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Selected AbstractsOptimization routine for identification of model parameters in soil plasticityINTERNATIONAL JOURNAL FOR NUMERICAL AND ANALYTICAL METHODS IN GEOMECHANICS, Issue 5 2001Hans Mattsson Abstract The paper presents an optimization routine especially developed for the identification of model parameters in soil plasticity on the basis of different soil tests. Main focus is put on the mathematical aspects and the experience from application of this optimization routine. Mathematically, for the optimization, an objective function and a search strategy are needed. Some alternative expressions for the objective function are formulated. They capture the overall soil behaviour and can be used in a simultaneous optimization against several laboratory tests. Two different search strategies, Rosenbrock's method and the Simplex method, both belonging to the category of direct search methods, are utilized in the routine. Direct search methods have generally proved to be reliable and their relative simplicity make them quite easy to program into workable codes. The Rosenbrock and simplex methods are modified to make the search strategies as efficient and user-friendly as possible for the type of optimization problem addressed here. Since these search strategies are of a heuristic nature, which makes it difficult (or even impossible) to analyse their performance in a theoretical way, representative optimization examples against both simulated experimental results as well as performed triaxial tests are presented to show the efficiency of the optimization routine. From these examples, it has been concluded that the optimization routine is able to locate a minimum with a good accuracy, fast enough to be a very useful tool for identification of model parameters in soil plasticity. Copyright © 2001 John Wiley & Sons, Ltd. [source] Complexity and the Culture of CurriculumEDUCATIONAL PHILOSOPHY AND THEORY, Issue 1 2008William E. Doll Abstract This paper has two main foci: (1) the history of curriculum design, and (2) implications from the new sciences of chaos and complexity for the development of new forms of curriculum design and teaching implementation. Regarding the first focus, the paper posits that there exist,to use Wittgenstein's phrase,,family resemblances' between Peter Ramus' 16th century curriculum design and that of Ralph Tyler in the 20th century. While this 400-year linkage is by no means linear, there are overlapping strands from Ramus to Comenius to the Puritans to colonial New England to Horace Mann to Ralph Tyler. What unites these strands, all belonging to the Protestant Methodization movement that swept across northern Europe into colonial America and the USA, is the concept of Method. Taylor's ,time and motion' studies set the stage for Tyler's Basic Principles of curriculum design,those starting with set goals and concluding with measured assessment. The second focus draws on the new sciences of chaos and complexity to develop a different sense of curriculum and instruction,open, dynamic, relational, creative, and systems oriented. The paper concludes with an integration of the rational/scientific with the aesthetic/spiritual into a view of education and curriculum informed by complexity. [source] An exploration of corporate attitudes to the significance of environmental information for stakeholdersCORPORATE SOCIAL RESPONSIBILITY AND ENVIRONMENTAL MANAGEMENT, Issue 4 2003David Collison This paper reports on a questionnaire survey sent to environmental managers in quoted UK firms from environmentally sensitive sectors. A total of 58 usable responses was received, with most but not all being returned by environmental managers. While contextual information regarding perceptions of their companies' environmental sensitivity and management systems was sought, the main focus of the questionnaire was on respondents' views about stakeholder concerns. There was broad agreement that external stakeholders attached importance to environmental communications. The results indicate that respondents' perceptions of these issues were associated with the formality of their internal management systems and with the role of the respondents within their firms. It was also found that shareholders were thought to be the least interested stakeholder group. Copyright © 2003 John Wiley & Sons, Ltd and ERP Environment. [source] DOES CRIME JUST MOVE AROUND THE CORNER?CRIMINOLOGY, Issue 3 2006A CONTROLLED STUDY OF SPATIAL DISPLACEMENT AND DIFFUSION OF CRIME CONTROL BENEFITS Recent studies point to the potential theoretical and practical benefits of focusing police resources on crime hot spots. However, many scholars have noted that such approaches risk displacing crime or disorder to other places where programs are not in place. Although much attention has been paid to the idea of displacement, methodological problems associated with measuring it have often been overlooked. We try to fill these gaps in measurement and understanding of displacement and the related phenomenon of diffusion of crime control benefits. Our main focus is on immediate spatial displacement or diffusion of crime to areas near the targeted sites of an intervention. Do focused crime prevention efforts at places simply result in a movement of offenders to areas nearby targeted sites,"do they simply move crime around the corner"? Or, conversely, will a crime prevention effort focusing on specific places lead to improvement in areas nearby,what has come to be termed a diffusion of crime control benefits? Our data are drawn from a controlled study of displacement and