Home About us Contact
|
Home About us Contact | ||
|
|
||
Managing Risk (managing + risk)
Selected AbstractsGovernment Managing Risk: Income-Contingent Loans for Social and Economic Progress.ECONOMICA, Issue 306 2010By BRUCE CHAPMAN No abstract is available for this article. [source] How to Achieve Confidence in Drug Discovery and Development: Managing Risk (from a Reductionist to a Holistic Approach)CHEMMEDCHEM, Issue 6 2009Annette Bakker Dr. Abstract Confidence in mechanism: Creating a more holistic understanding of disease pathophysiology and an early confidence in the mechanism under investigation could help facilitate the selection of not only the most appropriate targets but also the best mechanisms for disease intervention and how to select and optimise the best compounds. Drug target and candidate selection are two of the key decision points within the drug discovery process for which all companies use certain selection criteria to make decisions on which targets to accept into their discovery pipelines and which compounds will pass into development. These steps not only help define the overall productivity of every company but they are also decisions taken without full predictive knowledge of the risks that lie ahead or how best to manage them. In particular, the process of selecting new targets does not normally involve full evaluation of the risk(s) in the mechanism under investigation (the modulation of the target), which may result in an inability to fully connect in,vitro and animal model results to the disease (clinical) setting. The resulting poor progression statistics of many compounds in the clinic is at least partially the result of a lack of understanding of disease pathophysiology. Notably, the lack of efficacy is still a major reason for failure in the clinic.1 Creating a more holistic understanding of disease pathophysiology and an early confidence in the mechanism under investigation could help facilitate the selection of not only the most appropriate targets but also the best mechanisms for disease intervention and how to select and optimise the best compounds. [source] Managing Risks in Multiple Online Auctions: An Options Approach,DECISION SCIENCES, Issue 3 2005Ram Gopal ABSTRACT The scenario of established business sellers utilizing online auction markets to reach consumers and sell new products is becoming increasingly common. We propose a class of risk management tools, loosely based on the concept of financial options that can be employed by such sellers. While conceptually similar to options in financial markets, we empirically demonstrate that option instruments within auction markets cannot be developed employing similar methodologies, because the fundamental tenets of extant option pricing models do not hold within online auction markets. We provide a framework to analyze the value proposition of options to potential sellers, option-holder behavior implications on auction processes, and seller strategies to write and price options that maximize potential revenues. We then develop an approach that enables a seller to assess the demand for options under different option price and volume scenarios. We compare option prices derived from our approach with those derived from the Black-Scholes model (Black & Scholes, 1973) and discuss the implications of the price differences. Experiments based on actual auction data suggest that options can provide significant benefits under a variety of option-holder behavioral patterns. [source] Opioid Analgesia: Managing Risks and Obtaining BenefitsPAIN MEDICINE, Issue 2008Rollin M. Gallagher MD No abstract is available for this article. [source] Managing risk in global operationsJOURNAL OF CORPORATE ACCOUNTING & FINANCE, Issue 6 2003Marc F. Massoud Companies doing business abroad face two tough questions: How can we assess our risks? And what are the best strategies to minimize those risks? The authors explain how to develop a risk control strategy and how to lessen your risk using financial mechanisms. © 2003 Wiley Periodicals, Inc. [source] Managing risk through a flexible recipe frameworkAICHE JOURNAL, Issue 3 2008Sergio Ferrer-Nadal Abstract A novel approach is proposed that exploits the use of a flexible recipe framework as a better way to handle the risk associated with the scheduling under uncertainty of batch chemical plants. The proposed solution strategy relies on a novel two-stage stochastic formulation that explicitly includes the trade-off between risk and profit at the decision-making level. The model uses a continuous-time domain representation and the generalized notion of precedence. Management of risk is explicitly addressed by including a control measure (i.e., the profit in the worst scenario), as an additional objective to be considered, thus, leading to a multiobjective optimization problem. To overcome the numerical difficulties associated with such mathematical formulation, a decomposition strategy based on the sample average approximation (SAA) is introduced. The main advantages of this approach are illustrated through a case study, in which a set of solutions appealing to decision makers with different attitudes toward risk are obtained. The potential benefits of the proposed flexible recipe framework as a way of managing the risk associated with the plant operation under demand uncertainty are highlighted through comparison with the conventional approach that considers nominal operating conditions. Numerical results corroborate the advantages