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Makers
Kinds of Makers Terms modified by Makers Selected AbstractsIN MEMORIUM: VIRGINIA F. DURR, AN INVISIBLE DECISION MAKER WHO CHANGED HER WORLDPOLITICS & POLICY, Issue 3 2000Lois Duke Whitaker No abstract is available for this article. [source] REPRODUCTIVE TOURISM IN ARGENTINA: CLINIC ACCREDITATION AND ITS IMPLICATIONS FOR CONSUMERS, HEALTH PROFESSIONALS AND POLICY MAKERSDEVELOPING WORLD BIOETHICS, Issue 2 2010ELISE SMITH ABSTRACT A subcategory of medical tourism, reproductive tourism has been the subject of much public and policy debate in recent years. Specific concerns include: the exploitation of individuals and communities, access to needed health care services, fair allocation of limited resources, and the quality and safety of services provided by private clinics. To date, the focus of attention has been on the thriving medical and reproductive tourism sectors in Asia and Eastern Europe; there has been much less consideration given to more recent ,players' in Latin America, notably fertility clinics in Chile, Brazil, Mexico and Argentina. In this paper, we examine the context-specific ethical and policy implications of private Argentinean fertility clinics that market reproductive services via the internet. Whether or not one agrees that reproductive services should be made available as consumer goods, the fact is that they are provided as such by private clinics around the world. We argue that basic national regulatory mechanisms are required in countries such as Argentina that are marketing fertility services to local and international publics. Specifically, regular oversight of all fertility clinics is essential to ensure that consumer information is accurate and that marketed services are safe and effective. It is in the best interests of consumers, health professionals and policy makers that the reproductive tourism industry adopts safe and responsible medical practices. [source] Two tomato ,-expansins show distinct spatial and temporal expression patterns during development of nematode-induced syncytiaPHYSIOLOGIA PLANTARUM, Issue 3 2008Sylwia Fudali Cyst nematodes induce specific syncytial feeding structures within the root which develop from an initial cell by successive incorporation of neighbouring cells through local cell wall dissolutions followed by hypertrophy of included cells. Expansins are known to induce cell wall relaxation and extension in acidic pH, and they are involved in many processes requiring wall modification from cell expansion to cell wall disassembly. We studied the expression pattern of tomato (Lycopersicon esculentum L., cv. Money Maker) expansins during development of syncytia induced by the potato cyst nematode (Globodera rostochiensis Woll.). Based on semi-quantitative reverse transcription,polymerase chain reaction, two expansin genes, LeEXPA4 and LeEXPA5, were selected for detailed examinations because their expression was either elevated in infected roots (LeEXPA4) or specifically induced in the root upon nematode infection (LeEXPA5). Both genes have distinct spatial and temporal expression patterns that may reflect their different roles in syncytium development. LeEXPA4 transcripts were localized predominantly in parenchymatous vascular cylinder cells surrounding syncytia. This finding suggests that LeEXPA4 might be involved in cell wall disassembly or relaxation, mediating syncytium expansion and/or development of conductive tissues. By contrast, LeEXPA5 transcripts were localized in enlarging syncytial elements. Similarly, in immunogold localization experiments, polyclonal antibodies localized the LeEXPA5 protein in cell walls of syncytial elements. This expression pattern suggests that LeEXPA5 gene is specifically involved in enlargement of cells incorporated into syncytium. [source] Representational Altruism: The Wary Cooperator as Authoritative Decision MakerAMERICAN JOURNAL OF POLITICAL SCIENCE, Issue 4 2006Kevin B. Smith What drives policymakers to put the interests of others above their own? If human nature is inherently selfish, it makes sense to institutionalize incentives that counter decision makers' temptations to use their positions to benefit themselves over others. A growing literature rooted in evolutionary theories of human behavior, however, suggests that humans, under certain circumstances, have inherent predispositions towards "representational altruism," i.e., to make an authoritative decision to benefit another at one's own expense. Drawing on Hibbing and Alford's conception of the wary cooperator, a theoretical case is made for such behavioral expectations, which are confirmed in a series of original laboratory experiments. [source] Multilevel Social Dynamics Considerations for Project Management Decision Makers: Antecedents and Implications of Group Member Tie DevelopmentDECISION SCIENCES, Issue 3 2010Elliot Bendoly ABSTRACT Successful projects represent the effective culmination of management skills, planning, and individual project member strengths. In operations management, such strengths are often viewed predominantly from the perspective of skill base. However, it has become increasingly evident that behavioral traits associated with individuals play a very significant, if not