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Selected AbstractsSupply's Growing Status and Influence: A Sixteen-Year PerspectiveJOURNAL OF SUPPLY CHAIN MANAGEMENT, Issue 2 2006P. Fraser Johnson SUMMARY The recent completion of a major survey of large North American supply organizations in 2003 permits a longitudinal perspective on supply roles and responsibilities over a 16-year period. The latest survey complements two earlier studies in 1987 and 1995. All three surveys counted at least 280 responding large North American supply organizations, thereby providing a valuable opportunity to examine trends and changes over time. Major areas of investigation for respondents in both the manufacturing and services sectors include supply organizational structure, supply chain responsibilities, and chief purchasing officer (CPO) reporting line, title and background. This research provides solid evidence that in both manufacturing and services, today's CPOs have greater responsibilities, report higher in the organization and carry more significant titles than their predecessors. The conclusion is that, at least in large North American companies, supply has grown substantially in corporate status and influence since 1987, a particularly welcome discovery. [source] The mitochondrial proteome: A dynamic functional program in tissues and disease states,ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, Issue 5 2010Robert S. Balaban Abstract The nuclear DNA transcriptional programming of the mitochondria proteome varies dramatically between tissues depending on its functional requirements. This programming generally regulates all of the proteins associated with a metabolic or biosynthetic pathway associated with a given function, essentially regulating the maximum rate of the pathway while keeping the enzymes at the same molar ratio. This may permit the same regulatory mechanisms to function at low- and high-flux capacity situations. This alteration in total protein content results in rather dramatic changes in the mitochondria proteome between tissues. A tissues mitochondria proteome also changes with disease state, in Type 1 diabetes the liver mitochondrial proteome shifts to support ATP production, urea synthesis, and fatty acid oxidation. Acute flux regulation is modulated by numerous posttranslational events that also are highly variable between tissues. The most studied posttranslational modification is protein phosphorylation, which is found all of the complexes of oxidative phosphorylation and most of the major metabolic pathways. The functional significance of these modifications is currently a major area of research along with the kinase and phosphatase regulatory network. This near ubiquitous presence of protein phosphorylations, and other posttranslational events, in the matrix suggest that not all posttranslational events have functional significance. Screening methods are being introduced to detect the active or dynamic posttranslational sites to focus attention on sites that might provide insight into regulatory mechanisms. Environ. Mol. Mutagen., 2010. Published 2010 Wiley-Liss, Inc. [source] World Commission on Dams: implications for food and irrigation1,IRRIGATION AND DRAINAGE, Issue 2 2001Chris Perry barrages; l'irrigation; securité d'alimentation Abstract The World Commission on Dams has now published its report. Insights into the workings and conclusions of the Commission were published in the last edition of this Journal. While the WCD report brings together a number of important existing and new recommendations on ameliorating the negative impacts of large dams, it pays inadequate attention to the impacts in the major area (food production and security) for which dams have been built. Consideration of data presented by the WCD would suggest a more positive impact, and a brief review of national and world trends in food production suggests that irrigation , of which large dams are an intrinsic and central component , has underlain if not dominated the vast improvement in food availability that occurred in the second half of the last century. With water in crisis in many countries, planners, policymakers and politicians will continue to face challenging decisions on the allocation of limited freshwater supplies, and demands to increase the level of water resources development. Some guidance from the WCD is helpful, and some is flawed. Most importantly, much is missing, and to be useful, guidance must reflect rational and balanced, expert and rigorous assessment of all the impacts of the available options. Copyright © 2001 John Wiley & Sons, Ltd. La Commission Globale des Barrages a maintenant publiée son rapport. Quelques apercus sur les méthodes et les conclusions de la commission ont été données dans la dernière edition de ce journal. Quant le rapport CGB a se rassemblé quelques recommendations nouveaux et actuels pour amèliorer les impacts négatifs des grands barrages, il n'y a pas d'attention suffisante donnés aux impacts sur les questions importantes (comme le production et la sécurité d'alimentation) pour qui les barrages ont étés construits. Penser aux donnés du CGB suggère un impact plus positif et un critique des tendances nationale et globale du production d'alimentation denote que l'irrigation (dont les grands barrages sont un composant central et intrinsèque) a soutienne si non dominée l'immense amélioration de la disponibililité d'alimentation dans la dernière partie du XXe siècle. Avec la crise actuèlle de l'eau en beaucoup de pays, les planificateurs, les dirigants de politique et les politiciens se continuent de faire face aux decisions difficile sur les questions d'allocation d'eau limitée et les demands pour une augmentation de développement des resources en eau. Quelques conseils du CGB sont util mais quelques uns sont en défaut. Les plus importantes problèmes sont que le rapport manque beaucoup de choses et que, pour être utile, les conseils doivent réfléchir les impactes de tous les choix dans une façon rationale et équilibrée