Home About us Contact
|
Home About us Contact | ||
|
|
||
Major Factor (major + factor)
Terms modified by Major Factor Selected AbstractsBreast Cancer in Nigeria: Is Non-Adherence to Chemotherapy Schedules a Major Factor in the Reported Poor Treatment Outcome?THE BREAST JOURNAL, Issue 2 2010Adewale O. Adisa MBChB, FWACS No abstract is available for this article. [source] Monoclonal antibodies: a morphing landscape for therapeuticsDRUG DEVELOPMENT RESEARCH, Issue 10 2006Nicholas C. Nicolaides Abstract The concept of using antibodies as therapeutics to cure human diseases was postulated nearly 100 years ago by Paul Ehrlich and subsequently enabled by the discovery of hybridoma technology by Kohler and Milstein in 1975. While the use of monoclonal antibodies (mAbs) as drugs that can specifically target a disease-associated antigen is compelling, it has taken a quarter century for these molecules to be adopted as bona fide therapeutic agents. Despite their slow pursuit in drug development during the pioneering years, it is now estimated that there are nearly 500 mAb-based therapies in development. Major factors that have influenced the acceptance of monoclonal antibodies as therapeutics include their drug safety profiles, technological advancements for facilitating mAb discovery and development, and market success. Early on, it was demonstrated that antibodies could elicit clinical benefit by antagonizing a specific antigen without the common side effects that are prevalent with small chemical entities due to their nonspecific effects on homeostatic biochemical pathways. In addition, the significant technological advances that the biotechnology industry has established for developing and producing monoclonal antibodies at commercial scale in a more efficient and cost-effective manner has broadly enabled their use as therapeutics. However, despite the beneficial pharmacologic advantages and technological advances, it has been the sheer market success that monoclonal antibody products have achieved over the past few years that has propelled their vast pursuit by the biopharmaceutical industry in light of their value-creating potential. Here we provide an overview of the monoclonal antibody industry and discuss evolving technologies and strategies that are being pursued to overcome challenges in the changing marketplace. Drug Dev. Res. 67:781,789, 2006. © 2007 Wiley-Liss, Inc. [source] Determinants of economic well-being among U.S. farm operator householdsAGRICULTURAL ECONOMICS, Issue 3 2007Hisham S. El-Osta Farm households; Composite measure of economic well-being; ARMS data Abstract Participation in government programs has a mild impact on the economic well-being of U.S. farm households. Major factors that determine farm household prosperity are the primary operator's education level and ethnicity, education level of the spouse, and other characteristics such as forward purchasing of inputs, use of contract shipping of products, having a succession plan, farm ownership, and location in a metro area. This article uses the 2001 Agricultural Resource Management Survey (ARMS) as well as relative and an absolute measure to assess U.S. farm households' economic well-being. The relative measure compares the income and wealth position of farm households relative to median income and median wealth of the general population. The absolute measure adds annualized wealth to a farm household's income. [source] Untersuchungen zur Herstellung siliziumkarbid-partikelverstärkter Aluminiumpulver durch Hochenergiekugelmahlen.MATERIALWISSENSCHAFT UND WERKSTOFFTECHNIK, Issue 6 2010Fabrication of silicon carbide reinforced aluminium powders by high-energy ball-milling High-energy ball milling; Aluminium matrix composite; AA2017; SiC particle reinforcement; Microstructure Abstract Die Herstellung von Siliziumkarbid-Aluminium-Verbundpulver stellt die erste Stufe der pulvermetallurgischen Herstellungsroute für partikelverstärkte Aluminiumwerkstoffe dar. Der Prozess der Verbundpulverausbildung beim Mahlen in einer Hochenergiekugelmühle und der Einfluss von Prozessparametern werden anhand der Al-Legierung EN AW-2017 mit 10 und 15 Vol.-% Siliziumkarbidteilchen der Kornfraktion <2 ,m untersucht. Die Gefügeentwicklung des Pulvers wird materialografisch charakterisiert. Bestimmte Prozessparameter beeinflussen den Verbundpulverzustand zum Teil gegenläufig, so dass der erreichte Optimierungsstand als Kompromiss anzusehen ist. Lösungsvarianten für eine weitere Verbesserung werden aufgezeigt. The fabrication of aluminium silicon-carbide composite powder is the first step of the powder metallurgical production of particle-reinforced aluminium material. This paper deals with the production of silicon-carbide reinforced aluminium matrix (AA2017) composite powder through an high energy ball milling process by using simoloyer- and planetary high energy mills. The Stages of composite powder formation during the high-energy ball milling process will be shown by means of materialographic studies and by micro hardness. Major factors of influence as well as typical problems are discussed. [source] Representation of Pseudo Inter-reflection and Transparency by Considering Characteristics of Human VisionCOMPUTER GRAPHICS FORUM, Issue 3 2002H. Matsuoka We have succeeded in developing a quick and fully automated system that can generate photo-realistic 3D CG data based on a real object. A major factor in this success comes from our findings through psychophysical experiments that human observers do not have an accurate idea of what should be actually reflected as inter-reflections on the surface of an object. Taking advantage of this characteristic of human vision, we propose a new inter-reflection representation technique in which inter-reflections are simulated by allowing the same quantity of reflection components as there are in the background to pass