diffusion in Jersey City, New Jersey. Two sites with substantial street-level crime and disorder were targeted and carefully monitored during an experimental period. Two neighboring areas were selected as "catchment areas" from which to assess immediate spatial displacement or diffusion. Intensive police interventions were applied to each target site but not to the catchment areas. More than 6,000 20-minute social observations were conducted in the target and catchment areas. They were supplemented by interviews and ethnographic field observations. Our findings indicate that, at least for crime markets involving drugs and prostitution, crime does not simply move around the corner. Indeed, this study supports the position that the most likely outcome of such focused crime prevention efforts is a diffusion of crime control benefits to nearby areas. [source] Struggling to Save Cash: Seasonal Migration and Vulnerability in West Bengal, IndiaDEVELOPMENT AND CHANGE, Issue 4 2003Ben Rogaly This article concerns an important but overlooked means by which able-bodied poor people get hold of lump sums of cash in rural West Bengal: seasonal migration for agricultural wage work. Drawing on a regional study of four migration streams, our main focus here is on the struggle to secure this cash by landless households in just one of those streams, originating in Murshidabad District. Case studies are used to illustrate the importance for women in nuclear families of maintaining supportive networks of kin for periods when men are absent. A parallel analysis is made of the negotiations between male migrant workers and their employers, at labour markets, during the period of work, and afterwards. The article then briefly discusses some of the contrasting ways in which remittances are used by landless households and owners of very small plots of land, in the context of rapid ecological change, demographic pressure and growing inequality. [source] Lipid-lowering therapy in patients with type 2 diabetes: the case for early interventionDIABETES/METABOLISM: RESEARCH AND REVIEWS, Issue 4 2008Armin Steinmetz Abstract Chronic complications of type 2 diabetes, in particular, macrovascular complications, confer substantial morbidity and mortality and adversely affect a patient's quality of life. Early intensive intervention to control cardiovascular risk factors is essential in clinical management. Atherogenic dyslipidaemia characterized by elevated triglycerides, a low level of high-density lipoprotein cholesterol (HDL-C), and an increase in the preponderance of small, dense low-density lipoprotein (LDL) particles, is a key modifiable risk factor for macrovascular diabetic complications. Lowering low-density lipoprotein cholesterol (LDL-C) with a statin (or the combination of statin and ezetimibe) is the main focus for reducing cardiovascular risk in patients with diabetes. However, statins fail to address the residual cardiovascular risk associated with low HDL-C. Fibrates are effective against all components of the atherogenic dyslipidaemia associated with type 2 diabetes. Secondary analyses of the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study suggest a role for early treatment with fenofibrate in improving cardiovascular risk reduction in type 2 diabetes and provide safety data supporting the use of fenofibrate in combination with a statin. Data from the FIELD study suggest that fenofibrate may also have potential to impact on microvascular diabetic complications associated with type 2 diabetes. Data are awaited from the ongoing Action to Control Cardiovascular Risk in Diabetes (ACCORD) study to evaluate the outcome benefits of combining fenofibrate with a statin in patients with type 2 diabetes. Finally, in view of divergent study results and outstanding data, assessment of the risk of the individual with type 2 diabetes is mandatory to assist clinical decision-making when initiating lipid therapy. Copyright © 2008 John Wiley & Sons, Ltd. [source] Brief alcohol intervention,where to from here?ADDICTION, Issue 6 2010Challenges remain for research, practice ABSTRACT Brief intervention (BI) is intended as an early intervention for non-treatment-seeking, non-alcohol-dependent, hazardous and harmful drinkers. This text provides a brief summary of key BI research findings from the last three decades and discusses a number of knowledge gaps that need to be addressed. Five areas are described: patient intervention efficacy and effectiveness; barriers to BI implementation by health professionals; individual-level factors that impact on BI implementation; organization-level factors that impact on BI implementation; and society-level factors that impact on BI implementation. BI research has focused largely upon the individual patient and health professional levels, with the main focus upon primary health care research, and studies are lacking in other settings. However, research must, to a larger degree, take into account the organizational and wider context in which BI occurs, as well as interaction between factors at different levels, in order to advance the understanding of how wider implementation of BI can be achieved in various settings and how different population groups can be reached. It is also important to expand BI research beyond its current parameters to investigate more ambitious long-term educational programmes and new organizational models. More widespread implementation of BI will require many different interventions (efforts, actions, initiatives, etc.) at different interlinked levels, from implementation interventions targeting individual health professionals' knowledge, skills, attitudes