ultimately dominating, role in the effectiveness of certain group projects. Our aim in this study is to look into how certain individual attributes viewed as relevant to these project contexts may lead to social networking decisions that have impacts spanning multiple levels of analysis. Such insights are likely to prove valuable to decision makers managing project teams as well. We employ a controlled 4-month investigation of multiple projects, for which we are able to consider both objective, and subjective pre-, in situ, and postproject data. Our results demonstrate that the issues of perceived control, confidence, and conscientiousness are relevant not only in driving individual perceptions of the value of within-group interactions, and hence the development of associated ties, but are also ultimately relevant in helping to drive higher levels of group performance. [source] Decision Makers as Statisticians: Diversity, Ambiguity, and LearningECONOMETRICA, Issue 5 2009Nabil I. Al-Najjar I study individuals who use frequentist models to draw uniform inferences from independent and identically distributed data. The main contribution of this paper is to show that distinct models may be consistent with empirical evidence, even in the limit when data increases without bound. Decision makers may then hold different beliefs and interpret their environment differently even though they know each other's model and base their inferences on the same evidence. The behavior modeled here is that of rational individuals confronting an environment in which learning is hard, rather than individuals beset by cognitive limitations or behavioral biases. [source] Women as Policy Makers: Evidence from a Randomized Policy Experiment in IndiaECONOMETRICA, Issue 5 2004Raghabendra Chattopadhyay This paper uses political reservations for women in India to study the impact of women's leadership on policy decisions. Since the mid-1990's, one third of Village Council head positions in India have been randomly reserved for a woman: In these councils only women could be elected to the position of head. Village Councils are responsible for the provision of many local public goods in rural areas. Using a dataset we collected on 265 Village Councils in West Bengal and Rajasthan, we compare the type of public goods provided in reserved and unreserved Village Councils. We show that the reservation of a council seat affects the types of public goods provided. Specifically, leaders invest more in infrastructure that is directly relevant to the needs of their own genders. [source] Why Do Policy Makers Give (Permanent) Power to Policy Advisers?ECONOMICS & POLITICS, Issue 1 2001Otto H. Swank Using a simple game-theoretical model, this paper analyzes the role of policy advisers in the policy-making process. We show that policy makers are inclined to appoint advisers whose preferences coincide with their own preferences. Furthermore, we show that policy makers are biased towards erecting permanent advisory units. This result stems from the policy makers' desire to affect the actions of their successors. A permanent advisory unit induces future policy makers to act in accordance with the preferences of current policy makers. The policy-makers' bias towards erecting permanent advisory units may drive a wedge between actual policy outcomes and socially desired policy outcomes. [source] Inclusive Achievement Testing for Linguistically and Culturally Diverse Test Takers: Essential Considerations for Test Developers and Decision MakersEDUCATIONAL MEASUREMENT: ISSUES AND PRACTICE, Issue 1 2009Shelley B. Fairbairn Substantial growth in the numbers of English language learners (ELLs) in the United States and Canada in recent years has significantly affected the educational systems of both countries. This article focuses on critical issues and concerns related to the assessment of ELLs in U.S. and Canadian schools and emphasizes assessment approaches for test developers and decision makers that will facilitate increased equity, meaningfulness, and accuracy in assessment and accountability efforts. It begins by examining the crucial issue of defining ELLs as a group. Next, it examines the impact of testing originating from the No Child Left Behind Act of 2001 (NCLB) in the U.S. and government-mandated standards-driven testing in Canada by briefly describing each country's respective legislated testing requirements and outlining their consequences at several levels. Finally, the authors identify key points that test developers and decision makers in both contexts should consider in testing this ever-increasing group of students. [source] The Appreciative System of Urban ICT Policies: An Analysis of Perceptions of Urban Policy MakersGROWTH AND CHANGE, Issue 2 2004GALIT COHEN-BLANKSHTAIN ABSTRACT Information and Communication Technology (ICT) has become an important tool to promote a variety of public goals and policies. In the past years much attention has been given to the expected social benefits from deploying ICTs in different urban fields (transportation, education, public participation in planning, etc.) and to its potential to mitigate various current or emerging urban problems. The growing importance of ICTs in daily life, business activities, and governance