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Main Drivers (main + drivers)
Selected AbstractsFrom financial to sustainable profitCORPORATE SOCIAL RESPONSIBILITY AND ENVIRONMENTAL MANAGEMENT, Issue 2 2002Prof. Jacqueline Cramer This article explains why sustainable business has caught the spotlight at this particular time. Main drivers are the shift in power relationships between states, firms and households, the emergence of civil regulation and the communication through networks. The implication of this trend towards sustainable business is that firms will consciously need to focus on creating value not only in financial terms, but also in ecological and social terms. The challenge facing the business sector is how to set about meeting these expectations. Firms will need to change not only in themselves, but also in the way they interact with their environment. Copyright © 2002 John Wiley & Sons, Ltd. and ERP Environment [source] THIS IS NOT AMERICA: EMBEDDING THE COGNITIVE-CULTURAL URBAN ECONOMYGEOGRAFISKA ANNALER SERIES B: HUMAN GEOGRAPHY, Issue 2 2010Robert C. Kloosterman ABSTRACT. The aim of this article is to broaden the epistemological basis for investigating the current shift to cognitive-cultural economies and the resurgence of cities and its socio-spatial articulation. The point of departure here is that the drivers of the structural changes are indeed more or less ubiquitous, but are played out in different national institutional and urban contexts resulting in potentially diverging cognitive-cultural economies. Four main drivers of change after 1980 are distinguished. The first is the rise of a new technological paradigm based on digital technology. The second is the thrust towards deregulation and privatization as planks of the neo-liberal political programme. The third is the intensification of all kinds of linkages between regions across the globe. The fourth driver constitutes the processes of individualization and increasing reflexivity that have fragmented consumer markets. By identifying distinct filters which might shape and mould the impact of these more general drivers on concrete urban areas, a comprehensive framework is presented that can be used to analyse and compare the trajectories of cities while linking them to a larger narrative of societal change. A central line of reasoning is that agglomeration economies , pivotal in Allen Scott's analysis of the emergence of a cognitive-cultural economy , are themselves embedded in concrete social and institutional contexts which impact on how they are played out. To make this point, we build upon Richard Whitley's business systems. Given this institutional diversity, we expect that various institutional contexts will generate different cognitive-cultural economies. [source] Region-specific assessment of greenhouse gas mitigation with different manure management strategies in four agroecological zonesGLOBAL CHANGE BIOLOGY, Issue 12 2009SVEN G. SOMMER Abstract Livestock farming systems are major sources of trace gases contributing to emissions of the greenhouse gases (GHG) nitrous oxide (N2O) and methane (CH4), i.e. N2O accounts for 10% and CH4 for 30% of the anthropogenic contributions to net global warming. This paper presents scenario assessments of whole-system effects of technologies for reducing GHG emissions from livestock model farms using slurry-based manure management. Changes in housing and storage practice, mechanical separation, and incineration of the solid fraction derived from separation were evaluated in scenarios for Sweden, Denmark, France, and Italy. The results demonstrated that changes in manure management can induce significant changes in CH4 and N2O emissions and carbon sequestration, and that the effect of introducing environmental technologies may vary significantly with livestock farming practice and interact with climatic conditions. Shortening the in-house manure storage time reduced GHG emissions by 0,40%. The largest GHG reductions of 49 to, in one case, 82% were obtained with a combination of slurry separation and incineration, the latter process contributing to a positive GHG balance of the system by substituting fossil fuels. The amount and composition of volatile solids (VS) and nitrogen pools were main drivers in the calculations performed, and requirements to improve the assessment of VS composition and turnover during storage and in the field were identified. Nevertheless, the results clearly showed that GHG emission estimates will be unrealistic, if the assumed manure management or climatic conditions do not properly represent a given country or region. The results also showed that the mitigation potential of specific manure management strategies and technologies varied depending on current management and climatic conditions. [source] Proximity to death and participation in the long-term care marketHEALTH ECONOMICS, Issue 8 2009France Weaver Abstract The extent to which increasing longevity increases per capita demand for long-term care depends on the degree to which utilization is concentrated at the end of life. We estimate the marginal effect of proximity to death, measured by being within 2 years of death, on the probabilities of nursing home and formal home care use, and we determine whether this effect differs by availability of informal care , i.e. marital status and co-residence with an adult child. The analysis uses a sample of elderly aged 70+from the 1993,2002 Health and Retirement Study. Simultaneous probit models address the joint decisions to use long-term care and co-reside with an adult child. Overall, proximity to death significantly increases the