and behaviours concerning alcohol issues, BI and behaviour change counselling to efforts at the organizational and societal levels that influence the conditions for delivering BI as part of routine health care. [source] TK/TD dose,response modeling of toxicityENVIRONMETRICS, Issue 5 2007Munni Begum Abstract In environmental cancer risk assessment of a toxic chemical, the main focus is in understanding induced target organ toxicity that may in turn lead to carcinogenicity. Mathematical models based on systems of ordinary differential equations with biologically relevant parameters are tenable methods for describing the disposition of chemicals in target organs. In evaluation of a toxic chemical, dose,response assessment often addresses only toxicodynamics (TD) of the chemical, while its toxicokinetics (TK) do not enter into consideration. The primary objective of this research is to integrate both TK and TD in evaluation of toxic chemicals while performing dose,response assessment. Population models, with hierarchical setup and nonlinear predictors, for TK concentration and TD effect measures are considered. A one-compartment model with biologically relevant parameters, such as organ volume, uptake rate and excretion rate, or clearance, is used to derive the TK predictor while a two parameter Emax model is used as a predictor for TD measures. Inference of the model parameters with nonnegative and assay's Limit of Detection (LOD) constraints was carried out by Bayesian approaches using Markov Chain Monte Carlo (MCMC) techniques. Copyright © 2006 John Wiley & Sons, Ltd. [source] Comparison of spatial integration and surround suppression characteristics in spiking activity and the local field potential in macaque V1EUROPEAN JOURNAL OF NEUROSCIENCE, Issue 3 2008M. A. Gieselmann Abstract Neurons in primary visual cortex exhibit well documented centre,surround receptive field organization, whereby the centre is dominated by excitatory influences and the surround is generally dominated by inhibitory influences. These effects have largely been established by measuring the output of neurons, i.e. their spiking activity. How excitation and inhibition are reflected in the local field potential (LFP) is little understood. As this can bear on the interpretation of human fMRI BOLD data and on our understanding of the mechanisms of local field potential oscillations, we measured spatial integration and centre,surround properties in single- and multiunit recordings of V1 in the awake fixating macaque monkey, and compared these to spectral power in different frequency bands of simultaneously recorded LFPs. We quantified centre,surround organization by determining the size of the summation and suppression area in spiking activity as well as in different frequency bands of the LFP, with the main focus on the gamma band. Gratings extending beyond the summation area usually inhibited spiking activity while the LFP gamma-band activity increased monotonically for all grating sizes. This increase was maximal for stimuli infringing upon the near classical receptive field surround, where suppression started to dominate spiking activity. Thus, suppressive influences in primary cortex can be inferred from spiking activity, but they also seem to affect specific features of gamma-band LFP activity. [source] Moving up, moving down: Political careers across territorial levelsEUROPEAN JOURNAL OF POLITICAL RESEARCH, Issue 2 2003Klaus Stolz In the sparse literature on political careers in federal systems, regional positions are often seen as mere stepping stones on the way to federal office. But are they really? The recent professionalization of state politics in federal systems and the regionalization of former unitary states point to the strengthening of the regional level as a career arena in its own right. Could this lead to the emergence of a regional political class with a set of career interests distinct from those of national politicians? This article takes a first, comparative look at current patterns of career movements between regional and national parliaments in a wide range of federal and newly regionalized systems. The study shows that, contrary to general belief, the number of deputies actually moving from the regional to federal level is generally relatively low. While some cases show fairly integrated career structures, others exhibit a pattern of career development in which state or regional office functions as the main focus of political careers. The territorial structure of the political class is dependent upon a whole range of social, cultural and institutional factors. At the same time, it is also an important factor in the mechanics and institutional development of each federal system in question. [source] Convergence of fish communities from the littoral zone of reservoirsFRESHWATER BIOLOGY, Issue 6 2009KEITH B. GIDO Summary 1.,Understanding factors that regulate the assembly of communities is a main focus of ecology. Human-engineered habitats, such as reservoirs, may provide insight into these assembly processes because they represent novel habitats that are subjected to colonization by fishes from the surrounding river basin or transported by humans. By contrasting community similarity within and among reservoirs from different drainage basins to nearby stream communities, we can test the relative constraints of reservoir habitats and regional species pools in determining species composition of reservoirs. 