prompts the need to consider ICTs more explicitly in urban policies. Alongside the expectation that the private sector will play a major role in the ICT field, the expected benefits from ICTs also encourage urban authorities to formulate proper public ICT policies. Against this background, various intriguing research questions arise. What are the urban policy-makers' expectations about ICTs? And how do they assess the future implications of ICTs for their city? A thorough analysis of these questions will provide a better understanding of the extent to which urban authorities are willing to invest in and to adopt a dedicated ICT policy. This study is focusing on the way urban decision-makers perceive the opportunities of ICT policy. After a sketch of recent development and policy issues, a conceptual model is developed to map out the driving forces of urban ICT policies in cities in Europe. Next, by highlighting the importance of understanding the decision-maker's "black box," three crucial variables are identified within this box. In the remaining part of the paper these three variables will be operationalized by using a large survey comprising more than 200 European cities. By means of statistical multivariate methods (i.e., factor and cluster analysis), the decision-makers were able to be characterized according to the way they perceive their city (the concept of "imaginable city"), their opinion about ICT, and the way they assess the relevance of ICT policies to their city. Next, a solid explanatory framework will be offered by using a log-linear logit analysis to test the relationships between these three aspects. [source] Training Decision Makers , Tactical Decision GamesJOURNAL OF CONTINGENCIES AND CRISIS MANAGEMENT, Issue 4 2000Margaret T. Crichton There is growing recognition of the need to train non-technical skills, especially decision making, for emergency management in high reliability industries as well as in contained environments such as prisons. This article presents a training method, Tactical Decision Games, which appears to provide a good opportunity to practise the non-technical skills that would be required in the management of an emergency situation. Case studies from the UK nuclear power industry and the Scottish Prison Service (SPS) illustrate the adaptability and general application of TDGs for training of emergency response teams in a range of operational settings. [source] Educational Research and the Practical Judgement of Policy MakersJOURNAL OF PHILOSOPHY OF EDUCATION, Issue 2008DAVID BRIDGES [source] The Worshipful Company of Spectacle MakersOPHTHALMIC AND PHYSIOLOGICAL OPTICS, Issue 1 2003The Master's Prize 200 No abstract is available for this article. [source] How Can Research Organizations More Effectively Transfer Research Knowledge to Decision Makers?THE MILBANK QUARTERLY, Issue 2 2003JOHN N. LAVIS Applied research organizations invest a great deal of time, and research funders invest a great deal of money generating and (one hopes) transferring research knowledge that could inform decisions about health and health care. Basing these knowledge-transfer activities on our evolving understanding of the most effective approaches to knowledge transfer will help us achieve value for money in our individual and collective investments in health services and health policy research. Research organizations and research funders can probably be excused for not basing their activities on research evidence until now, however, because the variety of relevant questions, target audiences, and disciplinary perspectives and methodological approaches used in empirical studies has made the identification of take-home messages from this field of research a very difficult task. We provide an organizing framework for a knowledge-transfer strategy and an overview of our understanding of the current knowledge for each of the five elements of the framework. The framework provides an overall approach to knowledge transfer that can be evaluated as a whole over long periods of time, as well as specific elements that can be evaluated and fine-tuned over shorter periods of time. [source] Out of the Loop: Why Research Rarely Reaches Policy Makers and the Public and What Can be DoneBIOTROPICA, Issue 5 2009Patricia Shanley ABSTRACT Most of the world's population that derives their livelihoods or part of their livelihoods from forests are out of the information loop. Exclusion of public users of natural resources from access to scientific research results is not an oversight; it is a systemic problem that has costly ramifications for conservation and development. Results of a survey of 268 researchers from 29 countries indicate that institutional incentives support the linear, top-down communication of results through peer-reviewed journal articles, which often guarantees positive performance measurement. While the largest percentage of respondents (34%) ranked scientists as the most important audience for their work, only 15 percent of respondents considered peer-reviewed journals effective in promoting conservation and/or development. Respondents perceived that local initiatives (27%) and training (16%) were likely to lead to success in conservation and development; but few scientists invest in these