probability of nursing home use by 50.0% and of formal home care use by 12.4%. Availability of informal support significantly reduces the effect of proximity to death. Among married elderly, proximity to death has no effect on institutionalization. In conclusion, proximity to death is one of the main drivers of long-term care use, but changes in sources of informal support, such as an increase in the proportion of married elderly, may lessen its importance in shaping the demand for long-term care. Copyright © 2008 John Wiley & Sons, Ltd. [source] The recent declines of farmland bird populations in Britain: an appraisal of causal factors and conservation actionsIBIS, Issue 4 2004Ian Newton In this paper, the main aspects of agricultural intensification that have led to population declines in farmland birds over the past 50 years are reviewed, together with the current state of knowledge, and the effects of recent conservation actions. For each of 30 declining species, attention is focused on: (1) the external causes of population declines, (2) the demographic mechanisms and (3) experimental tests of proposed external causal factors, together with the outcome of (4) specific conservation measures and (5) agri-environment schemes. Although each species has responded individually to particular aspects of agricultural change, certain groups of species share common causal factors. For example, declines in the population levels of seed-eating birds have been driven primarily by herbicide use and the switch from spring-sown to autumn-sown cereals, both of which have massively reduced the food supplies of these birds. Their population declines have been associated with reduced survival rates and, in some species, also with reduced reproductive rates. In waders of damp grassland, population declines have been driven mainly by land drainage and the associated intensification of grassland management. This has led to reduced reproductive success, as a result of lowered food availability, together with increased disturbance and trampling by farm stock, and in some localities increased nest predation. The external causal factors of population decline are known (with varying degrees of certainty) for all 30 species considered, and the demographic causal factors are known (again with varying degrees of certainty) for 24 such species. In at least 19 species, proposed causal factors have been tested and confirmed by experiment or by local conservation action, and 12 species have been shown to benefit (in terms of locally increased breeding density) from options available in one or more agri-environment schemes. Four aspects of agricultural change have been the main drivers of bird population declines, each affecting a wide range of species, namely: (1) weed-control, mainly through herbicide use; (2) the change from spring-sown to autumn-sown cereal varieties, and the associated earlier ploughing of stubbles and earlier crop growth; (3) land drainage and associated intensification of grassland management; and (4) increased stocking densities, mainly of cattle in the lowlands and sheep in the uplands. These changes have reduced the amounts of habitat and/or food available to many species. Other changes, such as the removal of hedgerows and ,rough patches', have affected smaller numbers of species, as have changes in the timings of cultivations and harvests. Although at least eight species have shown recent increases in their national population levels, many others seem set to continue declining, or to remain at a much reduced level, unless some relevant aspect of agricultural practice is changed. [source] A macroevolutionary mosaic: episodic host-switching, geographical colonization and diversification in complex host,parasite systemsJOURNAL OF BIOGEOGRAPHY, Issue 9 2008Eric P. Hoberg Abstract Aim, To integrate ecological fitting, the oscillation hypothesis and the taxon pulse hypothesis into a coherent null model for the evolution of complex host,parasite associations. Location, Global. Methods, This paper reviews and synthesizes literature that focuses on phylogenetic analyses and reciprocal mapping of a model system of hosts and their parasites to determine patterns of host,parasite associations and geographical distributions through time. Results, Host-switching and geographical dispersal of parasites are common phenomena, occurring on many temporal and spatial scales. Diversification involving both co-evolution and colonization explains complex host,parasite associations. Across the expanse of Earth history, the major radiations in host,parasite assemblages have been preceded by ecological disruption, ecological breakdown and host-switching in a context that can be defined by the concept of ecological fitting. This cyclical process sets the stage for co-diversification during periods of relative stability, punctuated by host-switching during episodes of regional to global environmental disruption and climatological change. Main conclusions, Most observed host,parasite associations can be explained by an historical interaction between ecological fitting, oscillation (episodes of increasing host range alternating with isolation on particular hosts) and taxon pulses (cyclical episodes of expansion and isolation in geographical range). Major episodes of environmental change appear to be the main drivers for both the persistence and diversification of host,parasite systems, creating opportunities for host-switching during periods of geographical expansion and allowing for co-evolution and co-speciation during periods of geographical isolation. [source] Green Energy or Organic Food?: A Life-Cycle Assessment