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Terms modified by Manuscript Selected AbstractsDouble-Blind, Randomized, Placebo-Controlled, Dose-Response Study of the Safety and Efficacy of Botulinum Toxin Type A in Subjects with Crow's FeetDERMATOLOGIC SURGERY, Issue 3 2005Nicholas J. Lowe MD Background Published evidence suggests that botulinum toxin type A (BTX-A) is an effective treatment for crow's feet. However, few dose-ranging studies have been performed. Objectives To assess the safety and efficacy of a single treatment with one of four doses of BTX-A (Botox/Vistabel, Allergan Inc) compared with placebo for the improvement of crow's feet. Methods Subjects received a single bilateral treatment of 18, 12, 6, or 3 U of BTX-A or placebo injected into the lateral aspect of the orbicularis oculi muscle (parallel-group, double,blind design). Investigators and subjects rated crow's feet severity at maximum smile on day 7 and at 30-day intervals from days 30 to 180. Results As observed by both investigators and subjects, all doses of BTX-A resulted in improvements in crow's feet severity when compared with placebo. A dose-dependent treatment effect for efficacy was observed, with higher doses having an increased magnitude and duration of effect. However, a clear differentiation between the 18 U and 12 U doses was not apparent. Few adverse events were reported, with no statistically significant differences between BTX-A and placebo in the incidence of subjects experiencing adverse events. Conclusion BTX-A is safe and effective in decreasing the severity of crow's feet, with 12 U per side suggested as the most appropriate dose. THIS STUDY WAS FUNDED BY ALLERGAN, WHICH WAS ALSO INVOLVED IN THE DESIGN AND CONDUCT OF THE STUDY; COLLECTION, MANAGEMENT, ANALYSIS, AND INTERPRETATION OF THE DATA; AND PREPARATION, REVIEW, AND APPROVAL OF THE MANUSCRIPT. DRS. LOWE AND FRACZEK ARE PAID CONSULTANTS FOR ALLERGAN, DRS. KUMAR AND EADIE ARE EMPLOYEES OF ALLERGAN, AND DRS. LOWE AND KUMAR HOLD STOCK OPTIONS. [source] INTERNET-BASED SUBMISSIONS OF MANUSCRIPTSEVOLUTION, Issue 2 2002Article first published online: 9 MAY 200 No abstract is available for this article. [source] Calcium handling in afferent arteriolesACTA PHYSIOLOGICA, Issue 4 2004M. Salomonsson Abstract The cytosolic intracellular calcium concentration ([Ca2+]i) is a major determining factor in the vascular smooth muscle tone. In the afferent arteriole it has been shown that agonists utilizing G-protein coupled receptors recruit Ca2+ via release from intracellular stores and entry via pathways in the plasma membrane. The relative importances of entry vs. mobilization seem to differ between different agonists, species and preparations. The entry pathway might include different types of voltage sensitive Ca2+ channels located in the plasmalemma such as dihydropyridine sensitive L-type channels, T-type channels and P/Q channels. A role for non-voltage sensitive entry pathways has also been suggested. The importance of voltage sensitive Ca2+ channels in the control of the tone of the afferent arteriole (and thus in the control of renal function and whole body control of extracellular fluid volume and blood pressure) sheds light on the control of the membrane potential of afferent arteriolar smooth muscle cells. Thus, K+ and Cl, channels are of importance in their role as major determinants of membrane potential. Some studies suggest a role for calcium-activated chloride (ClCa) channels in the renal vasoconstriction elicited by agonists. Other investigators have found evidence for several types of K+ channels in the regulation of the afferent arteriolar tone. The available literature in this field regarding afferent arterioles is, however, relatively sparse and not conclusive. This review is an attempt to summarize the results obtained by others and ourselves in the field of agonist induced afferent arteriolar Ca2+ recruitment, with special emphasis on the control of voltage sensitive Ca2+ entry. Outline of the Manuscript: This manuscript is structured as follows: it begins with an introduction where the general role for [Ca2+]i as a key factor in the regulation of the tone of vascular smooth muscles (VSMC) is detailed. In this section there is an emphasis is on observations that could be attributed to afferent arteriolar function. We then investigate the literature and describe our results regarding the relative roles for Ca2+ entry and intracellular release in afferent arterioles in response to vasoactive