activities. Engagement with the media (5%), production of training and educational materials (4%) and popular publications (5%) as outlets for scientific findings was perceived as inconsequential (<14%) in measuring scientific performance. Less than 3 percent of respondents ranked corporate actors as an important audience for their work. To ensure science is shared with those who need it, a shift in incentive structures is needed that rewards actual impact rather than only ,high-impact' journals. Widely used approaches and theoretical underpinnings from the social sciences, which underlie popular education and communication for social change, could enhance communication by linking knowledge and action in conservation biology. [source] FROM DISCRETE-TIME MODELS TO CONTINUOUS-TIME, ASYNCHRONOUS MODELING OF FINANCIAL MARKETSCOMPUTATIONAL INTELLIGENCE, Issue 2 2007Katalin Boer Most agent-based simulation models of financial markets are discrete-time in nature. In this paper, we investigate to what degree such models are extensible to continuous-time, asynchronous modeling of financial markets. We study the behavior of a learning market maker in a market with information asymmetry, and investigate the difference caused in the market dynamics between the discrete-time simulation and continuous-time, asynchronous simulation. We show that the characteristics of the market prices are different in the two cases, and observe that additional information is being revealed in the continuous-time, asynchronous models, which can be acted upon by the agents in such models. Because most financial markets are continuous and asynchronous in nature, our results indicate that explicit consideration of this fundamental characteristic of financial markets cannot be ignored in their agent-based modeling. [source] Decision Making with Uncertain Judgments: A Stochastic Formulation of the Analytic Hierarchy Process*DECISION SCIENCES, Issue 3 2003Eugene D. Hahn ABSTRACT In the analytic hierarchy process (AHP), priorities are derived via a deterministic method, the eigenvalue decomposition. However, judgments may be subject to error. A stochastic characterization of the pairwise comparison judgment task is provided and statistical models are introduced for deriving the underlying priorities. Specifically, a weighted hierarchical multinomial logit model is used to obtain the priorities. Inference is then conducted from the Bayesian viewpoint using Markov chain Monte Carlo methods. The stochastic methods are found to give results that are congruent with those of the eigenvector method in matrices of different sizes and different levels of inconsistency. Moreover, inferential statements can be made about the priorities when the stochastic approach is adopted, and these statements may be of considerable value to a decision maker. The methods described are fully compatible with judgments from the standard version of AHP and can be used to construct a stochastic formulation of it. [source] Quantitative Comparison of Approximate Solution Sets for Bi-criteria Optimization Problems,DECISION SCIENCES, Issue 1 2003W. Matthew Carlyle ABSTRACT We present the Integrated Preference Functional (IPF) for comparing the quality of proposed sets of near-pareto-optimal solutions to bi-criteria optimization problems. Evaluating the quality of such solution sets is one of the key issues in developing and comparing heuristics for multiple objective combinatorial optimization problems. The IPF is a set functional that, given a weight density function provided by a decision maker and a discrete set of solutions for a particular problem, assigns a numerical value to that solution set. This value can be used to compare the quality of different sets of solutions, and therefore provides a robust, quantitative approach for comparing different heuristic, a posteriori solution procedures for difficult multiple objective optimization problems. We provide specific examples of decision maker preference functions and illustrate the calculation of the resulting IPF for specific solution sets and a simple family of combined objectives. [source] CK19 mRNA expression in the bone marrow of patients with esophageal squamous cell carcinoma and its clinical significanceDISEASES OF THE ESOPHAGUS, Issue 5 2010X. Zhang SUMMARY The 5-year survival rate in resectable patients with esophageal cancer is only 20% to 36%. Regional relapse and distant metastasis are responsible for the failure of treatment and the majority of cancer-related deaths. Earlier detection of metastases, especially micrometastases, has the potential for more accurate risk stratification in subsequent therapy decisions. No effective techniques have yet been found to detect metastases in erroneously thought to have early stage disease. This study was designed to investigate the clinical significance of bone marrow micrometastases detected by reverse transcriptase-polymerase chain reaction (RT-PCR) in patients with esophageal cancer. Expression of CK19 mRNA in the bone marrow of 61 patients with esophageal squamous cell carcinoma (ESCC) and 15 benign pulmonary and esophageal disease patients was assessed via RT-PCR. Correlation of CK19 mRNA expression to the clinicopathologic features and prognosis of the 61 patients was analyzed: 