Comparing Two Uses of Set-Aside LandJOURNAL OF INDUSTRIAL ECOLOGY, Issue 3 2001Richard van den Broek Summary Bioenergy has a large worldwide potential in future climate change abatement, although its application may become limited by demands for land for other functions. The aim of this study was to make an environmental assessment of the use of energy crops in the Netherlands in a context that incorporates scarcity of land. A base case system was defined, consisting of conventional winter wheat production, set-aside land (1 hectare, together), and the production of coal-based electricity. Using life-cycle assessment, we compared this system with (1) a green energy system in which willow is cultivated on the set-aside land to replace the coal-based electricity and (2) an organic agriculture system in which the full hectare produces wheat under the Dutch EKO organic agriculture standard. In this way, the functional unit and the amount of land used is the same in each system. The final system comparison was based on normalized scores per environmental theme. The green energy system scored the best with respect to acidification, climate change, and energy carrier depletion. The organic food system scored best on terrestrial eco-toxicity and slightly better on the mutually related themes of seawater and seawater sediment eco-toxicity. The base case system performed slightly better with regard to eutrophication. Preferences, from an environmental point of view, for one of the systems should be determined by environmental policy priorities and the severity of local environmental problems. The case studied here shows that when climate change, energy carrier depletion, and acidification are the main drivers behind environmental policy, one should focus not on the extensification of agriculture, but rather dedicate more land to energy crops. Extensification of agriculture would be the preferred system when toxicity from pesticides is considered the main problem. [source] Marginal Land-based Biomass Energy Production in ChinaJOURNAL OF INTEGRATIVE PLANT BIOLOGY, Issue 1 2010Ya Tang Fast economic development in China has resulted in a significant increase in energy demand. Coal accounts for 70% of China's primary energy consumption and its combustion has caused many environmental and health problems. Energy security and environmental protection requirements are the main drivers for renewable energy development in China. Small farmland and food security make bioenergy derived from corn or sugarcane unacceptable to China: the focus should be on generating bioenergy from ligno-cellulosic feedstock sources. As China cannot afford biomass energy production from its croplands, marginal lands may play an important role in biomass energy production. Although on a small scale, marginal land has already been used for various purposes. It is estimated that some 45 million hm2 of marginal land could be brought into high potential biomass energy production. For the success of such an initiative, it will likely be necessary to develop multipurpose plants. A case study, carried out on marginal land in Ningnan County, Sichuan Province with per capita cropland of 0.07 ha, indicated that some 380 000 tons of dry biomass could be produced each year from annual pruning of mulberry trees. This study supports the feasibility of producing large quantities of biomass from marginal land sources. [source] Factors That Influence Chief Purchasing Officer CompensationJOURNAL OF SUPPLY CHAIN MANAGEMENT, Issue 3 2002Jeffrey A. Ogden SUMMARY While several previous surveys have examined the salaries of purchasing professionals, none have addressed the specific issues related to chief purchasing officer (CPO) compensation. This article presents the results of a CAPS Research survey investigating job related and personal characteristics that influence Fortune 500 chief purchasing officer compensation. Logistic regression was used to deriveodds ratios to analyze the surve data. Empirical results indicate that the following are the main drivers of CPO compensation: (1) industry, (2) size of organization as measured by annual sales, (3) spend as a percent of sales, (4) total number of employees reporting, (5) levels of management between the CPO and CEO, (6) years of businessrelated, non-purchasing experience, (7) CPO age, and (8) professional certifications. Implications of the research findings are discussed throughout the article. [source] Plant functional group composition and large-scale species richness in European agricultural landscapesJOURNAL OF VEGETATION SCIENCE, Issue 1 2008Jaan Liira Abstract Question: Which are the plant functional groups responding most clearly to agricultural disturbances? Which are the relative roles of habitat availability, landscape configuration and agricultural land use intensity in affecting the functional composition and diversity of vascular plants in agricultural landscapes? Location: 25 agricultural landscape areas in seven European countries. Methods: We examined the plant species richness and abundance in 4 km × 4 km landscape study sites. The plant functional group classification was derived from the BIOLFLOR database. Factorial decomposition of functional groups was applied. Results: Natural habitat availability and low land use intensity supported the abundance and richness of perennials, sedges, pteridophytes and high nature quality indicator species. The abundance of clonal species, C and S strategists was also correlated with habitat area. An increasing density of field edges explained a decrease in richness of high nature quality species and an increase in richness of