through the object. Since inter-reflection and transparency are calculated by the same algorithm, our system can capture 3D CG data from various real objects having a strong inter-reflection, such as plastic and porcelain items or translucent glass and acrylic resin objects. The synthetic images from the 3D CG data generated with this pseudo inter-reflection and transparency look very natural. In addition, the 3D CG data and synthetic images are produced quickly at a lower cost. [source] Hydrogels as a Platform for Stem Cell Delivery to the HeartCONGESTIVE HEART FAILURE, Issue 3 2010Mazen Kurdi PhD Stem cell therapy offers great promise to repair the injured or failing heart. The outcomes of clinical trials to date, however, have shown that the actual benefit realized falls far short of the promise. A number of factors may explain why that is the case, but poor stem cell retention and engraftment in the hostile environment of the injured heart would seem to be a major factor. Improving stem cell retention and longevity once delivered would seem a logical means to enhance their reparative function. One way to accomplish this goal may be injectable hydrogels, which would serve to fix stem cells in place while providing a sheltering environment. Hydrogels also provide a means to allow for the paracrine factors produced by encapsulated stem cells to diffuse into the injured myocardium. Alternatively, hydrogels themselves can be used for the sustained delivery of reparative factors. Here the authors discuss chitosan-based hydrogels. Congest Heart Fail. 2010;16:132,135. © 2010 Wiley Periodicals, Inc. [source] Information Processing and Firm-Internal Environment Contingencies: Performance Impact on Global New Product DevelopmentCREATIVITY AND INNOVATION MANAGEMENT, Issue 3 2010Elko Kleinschmidt Innovation in its essence is an information processing activity. Thus, a major factor impacting the success of new product development (NPD) programs, especially those responding to global markets, is the firm's ability to access, share and apply NPD information, which is often widely dispersed, functionally, geographically and culturally. To this end, an IT-communication strength is essential, one that is nested in an internal organizational environment that ensures its effective functioning. Using organizational information processing (OIP) theory as a framework, superior global NPD program performance is shown to result from an effective IT/Communication strength and the commitment components of the firm's internal environment, which are hypothesized to moderate this relationship. IT/Communication strength is identified in this study in terms of two components including the IT/Comm Infrastructure and IT/Comm Capability of the firm, whereas the moderating internal environment of the firm incorporates Resource Commitment and Senior Management Involvement. Data from a major empirical study of international NPD programs (382 SBUs) are used to develop and test this model. Based on a hierarchical regression analysis, the results are substantially supportive, with some unexpected findings. These shed light on the complex relationships of the firm's internal environment, OIP competency, and global NPD program performance. [source] Early lens development in the zebrafish: A three-dimensional time-lapse analysisDEVELOPMENTAL DYNAMICS, Issue 9 2009Teri M.S. Greiling Abstract In vivo, high-resolution, time-lapse imaging characterized lens development in the zebrafish from 16 to 96 hr postfertilization (hpf). In zebrafish, the lens placode appeared in the head ectoderm, similar to mammals. Delamination of the surface ectoderm resulted in the formation of the lens mass, which progressed to a solid sphere of cells separating from the developing cornea at approximately 24 hpf. A lens vesicle was not observed and apoptosis was not a major factor in separation of the lens from the future cornea. Differentiation of primary fibers began in the lens mass followed by formation of the anterior epithelium after delamination was complete. Secondary fibers differentiated from elongating epithelial cells near the posterior pole. Quantification characterized three stages of lens growth. The study confirmed the advantages of live-cell imaging for three-dimensional quantitative structural characterization of the mechanism(s) responsible for cell differentiation in formation of a transparent, symmetric, and refractile lens. Developmental Dynamics 238:2254,2265, 2009. © 2009 Wiley-Liss, Inc. [source] Roles of glutamate and GABA receptors in setting the developmental timing of spontaneous synchronized activity in the developing mouse cortexDEVELOPMENTAL NEUROBIOLOGY, Issue 12 2007Annette K. McCabe Abstract Spontaneous, synchronized electrical activity (SSA) plays important roles in nervous system development, but it is not clear what causes it to start and stop at the appropriate times. In previous work, we showed that when SSA in neonatal mouse cortex is blocked by TTX in cultured slices during its normal time of occurrence (E17,P3), it fails to stop at P3 as it does in control cultured slices, but instead persists through at least P10. This indicates that SSA is self-extinguishing. Here we use whole-cell recordings and [Ca2+]i imaging to compare control and TTX-treated slices to isolate the factors that normally extinguish SSA on schedule. In TTX-treated slices, SSA bursts average 4 s in duration, and have two components. The first, lasting about 1 s, is mediated by AMPA receptors; the second, which extends the burst to 4 s and is responsible for most of the action potential generation during the burst, is mediated by NMDA receptors. In later stage (P5,P9) control slices, after SSA has declined to about 4% of its peak frequency, bursts lack this long NMDA component. Blocking this NMDA component in P5,P9 TTX-treated slices reduces SSA frequency, but