21.3% (13/61) were positive for expression of CK19 mRNA in patients with ESCC. No CK19 mRNA was detected of the 15 benign pulmonary and esophageal disease patients. CK19 mRNA expression did not correlate with the clinicopathologic features of the patients with ESCC, but patients with CK19 mRNA-positive bone marrow had earlier recurrence and shorter survival after surgery. In multivariate analysis, CK19 mRNA was found to be an independent predictor of a poor outcome. CK19 mRNA may be used as a molecular maker to detect bone marrow micrometastases in patients with ESCC and may help to select the proper therapy and predict the prognosis. [source] Post-earthquake bridge repair cost and repair time estimation methodologyEARTHQUAKE ENGINEERING AND STRUCTURAL DYNAMICS, Issue 3 2010Kevin R. Mackie Abstract While structural engineers have traditionally focused on individual components (bridges, for example) of transportation networks for design, retrofit, and analysis, it has become increasingly apparent that the economic costs to society after extreme earthquake events are caused at least as much from indirect costs as direct costs due to individual structures. This paper describes an improved methodology for developing probabilistic estimates of repair costs and repair times that can be used for evaluating the performance of new bridge design options and existing bridges in preparation for the next major earthquake. The proposed approach in this paper is an improvement on previous bridge loss modeling studies,it is based on the local linearization of the dependence between repair quantities and damage states so that the resulting model follows a linear relationship between damage states and repair points. The methodology uses the concept of performance groups (PGs) that account for damage and repair of individual bridge components and subassemblies. The method is validated using two simple examples that compare the proposed method to simulation and previous methods based on loss models using a power,law relationship between repair quantities and damage. In addition, an illustration of the method is provided for a complete study on the performance of a common five-span overpass bridge structure in California. Intensity-dependent repair cost ratios (RCRs) and repair times are calculated using the proposed approach, as well as plots that show the disaggregation of repair cost by repair quantity and by PG. This provides the decision maker with a higher fidelity of data when evaluating the contribution of different bridge components to the performance of the bridge system, where performance is evaluated in terms of repair costs and repair times rather than traditional engineering quantities such as displacements and stresses. Copyright © 2009 John Wiley & Sons, Ltd. [source] Optimal seismic design of steel frame buildings based on life cycle cost considerationsEARTHQUAKE ENGINEERING AND STRUCTURAL DYNAMICS, Issue 9 2003Min Liu Abstract A multi-objective optimization procedure is presented for designing steel moment resisting frame buildings within a performance-based seismic design framework. Life cycle costs are considered by treating the initial material costs and lifetime seismic damage costs as two separate objectives. Practical design/construction complexity, important but difficult to be included in initial cost analysis, is taken into due account by a proposed diversity index as another objective. Structural members are selected from a database of commercially available wide flange steel sections. Current seismic design criteria (AISC-LRFD seismic provisions and 1997 NEHRP provisions) are used to check the validity of any design alternative. Seismic performance, in terms of the maximum inter-storey drift ratio, of a code-verified design is evaluated using an equivalent single-degree-of-freedom system obtained through a static pushover analysis of the original multi-degree-of-freedom frame building. A simple genetic algorithm code is used to find a Pareto optimal design set. A numerical example of designing a five-storey perimeter steel frame building is provided using the proposed procedure. It is found that a wide range of valid design alternatives exists, from which a decision maker selects the one that balances different objectives in the most preferred way. Copyright © 2003 John Wiley & Sons, Ltd. [source] Structure and vertical stratification of plant galler,parasitoid food webs in two tropical forestsECOLOGICAL ENTOMOLOGY, Issue 3 2009MIGUEL R. PANIAGUA Abstract 1.,Networks of feeding interactions among insect herbivores and natural enemies such as parasitoids, describe the structure of these assemblages and may be critically linked to their dynamics and stability. The present paper describes the first quantitative study of parasitoids associated with gall-inducing insect assemblages in the tropics, and the first investigation of vertical stratification in quantitative food web structure. 2.,Galls and associated parasitoids were sampled in the understorey and canopy of Parque Natural Metropolitano in the Pacific forest, and in the understorey of San Lorenzo Protected Area in the Caribbean forest of Panama. Quantitative host,parasitoid food webs were constructed for each assemblage, including 34 gall maker species, 28 host plants, and 57 parasitoid species. 