had received little help and support from health professionals when attempting to stop smoking. Most of the former smokers believed that stopping smoking in later life had been beneficial to their health. In conclusion, members of the primary care team have a key role to play in encouraging older people to stop smoking. In order to function effectively, it is essential that they take account of older smokers' health beliefs and that issues, such as knowledge of smoking cessation resources, are addressed. [source] When doctors disagree: a qualitative study of doctors' and parents' views on the risks of childhood food allergyHEALTH EXPECTATIONS, Issue 3 2008Wendy Hu MBBS Dip Paed MHA PhD FRACGP Abstract Objective, To examine the views of doctors which underpin clinical practice variation concerning an uncertain health risk, and the views of parents who had sought advice from these doctors, using the example of childhood food allergy. Study design, Qualitative study involving in-depth interviews and participant observation over 16 months. Focus groups and consultation audio-recordings provided corroborative data. Setting, Three specialist allergy clinics located in one metropolitan area. Participants, Eighteen medical specialists and trainees in allergy, and 85 parents (from 69 families) with food allergic children. Results, Doctors expressed a spectrum of views. The most divergent views were characterized by: scientific scepticism rather than precaution in response to uncertainty; emphasis on quantifiable physical evidence rather than parental histories; professional roles as providers of physical diagnosis and treatment rather than of information and advocacy; libertarian rather than communitarian perspectives on responsibility for risk; and values about allergy as a disease and normal childhood. Parents held a similar, but less divergent range of views. The majority of parents preferred more moderate doctors' views, with 43% (30 of 69) of families expressing their dissatisfaction by seeking another specialist opinion. Many were confused by variation in doctors' opinions, preferring relationships with doctors that recognized their concerns, addressed their information needs, and confirmed that they were managing their child's allergy appropriately. Conclusions, In uncertain clinical situations, parents do not expect absolute certainty from doctors; inflexible certainty may not allow parental preferences to be acknowledged or accommodated, and is associated with the seeking of second opinions. [source] Engineering Nanoassemblies of PolysaccharidesADVANCED MATERIALS, Issue 28 2010Soheil Boddohi Abstract Polysaccharides offer a wealth of biochemical and biomechanical functionality that can be used to develop new biomaterials. In mammalian tissues, polysaccharides often exhibit a hierarchy of structure, which includes assembly at the nanometer length scale. Furthermore, their biochemical function is determined by their nanoscale organization. These biological nanostructures provide the inspiration for developing techniques to tune the assembly of polysaccharides at the nanoscale. These new polysaccharide nanostructures are being used for the stabilization and delivery of drugs, proteins, and genes, the engineering of cells and tissues, and as new platforms on which to study biochemistry. In biological systems polysaccharide nanostructures are assembled via bottom-up processes. Many biologically derived polysaccharides behave as polyelectrolytes, and their polyelectrolyte nature can be used to tune their bottom-up assembly. New techniques designed to tune the structure and composition of polysaccharides at the nanoscale are enabling researchers to study in detail the emergent biological properties that arise from the nanoassembly of these important biological macromolecules. [source] ,Testimony (to some extent fictitious)': proofs of age in the first half of the fifteenth century*HISTORICAL RESEARCH, Issue 218 2009Matthew Holford This article offers an assessment of the reliability and value of proofs of age produced c.1400,50. It argues that the testimonies recorded in these proofs must be treated with considerable scepticism. From around 1420 onwards, proofs with demonstrably fictitious or conventional testimonies were produced in increasingly large numbers. The documents had become something of a formality, and it was not expected that they would be closely scrutinized. But despite these caveats, proofs of age cannot simply be dismissed. Many are not obviously conventional in their contents; and even in certain apparently fictitious documents, care was taken to provide some accurate information. [source] Attitudes and opinions of oral health and oral care among community-dwelling elderly subjects in Sweden: an interview studyINTERNATIONAL JOURNAL OF DENTAL HYGIENE, Issue 1 2004K Andersson Objective: The aim of this study was to investigate attitudes and opinions of old, independently living people about their oral health and how it has affected them through life. Material and methods: A random selection of 12 individuals was made in a group of 79 individuals who earlier participated in a study about self-reported oral health. The average age was 78.4 years. An interview guide was used as support to focus on oral health. The respondents themselves decided what was important within the topics. The respondents were encouraged to speak freely about their childhood, family, social relations, memories from early dental care, general health situation, experience from health care, life and their future. The interviews were recorded and extended from 60 to 90 min. All of them were transcribed and analysed with phenomenological method inspired by Giogi. The analysis was made by two researchers independently. After 11 interviews, no new information was found; similar opinions, answers and stories recurred. Results: Seven of 11 respondents were born and grown up