of exploiting the capabilities of the proposed flexible recipe framework for risk management purposes. © 2008 American Institute of Chemical Engineers AIChE J, 2008 [source] Weather derivatives: Managing risk in a climate of changeNATURAL GAS & ELECTRICITY (PREVIOUSLY : NATURAL GAS), Issue 7 2000Richard G. Morgan [source] Managing risk and vulnerability in Asia: A (re)study from Thailand, 1982,83 and 2008ASIA PACIFIC VIEWPOINT, Issue 3 2009Jonathan Rigg Abstract In the 1980s, rural settlements in the Northeast of Thailand were farming focused, and strategies of living were structured around the need to secure subsistence in the face of a capricious environment and a weak developmental state. More than half of households in the region lived below the poverty line, and the immediate prospects for ,development' were not bright. Drawing on a 25-year longitudinal study of two villages in Mahasarakham, the paper describes and reflects on how risk and vulnerability have been re-shaped during a quarter of a century of profound economic and social change. From largely environmental and local, the pattern of risk and opportunity have become increasingly economic and non-local as external events wash across the shores of rural settlements like Ban Non Tae and Ban Tha Song Korn. [source] Community psychiatric nurses' experience of working with people who engage in deliberate self-harmINTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING, Issue 3 2008Andrew R. Thompson ABSTRACT:, This paper reports on a study that explored community psychiatric nurses' experiences of working with people who self-harm. Interpretative Phenomenological Analysis was used with eight experienced community psychiatric nurses who participated in semi-structured interviews. Established quality control procedures were utilized including audit of the analysis process and validating the results with participants. The participants described struggling to conceptualize self-harm behaviour and generally reported finding working with people who self-harm stressful particularly in terms of managing the emotional impact upon themselves and the boundaries of their professional responsibilities in relation to managing risk. The therapeutic relationship was viewed as crucial and a variety of coping methods to manage the impact of the work, which had largely developed through ,on the job', experience were described. The results highlight the potential difficulties faced by community staff and can be translated into clear recommendations for training and support. [source] Dementia and risk: contested territories of everyday lifeJOURNAL OF NURSING AND HEALTHCARE OF CHRONIC ILLNE SS: AN INTERNATIONAL INTERDISCIPLINARY JOURNAL, Issue 2 2010Charlotte L Clarke DSocSc clarke cl, keady j, wilkinson h, gibb ce, luce a, cook a & williams l (2010) Journal of Nursing and Healthcare of Chronic Illness 2, 102,112 Dementia and risk: contested territories of everyday life Aims., The project aimed to understand the construction of risk in dementia care from the perspective of the person with dementia, family carers and practitioners with the intention of developing negotiated partnerships in risk management. Background., This paper addresses a gap in the literature by embedding constructions of risk within everyday events and social contexts, and communicates such constructions through the voices of people with dementia, carers and practitioners. Method., This symbolic interactionalist study involved data collection by interview with 55 people with dementia (sometimes twice), and their nominated carer and practitioner. The sample was drawn from three regions of the United Kingdom. Data were collected during 2004. Conclusions., Five ,contested territories' of everyday living with dementia are outlined in this paper: friendships, smoking, going out, domestic arrangements, and occupation and activity. These contested territories are purposeful and allow for sense making, maintenance of self, claiming and relinquishing decision making, and creating purpose(lessness) in people's lives. Relevance to clinical practice., Assessing and managing risk in a way that respects the dynamics and purposes of contested territories will support care that is person centred, and moreover respectful of the relationships that contribute to maintaining the individual's sense of self and purpose. [source] Legislative Issues Impacting On The Practice Of The South African Nurse PractitionerJOURNAL OF THE AMERICAN ACADEMY OF NURSE PRACTITIONERS, Issue 1 2002Nelouise Geyer Purpose To present an overview of the impact of the nurse practitioner (NP) on the South African health care arena and describe the legislative framework for NP practice. Data Sources Statutes and laws of the government of South Africa; published professional guidelines; authors' experiences. Conclusions The key challenges for NPs in South Africa lie in lobbying for enabling legislation, obtaining access to education and training opportunities, and managing risks within the rapidly changing environment. Implications for Practice Some aspects of the NP's accountability and responsibilities have as yet not been adequately addressed in the current legislative framework and will certainly increase the risk for malpractice. South African NPs will have to establish partnerships with important role players, not only in South Africa, but also internationally, to ensure that an enabling environment for quality health services is created. [source] | ||||||||||||||||