2.,We used a large spatial database that included intensive collections from 143 stream and 28 reservoir sites within three major river basins in the Great Plains, U.S.A., to compare patterns of species diversity and community structure between streams and reservoirs and to characterize variation in fish community structure within and among major drainage basins. We expected reservoir fish faunas to reflect the regional species pool, but would be more homogeneous that stream communities because similar species are stocked and thrive in reservoirs (e.g. planktivores and piscivores), and they lack obligate stream organisms that are not shared among regional species pools. 3.,We found that fish communities from reservoirs were a subset of fishes collected from streams and dominant taxa had ecological traits that would be favoured in lentic environments. Although there were regional differences in reservoir fish communities, species richness, patterns of rank abundance and community structure in reservoir communities were more homogonous across three major drainage basins than for stream communities. 4.,The general pattern of convergence of reservoir fish community structure suggests their assembly is constrained by local factors such as habitat and biotic interactions, and facilitated by the introduction of species among basins. Because there is a reciprocal transfer of biota between reservoirs and streams, understanding factors structuring both habitats is necessary to evaluate the long-term dynamics of impounded river networks. [source] The evolutionary ecology of senescenceFUNCTIONAL ECOLOGY, Issue 3 2008P. Monaghan Summary 1Research on senescence has largely focused on its underlying causes, and is concentrated on humans and relatively few model organisms in laboratory conditions. To understand the evolutionary ecology of senescence, research on a broader taxonomic range is needed, incorporating field, and, where possible, longitudinal studies. 2Senescence is generally considered to involve progressive deterioration in performance, and it is important to distinguish this from other age-related phenotypic changes. We outline and discuss the main explanations of why selection has not eliminated senescence, and summarise the principal mechanisms thought to be involved. 3The main focus of research on senescence is on age-related changes in mortality risk. However, evolutionary biologists focus on fitness, of which survival is only one component. To understand the selective pressures shaping senescence patterns, more attention needs to be devoted to age-related changes in fecundity. 4Both genetic and environmental factors influence the rate of senescence. However, a much clearer distinction needs to be drawn between life span and senescence rate, and between factors that alter the overall risk of death, and factors that alter the rate of senescence. This is particularly important when considering the potential reversibility and plasticity of senescence, and environmental effects, such as circumstances early in life. 5There is a need to reconcile the different approaches to studying senescence, and to integrate theories to explain the evolution of senescence with other evolutionary theories such as sexual and kin selection. [source] Death of a migrant: transnational death rituals and gender among British SylhetisGLOBAL NETWORKS, Issue 3 2002Katy Gardner In this article I discuss transnational burial rituals carried out in London and Sylhet. While collective identity and reaffirming social ties are important issues in discussing the burial of migrants in Sylhet, the main focus of the article is on gender. The analysis of what happens when Londonis die reveals a great deal about the differential effects of living between two places on men and women. While transnationalism may in some contexts be understood as potentially subversive, for the majority of Sylhetis in Britain movement between places is highly constrained by poverty and British immigration controls, as well as by particular gender and household relations. These in turn impact on men and women's experiences of bereavement, as well as on their access to and relationship with the British state. [source] Internet-based information-seeking behaviour amongst doctors and nurses: a short review of the literatureHEALTH INFORMATION & LIBRARIES JOURNAL, Issue 1 2010Paula Younger Background:, Reviews of how doctors and nurses search for online information are relatively rare, particularly where research examines how they decide whether to use Internet-based resources. Original research into their online searching behaviour is also rare, particularly in real world clinical settings. as is original research into their online searching behaviour. This review collates some of the existing evidence, from 1995 to 2009. Objectives:, To establish whether there are any significant differences in the ways and reasons why doctors and nurses seek out online information; to establish how nurses and doctors locate information online; to establish whether any conclusions can be drawn from the existing evidence that might assist health and medical libraries in supporting users. Methods:, An initial scoping literature search was carried out on PubMed and CINAHL to identify existing reviews of the subject area and relevant original research between 1995 and 2009. Following refinement, further searches were carried out on Embase (Ovid), LISA and LISTA. Following the initial scoping search, two journals were identified as particularly relevant for further table of contents searching. Articles were exclused where the main focus was on patients searching for information or where the focus was the evaluation of online-based educational software or tutorials. Articles were included if they were review or