avec une évaluation experte et rigoureuse. Copyright © 2001 John Wiley & Sons, Ltd. [source] Outcomes of the International Union of Crystallography Commission on Powder Diffraction Round Robin on Quantitative Phase Analysis: samples 1a to 1hJOURNAL OF APPLIED CRYSTALLOGRAPHY, Issue 4 2001Ian C. Madsen The International Union of Crystallography (IUCr) Commission on Powder Diffraction (CPD) has sponsored a round robin on the determination of quantitative phase abundance from diffraction data. Specifically, the aims of the round robin were (i) to document the methods and strategies commonly employed in quantitative phase analysis (QPA), especially those involving powder diffraction, (ii) to assess levels of accuracy, precision and lower limits of detection, (iii) to identify specific problem areas and develop practical solutions, (iv) to formulate recommended procedures for QPA using diffraction data, and (v) to create a standard set of samples for future reference. Some of the analytical issues which have been addressed include (a) the type of analysis (integrated intensities or full-profile, Rietveld or full-profile, database of observed patterns) and (b) the type of instrument used, including geometry and radiation (X-ray, neutron or synchrotron). While the samples used in the round robin covered a wide range of analytical complexity, this paper reports the results for only the sample 1 mixtures. Sample 1 is a simple three-phase system prepared with eight different compositions covering a wide range of abundance for each phase. The component phases were chosen to minimize sample-related problems, such as the degree of crystallinity, preferred orientation and microabsorption. However, these were still issues that needed to be addressed by the analysts. The results returned indicate a great deal of variation in the ability of the participating laboratories to perform QPA of this simple three-component system. These differences result from such problems as (i) use of unsuitable reference intensity ratios, (ii) errors in whole-pattern refinement software operation and in interpretation of results, (iii) operator errors in the use of the Rietveld method, often arising from a lack of crystallographic understanding, and (iv) application of excessive microabsorption correction. Another major area for concern is the calculation of errors in phase abundance determination, with wide variations in reported values between participants. Few details of methodology used to derive these errors were supplied and many participants provided no measure of error at all. [source] Strategies for Directing the Differentiation of Stem Cells Into the Osteogenic Lineage In Vitro,JOURNAL OF BONE AND MINERAL RESEARCH, Issue 9 2004Boon Chin Heng Abstract A major area in regenerative medicine is the application of stem cells in bone reconstruction and bone tissue engineering. This will require well-defined and efficient protocols for directing the differentiation of stem cells into the osteogenic lineage, followed by their selective purification and proliferation in vitro. The development of such protocols would reduce the likelihood of spontaneous differentiation of stem cells into divergent lineages on transplantation, as well as reduce the risk of teratoma formation in the case of embryonic stem cells. Additionally, such protocols could provide useful in vitro models for studying osteogenesis and bone development, and facilitate the genetic manipulation of stem cells for therapeutic applications. The development of pharmokinetic and cytotoxicity/genotoxicity screening tests for bone-related biomaterials and drugs could also use protocols developed for the osteogenic differentiation of stem cells. This review critically examines the various strategies that could be used to direct the differentiation of stem cells into the osteogenic lineage in vitro. [source] Getting personal: an exploratory study of intimate and personal care provision for people with profound and multiple intellectual disabilitiesJOURNAL OF INTELLECTUAL DISABILITY RESEARCH, Issue 2 2002S. Carnaby Abstract Background Intimate and personal care is a major area of support and provision for people with intellectual disability (ID), particularly those with profound and multiple ID. However, its management and practice has largely been neglected outside the use of individual guidelines and same-gender intimate care policies, with little research evidence or theoretical literature to inform the planning, conduct and organization of associated care tasks. Results The present paper reports on the methodology and findings of an exploratory study designed to map the key management and practice issues, and suggest ways forward for the providers of services for people with ID in relation to the quality and outcomes of intimate and personal care. [source] Review of plant biogeographic studies in BrazilJOURNAL OF SYSTEMATICS EVOLUTION, Issue 5 2009Pedro FIASCHI Abstract, Molecular phylogenetic studies have become a major area of interest in plant systematics, and their impacts on historical biogeographic hypotheses are not to be disregarded. In Brazil, most historical biogeographic studies have relied on animal phylogenies, whereas plant biogeographic studies have largely lacked a phylogenetic component, having a limited utility for historical biogeography. That country, however, is of great importance for most biogeographic studies of lowland tropical South America, and it includes areas from a number of biogeographic regions of the continent. Important biogeographic reports have been published as part of phylogenetic studies, taxonomic monographs, and regional accounts for small areas or phytogeographic domains, but the available information is subsequently scattered and sometimes hard to find. In this paper we review some relevant angiosperm biogeographic studies in Brazil. Initially we briefly discuss the importance of other continents as source areas for the South American flora. Then we present a subdivision of Brazil into