annual graminoids. Intensive agriculture enhanced the richness of annuals and low nature quality species. Conclusions: Habitat patch availability and habitat quality are the main drivers of functional group composition and plant species richness in European agricultural landscapes. Linear elements do not compensate for the loss of habitats, as they mostly support disturbance tolerant generalist species. In order to conserve vascular plant species diversity in agricultural landscapes, the protection and enlargement of existing patches of (semi-) natural habitats appears to be more effective than relying on the rescue effect of linear elements. This should be done in combination with appropriate agricultural management techniques to limit the effect of agrochemicals to the fields. [source] Edge effects as the principal cause of area effects on birds in fragmented secondary forestOIKOS, Issue 6 2010Cristina Banks-Leite Bird communities in tropical forests are strongly affected by both patch area and habitat edges. The fact that both effects are intrinsically confounded in space raises questions about how these two widely reported ecological patterns interact, and whether they are independent or simply different spatial manifestations of the same phenomenon. Moreover, do small patches of secondary forest, in landscapes where the most sensitive species have gone locally extinct, exhibit similar patterns to those previously observed in fragmented and continuous primary forests? We addressed these questions by testing edge-related differences in vegetation structure and bird community composition at 31 sites in fragmented and continuous landscapes in the imperilled Atlantic forest of Brazil. Over a two-year period, birds were captured with mist nets to a standardized effort of 680 net-hours at each site (,22 000 net-hours resulting in 3381 captures from 114 species). We found that the bird community in patches of secondary forest was degraded in species composition compared to primary continuous forest, but still exhibited a strong response to edge effects. In fragmented secondary forests, edge and area effects also interacted, such that the magnitude of edge to interior differences on bird community composition declined markedly with patch size. The change in bird species composition between forest interiors and edges was similar to the change in community composition between large and small patches (because species had congruent responses to edge and area), but after controlling for edge effects community composition was no longer affected by patch area. Our results show that although secondary forests hold an impoverished bird community, ecological patterns such as area and edge effects are similar to those reported for primary forests. Our data provide further evidence that edge effects are the main drivers of area effects in fragmented landscapes. [source] The drivers behind the globalization of natural gas marketsOPEC ENERGY REVIEW, Issue 2 2006Ahmed El Hachemi Mazighi Today, the globalisation of natural gas markets is a topic much discussed amongst gas industry practitioners, policy makers and academics. If there is a consensus on a tendency towards the "commoditisation" of natural gas markets, there is less agreement on the certainty of the global approach to gas marketing. The aim of this paper is to untangle the main drivers behind the globalisation of natural gas markets, both on the demand and supply sides, and to discuss problems related to the market structure, such as price arbitrages and organised markets. The paper will conclude that the globalisation of natural gas markets cannot be approached as a deterministic problem and as a consequence, there is still no precise answer as to when the different regional gas markets will forge a global one. [source] Sensitivity analyses for four pesticide leaching modelsPEST MANAGEMENT SCIENCE (FORMERLY: PESTICIDE SCIENCE), Issue 9 2003Igor G Dubus Abstract Sensitivity analyses using a one-at-a-time approach were carried out for leaching models which have been widely used for pesticide registration in Europe (PELMO, PRZM, PESTLA and MACRO). Four scenarios were considered for simulation of the leaching of two theoretical pesticides in a sandy loam and a clay loam soil, each with a broad distribution across Europe. Input parameters were varied within bounds reflecting their uncertainty and the influence of these variations on model predictions was investigated for accumulated percolation at 1-m depth and pesticide loading in leachate. Predictions for the base-case scenarios differed between chromatographic models and the preferential flow model MACRO for which large but transient pesticide losses were predicted in the clay loam. Volumes of percolated water predicted by the four models were affected by a small number of input parameters and to a small extent only, suggesting that meteorological variables will be the main drivers of water balance predictions. In contrast to percolation, predictions for pesticide loss were found to be sensitive to a large number of input parameters and to a much greater extent. Parameters which had the largest influence on the prediction of pesticide loss were generally those related to chemical sorption (Freundlich exponent nf and distribution coefficient Kf) and degradation (either degradation rates or DT50, QTEN value). Nevertheless, a significant influence of soil properties (field capacity, bulk density or parameters defining the boundary between flow domains in MACRO) was also noted in at least one scenario for all models. Large sensitivities were reported for all models, especially PELMO and PRZM, and sensitivity was greater where only limited leaching was simulated. Uncertainty should be addressed in risk assessment procedures for crop-protection products. Copyright © 2003 Society of Chemical Industry [source] An ecosystem-scale predictive model of coastal seagrass distributionAQUATIC CONSERVATION: MARINE AND FRESHWATER ECOSYSTEMS, Issue 4 2010A. Grech Abstract 1.Maintaining ecological processes that underpin the functioning of marine ecosystems requires planning and management of marine resources at an appropriate spatial scale. 