not to the low values found in control slices, implying that additional factors help extinguish SSA. GABAA inhibitors restore SSA in control slices, indicating that the emergence of GABAA -mediated inhibition is another major factor that helps terminate SSA. © 2007 Wiley Periodicals, Inc. Develop Neurobiol, 2007 [source] Dispersal frequency affects local biomass production by controlling local diversityECOLOGY LETTERS, Issue 6 2006Birte Matthiessen Abstract Dispersal is a major factor regulating the number of coexisting species, but the relationship between species diversity and ecosystem processes has mainly been analysed for communities closed to dispersal. We experimentally investigated how initial local diversity and dispersal frequency affect local diversity and biomass production in open benthic microalgal metacommunities. Final local species richness and local biomass production were strongly influenced by dispersal frequency but not by initial local diversity. Both final local richness and final local biomass showed a hump-shaped pattern with increasing dispersal frequency, with a maximum at intermediate dispersal frequencies. Consequently, final local biomass increased linearly with increasing final richness. We conclude that the general relationship between richness and ecosystem functioning remains valid in open systems, but the maintenance of ecosystem processes significantly depends on the effects of dispersal on species richness and local interactions. [source] Alcohol consumption in homicide victims in the city of São PauloADDICTION, Issue 12 2009Gabriel Andreuccetti ABSTRACT Aims To assess the association between alcohol use and victimization by homicide in individuals autopsied at the Institute of Legal Medicine in São Paulo, Brazil. Design Cross-sectional study. Setting Excessive consumption of alcohol is a serious public health issue and a major factor in triggering violent situations, which suggests a strong association between alcohol ingestion and becoming a victim of homicide. Participants Data from 2042 victims of homicides in 2005 were obtained from medical examiner reports. Measurements The victim's gender, age, ethnicity and blood alcohol concentration (BAC) were collected. The method of death and homicide circumstances, as well as the date, time and place of death were also studied. Findings Alcohol was detected in blood samples of 43% of the victims, and mean BAC levels were 1.55 ± 0.86 g/l. The prevalence of positive BAC levels was higher among men (44.1%) than women (26.6%), P < 0.01. Firearms caused most of the deaths (78.6%), and alcohol consumption was greater among victims of homicide by sharp weapons (P < 0.01). A greater proportion of victims with positive BAC were killed at weekends compared to weekdays (56.4 and 38.5%, respectively; P < 0.01), and the correlation between homicide rates and the average BAC for the central area of the city was positive (rs = 0.90; P < 0.01). Conclusions These results highlight alcohol as a contributing factor for homicide victimization in the greatest urban center in South America, supporting public strategies and future research aiming to prevent homicides and violence related to alcohol consumption. [source] Characterizing sediment acid volatile sulfide concentrations in European streamsENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 1 2007G. Allen Burton Abstract Sediment acid volatile sulfide (AVS) concentrations were measured in wadeable streams of a wide variety of ecoregions of western Europe (84 sites in 10 countries and nine ecoregions) to better understand spatial distribution and ecoregion relationships. Acid volatile sulfide has been shown to be a major factor controlling the bioavailability and toxicity of many common trace metals, such as Cd, Cu, Ni, Pb, and Zn. Sediment characteristics varied widely. The ratio of the sum of the simultaneously extracted metals (SEM) to AVS ranged from 0.03 to 486.59. The ,SEM-AVS ranged from ,40.02 to 17.71 ,mol/g. On a regional scale, sediment characteristics such as dominant parent soil material showed significant trends in AVS distribution and variation by ecoregion. Total Fe and Mn were correlated weakly with SEM concentrations. Three AVS model approaches (i.e., the SEMAVS ratio, SEM-AVS difference, and carbon normalization) were compared at threshold exceedance levels of SEM/AVS > 9, SEM-AVS > 2, and SEM-AVS/foc > 150 ,mol/g organic carbon (OC). Only 4.76% of the sediments exceeded all three AVS thresholds; 22.6% of the sediments exceeded two models; and 13% of the sediments exceeded one model only. Using the SEM:AVS, SEM-AVS, and fraction of organic carbon models, and including site-specific data and regional soil characteristics, ecoregions 1 (Portugal), 3 (Italy), 4 (Switzerland), and 9 (Belgium/Germany) had the highest potential metals toxicity; ecoregions 13 and 8 (Belgium/France) showed the lowest potential toxicity. However, because AVS can vary widely spatially and temporally, these data should not be considered as representative of the sampled ecoregions. The general relationship between AVS levels and sediment characteristics provides some predictive capability for wadeable streams in the European ecoregions. [source] Polygenic Control of Idiopathic Generalized Epilepsy Phenotypes in the Genetic Absence Rats from Strasbourg (GAERS)EPILEPSIA, Issue 4 2004Gabrielle Rudolf Summary: Purpose: Generalized nonconvulsive absence seizures are characterized by the occurrence of synchronous and bilateral spike-and-wave discharges (SWDs) on electroencephalographic recordings, concomitant with behavioral arrest. The GAERS (genetic absence rats from Strasbourg) strain, a well-characterized inbred model for idiopathic generalized epilepsy, spontaneously develops EEG paroxysms that resemble those of typical absence seizures. The purpose of this study was to investigate the genetic