meta-analysis articles, where they reported original research, and where the primary focus of the online search was for participants' ongoing Continuing Professional Development (CPD). The relevant articles are outlined, with details of numbers of participants, response rates, and the user groups. Results:, There appear to be no significant differences between the reasons why doctors and nurses seek online Internet-based evidence, or the ways in which they locate that evidence. Reasons for searching for information online are broadly the same: primarily patient care and CPD (Continuing Professional Development). The perceived barriers to accessing online information are the same in both groups. There is a lack of awareness of the library as a potential online information enabler. Conclusions:, Libraries need to examine their policy and practice to ensure that they facilitate access to online evidence-based information, particularly where users are geographically remote or based in the community rather than in a hospital setting. Librarians also need to take into account the fact that medical professionals on duty may not be able to take advantage of the academic model of online information research. Further research is recommended into the difference between the idealised academic model of searching and real world practicalities; and how other user groups search, for example patients. [source] Diagnosis of Helicobacter pylori InfectionHELICOBACTER, Issue 2004Athanasios Makristathis ABSTRACT While there are some attempts to improve culture of Helicobacter pylori, molecular methods have been the main focus of this interest. Their main application concerns the development of rapid tests also allowing the determination of bacterial resistance, i.e. real-time polymerase chain reaction (PCR) or fluorescence in situ hybridization (FISH), or to genotype the strains. Attempts to improve, simplify or explain the discrepancies of urea breath test results have been made and new generation of stool antigen test with monoclonal antibodies either using the standard ELISA format or rapid immunoenzymatic detection have confirmed their value. With regard to serology, studies have mainly focused on the distinction of infections with more pathogenic strains and the ability to diagnose atrophic gastritis with the Gastropanel. [source] Polyphenylene-Based Materials: Control of the Electronic Function by Molecular and Supramolecular ComplexityADVANCED MATERIALS, Issue 10-11 2009Bruno Schmaltz Abstract Organic electronics is one of the hottest and most exciting research topics today. However, its performance still lags behind that of inorganic-based electronics. This Progress Report demonstrates that by controlling the complexity of organic molecules at the molecular and at the supramolecular level as well as by choosing suitable processing techniques, the desired function for applications in electronics can be achieved. Our main focus is on polyphenylene-based nanomaterials, versatile organic molecules that allow access to novel intricate materials. We emphasize the molecular complexity as well as the supramolecular organization and the interfacing of novel organic materials as key guidelines. [source] Holographic digital Fourier microscopy for selective imaging of biological tissueINTERNATIONAL JOURNAL OF IMAGING SYSTEMS AND TECHNOLOGY, Issue 6 2004Sergey A. Alexandrov Abstract We present an application of digital Fourier holography for selective imaging of scatterers with different sizes in turbid media such as biological tissues. A combination of Fourier holography and high-resolution digital recording, digital Fourier microscopy (DFM) permits crucial flexibility in applying filtering to highlight scatterers of interest in the tissue. The high-resolution digital hologram is a result of the collation of Fourier holographic frames to form a large-size composite hologram. It is expected that DFM has an improved signal-to-noise ratio as compared to conventional direct digital imaging, e.g., phase microscopy, as applied to imaging of small-size objects. The demonstration of the Fourier filtering capacity of DFM using a biological phantom represents the main focus of this article. © 2005 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 14, 253,258, 2004; Published online inWiley InterScience (www.interscience.wiley.com). DOI 10.1002/ima.20031 [source] Illegal Migration: What Can We Know And What Can We Explain?INTERNATIONAL MIGRATION REVIEW, Issue 3 2004The Case of Germany Methodological problems in the study of illegal migration as defined in this article relate to questions of indicators for illegal migration, with special reference to Germany. It is argued and demonstrated that illegal immigrants are traceable, to some degree, in official statistics and that these can be analyzed for trends. In present-day migration processes, illegal immigration frequently is undertaken with the support of human smugglers. The analysis of the social organization of different forms of smuggling is the other main focus of the article. From a methodological point of view, the literature and public discourse lack adequate concepts for describing and explaining the social organization of human smuggling. The theory of organized crime as a main actor in human smuggling is criticized. The study borrows concepts from market and networks theory and applies these to different forms of human smuggling and illegal migration. The social and technological organization of smuggling is under constant pressure to adapt to new conditions. The dynamism for this change results mainly from an "arms race" between smugglers and law