agents, with the focus on noradrenalin (NA) and angiotensin II (Ang II). Finally, we examine the role of ion channels (i.e. K+ and Cl, channels) for the membrane potential, and thus activation of voltage sensitive Ca2+ channels. [source] Unpublished Elizabethan Verse in a Huntington Manuscript [with texts]ENGLISH LITERARY RENAISSANCE, Issue 1 2004EDWARD DOUGHTIE First page of article [source] John Colet and a Lost Manuscript of 1506HISTORY, Issue 294 2004Jonathan Arnold John Colet, the humanist, attempted clerical reform early in his tenure as Dean of St Paul's (1505,19), by reminding certain members of the cathedral personnel of the existing statutes and by seeking to impose some visitation injunctions upon them. A 1506 manuscript, containing details of these efforts, is now lost. This article examines the contents of the manuscript, which are known from a nineteenth-century transcription, and investigates the minor clergy, whom it concerned. It also discusses the possible whereabouts of the original manuscript; Colet's possible motivation for writing the proposals; the reaction to Colet's ideas; and how his clerical colleagues perceived Colet. The article concludes that Colet's inappropriate approach to reform hindered his success. [source] Publishing Your Manuscript in the Electronic AgeJOURNAL OF THE AMERICAN ACADEMY OF NURSE PRACTITIONERS, Issue 6 2000Charon A. Pierson PhD No abstract is available for this article. [source] The Mathematical Contributions of Francesco Maurolico to the Theory of Music of the 16th Century (The Problems of a Manuscript)CENTAURUS, Issue 3 2006Tito M. Tonietti Here, in part I, his main results are presented and also their differences compared with the classical tradition of the mathematical theory of music. These results are a new proof of the number of commas in the tone, the theory of ,ictus', and a new notation for the composition of proportions. This is followed, in part II, by an explanation of how the original corpus of these folios was put together. Finally, part III discusses the complex puzzle of the manuscripts (one still extant, another probably lost, ,) and of their possible connections with the 1575 edition of a part of the corpus. Possible scenarios of the story of the manuscripts and probable interventions of the Jesuits on this edition are described. [source] Submission of Manuscripts to the Econometric Society Monograph SeriesECONOMETRICA, Issue 4 2009Article first published online: 21 JUL 200 No abstract is available for this article. [source] Submission of Manuscripts to the Econometric Society Monograph SeriesECONOMETRICA, Issue 1 2009Article first published online: 15 DEC 200 No abstract is available for this article. [source] Submission of Manuscripts to the Econometric Society Monograph SeriesECONOMETRICA, Issue 4 2006Article first published online: 19 JUN 200 No abstract is available for this article. [source] Submission of Manuscripts to the Econometric Society Monograph SeriesECONOMETRICA, Issue 1 2006Article first published online: 13 DEC 200 No abstract is available for this article. [source] Submission of Manuscripts to EconometricaECONOMETRICA, Issue 1 2003Article first published online: 28 JUN 200 First page of article [source] Submission of Manuscripts to EconometricaECONOMETRICA, Issue 3 2002Article first published online: 12 DEC 200 No abstract is available for this article. [source] Submission of Manuscripts To EconometricaECONOMETRICA, Issue 5 2001Article first published online: 12 DEC 200 No abstract is available for this article. [source] Submission of Manuscripts to the Econometric Society Monograph SeriesECONOMETRICA, Issue 4 2001Article first published online: 9 FEB 200 No abstract is available for this article. [source] Submission of Manuscripts To EconometricaECONOMETRICA, Issue 4 2001Article first published online: 9 FEB 200 No abstract is available for this article. [source] Submission of Manuscripts To the Econometric Society Monograph SeriesECONOMETRICA, Issue 1 2001Article first published online: 12 DEC 200 No abstract is available for this article. [source] Submission of Manuscripts to the Econometric Society Monograph SeriesECONOMETRICA, Issue 4 2000Article first published online: 10 DEC 200 No abstract is available for this article. [source] Manuscripts Accepted for PublicationJOURNAL OF RESEARCH ON ADOLESCENCE, Issue 4 2009Article first published online: 19 NOV 200 [source] A Survey of Evidence in the Journal of Veterinary Internal Medicine Oncology Manuscripts from 