control of SWD variables by using a combination of genetic analyses and electrophysiological measurements in an experimental cross derived from GAERS and Brown Norway (BN) rats. Methods: SWD subphenotypes were quantified on EEG recordings performed at both 3 and 6 months in a cohort of 118 GAERS × BN F2 animals. A genome-wide scan of the F2 progenies was carried out with 146 microsatellite markers that were used to test each marker locus for evidence of genetic linkage to the SWD quantitative traits. Results: We identified three quantitative trait loci (QTLs) in chromosomes 4, 7, and 8 controlling specific SWD variables in the cross, including frequency, amplitude, and severity of SWDs. Age was a major factor influencing the detection of genetic linkage to the various components of the SWDs. Conclusions: The identification of these QTLs demonstrates the polygenic control of SWDs in the GAERS strain. Genetic linkages to specific SWD features underline the complex mechanisms contributing to SWD development in idiopathic generalized epilepsy. [source] Body composition in young Standardbreds in training: relationships to body condition score, physiological and locomotor variables during exerciseEQUINE VETERINARY JOURNAL, Issue S36 2006C. LELEU Summary Reasons for performing study: Body composition is an essential factor in athletic performance of human sprinters and long distance runners. However, in horses, many questions remain concerning relationships between body composition and performance in the different equine activities. Objectives: To determine relationships between body composition, body score, physiological and locomotor variables in a population of young Standardbreds in training. Methods: Twenty-four 2-year-old Standardbreds were studied, body condition on a scale 0,5 and bodyweight recorded, and height at withers measured. Percentage of fat (%F), fat mass (FM) and fat free mass (FFM) were estimated echographically. During a standardised exercise test on the track, velocity, heart rate, respiratory frequency and blood lactate concentrations were measured. V4 and V200 (velocity for a blood lactate concentration of 4 mmol/1 and velocity of 200 beats/min) calculated. Basic gait variables were measured at 3 different speeds with an accelerometric device. Results: Body composition variables: %F and FM were significantly related to body condition score and physiological variables. Body score was highly correlated to %F (r=0.64) and FM (r = 0.71). V4 was negatively correlated to %V (r=-0.59) and FM (r = -0.60), P<0.05. V200 was also negatively related to %F and FM, (r=-0.39 and r = -0.37, respectively, P<0.1). No relationships were found between body composition and gait characteristics. Conclusions: Body composition was closely related to indirect measurements of aerobic capacity, which is a major factor of athletic performance in middle distance running horses. Potential relevance: As in human athletes, trainers should take special note to evaluate optimal bodyweight and body composition of race horses to optimise performance. [source] REVIEW: Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked?ADDICTION BIOLOGY, Issue 2 2010Markus Heilig ABSTRACT The role of withdrawal-related phenomena in the development and maintenance of alcohol addiction remains under debate. A ,self-medication' framework postulates that emotional changes are induced by a history of alcohol use, persist into abstinence, and are a major factor in maintaining alcoholism. This view initially focused on negative emotional states during early withdrawal: these are pronounced, occur in the vast majority of alcohol-dependent patients, and are characterized by depressed mood and elevated anxiety. This concept lost popularity with the realization that in most patients, these symptoms abate over 3,6 weeks of abstinence, while relapse risk persists long beyond this period. More recently, animal data have established that a prolonged history of alcohol dependence induces more subtle neuroadaptations. These confer altered emotional processing that persists long into protracted abstinence. The resulting behavioral phenotype is characterized by excessive voluntary alcohol intake and increased behavioral sensitivity to stress. Emerging human data support the clinical relevance of negative emotionality for protracted abstinence and relapse. These developments prompt a series of research questions: (1) are processes observed during acute withdrawal, while transient in nature, mechanistically related to those that remain during protracted abstinence?; (2) is susceptibility to negative emotionality in acute withdrawal in part due to heritable factors, similar to what animal models have indicated for susceptibility to physical aspects of withdrawal?; and (3) to what extent is susceptibility to negative affect that persists into protracted abstinence heritable? [source] Ericoid mycorrhiza: a partnership that exploits harsh edaphic conditionsEUROPEAN JOURNAL OF SOIL SCIENCE, Issue 4 2003J. W. G. Cairney Summary Plants that form ericoid mycorrhizal associations are widespread in harsh habitats. Ericoid mycorrhizal fungal endophytes are a genetically diverse group, and they appear to be able to alleviate certain environmental stresses and so facilitate the establishment and survival of Ericaceae. Some of the fungal taxa that form ericoid mycorrhizas, or at least closely related strains, also form associations with other plant hosts (trees and leafy liverworts). The functional significance of these associations and putative mycelial links between Ericaceae and other plant taxa, however, remain unclear. Evidence from environments that are contaminated by toxic metals indicates that ericoid mycorrhizal fungal endophytes, and in some instances their plant hosts, can evolve resistance to these metals. The apparent ability of these endophytes to develop