3.,Species richness was higher in the understorey for parasitoids, but higher in the canopy for gall makers. There was an almost complete turnover in gall maker and parasitoid assemblage composition between strata, and the few parasitoid species shared between strata were associated with the same host species. 4.,Most parasitoid species were host specific, and the few polyphagous parasitoid species were restricted to the understorey. 5.,These results suggest that, in contrast to better-studied leaf miner,parasitoid assemblages, the influence of apparent competition mediated by shared parasitoids as a structuring factor is likely to be minimal in the understorey and practically absent in the canopy, increasing the potential for coexistence of parasitoid species. 6.,High parasitoid beta diversity and high host specificity, particularly in the poorly studied canopy, indicate that tropical forests may be even more species rich in hymenopteran parasitoids than previously suspected. [source] Probabilities as Similarity-Weighted FrequenciesECONOMETRICA, Issue 4 2005Antoine Billot A decision maker is asked to express her beliefs by assigning probabilities to certain possible states. We focus on the relationship between her database and her beliefs. We show that if beliefs given a union of two databases are a convex combination of beliefs given each of the databases, the belief formation process follows a simple formula: beliefs are a similarity-weighted average of the beliefs induced by each past case. [source] Expedient and Monotone Learning RulesECONOMETRICA, Issue 2 2004Tilman Börgers This paper considers learning rules for environments in which little prior and feedback information is available to the decision maker. Two properties of such learning rules are studied: absolute expediency and monotonicity. Both require that some aspect of the decision maker's performance improves from the current period to the next. The paper provides some necessary, and some sufficient conditions for these properties. It turns out that there is a large variety of learning rules that have the properties. However, all learning rules that have these properties are related to the replicator dynamics of evolutionary game theory. For the case in which there are only two actions, it is shown that one of the absolutely expedient learning rules dominates all others. [source] Testing for trends in the violation frequency of an environmental threshold in riversENVIRONMETRICS, Issue 1 2009Lieven Clement Abstract Nutrient pollution in rivers is a common problem. It can provoke algae blooms which are related to increased fish mortality. To restore the water status, the regulator recently has promulgated more restrictive regulations. In Flanders for instance, the government has introduced several manure decrees (MDs) to restrict nutrient pollution. Environmental regulations are commonly expressed in terms of threshold levels. This provides a binary response to the decision maker. To handle such data, we propose the use of marginalised generalised linear mixed models. They provide valid inference on trends in the exceedance frequency. The spatio-temporal dependence of the river monitoring network is incorporated by the use of a latent variable. The temporal dependence is assumed to be AR(1) and the spatial dependence is derived from the river topology. The mean model contains a term for the trend and corrects for seasonal variation. The model formulation allows an assessment on the level of individual sampling locations and on a more regional scale. The methodology is applied to a case study on the river Yzer (Flanders). It assesses the impact of the MDs on the violation probability of the nitrate standard. A trend change is detected after the introduction of the second MD. Copyright © 2008 John Wiley & Sons, Ltd. [source] Managing the Unique Size-related Issues of Pediatric Resuscitation: Reducing Cognitive Load with Resuscitation AidsACADEMIC EMERGENCY MEDICINE, Issue 8 2002Robert Luten MD Abstract A resuscitation is a complicated event that requires for its optimal outcome the effective completion of a distinct series of actions, some simple, some complex, most occurring simultaneously or in close proximity. In children, these actions are determined not only by the clinical situation, but also by a series of age and size factors particular to each child. Different tasks require different levels of cognitive load, or mental effort. Cognitive load describes the mental burden experienced by the decision maker and will be higher when the task is less familiar or more demanding. In the setting of resuscitation, it refers to the cumulative demands of patient assessment, the ongoing decisions for each of the various steps, and decisions around procedural intervention (e.g., intubation). In children, the level of task complexity and, hence, cognitive load is increased by the unique component of variability of pediatric age and size, introducing logistical factors, many of which involve computations. The purpose of this paper is to examine the effects of age/size-related variables on the pediatric resuscitative process and to explore how these effects can be mitigated using resuscitation aids. The concept