1999 to 2007JOURNAL OF VETERINARY INTERNAL MEDICINE, Issue 1 2010A. Sahora Objectives: To survey and monitor trends in evidence for oncology manuscripts published in the Journal of Veterinary Internal Medicine (JVIM) between 1999 and 2007 based on an evidence-based medicine (EBM) standard. Methods: All veterinary oncology-related articles published in JVIM and 7 other high-impact journals from 1999 to 2007 were collected by database searches. Relevant manuscripts then were characterized including investigator affiliation, subject matter investigated, retrospective or prospective study design, manuscript type, and classifications of manuscripts using an EBM standard. Results: A total of 172 relevant veterinary oncology manuscripts were identified in JVIM between 1999 and 2007. The proportion of oncology manuscripts published each year rose with the total number of manuscripts published in JVIM (mean, 13%; range, 8,15%). The author affiliations and subject matter were similar during this evaluation period. Case series represented the most common manuscript type (40%). With the exception of a progressive increase in prospective manuscripts and a reduction in case reports, no significant changes in the classification of manuscripts using EBM standards were seen. During this same period, veterinary oncology manuscripts published in 7 high-impact journals were associated with higher standards of evidence including prospective studies and randomized trials. Conclusions: The standards of evidence for veterinary oncology manuscripts published in JVIM have remained static between 1999 and 2007. This survey provides an informative benchmark for the state of evidence in previous JVIM oncology manuscripts and may be useful in identifying specific opportunities that may raise the standards of evidence in future publications in JVIM. [source] The Preservation, Study and Presentation of Manuscripts at the Bibliotheca AlexandrinaMUSEUM INTERNATIONAL, Issue 1-2 2005Youssef Ziedan [source] Who Contributes to Public Administration Review?PUBLIC ADMINISTRATION REVIEW, Issue 1 2005Examining the Characteristics of Authors Who Submit Manuscripts to the Journal This study examines data collected through a survey of authors who submitted manuscripts to Public Administration Review. Information on the authors' level of education, career path, longevity in the profession, race/ethnicity, gender, and ASPA affiliation is reviewed. Results show that PAR submission rates from both practitioners and individuals of color are far lower than submissions from academicians and white authors. In fact, minority submissions are lower than their presence on the faculties of NASPAA-affiliated public affairs programs would lead one to expect. In addition, manuscripts from white authors are more likely to be accepted than those from minority authors, even when controlling for academic rank. Manuscripts from women, however, were accepted at a higher rate than those from men. [source] The Earliest Christian Artifacts: Manuscripts and Christian Origins , By Larry W. HurtadoRELIGIOUS STUDIES REVIEW, Issue 3 2007Michael W. Holmes No abstract is available for this article. [source] "The Luminous Flash of a Single Sentence": Using Mark Twain's Digital Manuscripts in the Pedagogy of CompositionTHE MARK TWAIN ANNUAL, Issue 1 2005Matthew D. Klauza First page of article [source] Online Submission of Manuscripts (OSM)CHEMICAL VAPOR DEPOSITION, Issue 2 2004M.L. Hitchman It is now possible for authors to submit their manuscripts online to CVD. The system provides many advantages for authors and in this editorial Michael Hitchman explains the system and outlines its use. [source] Manuscripts Accepted for PublicationCHILD DEVELOPMENT, Issue 3 2010Article first published online: 13 MAY 2010 No abstract is available for this article. [source] Manuscripts Accepted for PublicationCHILD DEVELOPMENT, Issue 4 2009Article first published online: 15 JUL 200 No abstract is available for this article. [source] Manuscripts Accepted for PublicationCHILD DEVELOPMENT, Issue 3 2009Article first published online: 15 MAY 200 No abstract is available for this article. [source] Manuscripts Accepted for PublicationCHILD DEVELOPMENT, Issue 2 2009Article first published online: 29 APR 200 No abstract is available for this article. [source] Manuscripts Accepted for PublicationCHILD DEVELOPMENT, Issue 4 2008Article first published online: 14 JUL 200 No abstract is available for this article. [source] | |||||||||||||||||||||||||||||||