2.The Great Barrier Reef World Heritage Area (GBR) is the world's largest World Heritage Area (approximately 348,000,km2) and second largest marine protected area. It is difficult to inform the planning and management of marine ecosystems at that scale because of the high cost associated with collecting data. To address this and to inform the management of coastal (approximately 15,m below mean sea level) habitats at the scale of the GBR, this study determined the presence and distribution of seagrass by generating a Geographic Information System (GIS)-based habitat suitability model. 3.A Bayesian belief network was used to quantify the relationship (dependencies) between seagrass and eight environmental drivers: relative wave exposure, bathymetry, spatial extent of flood plumes, season, substrate, region, tidal range and sea surface temperature. The analysis showed at the scale of the entire coastal GBR that the main drivers of seagrass presence were tidal range and relative wave exposure. Outputs of the model include probabilistic GIS-surfaces of seagrass habitat suitability in two seasons and at a planning unit of cell size 2,km×2,km. 4.The habitat suitability maps developed in this study extend along the entire GBR coast, and can inform the management of coastal seagrasses at an ecosystem scale. The predictive modelling approach addresses the problems associated with delineating habitats at the scale appropriate for the management of ecosystems and the cost of collecting field data. Copyright © 2010 John Wiley & Sons, Ltd. [source] Assessing the Equilibrium Exchange Rate of the Malaysian Ringgit: A Comparison of Alternative ApproachesASIAN ECONOMIC JOURNAL, Issue 2 2008Isabell Koske F3; F31; F32 Drawing on the behavioral equilibrium exchange rate and the fundamental equilibrium exchange rate approaches, this paper assesses the equilibrium value of the real effective exchange rate of the Malaysian ringgit over the past 25 years. For 2005, when the Malaysian authorities exited from the peg with the US dollar, both models determine a slight undervaluation of the currency. Openness and real GDP per capita have been the main drivers of real exchange rate movements in the past, although non-tradable productivity, government consumption, and net foreign assets have also had a sizable impact. The paper also highlights the limitations of applying the two approaches in the context of emerging countries. [source] Environmental challenges in the energy sector: a chemical engineering perspective,ASIA-PACIFIC JOURNAL OF CHEMICAL ENGINEERING, Issue 4 2010Philippe A. Tanguy Abstract The supply of energy in sufficient quantities and the access to clean water are among the most significant global challenges to address in the decades to come, as these are key elements of human well-being and further development. These challenges are of course related, and future practices must consider their connectivity. As the present energy system is clearly reaching its limits in terms of sustainability, new approaches have been proposed based on much improved energy efficiency, development of renewable and new energy sources, and the use of carbon capture and storage for fossil resources. The industrial deployment of these alternate scenarios is intrinsically related to the availability of water on a large scale. Because the access to freshwater is becoming scarce in many countries, better water practices and the exploitation of new water resources must be developed for the supply of industrial water. This paper begins with a brief description of our present energy system based on fossil resources, this being a legacy of the industrial revolution. We then review the main drivers supporting the energy and water demand, and the constraints they are facing. The final section considers several chemical engineering challenges that arise when proposing ways of dealing with the energy-environment nexus in the future. Copyright © 2010 Curtin University of Technology and John Wiley & Sons, Ltd. [source] SCG0018-4854: A young and dynamic compact groupASTRONOMISCHE NACHRICHTEN, Issue 9-10 2009V. Presotto Abstract It is widely recognized in the literature that processes taking place within the group environment are among the main drivers of galaxy evolution. SCG0018-4854 is a compact group of galaxies located at a distance of v , 3200 km s,1. It is composed of four galaxy members, very close to each other on the sky: their median projected distance is only ,20 Kpc (H = 70 km s,1Mpc,1). The remarkably high local galaxy density coupled with the low velocity dispersion (,100 km s,1) characterizing this group, makes SCG001 8-4854 a test case to study in detail the interplay between the environment and the galaxy properties. We present here some of the properties of the group members that are related to their mutual interaction, as derived from our kinematical and morphological analysis (© 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] Variation in ecophysiology and carbon economy of invasive and native woody vines of riparian zones in south-eastern QueenslandAUSTRAL ECOLOGY, Issue 6 