phytogeographic domains, and we cite studies that have explored the detection of biogeographic units (areas of endemism) and how they are historically related among those domains. Examples of plant taxa that could be used to test some biogeographic hypotheses are provided throughout, as well as taxa that exemplify several patterns of endemism and disjunction in the Brazilian angiosperm flora. [source] Calcium Phosphate-Based Resorbable Ceramics: Influence of MgO, ZnO, and SiO2 DopantsJOURNAL OF THE AMERICAN CERAMIC SOCIETY, Issue 9 2006Amit Bandyopadhyay Resorbable calcium phosphate (CaP)-based biomaterials are important because they can significantly improve health care by shortening the time necessary for restoration of functional loading of grafted bones. Although synthetic CaPs show exceptional similarities to natural bone, however, they are deficient in one major area, in that they do not have the same mineral content of bone. The focus of our work is to understand the influence of dopants on the physical, mechanical, and biological properties of tricalcium phosphate (TCP) resorbable ceramics with special emphasis toward in vitro strength degradation and cell,materials interactions as a function of time. For this purpose, ,-TCP was doped with magnesia (MgO), zinc oxide (ZnO), and silica (SiO2). Those dopants were added as individual dopants, and their binary and ternary compositions. It was found that these dopants significantly influenced densification behavior and as sintered microstructures of TCP. In vitro mineralization studies in simulated body fluids (SBF) for 12 weeks showed apatite growth on the highly porous compositions either on the surface or inside. From scanning electron microscopic analysis it was evident that surface degradation occurred on all compositions in SBF. Compression strengths for samples up to 12 weeks in SBF showed that it is possible to tailor strength loss behavior through compositional modifications. The highest compression strength was found for binary MgO,ZnO doped TCP. Overall, samples showed either a similar strength level during the 12 weeks test period, or a continuous decrease or a continuous increase in strength depending on dopant chemistry or amount. In vitro human osteoblast cell culture was used to determine influence of dopants on cell-materials interactions. All samples were non-toxic and biocompatible. Dopant chemistry also influenced adhesion, proliferation, and differentiation of osteoblastic precursor cell line 1 (OPC1) cells on these matrices. [source] Helicobacter pylori vaccines,the current statusALIMENTARY PHARMACOLOGY & THERAPEUTICS, Issue 9 2000Sutton In this review, we take a look at the current status in the development of a vaccine against the human pathogenic bacterium, Helicobacter pylori, a major aetiological factor in peptic ulcer disease and gastric adenocarcinoma. Various animal models are now in use from mice infected with H. pylori, through gnotobiotic pigs and primates to ferrets naturally infected with their own Helicobacter, H. mustelae. A significant problem remains the requirement for a suitable mucosal adjuvant. Detoxification or the use of low doses of adjuvants already available may provide a solution and new immune stimulating compounds have been tested with some success. New approaches include the delivery of Helicobacter antigens by DNA immunization, microparticles or live vectors such as attenuated salmonella and the examination of alternative routes of vaccine administration. The phenomenon of post-immunization gastritis and improvements in vaccine efficacy are also discussed. A major area of interest is the mechanism by which immunization actually influences Helicobacter colonization. This remains a mystery: antibodies appear to be unimportant whereas CD4+ T-cells essential. Finally, a viewpoint is given on whom should be immunized when a final vaccine becomes available. [source] Peripheral Nerve Stimulation: A Treatment for Chronic Low Back Pain and Failed Back Surgery Syndrome?NEUROMODULATION, Issue 1 2009Paul Verrills MD ABSTRACT Objective., This study aims to evaluate the usefulness of peripheral nerve stimulation as a treatment option for patients with chronic low back pain. Materials and Methods., More than 12 months, we collected data on consecutive patients who had successful trials and were subsequently implanted with octrode percutaneous leads placed subcutaneously within the major area of pain. Eleven patients met diagnostic criteria for failed back surgery syndrome. A questionnaire assessed outcomes including: pain, analgesic use, and patient satisfaction. The response rate was 93% (13/14): average follow-up time was seven months. Results., There was a significant decrease in pain levels: an average reduction of 3.77 visual analog scale points. Eleven patients (85%) reported successful outcomes and an average pain reduction of 4.18 points but two reported a poor response. Pain relief was highly correlated with reduced analgesia and patient satisfaction. No complications were reported. Conclusion., This study demonstrates a treatment option that is safe, nonpharmacologic, reversible, and effective for patients with chronic low back pain that have exhausted other treatment options. [source] The use of uncertainty analysis for the design of container closuresPACKAGING TECHNOLOGY AND SCIENCE, Issue 3 2006By A. Yoxall Abstract Understanding how easy packaging is to open is becoming a major area of interest for the packaging industry. Designing packaging to meet the direct needs of the consumer has been termed ,inclusive design'. However, there are differing parameters that may affect the ease of opening a product. This paper outlines how the use of uncertainty analysis coupled with ,inclusive design' techniques can help manufacturers understand which parameters are important for product ,openability'. Copyright © 2006 John Wiley & Sons, Ltd. [source] Crystallization of IgG1 by mapping its liquid,liquid phase separation curvesBIOTECHNOLOGY & BIOENGINEERING, Issue 5 2006Adam