in the countryside and had moved to Stockholm in the forties. Awareness about dental care was generally low. Many of them have terrible memories from early dental visits, and the dentist was authoritarian and rough. Many had no memories of brushing their teeth as a child. Most of the respondents went to dentists as adults and when they could afford to pay by themselves. After retirement, all have continuous dental care and have visited a dental hygienist during the last 20 years. Nine of 11 have regular contact with a dental hygienist. Most of them are satisfied with their oral health and want to continue being clean and healthy in the mouth. Conclusions: Most of the respondents experienced an improved oral health, information and instructions from the dental hygienist have affected their self-care. Many tell that they have become more aware and carry out the oral hygiene more carefully after retirement. All of them experience that oral health affects the quality of life. [source] Neoliberalism, Contingency and Urban Policy: The Case of Social Housing in OntarioINTERNATIONAL JOURNAL OF URBAN AND REGIONAL RESEARCH, Issue 3 2006JASON HACKWORTH Various authors have argued that common understandings of neoliberalism are flawed because they do not adequately account for its geographical contingency or internal contradictions. Many have suggested that neoliberalism is either too internally riven with contradiction to be considered a singular consistent project, or that its implementation is so locally contingent that we cannot plausibly speak of one ideal-type placeless ideology. Primarily based on interviews with over half of the municipal housing providers in Ontario, this article explores the extent to which the meta-ideas of neoliberalism are filtered and manifest (or not) locally. Social policy has been neoliberalized in Ontario at least since the advent of the ,common sense revolution' in 1995, when a Tory government was elected on a platform of neoliberal reform. The experience of social housing in the province, before, after and during the transition offers a useful window into the debate about the dissonance (or lack thereof) between ideal-type and contingent neoliberalism. Based on this case, we argue that, despite its obvious conceptual flaws, it is politically and analytically important to understand ideal-type neoliberalism better. [source] U.S. Deportation Policy, Family Separation, and Circular MigrationINTERNATIONAL MIGRATION REVIEW, Issue 1 2008Jacqueline Hagan Since the mid-1990s the United States has enacted a series of laws that make it easier to deport noncitizens. Drawing on findings from interviews with a random sample of 300 Salvadoran deportees, we examine how family relations, ties, remittance behavior, and settlement experiences are disrupted by deportation, and how these ties influence future migration intentions. We find that a significant number of deportees were long-term settlers in the United States. Many had established work histories and had formed families of their own. These strong social ties in turn influence the likelihood of repeat migration to the United States. [source] Because One Is Too Many: Catholic Health Initiatives' Success in Reducing Preventable Birth InjuriesJOURNAL FOR HEALTHCARE QUALITY, Issue 4 2010Mary Osborne Abstract: Catholic Health Initiatives (CHI) set a goal of reducing birth injuries throughout the system. Although the number of injuries was small, clinical and risk leadership agreed that even one injury is too many. Through a multidisciplinary partnership to initiate perinatal bundles, the CHI Perinatal Care Collaborative was able to continue the reduction of injuries each year. [source] Psychosocial interventions for non-professional carers of people with Parkinson's disease: a systematic scoping reviewJOURNAL OF ADVANCED NURSING, Issue 3 2008Susanne Hempel Abstract Title.,Psychosocial interventions for non-professional carers of people with Parkinson's disease: a systematic scoping review. Aim., This paper is a report of a scoping review to systematically identify and collate the evidence on psychosocial interventions for non-professional carers of people with Parkinson's disease. Background., Carers are critical to people with Parkinson's disease maintaining independent living and quality of life. Parkinson's disease imposes a challenging constellation of symptoms and no summary of effective interventions for carers and their unique support needs exists. Data sources., Thirty electronic databases were searched from their inception to July 2006, and bibliographies and specific internet sites were scanned. Methods., Eligible studies were categorized according to design, type of economic evaluation where applicable, number of participants, country of evaluation, intervention, orientation, provider, setting, method of delivery, carer population, patient population, carer outcomes, patient outcomes and authors' conclusions. Data were extracted by one reviewer and checked by another reviewer; discrepancies were resolved through discussion or arbitration by a third reviewer. Findings., Thirty studies met the inclusion criteria. Most investigated relatively unique interventions involving multiple elements; the majority were not aimed primarily at carers but were embedded in patient treatment programmes. Many were pilot studies, employing weak research designs and involving very small numbers of participants and most were not designed to assess the clinical or cost effectiveness of the intervention for the carers. Conclusion., Several interventions merit further investigation but there is currently little evidence to show which approaches are effective and cost effective in supporting carers. Future studies need to employ appropriate and rigorous research designs with adequate samples and outcome measures, and with more focus on the carer. [source] | ||||||||||||||||||||||||||||||||||||||||||||||