resistance enables ericoid mycorrhizal plants to colonize polluted soil. This seems to be a major factor in the success of ericoid mycorrhizal taxa in a range of harsh environments. [source] Starvation-induced changes in the cell surface of Azospirillum lipoferumFEMS MICROBIOLOGY ECOLOGY, Issue 1 2000Thelma Castellanos Abstract Three starvation regimes (a deficient culture medium, a saline buffer solution and distilled water) were evaluated for their possible effect on cell surface characteristics of Azospirillum lipoferum 1842 related to the initial adsorption of the bacterium to surfaces. The bacteria survived for 7 days in all media although they did not multiply. Upon transfer from a rich growth medium (nutrient agar) to starvation conditions, cell surface hydrophobicity dropped sharply but recovered its initial value within 24 to 48 h, except in phosphate-buffered saline, the length of the recovery period depending on the starvation medium. Starvation affected the sugar affinity of the A. lipoferum cell surface mainly towards p -aminophenyl-,- D -mannopyranoside, to a lesser extent to glucose, but not to other monosaccharides tested. Starvation changed the concentration of several cell surface proteins but did not induce the synthesis of new ones. The cell surface hydrophobic protein (43 kDa) of A. lipoferum 1842 was unaffected by any starvation treatment for a period of up to 48 h, but later disappeared. These data showed that starvation is not a major factor in inducing changes in the cell surface which lead to the primary phase of attachment of Azospirillum to surfaces. [source] Uncertainty about estimating total returns of Atlantic salmon, Salmo salar to the Gander River, Newfoundland, Canada, evaluated using a fish counting fenceFISHERIES MANAGEMENT & ECOLOGY, Issue 1 2003M. F. O'Connell Abstract ,For a number of rivers in Newfoundland, Atlantic salmon, Salmo salar L., is managed in relation to river-specific conservation spawning requirements. One such river is the Gander River, where between 1989 and 1999, the escapement of Atlantic salmon, a major factor in assessing the status of stock, was determined using a fish counting fence. In 2000, the counting fence was discontinued and alternative means of calculating total returns were explored. Regression and simulation methods, using relationships between total returns and salmon counts at an upstream tributary during 1989,99, formed the basis for estimates of returns for 2000, and the uncertainty around estimates. The accuracy of methods is evaluated by retrospective comparisons with actual total returns between 1989 and 1999. Estimates of total returns deviated from the actual by as much as 50,60%, depending on the method. Management implications of the approach are discussed. [source] Biodiversity and resource use of larval chironomids in relation to environmental factors in a large riverFRESHWATER BIOLOGY, Issue 6 2002CHRISTIAN FESL 1.,Larval chironomids were examined at four sites on a cross-section of the River Danube in Austria between September 1995 and August 1996. The sites differed in hydraulics, sediment composition and habitat stability. 2.,Species,accumulation curves, showing the increase in number of species with increasing sampling effort, from three main channel sites were best described by a logarithmic model, suggesting that most of the species occurring at these sites were found. Data from a site connected to a backwater fitted best to a power model, indicating a random assemblage with additional species immigrating from the backwater area. 3.,Properties of the community were estimated using Jackknife techniques: species richness (range of mean values at the four sites: 32,91), H, diversity (1.5,2.3), evenness (0.23,0.28), spatial resource width (0.01,0.06), spatial resource overlap (0.13,0.20), spatial species aggregation (0.60,0.77), temporal community persistence (Kendal's correlation coefficient: 0.47,0.60) and beta-diversity (6.2,9.7). 4.,Redundancy analysis (RDA) was used to relate the community properties and species abundance to environmental factors. Habitat stability was the major factor associated with community structure. Higher sediment turnover led to higher spatial aggregation and, consequently, a decrease in spatial resource width and overlap, and to a decline in larval density and species richness. 5.,Species-abundance patterns agreed well with the log-normal model. Moderate community persistence and stability of the streambed sediments suggest that the log-normal model may be a good descriptor for communities of intermediately disturbed habitats, like large rivers, rather than stable habitats. [source] The effect of temperature and daylength on heading in tetraploid cultivars of rhodesgrass (Chloris gayana Kunth)GRASSLAND SCIENCE, Issue 4 2005Isao Tarumoto Abstract The present study was conducted to clarify the effect of temperature and daylength on heading in tetraploid cultivars of rhodesgrass (Chloris gayana Kunth). Five cultivars, Tochiraku-kei (2,), Fords Katambora (2,), Callide (4,), Masaba (4,) and Pokot (4,), were planted on three dates at 1-month intervals (4 May, 4 June and 4 July) in three of the Ministry of Agriculture, Forestry and Fisheries research institutions in Ishigaki (Tropical Agriculture Research Center), Nishigoshi (Kyushu National Agricultural Experiment Station) and Nishinasuno (National Grassland Research Institute) in 1978. Three tetraploid cultivars were planted on three dates at 1-month intervals (4 May, 4 June and 4 July) under four daylength-treatments of natural daylength (ND), 12 h daylength [12 h], ND/12 h and 12 h/ND, and changed daylength at the eighth leaf stage, in Nishinasuno in 1978. Under natural daylength, although heading was not observed for Masaba and Pokot, heading was observed in all plots for Tochiraku-kei, Fords Katambora and Callide, and their days to heading (DH) linearly decreased with increases in daily mean temperature (DMT). The result indicated that, under natural daylength in summer, temperature was a major factor in determining DH in tetraploid Callide, which was the same as in diploid rhodesgrass cultivars. Callide reached heading under all four daylength treatments. However, Masaba and Pokot reached heading only under 12 h and ND/12 h treatments, suggesting that Masaba and Pokot have qualitative sensitivity to photoperiods that operate after the ninth leaf stage. These findings would be useful in tetraploid rhodesgrass for estimating foliage harvesting time in the field and for conducting cross-pollination in a greenhouse during winter. [source] Geographies of Housing Finance: The Mortgage Market in Milan, ItalyGROWTH AND CHANGE, Issue 2 2007MANUEL B. AALBERS ABSTRACT The geography of financial exclusion has mainly focused on exclusion from retail banking. Alternatively, and following the work of David Harvey, this paper presents a geography of access to and exclusion from home mortgage finance. The case of Milan shows that capital switching to the built environment is partly a sign of economic crisis and partly a sign of the intrinsic opportunities that the built environment provides. A major factor in both is the deregulation of the mortgage market that has enabled the loosening of historically stringent lending criteria, leading to a tremendous growth of the mortgage market, while leaving the co-evolution of family and home ownership intact. In addition, capital switches within sectors of the economy and between places. In Milan, once "unattractive" but currently gentrified nineteenth-century districts underwent cycles of devalorisation and revalorisation. Even though access to mortgages has increased throughout Milan, geographical disparities in mortgage lending persist: at present, yellowlining (differential access, based on less favourable terms) is common in parts of the Milanese periphery. The creation of boundaries makes the realisation of class-monopoly rent possible; while the subsequent redrawing of these boundaries creates new submarkets in which surplus value can be extracted. Based on the Milan case, one cannot explain the timing and geography of formation and reformation of submarkets in other cities, but it helps us to see how Harvey's abstract ideas of class-monopoly rent, submarket creation, and capital switching take place in the real world. [source] Research on the human thermal model with a poly-segmented handHEAT TRANSFER - ASIAN RESEARCH (FORMERLY HEAT TRANSFER-JAPANESE RESEARCH), Issue 2 2008Ding Li Abstract A more integral human thermal model was built by combining the human thermal cylindrical model and the manual poly-segment thermal model. Finite element methods (FEM) was used to define the body thermal model. It was in good agreement with the experimental results. The results show: the experimental results are consistent with the calculated value, when suitable blood flux is taken into consideration. The blood flux is in a certain range when the manual temperature is stable. Blood flux is the major factor in the manual temperature field. Body temperature and intake artery temperature have little effect on the hand temperature. © 2008 Wiley Periodicals, Inc. Heat Trans Asian Res, 37(2): 94,100, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/htj.20187 [source] cag Pathogenicity Island of Helicobacter pylori in Korean ChildrenHELICOBACTER, Issue 4 2002Jae Sung Ko Abstract Background.cag pathogenicity island is reported to be a major virulence factor of Helicobacter pylori. The aim of this study was to investigate the status of cag pathogenicity island genes and gastric histology in Korean children with H. pylori gastritis. Methods.Helicobacter pylori DNA was extracted from antral biopsy specimens from 25 children with H. pylori gastritis. Specific polymerase chain reaction assays were used for four genes of cag pathogenicity island. The features of gastritis were scored in accordance with the updated Sydney System. Results.cagA was present in 23 (92%) of 25 children, and cagE in 24 (96%). Twenty-two (88%) children were cagT positive and 19 (76%) virD4 positive. All of the selected genes of the cag pathogenicity island were present in 17 (68%) children and completely deleted in one child. There were no differences in neutrophil activity and chronic inflammation between children infected with intact cag pathogenicity island strains and those with partially or totally deleted- cag pathogenicity island strains. Conclusion.cag pathogenicity island is not a uniform, conserved entity in Korea. Completeness of cag pathogenicity island may not be the major factor to determine the severity of H. pylori gastritis in children. [source] Soil piping and catchment responseHYDROLOGICAL PROCESSES, Issue 12 2010J. A. A. Jones Abstract Over the 40 years, since soil piping was first considered to be a potential factor in the hydrological response of catchments, research has revealed a considerable amount about its hydrological role and its geographical, climatic and pedological distribution. Piping has been shown to be a major factor supporting the hypothesis that subsurface flow can be a significant contributor to quickflow by field experiments ranging from the United Kingdom to Canada, India and China. This research has demonstrated that, at least in some areas, soil pipes may contribute up to nearly 50% of stormwater discharge. Piping processes therefore merit inclusion within rainfall,runoff simulation models, but this has yet to be achieved. Some progress has been made in modelling pipeflow itself, but integration within a catchment model presents major problems, not least in quantifying or parameterizing the nature and distribution of pipe networks. The wider environmental implications of soil piping are also only just beginning