Idu Jion Abstract Monoclonal antibody therapeutics is an important and fast expanding market. While production of these molecules has been a major area of research, much less is known regarding the stabilization of these proteins for delivery as drugs. Crystallization of antibodies is one such promising route for protein stabilization at high titers, and here we took a systematic approach to initiate crystallization through nucleation in a simple PEG (polyethylene glycol), protein in water solution. A ternary mixture of globular proteins, PEG, and water will undergo a liquid,liquid phase separation (LLPS) as shown in a phase diagram or a Binodal curve. Of particular interest within the phase diagram is the position of the critical point, which is where nucleation occurs most rapidly. Detailed LLPS maps were created by increasing concentrations of PEG (from 5% to 11%) and IgG (from 1 to 20 mg/mL). By increasing the molecular weight (MW) of PEG (and hence its radius of gyration) from 1,000 to 6,000 g/mol, the temperatures of the critical point of nucleation were shown to increase. Once these curves were determined, nucleation experiments were conducted close to a chosen critical point (10.5 mg/mL IgG in 11% PEG 1000) and after 3 weeks, crystals of IgG of approximately 100 ,m in size were successfully formed. This is the first example of crystallization of an antibody through systematic mapping of LLPS curves, which is a fundamental step towards the scale-up of antibody crystallization. © 2006 Wiley Periodicals, Inc. [source] Recent Approaches to Antifungal Therapy for Invasive MycosesCHEMMEDCHEM, Issue 3 2009Bijoy Abstract Antimycotic agents: Diverse classes of antimycotic drugs have been developed over the past decades with the goal of improving selectivity and efficacy. This review discusses both conventional and novel targets for antifungal agents and the possibility of vaccination in the treatment of invasive fungal infections. Invasive fungal infections with primary and opportunistic mycoses have become increasingly common in recent years and pose a major diagnostic and therapeutic challenge. They represent a major area of concern in today's medical fraternity. The occurrence of invasive fungal diseases, particularly in AIDS and other immunocompromised patients, is life-threatening and increases the economic burden. Apart from the previously known polyenes and imidazole-based azoles, newly discovered triazoles and echinocandins are more effective in terms of specificity, yet some immunosuppressed hosts are difficult to treat. The main reasons for this include antifungal resistance, toxicity, lack of rapid and microbe-specific diagnoses, poor penetration of drugs into sanctuary sites, and lack of oral or intravenous preparations. In addition to combination antifungal therapy, other novel antimycotic treatments such as calcineurin signaling pathway blockers and vaccines have recently emerged. This review briefly summarizes recent developments in the pharmacotherapeutic treatment of invasive fungal infections. [source] Complementary and integrative medical therapies, the FDA, and the NIH: definitions and regulationDERMATOLOGIC THERAPY, Issue 2 2003Michael H. Cohen ABSTRACT: ,,The National Center for Complementary and Alternative Medicine (NCCAM) presently defines complementary and alternative medicine (CAM) as covering "a broad range of healing philosophies (schools of thought), approaches, and therapies that mainstream Western (conventional) medicine does not commonly use, accept, study, understand, or make available. The research landscape, including NCCAM-funded research, is continually changing and subject to vigorous methodologic and interpretive debates. Part of the impetus for greater research dollars in this arena has been increasing consumer reliance on CAM to dramatically expand. State (not federal) law controls much of CAM practice. However, a significant federal role exists in the regulation of dietary supplements. The U.S. Food and Drug Administration (FDA) regulates foods, drugs, and cosmetics in interstate commerce. No new "drug" may be introduced into interstate commerce unless proven "safe" and "effective" for its intended use, as determined by FDA regulations. "Foods", however, are subject to different regulatory requirements, and need not go through trials proving safety and efficacy. The growing phenomenon of consumer use of vitamins, minerals, herbs, and other "dietary supplements" challenged the historical divide between drugs and foods. The federal Dietary Supplements Health Education Act (DSHEA) allows manufacturers to distribute dietary supplements without having to prove safety and efficacy, so long as the manufacturers make no claims linking the supplements to a specific disease. State law regulates the use of CAM therapies through a variety of legal rules. Of these, several major areas of concern for clinicians are professional licensure, scope of practice, and malpractice. Regarding licensure, each state has enacted medical licensing that prohibits the unlicensed practice of medicine and thereby criminalizes activity by unlicensed CAM providers who offer health care services to patients. Malpractice is defined as unskillful practice which fails to conform to a standard of care in the profession and results in injury. The definition is no different in CAM than in general medicine; its application to CAM, however, raises novel questions. Courts rely on medical consensus regarding the appropriateness of a given therapy. A framework for assessing potential liability risk involves assessing the medical evidence concerning safety and efficacy, and then aligning clinical decisions with liability concerns. Ultimately research will or will not establish a specific CAM therapy as an important part of the standard of care for the condition in question. Legal rules governing CAM providers and practices are, in many cases, new and evolving. Further, laws vary by state and their application depends on the specific clinical scenario in question. New