of cognitive load and its relation to performance in resuscitation is introduced and is used to demonstrate the effect of the various aids in the pediatric resuscitative process. [source] Is NF-,B from astrocytes a decision maker of neuronal life or death? (Commentary on Dvoriantchikova et al.)EUROPEAN JOURNAL OF NEUROSCIENCE, Issue 2 2009Nicolas G. BazanArticle first published online: 15 JUL 200 No abstract is available for this article. [source] Following START: Risk Acceptance and the 1991,1992 Presidential Nuclear InitiativesFOREIGN POLICY ANALYSIS, Issue 1 2008Matthew Fuhrmann In September 1991, U.S. President George H.W. Bush launched the Presidential Nuclear Initiatives (PNIs), which were unilateral measures that led to the largest reductions in the American and Soviet/Russian nuclear arsenals to date. Despite their eventual success, the United States took on significant risks in launching the PNIs. To uncover the best theoretical explanation for their onset, this article uses realism, neorealism, the bureaucratic politics model, expected utility theory, and prospect theory to generate ex ante predictions regarding nuclear arms control at the end of the Cold War. It then tests the theories' predictions against the empirical record. The results suggest that a focus on an individual decision maker,President Bush,is necessary to fully understand the PNIs and that an explanation rooted in prospect theory offers the most explanatory power. This study speaks to an important debate in discipline regarding the significance of individuals, while underscoring the value of exploring foreign policy decision making from multiple levels of analysis. It also advances the literatures on risk acceptance and prospect theory by shifting their applications away from militarized conflict and crises to diplomatic negotiations and cooperation. [source] A dictionary model for haplotyping, genotype calling, and association testingGENETIC EPIDEMIOLOGY, Issue 7 2007Kristin L. Ayers Abstract We propose a new method for haplotyping, genotype calling, and association testing based on a dictionary model for haplotypes. In this framework, a haplotype arises as a concatenation of conserved haplotype segments, drawn from a predefined dictionary according to segment specific probabilities. The observed data consist of unphased multimarker genotypes gathered on a random sample of unrelated individuals. These genotypes are subject to mutation, genotyping errors, and missing data. The true pair of haplotypes corresponding to a person's multimarker genotype is reconstructed using a Markov chain that visits haplotype pairs according to their posterior probabilities. Our implementation of the chain alternates Gibbs steps, which rearrange the phase of a single marker, and Metropolis steps, which swap maternal and paternal haplotypes from a given maker onward. Output of the chain include the most likely haplotype pairs, the most likely genotypes at each marker, and the expected number of occurrences of each haplotype segment. Reconstruction accuracy is comparable to that achieved by the best existing algorithms. More importantly, the dictionary model yields expected counts of conserved haplotype segments. These imputed counts can serve as genetic predictors in association studies, as we illustrate by examples on cystic fibrosis, Friedreich's ataxia, and angiotensin-I converting enzyme levels. Genet. Epidemiol. © 2007 Wiley-Liss, Inc. [source] Democracy and sustainable development,what is the alternative to cost,benefit analysis?INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT, Issue 2 2006Peter Söderbaum Abstract Cost,benefit analysis (CBA) is part of neoclassical economics, a specific paradigm, or theoretical perspective. In searching for alternatives to CBA, competing theoretical frameworks in economics appear to be a natural starting point. Positional analysis (PA) as an alternative to CBA is built on institutional theory and a different set of assumptions about human beings, organizations, markets, etc. Sustainable development (SD) is a multidimensional concept that includes social and ecological dimensions in addition to monetary aspects. If the political commitment to SD in the European Union and elsewhere is taken seriously, then approaches to decision making should be chosen that 1st open the door for multidimensional analysis rather than close it. Sustainable development suggests a direction for development in a broad sense but is still open to different interpretations. Each such interpretation is political in kind, and a 2nd criterion for judging different approaches is whether they are ideologically open rather than closed. Although methods for decision making have traditionally been connected with mathematical objective functions and optimization, the purpose of PA is to illuminate a decision situation in a many-sided way with respect to possibly relevant ideological orientations, alternatives, and consequences. Decisions are understood in terms of matching the ideological orientation of each decision maker with the expected effects profile of each alternative considered. Appropriateness and pattern recognition are other concepts in understanding this process. [source] | |||||||||||||||||||||||||||||||||||||||||||||||||||||||