enforcement. Since control over territory and population are central elements of state sovereignty, the state cannot simply withdraw from this race. [source] Karl Pearson and the Establishment of Mathematical StatisticsINTERNATIONAL STATISTICAL REVIEW, Issue 1 2009M. Eileen Magnello Summary At the end of the nineteenth century, the content and practice of statistics underwent a series of transitions that led to its emergence as a highly specialised mathematical discipline. These intellectual and later institutional changes were, in part, brought about by a mathematical-statistical translation of Charles Darwin's redefinition of the biological species as something that could be viewed in terms of populations. Karl Pearson and W.F.R. Weldon's mathematical reconceptualisation of Darwinian biological variation and "statistical" population of species in the 1890s provided the framework within which a major paradigmatic shift occurred in statistical techniques and theory. Weldon's work on the shore crab in Naples and Plymouth from 1892 to 1895 not only brought them into the forefront of ideas of speciation and provided the impetus to Pearson's earliest statistical innovations, but it also led to Pearson shifting his professional interests from having had an established career as a mathematical physicist to developing one as a biometrician. The innovative statistical work Pearson undertook with Weldon in 1892 and later with Francis Galton in 1894 enabled him to lay the foundations of modern mathematical statistics. While Pearson's diverse publications, his establishment of four laboratories and the creation of new academic departments underscore the plurality of his work, the main focus of his life-long career was in the establishment and promulgation of his statistical methodology. [source] Quantitative analysis of passenger and baggage security screening at airportsJOURNAL OF ADVANCED TRANSPORTATION, Issue 2 2007Alexandre G. de Barros The terrorist attacks in the United States in 2001 opened a new era in air transportation. The realization that civil aircraft can be used as powerful weapons of mass destruction by a small group of people has drastically increased the need for security screening procedures to protect civil flights. Serving as the interface between the air and land transportation modes, airports have become the main focus in the implementation of those procedures. The need to more thoroughly screen passengers and baggage, and the consequent increase in processing time, has created the need for more space for security checkpoints and baggage screening inside passenger terminal buildings,space that is costly and very difficult to find in existing buildings. This paper evaluates the impact those measures have had on the planning and operation of airport passenger terminals. Quantification of those impacts is performed with the use of discrete-event simulation and spreadsheet models. [source] Normal mixture GARCH(1,1): applications to exchange rate modellingJOURNAL OF APPLIED ECONOMETRICS, Issue 3 2006Carol Alexander Some recent specifications for GARCH error processes explicitly assume a conditional variance that is generated by a mixture of normal components, albeit with some parameter restrictions. This paper analyses the general normal mixture GARCH(1,1) model which can capture time variation in both conditional skewness and kurtosis. A main focus of the paper is to provide evidence that, for modelling exchange rates, generalized two-component normal mixture GARCH(1,1) models perform better than those with three or more components, and better than symmetric and skewed Student's t -GARCH models. In addition to the extensive empirical results based on simulation and on historical data on three US dollar foreign exchange rates (British pound, euro and Japanese yen), we derive: expressions for the conditional and unconditional moments of all models; parameter conditions to ensure that the second and fourth conditional and unconditional moments are positive and finite; and analytic derivatives for the maximum likelihood estimation of the model parameters and standard errors of the estimates. Copyright © 2006 John Wiley & Sons, Ltd. [source] Effect of filler content and size on the properties of ethylene vinyl acetate copolymer,wood fiber compositesJOURNAL OF APPLIED POLYMER SCIENCE, Issue 6 2007D. G. Dikobe Abstract In this study, the main focus was on the effect of wood fiber (WF) content and particle size on the morphology and mechanical, thermal, and water-absorption properties of uncompatibilized and ethylene glycidyl methacrylate copolymer (EGMA) compatibilized ethylene vinyl acetate copolymer,WF composites. For uncompatibilized composites, the tensile strength decreased with increasing WF content, whereas for compatibilized composites, the tensile strength initially decreased, but it increased for composites containing more than 5% WF. Small-WF-particle-containing composites had higher tensile strengths than composites containing larger WF particles, both in the presence and absence of EGMA. WF particle size did not seem to have much influence on the degradation behavior of the composites, whereas water absorption by the composites seemed to be higher in composites with smaller particle sizes for both compatibilized and uncompatibilized composites. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 3645,3654, 2007 [source] Exploring consumer status and conspicuous consumptionJOURNAL OF CONSUMER BEHAVIOUR, Issue 1 2004Professor Aron O'Cass Abstract In seeking to expand an understanding of consumption, this study assesses the relationship between status consumption and conspicuous consumption. Theoretically, the relationship between status consumption and conspicuous consumption is problematic and, therefore, the main focus of this paper examines the theoretical and empirical separation of consumers' status consumption and conspicuous consumption. Data were gathered via a survey of individuals aged between 18 and 25. The findings indicate that status consumption and conspicuous consumption are distinct constructs. Differences in status consumption tendencies between males and females were not found; however, in relation to conspicuous consumption gender differences were found. Status consumption was affected by self-monitoring and interpersonal influences, but conspicuous consumption was affected only by interpersonal influences. The brands examined also clearly differed in terms of status and conspicuous consumption perceptions. Copyright © 2004 Henry Stewart Publications Ltd. [source] Common single nucleotide polymorphism of hypoxia-inducible factor-1, and its impact on the clinicopathological features of esophageal squamous cell carcinomaJOURNAL OF DIGESTIVE DISEASES, Issue 4 2005Ting Sheng LING OBJECTIVE: Angiogenesis is one of the most important molecular events in solid tumor development and growth, in which hypoxia-inducible factor (HIF)-1, is a key regulator and plays an important role. Studies have shown that a single nucleotide polymorphism (C1772T) in the HIF-1, gene exerts a large effect on the phenotype of human head and neck squamous cell carcinoma and renal cell carcinoma. But the impact of the C1772T polymorphism on the clinicopathological features of human esophageal squamous cell carcinoma (ESCC) remains unknown, and thus it is the main focus of our study. METHODS: The C1772T genotype of 95 ESCC patients and 104 healthy controls were studied by using the polymerase chain reaction and restriction fragment length polymorphism. Mutations were confirmed by direct DNA sequencing. The impact of C1772T on tumor size, invasive depth, lymph node metastasis, distant metastasis, histological grade and TNM stage was also studied. RESULTS: The genotype frequency observed in the patients and controls was 11.58% versus 10.58%, respectively, for genotype C/T (P > 0.05). Genotype T/T was not found in our study. Larger tumors and a higher rate of lymph node metastasis was found for the C/T group. CONCLUSIONS: Although there is no significant difference of genotype distribution between ESCC patients and healthy controls, genotype C/T is associated with larger tumor and higher rate of lymph node metastasis. [source] The State as Parent: The Reluctant Parent?JOURNAL OF LAW AND SOCIETY, Issue 1 2008The Problems of Parents of Last Resort This paper will explore the idea of the local authority as a reluctant parent. It will consider the extent to which this reluctance is produced by the care proceedings system and its consequences for children. Local authorities are both expected to refrain from intervening (care proceedings are a measure of last resort) and to be fully prepared for intervention (whilst leaving children with their parents). Amongst the themes which will be developed here are the impact of the juridification of social work and the emphasis on the courts for holding local authorities to account; the balance between voluntary accommodation and compulsory care; and the problems of resourcing care services. Its main focus will be on children who enter care because of abuse or neglect. Its thesis is that the conflicting expectations on local authorities, resource constraints, and considerations of legal process make them reluctant parents. [source] Organic dyes as small molecule protein,protein interaction inhibitors for the CD40,CD154 costimulatory interactionJOURNAL OF MOLECULAR RECOGNITION, Issue 1 2010Peter Buchwald Abstract It is becoming increasingly clear that small molecules can often act as effective protein,protein interaction (PPI) inhibitors, an area of increasing interest for its many possible therapeutic applications. We have identified several organic dyes and related small molecules that (i) concentration-dependently inhibit the important CD40,CD154 costimulatory interaction with activities in the low micromolar (µM) range, (ii) show selectivity toward this particular PPI, (iii) seem to bind on the surface of CD154, and (iv) concentration-dependently inhibit the CD154-induced B cell proliferation. They were identified through an iterative activity screening/structural similarity search procedure starting with suramin as lead, and the best smaller compounds, the main focus of the present work, achieved an almost 3-fold increase in ligand efficiency (,G0/nonhydrogen atom,=,0.8,kJ/NnHa) approaching the average of known promising small-molecule PPI inhibitors (,1.0,kJ/NnHa). Since CD154 is a member of the tumor necrosis factor (TNF) superfamily of cell surface interaction molecules, inhibitory activities on the TNF-R1,TNF- , interactions were also determined to test for specificity, and the compounds selected here all showed more than 30-fold selectivity toward the CD40,CD154 interaction. Because of their easy availability in various structural scaffolds and because of their good protein-binding ability, often explored for tissue-specific staining and other purposes, such organic dyes can provide a valuable addition to the chemical space searched to identify small molecule PPI inhibitors in general. Copyright © 2009 John Wiley & Sons, Ltd. [source] Process intensification aspects for steam methane reforming: An overviewAICHE JOURNAL, Issue 2 2009Shrikant A. Bhat Abstract Steam methane reforming (SMR) is the