research is constantly emerging, as are federal and state legislative developments and judicial opinions resulting from litigation. [source] Antipsychotic-induced weight gainDIABETES OBESITY & METABOLISM, Issue 5 2005A. J. Goudie Abstract:, Novel ,atypical' antipsychotic drugs represent a substantial improvement on older ,typical' drugs. However, clinical experience has shown that some, but not all, of these drugs can induce substantial weight gain. This interferes with compliance with drug taking and has expected effects on morbidity and mortality. In this review, we summarize current thinking on: (i) the extent to which different ,atypical' drugs induce weight gain; (ii) the possible roles of various neurotransmitters and neuropeptides in this adverse drug reaction; and (iii) the state of development of animal models in this area. We also outline major areas for future research. [source] Spatial and temporal patterns of walleye pollock (Theragra chalcogramma) spawning in the eastern Bering Sea inferred from egg and larval distributionsFISHERIES OCEANOGRAPHY, Issue 2 2010NATHAN M. BACHELER Abstract Walleye pollock Theragra chalcogramma (pollock hereafter) is a key ecological and economic species in the eastern Bering Sea, yet detailed synthesis of the spatial and temporal patterns of pollock ichthyoplankton in this important region is lacking. This knowledge gap is particularly severe considering that egg and larval distribution are essential to reconstructing spawning locations and early life stages drift pathways. We used 19 yr of ichthyoplankton collections to determine the spatial and temporal patterns of egg and larval distribution. Generalized additive models (GAMs) identified two primary temporal pulses of pollock eggs, the first occurring from 20 February to 31 March and the second from 20 April to 20 May; larvae showed similar, but slightly lagged, pulses. Based on generalized cross-validation and information theory, a GAM model that allowed for different seasonal patterns in egg density within three unique areas outperformed a GAM that assumed a single fixed seasonal pattern across the entire eastern Bering Sea. This ,area-dependent' GAM predicted the highest densities of eggs (i.e., potential spawning locations) in three major areas of the eastern Bering Sea: near Bogoslof Island (February,April), north of Unimak Island and the Alaska Peninsula (March,April), and around the Pribilof Islands (April,August). Unique temporal patterns of egg density were observed for each area, suggesting that pollock spawning may be more spatially and temporally complex than previously assumed. Moreover, this work provides a valuable baseline of pollock spawning to which future changes, such as those resulting from climate variability, may be compared. [source] Quality of life in patients with primary biliary cirrhosisHEPATOLOGY, Issue 2 2004Renée Eugénie Poupon The impact of primary biliary cirrhosis (PBC) on health-related quality of life (HRQOL) is poorly documented. We assessed quality of life in a group of 276 unselected patients with PBC using the Nottingham Health Profile (NHP). This is a generic scale that assesses six major areas commonly associated with HRQOL. Data were compared with those of a sex- and age-matched control group. The associations between NHP scores and the severity of PBC were tested. Patients (86% women) had a median age of 62 years (range 33,87). Most patients were treated with UDCA. PBC patients showed a strong statistically significant difference in energy compared to controls (respectively, 40.6 vs. 22.9, P < .0001) and had worse scores for emotional reactions (22.2 vs. 16.1, P < .005). No other differences were observed. No associations of the dimension subscores were found with biochemical liver tests, histological stages, or duration of the disease. Among the signs or symptoms, fatigue was the finding most often associated with the dimension subscores. In conclusion, patients with PBC feel that their overall quality of life is worse than that of the control population. This difference is mainly due to the decrease in the subscores of energy and emotional reactions, both associated with fatigue. These effects must be taken into account by clinicians when treating these patients, as they constitute the clinical outcomes that have the most impact on patients' lifestyle and adherence to treatment. (HEPATOLOGY 2004;40:489,494.) [source] Moving from the quality of life concept to a theoryJOURNAL OF INTELLECTUAL DISABILITY RESEARCH, Issue 10 2005R. A. Cummins Abstract Background The Special Interest Quality of Life Group has updated its set of statements defining the quality of life (QOL) construct to reflect emerging areas of agreement and the framework for understanding better the QOL construct. Method This article examines the major areas currently under discussion involving the objective,subjective dichotomy, needs, and core domains. Results It is concluded that while the new statements constitute a significant advance, further progress requires testable theory. In order to facilitate such future research, a conceptual model is proposed that distinguishes causal and indicator variables within the framework of a homeostatic management system. Conclusion Several lines of empirical investigation are suggested to test this and similar theoretical models with a view to taking our conceptualization of QOL to the next level. [source] Functional MRI of the rodent somatosensory pathway using multislice echo planar imaging,MAGNETIC RESONANCE IN MEDICINE, Issue 1 2004Shella D. Keilholz Abstract A multislice EPI sequence was used to obtain functional MR images of the entire rat brain with BOLD contrast at 11.7 T. Ten to 11 slices covering the rat brain, with an in-plane resolution of 300 ,m, provided enough sensitivity to detect activation in brain regions known to be involved in the somatosensory pathway during stimulation of the forelimbs. These regions were identified by warping a digitized rat brain atlas to each set of images. Data analysis