to be recognized. These range from the effects of changing residence times on water chemistry, especially on the acidification of surface waters, to the effects of hillslope drainage patterns on soil development and vegetation diversity. Copyright © 2010 John Wiley & Sons, Ltd. [source] Challenges and Progress in High-Throughput Screening of Polymer Mechanical Properties by IndentationADVANCED MATERIALS, Issue 35 2009Johannes M. Kranenburg Abstract Depth-sensing or instrumented indentation is an experimental characterization approach well-suited for high-throughput investigation of mechanical properties of polymeric materials. This is due to both the precision of force and displacement, and to the small material volumes required for quantitative analysis. Recently, considerable progress in the throughput (number of distinct material samples analyzed per unit time) of indentation experiments has been achieved, particularly for studies of elastic properties. Future challenges include improving the agreement between various macroscopic properties (elastic modulus, creep compliance, loss tangent, onset of nonlinear elasticity, energy dissipation, etc.) and their counterpart properties obtained by indentation. Sample preparation constitutes a major factor for both the accuracy of the results and the speed and efficiency of experimental throughput. It is important to appreciate how this processing step may influence the mechanical properties, in particular the onset of nonlinear elastic or plastic deformation, and how the processing may affect the agreement between the indentation results and their macroscopic analogues. [source] In vitro and in vivo studies on the generation of the primary T-cell receptor repertoireIMMUNOLOGICAL REVIEWS, Issue 1 2004Ferenc Livák Summary:, The primary T-cell receptor repertoire is generated by somatic rearrangement of discontinuous gene segments. The shape of the combinatorial repertoire is stereotypical and, in part, evolutionarily conserved among mammals. Rearrangement is initiated by specific interactions between the recombinase and the recombination signals (RSs) that flank the gene segments. Conserved sequence variations in the RS, which modulate its interactions with the recombinase, appear to be a major factor in shaping the primary repertoire. In vitro, biochemical studies have revealed distinct steps in these complex recombinase,RS interactions that may determine the final frequency of gene segment rearrangement. These studies offer a plausible model to explain gene segment selection, but new, more physiological approaches will have to be developed to verify and refine the mechanism by which the recombinase targets the RS in its endogenous chromosomal context in vivo. [source] Sibling rivalry: competition between Pol X family members in V(D)J recombination and general double strand break repairIMMUNOLOGICAL REVIEWS, Issue 1 2004Stephanie A. Nick McElhinny Summary:, The nonhomologous end-joining pathway is a major means for repairing double-strand breaks (DSBs) in all mitotic cell types. This repair pathway is also the only efficient means for resolving DSB intermediates in V(D)J recombination, a lymphocyte-specific genome rearrangement required for assembly of antigen receptors. A role for polymerases in end-joining has been well established. They are a major factor in determining the character of repair junctions but, in contrast to ,core' end-joining factors, typically appear to have a subtle impact on the efficiency of end-joining. Recent work implicates several members of the Pol X family in end-joining and suggests surprising complexity in the control of how these different polymerases are employed in this pathway. [source] Evaporative climate change in the British IslesINTERNATIONAL JOURNAL OF CLIMATOLOGY, Issue 9 2008Gerald Stanhill Abstract Evaporation measurements made at 16 sites in the British Isles were analysed for evidence of long-term changes. Half of the series were from sites in Ireland measured with Class A evaporation pans between 1963 and 2005 and half in England and Scotland measured with the British Meteorological Office (MO) sunken evaporation tank between 1885 and 1968. Four of the Irish series showed significant linear trends, three of increasing and one of decreasing evaporation. These significant changes ranged between , 0.1 and + 0.1 mm year,1 equivalent to annual changes between , 0.22 and + 0.15%. Five of the UK series showed statistically significant linear trends, three of them decrease and two increase: These ranged in size between , 3.7 and + 2.1 mm year,1, equivalent to annual changes of , 1.05 to + 0.40% of the mean. Curvilinear time trends accounted for twice the amount of inter-annual variation in evaporation as did the linear trends. Differences in sunshine duration (SD), used as a proxy for global radiation, were found to be the major factor explaining spatial as well as temporal changes in evaporation in the British Isles. The pooled Irish data, expressed as normalized anomalies, showed a small and significant linear increase in evaporation over the last 40 years. Similarly parameterized the UK measurements showed no significant trend up till 1968; the one UK series that did extend till 2004 indicated a marked increase during the last 20 years. The long-term changes found in annual evaporation were similar to those in air temperatures both in Ireland and England. The relevance of these findings to the hypothesis of an acceleration in the hydrological cycle is discussed. Copyright © 2007 Royal Meteorological Society [source] Consumers' awareness and information need about food hygiene in Korea: focused on pesticide residues and food borne illnessINTERNATIONAL JOURNAL OF CONSUMER STUDIES, Issue 3 2003Meera Kim This study investigated consumers' awareness and information need about food hygiene especially focused on pesticide