most widely used process in industry for the production of hydrogen, which is considered as the future generation energy carrier. Having been perceived as an important source of H2, there are abundant incentives for design and development of SMR processes mainly through the consideration of process intensification and multiscale modeling; two areas which are considered as the main focus of the future generation chemical engineering to meet the global energy challenges. This article presents a comprehensive overview of the process integration aspects for SMR, especially the potential for multiscale modeling in this area. The intensification for SMR is achieved by coupling with adsorption and membrane separation technologies, etc., and using the concept of multifunctional reactors and catalysts to overcome the mass transfer, heat transfer, and thermodynamic limitations. In this article, the focus of existing and future research on these emerging areas has been drawn. © 2009 American Institute of Chemical Engineers AIChE J, 2009 [source] Training in cognitive behavioural interventions on acute psychiatric inpatient wardsJOURNAL OF PSYCHIATRIC & MENTAL HEALTH NURSING, Issue 2 2005E. McCANN phd msc rmn dip psi pgdip (academic practice) There has been a drive towards addressing the types of care and therapeutic interventions available to people with serious mental illness, which is reflected in the latest government mental health policy initiatives. Recent evidence strongly supports the implementation of psychological and social interventions for people with psychosis, and in particular the use of cognitive behavioural techniques. Until now, the main focus has been on people living in the community. This study examines the delivery of psychosocial interventions training to qualified psychiatric nurses and unqualified staff on seven acute psychiatric admission wards in London, UK. The approach had the strength of on-site delivery, follow-up role modelling of the interventions and clinical supervision. Despite this, in some cases the training was less successful, mainly because of staffing and leadership weaknesses. The impact of training in these methods and the implications for mental health education and practice development are discussed. [source] Economic interest groups and the consolidation of democracy in the Czech RepublicJOURNAL OF PUBLIC AFFAIRS, Issue 1-2 2008Robert K. Evanson This paper discusses organized economic interest groups in the Czech Republic placed in the context of the development of interest group activity in the post communist era and how this bodes for the consolidation of Czech democracy. After a brief overview of Czech political and economic developments since the end of communist rule, the origins, evolution and present state of interest groups are outlined. There has been a proliferation of economic interest groups, particularly in the business arena. However, there are some concerns about interest groups activity, which are examined next. The paper then moves to its main focus,the examination of economic interests. It does this by explaining the interaction among business, labour and government in the policy-making arena and explaining apparent contradictions in the perceived influence of business. This is followed by a similar look at Czech agriculture. The paper concludes with some speculation about the likely future development of interest groups and what this might mean for the nature of Czech democracy. Copyright © 2008 John Wiley & Sons, Ltd. Copyright © 2008 John Wiley & Sons, Ltd. [source] User perspectives on relevance criteria: A comparison among relevant, partially relevant, and not-relevant judgmentsJOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY, Issue 5 2002Kelly L. Maglaughlin This study investigates the use of criteria to assess relevant, partially relevant, and not-relevant documents. Study participants identified passages within 20 document representations that they used to make relevance judgments; judged each document representation as a whole to be relevant, partially relevant, or not relevant to their information need; and explained their decisions in an interview. Analysis revealed 29 criteria, discussed positively and negatively, that were used by the participants when selecting passages that contributed or detracted from a document's relevance. These criteria can be grouped into six categories: abstract (e.g., citability, informativeness), author (e.g., novelty, discipline, affiliation, perceived status), content (e.g., accuracy/validity, background, novelty, contrast, depth/scope, domain, citations, links, relevant to other interests, rarity, subject matter, thought catalyst), full text (e.g., audience, novelty, type, possible content, utility), journal/publisher (e.g., novelty, main focus, perceived quality), and personal (e.g., competition, time requirements). Results further indicate that multiple criteria are used when making relevant, partially relevant, and not-relevant judgments, and that most criteria can have either a positive or negative contribution to the relevance of a document. The criteria most frequently mentioned by study participants were content, followed by criteria characterizing the full text document. These findings may have implications for relevance feedback in information retrieval systems, suggesting that systems accept and utilize multiple positive and negative relevance criteria from users. Systems designers may want to focus on supporting content criteria followed by full text criteria as these may provide the greatest cost benefit. [source] | ||||||||||||||||||||||||||||||||||||||||