was constrained to four major areas of the somatosensory pathway: primary and secondary somatosensory cortices, thalamus, and cerebellum. Incidence maps were generated. Electrical stimulation at 3 Hz led to significant activation in the primary sensory cortex in all rats. Activation in the secondary sensory cortex and cerebellum was observed in 70% of the studies, while thalamic activation was observed in 40%. The amplitude of activation was measured for each area, and average response time courses were calculated. Finally, the frequency dependence of the response to forepaw stimulation was measured in each of the activated areas. Optimal activation occurred in all areas at 3 Hz. These results demonstrate that whole-brain fMRI can be performed on rodents at 11.7 T to probe a well-defined neural network. Magn Reson Med 52:89,99, 2004. Published 2004 Wiley-Liss, Inc. [source] Biogeography of common dolphins (genus Delphinus) in the Southwestern Atlantic OceanMAMMAL REVIEW, Issue 1 2010Maurício TAVARES ABSTRACT 1The common dolphins (genus Delphinus) have one of most problematic taxonomies and complex distribution patterns of all cetaceans. Although the taxonomy and the distribution seem to have been clarified somewhat in the eastern North Pacific and Indo-Pacific Oceans, many questions remain in the Southwestern Atlantic Ocean (SWA). We review the biogeography of Delphinus in the SWA. 2We reviewed data from strandings, incidental catches and sightings since 1922. Systematic surveys were conducted in five major areas. Twenty-one natural history collections were examined, and 135 skulls were measured. 3A total of 184 records of common dolphins were compiled. Delphinus apparently occurs in three stocks in the SWA: one located in northern Brazil and two from southeastern Brazil (,22°S) to central Argentina (,42°S). Two distinct patterns in habitat use were observed by depth: in southeastern Brazil, sightings were restricted to coastal waters with water depths ranging from 18m to 70m. On the other hand, in the area that extends from southern Brazil to Central Argentina (from 28°S to 42°S), sightings were recorded in deeper waters, ranging from 71m to 1435m, with the exception of occasional coastal sightings. The cranial analyses demonstrated that both short-beaked common dolphins Delphinus delphis and long-beaked common dolphins Dephinus capensis occur in the SWA. 4In the SWA, Delphinus seems to occur near areas of high productivity. One stock is associated with the productive waters discharged by the Amazon River and possibily with the coastal upwelling system off the coast of Venezuela, while the other stocks are associated with the Cabo Frio upwelling system and the Subtropical Convergence. Our results indicate that the current taxonomy does not adequately reflect the amount of variation within the genus in the world. [source] Terrestrial carnivores and human food production: impact and managementMAMMAL REVIEW, Issue 2-3 2008PHILIP J. BAKER ABSTRACT 1The production of food for human consumption has led to an historical and global conflict with terrestrial carnivores, which in turn has resulted in the extinction or extirpation of many species, although some have benefited. At present, carnivores affect food production by: (i) killing human producers; killing and/or eating (ii) fish/shellfish; (iii) game/wildfowl; (iv) livestock; (v) damaging crops; (vi) transmitting diseases; and (vii) through trophic interactions with other species in agricultural landscapes. Conversely, carnivores can themselves be a source of dietary protein (bushmeat). 2Globally, the major areas of conflict are predation on livestock and the transmission of rabies. At a broad scale, livestock predation is a customary problem where predators are present and has been quantified for a broad range of carnivore species, although the veracity of these estimates is equivocal. Typically, but not always, losses are small relative to the numbers held, but can be a significant proportion of total livestock mortality. Losses experienced by producers are often highly variable, indicating that factors such as husbandry practices and predator behaviour may significantly affect the relative vulnerability of properties in the wider landscape. Within livestock herds, juvenile animals are particularly vulnerable. 3Proactive and reactive culling are widely practised as a means to limit predation on livestock and game. Historic changes in species' distributions and abundance illustrate that culling programmes can be very effective at reducing predator density, although such substantive impacts are generally considered undesirable for native predators. However, despite their prevalence, the effectiveness, efficiency and the benefit:cost ratio of culling programmes have been poorly studied. 4A wide range of non-lethal methods to limit predation has been studied. However, many of these have their practical limitations and are unlikely to be widely applicable. 5Lethal approaches are likely to dominate the management of terrestrial carnivores for the foreseeable future, but animal welfare considerations are increasingly likely to influence management strategies. The adoption of non-lethal approaches will depend upon proof of their effectiveness and the willingness of stakeholders to implement them, and, in some cases, appropriate licensing and legislation. 