residues and food borne illness in Korea. The data were collected from 350 adults living in Daegu and Busan, Korea by a self-administered questionnaire. Frequency and chi-square tests were conducted by SPSS. The results of the survey were as follows: Firstly the consumers' concerns about food hygiene were high. About three-fourths of the respondents answered that they were ,somewhat' or ,highly' concerned about pesticide residues and food borne illness. Especially women and the older showed more concerns than men and the younger. Secondly, the respondents worried about eating vegetables, fruits and grains in turn because of pesticide residues, and did not trust the results from food hygiene tests by the Government. Thirdly, three-fourths of the respondents used the way to wash food stuffs with water several times to clean pesticide residues. Fourth, about four-fifths of the subjects worried about food borne illness caused by fish to the extreme and about two-thirds answered that un-fresh or contaminated food stuffs were the major factor of food borne illness in cooking. Finally, the respondents primarily wanted to get the information about harmfulness of pesticide residues in foods, and methods to choose fresh food regarding food borne illness. Under the situation of the lack of educational programs for food hygiene in Korea, the educational contents for food hygiene to improve public health can be developed on the basis of this study. [source] Stratum corneum keratin structure, function and formation , a comprehensive reviewINTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Issue 6 2006L. Norlén Synopsis A comprehensive review on stratum corneum keratin organization, largely based on the recently published cubic rod-packing and membrane templating model [J. Invest. Dermatol., 123, 2004, 715], is presented. Keratin is the major non-aqueous component (wt/wt) of stratum corneum. As 90,100% of the stratum corneum water is thought to be located intracellularly one may presume that keratin also is a major factor (together with filaggrin-derived free amino acids) determining stratum corneum hydration level and water holding capacity. This water holding capacity depends in turn on the structural organization of the corneocyte keratin intermediate filament network. The cubic rod-packing model for the structure and function of the stratum corneum cell matrix postulates that corneocyte keratin filaments are arranged according to a cubic-like rod-packing symmetry. It is in accordance with the cryo-electron density pattern of the native corneocyte keratin matrix and could account for the swelling behaviour and the mechanical properties of mammalian stratum corneum. The membrane templating model for keratin dynamics and for the formation of the stratum corneum cell matrix postulates the presence in viable epidermal cellular space of a highly dynamic small lattice parameter (<30 nm) membrane structure with cubic-like symmetry, to which keratin is associated. It further proposes that membrane templating, rather than spontaneous self-assembly, is responsible for keratin intermediate filament formation and dynamics. It is in accordance with the cryo-electron density patterns of the native keratinocyte cytoplasmic space and could account for the characteristic features of the keratin network formation process, the dynamic properties of keratin intermediate filaments, the close lipid association of keratin, the insolubility in non-denaturating buffers and pronounced polymorphism of keratin assembled in vitro, and the measured reduction in cell-volume and hydration level between stratum granulosum and stratum corneum. Résumé, La kératine est le composant majeur anhydre de la couche cornée. Etant donné que l'on considère que 90 à 100% de l'eau de la couche cornée est localisée à l'intérieur des cellules, on peut penser que la kératine joue également un rôle important (en association avec les acides aminés libres dérivés de la filagrine) dans le niveau d'hydratation de la couche cornée et sa capacité de rétention de l'eau. Cette capacité de rétention de l'eau dépend elle-même de l'organization structurelle du réseau de filaments intermédiaires de la kératine des cornéocytes. Le modèle de cylindre en réseau cubique appliquéà la structure et aux fonctions de la matrice des cellules de la couche cornée stipule que les filaments de la kératine des cornéocytes sont disposés symétriquement, les paquets de fibrilles formant une structure cubique. Ceci est conforme au modèle de densité cryo-électronique de la matrice kératinique des cornéocytes natifs et pourrait expliquer le comportement de gonflement et les propriétés mécaniques de la couche cornée des mammifères. Le modèle d'assemblage membranaire appliquéà la dynamique de la kératine et à la formation de la matrice cellulaire du stratum cornéum postule la présence dans l'espace cellulaire viable de l'épiderme d'une structure membranaire hautement dynamique présentant un petit paramètre de maille (<30 nm) et une organization en forme de cube, à laquelle la kératine est associée. D'autre part, ce modèle suggère qu'un assemblage membranaire plutôt qu'un auto-assemblage spontané puisse être à l'origine de la formation des filaments intermédiaires de kératine et de leur dynamique. Ceci concorde avec les modèles de densité cryo-électronique du cytoplasme des kératinocytes natifs et pourrait expliquer les caractéristiques du processus de formation du réseau kératinique, les propriétés dynamiques des filaments intermédiaires de kératine, l'association de la kératine avec les lipides, l'insolubilité dans les tampons non dénaturants, le polymorphisme caractéristique de la kératine assemblée in vitro, ainsi que la diminution mesurée du volume cellulaire et du niveau d'hydratation entre le stratum granulosum et le stratum corneum. [source] | ||||||||||||||||||||||||||||||||||||||||||||||