6Overall, it is apparent that we still understand relatively little about the importance of factors affecting predation on livestock and how to manage this conflict effectively. We consider the following avenues of research to be essential: (i) quantified assessments of the loss of viable livestock; (ii) landscape-level studies of contiguous properties to quantify losses associated with variables such as different husbandry practices; (iii) replicated experimental manipulations to identify the relative benefit of particular management practices, incorporating (iv) techniques to identify individual predators killing stock; and (v) economic analyses of different management approaches to quantify optimal production strategies. [source] THE RISE AND DECLINE OF THE TUTANKHAMUN-CLASS CHARIOTOXFORD JOURNAL OF ARCHAEOLOGY, Issue 2 2004BELA I. SANDOR Summary. The Tutankhamun-class chariot, the earliest high-performance machine, existed in its refined form for about five centuries. Eight complete vehicles have survived and support the argument that they surpass all monumental structures of the pharaohs in engineering sophistication. There is no evidence of chariot racing from that era, but these chariots have many technical features that imply a pedigree based on racing. Several elements hint of thoughtful invention, advanced physical modelling and experimentation, with results that sometimes drastically and favourably differ from our concepts of vehicle design. It is difficult for us to envision a substantially better chariot made with the ancient materials of construction even if we were to apply our most advanced formulas and methods. There are two major areas of chariot analysis from an engineering standpoint, and both are accessible to non-specialists. The complex suspension system of springs and shock absorbers has advantages in structural dynamics, ride quality and safety. An example of the latter is a dual-purpose anti-roll device. The chariots' wheels have aircraft-like damage tolerance, and have fundamentally more perfect spokes and joints for carrying multi-axial loads than the wooden spokes of any classic car. This paper covers the essential technical features and historical perspectives of these chariots for archaeologists. [source] An evaluation of the evidence for, and implications of, cytoplasmic nitrate homeostasisPLANT CELL & ENVIRONMENT, Issue 10 2002M. Y. Siddiqi Abstract A review of literature, reporting values of cytoplasmic/cytosolic [NO3,] in plant cells, identified two major areas of disagreement: (1) disparity in the absolute values within the same system, and (2) constancy versus variability in cytoplasmic/cytosolic [NO3,] with varying [NO3,]o. These differences are related to the techniques used by the different authors. Estimates of cytoplasmic [NO3,] by compartmental analysis and by cell fractionation were consistently higher than the estimates by NO3,selective microelectrodes and by techniques based upon in vivo and in vitro nitrate reductase activity (NRA). A model recognizing more than one cytoplasmic ionic pool would satisfactorily reconcile the differences in both aspects, i.e. absolute values and constancy. Compartmental analysis and cell fractionation techniques may measure the amount of NO3, in the cytoplasm as a whole (including organelles); by contrast, NO3, selective microelectrodes and NRA estimate only the cytosolic NO3, and, hence, may result in lower estimates. Thus, variable organellar pool(s) may maintain a constant cytosolic pool as estimated by microelectrodes. However, certain observations remain at odds with the notion of a constant cytosolic [NO3,]. [source] Codex final definition of dietary fibre: issues of implementationQUALITY ASSURANCE & SAFETY OF CROPS & FOOD, Issue 4 2009Joanne R. Lupton Abstract Introduction At its 30th session in South Africa in November 2008, the Codex Committee on Nutrition and Foods for Special Dietary Uses (CCNFSDU) agreed on a definition of dietary fibre. Although many aspects of what can be called "dietary fibre" were resolved, the application of this definition raises additional issues in need of resolution. Objectives The goal of this paper is to discuss the major areas at issue in implementing the new Codex definition of dietary fibre: (1) the footnote that individual countries can decide whether they accept oligosaccharides with a degree of polymerization (DP) from 3 to 9 (included) as being fibre; and 2) guidance on which physiological effects are beneficial. Less critical but still important is the issue of animal sources of fibre not requiring proof of a beneficial physiological effect; and the effect of processing on fibre. Results and conclusion Unless all countries accept (or do not accept) that carbohydrate polymers with 3,9 monomeric units are dietary fibre, there will be two, rather than one definition. Again, if each country has its own criteria as to the physiological benefits of fibre and how to verify those benefits there will be as many "definitions" of fibre as there are effects accepted by all the member states. Given the importance to consumers, food companies, researchers, and regulatory agencies in having one definition, it is incumbent on all of us in the field to work toward that end. [source] Global R&D Project Management and Organization: A TaxonomyTHE JOURNAL OF PRODUCT INNOVATION MANAGEMENT, Issue 5 2000Vittorio Chiesa This work studies the management and organization of global R&D projects, i.e. projects leading to innovations to be exploited in multiple countries. It provides a taxonomy of how firms conduct such projects. The empirical base is composed of twelve multinational companies, from the three major areas (Europe, Japan, North America), operating technology-intensive businesses. Two basic structures are identified: the specialization based, where one foreign lab (the firm's center of excellence) is assigned the responsibility for developing a new product, process or technology on the basis of a global mandate, and the integration based, where different units contribute to technology development programs and global innovations are the result of the joint work of these units. In each categories two sub-cases have been found: the center of excellence and the supported specialization, on the one hand, and the network and specialized contributor structures, on the other. The four structures have been studied in relation to: the key characteristics of the organization and management of global projects (in each phase, from conception to introduction into the market), the organizational factors affecting the success, the context conditions in which the structure is considered appropriate. [source] A Canadian Copyright NarrativeTHE JOURNAL OF WORLD INTELLECTUAL PROPERTY, Issue 5-6 2008Daniel J. Gervais Copyright policy, like other major areas of public policy, requires a solid anchoring in fundamental principles. The perceived need to anchor copyright debates in a solid policy context and, hence, to develop a coherent (and hopefully convincing) narrative has been the subject of excellent contemporary research. We are indebted to a number of scholars for their work in this area. The attempt to find normative applications from a historically derived model for copyright is not either. However, the research thus far tends to provide a blurred picture, by espousing justiflcatory theories based on one or many of the following: commercial and personal Interests of authors, understood as property and/or liability rules; commercial interests of publishers and other "rights holders"; and/or the social costs of overprotection and the related economic-driven search for an optimal point of protection. This article looks at pieces in the Canadian narrative puzzle and tries to present a faithful picture of its current stage of evolution. To do so, however, a detour via England is required, because that is whence the soil from Which the Canadian narrative comes. This historical detour will be the focus of Part 1. Part III will suggest a path for the next stages of the Canadian narrative that is both consistent with international norms and hopefully useful in moving the debate forward. The part ends with a brief look at the impact that the linkage with trade rules may have on copyright. [source] Recent Progress and New Perspectives in Studying T Cell Responses to AllograftsAMERICAN JOURNAL OF TRANSPLANTATION, Issue 5 2010A. Valujskikh Studies in the past decade advanced our understanding of the development, execution and regulation of T-cell-mediated allograft rejection. This review outlines recent progress and focuses on three major areas of investigation that are likely to guide the development of graft-prolonging therapies in the future. The discussed topics include the contribution of recently discovered molecules to the activation and functions of alloreactive T cells, the emerging problem of alloreactive memory T cells and recently gained insights into the old question of transplantation tolerance. [source] Acidification of sandy grasslands , consequences for plant diversityAPPLIED VEGETATION SCIENCE, Issue 3 2009Pål Axel Olsson Abstract Questions: (1) Does soil acidification in calcareous sandy grasslands lead to loss of plant diversity? (2) What is the relationship between the soil content of lime and the plant availability of mineral nitrogen (N) and phosphorus (P) in sandy grasslands? Location: Sandy glaciofluvial deposits in south-eastern Sweden covered by xeric sand calcareous grasslands (EU habitat directive 6120). Methods: Soil and vegetation were investigated in most of the xeric sand calcareous grasslands in the Scania region (136 sample plots distributed over four or five major areas and about 25 different sites). Environmental variables were recorded at each plot, and soil samples were analysed for exchangeable P and N, as well as limestone content and pH. Data were analysed with regression analysis and canonical correspondence analysis. Results: Plant species richness was highest on weakly acid to slightly alkaline soil; a number of nationally red-listed species showed a similar pattern. Plant species diversity and number of red-listed species increased with slope. Where the topsoil had been acidified, limestone was rarely present above a depth of 30 cm. The presence of limestone restricts the availability of soil P, placing a major constraint on primary productivity in sandy soils. Conclusions: Acidification of sandy grasslands leads to reduced abundance of desirable species, although the overall effect is rather weak between pH 5 and pH 9. Slopes are important for high diversity in sandy grasslands. Calcareous soils cannot be restored through shallow ploughing, but deep perturbation could increase the limestone content of the topsoil and favour of target species. [source] Isotopic ecology ten years after a call for more laboratory experimentsBIOLOGICAL REVIEWS, Issue 1 2009Carlos Martínez del Rio Abstract About 10 years ago, reviews of the use of stable isotopes in animal ecology predicted explosive growth in this field and called for laboratory experiments to provide a mechanistic foundation to this growth. They identified four major areas of inquiry: (1) the dynamics of isotopic incorporation, (2) mixing models, (3) the problem of routing, and (4) trophic discrimination factors. Because these areas remain central to isotopic ecology, we use them as organising foci to review the experimental results that isotopic ecologists have collected in the intervening 10 years since the call for laboratory experiments. We also review the models that have been built to explain and organise experimental results in these areas. [source] Wildlife Population Assessment: Past Developments and Future DirectionsBIOMETRICS, Issue 1 2000S. T. Buckland Summary. We review the major developments in wildlife population assessment in the past century. Three major areas are considered: mark-recapture, distance sampling, and harvest models. We speculate on how these fields will develop in the next century. Topics for which we expect to see methodological advances include integration of modeling with Geographic Information Systems, automated survey design algorithms, advances in model-based inference from sample survey data, a common inferential framework for wildlife population assessment methods, improved methods for estimating population trends, the embedding of biological process models into inference, substantially improved models for conservation management, advanced spatiotemporal models of ecosystems, and greater emphasis on incorporating model selection uncertainty into inference. We discuss the kind of developments that might be anticipated in these topics. [source] | ||||||||||||||||||||||||||||