2010OLUSEGUN O. OSUNKOYA Abstract Exotic and invasive woody vines are major environmental weeds of riparian areas, rainforest communities and remnant natural vegetation in coastal eastern Australia, where they smother standing vegetation, including large trees, and cause canopy collapse. We investigated, through glasshouse resource manipulative experiments, the ecophysiological traits that might facilitate faster growth, better resource acquisition and/or utilization and thus dominance of four exotic and invasive vines of South East Queensland, Australia, compared with their native counterparts. Relative growth rate was not significantly different between the two groups but water use efficiency (WUE) was higher in the native species while the converse was observed for light use efficiency (quantum efficiency, AQE) and maximum photosynthesis on a mass basis (). The invasive species, as a group, also exhibited higher respiration load, higher light compensation point and higher specific leaf area. There were stronger correlations of leaf traits and greater structural (but not physiological) plasticity in invasive species than in their native counterparts. The scaling coefficients of resource use efficiencies (WUE, AQE and respiration efficiency) as well as those of fitness (biomass accumulated) versus many of the performance traits examined did not differ between the two species-origin groups, but there were indications of significant shifts in elevation (intercept values) and shifts along common slopes in many of these relationships , signalling differences in carbon economy (revenue returned per unit energy invested) and/or resource usage. Using ordination and based on 14 ecophysiological attributes, a fair level of separation between the two groups was achieved (51.5% explanatory power), with AQE, light compensation point, respiration load, WUE, specific leaf area and leaf area ratio, in decreasing order, being the main drivers. This study suggests similarity in trait plasticity, especially for physiological traits, but there appear to be fundamental differences in carbon economy and resource conservation between native and invasive vine species. [source] Meeting the environmental challenge: a case of win,win or lose,win?BUSINESS STRATEGY AND THE ENVIRONMENT, Issue 3 2004A study of the UK baking, refrigeration industries The idea that what is good for the environment is good for business has come to dominate environmental thinking and provides one of the cornerstones of ecological modernization. Studies of this win,win philosophy have tended to concentrate on large companies. This study considers how the UK refrigeration and baking industries have responded to the main drivers for change. By eliciting managers' views of environmental issues through semi-structured interviews, the problems and opportunities facing these two industries are explored. The responses were remarkably similar, given the different characteristics of the two industries. The interviews revealed that legislation maintains its pre-eminence as a motivation for change. Win,win situations arising out of environmental legislation were found in some SMEs; however, for most the perception was one of lose,win. The demand for environmental products and processes, necessary for win,win, has yet to materialize. Companies, therefore, remain driven by the commercial, rather than the environmental, imperative. Copyright © 2004 John Wiley & Sons, Ltd and ERP Environment. [source] It takes two to tango: Combinations of conventional cytotoxics with compounds targeting the vascular endothelial growth factor,vascular endothelial growth factor receptor pathway in patients with solid malignanciesCANCER SCIENCE, Issue 1 2010Ingrid A. Boere Through advances in molecular biology, insight into the mechanisms driving malignancies has improved immensely and as a result, various factors playing an essential role in the biology of numerous tumor types have been revealed. By using compounds that specifically block the function of a single factor being crucial for tumor pathogenesis, it was hoped to exert antitumor activity while avoiding toxicities characteristic for conventional chemotherapy. One of the processes of crucial importance in the development of cancer, and consequently an attractive target, is angiogenesis. In recent years, several key factors for angiogenesis have been identified, including ligands, receptors, and transduction signaling factors. Of these, the vascular endothelial growth factor (VEGF) pathway has been found to be activated in numerous tumor types and considered one of the main drivers of angiogenesis. Roughly, VEGF-mediated angiogenesis can be inhibited by two approaches: either by monoclonal antibodies directed towards VEGF or its corresponding receptors, or by kinase inhibitors targeting the signal transduction of the VEGF receptors. As monotherapy, several kinase inhibitors exert antitumor activity in tumor types such as renal cell carcinoma. However, in most tumor types, the antitumor activity of compounds targeting the VEGF pathway is limited. In recent years, evidence is mounting that the paradigm of one single factor that drives malignant behavior applies rarely and is an oversimplification for most tumors in which there are multiple driving pathways. Consequently, multitargeting rather than single-targeting approaches are required. One of the means is by combining targeted agents with conventional cytotoxics. As the VEGF pathway also affects the sensitivity of tumor cells to chemotherapeutics, combinations of compounds targeting this pathway and conventional cytotoxics have been explored. This review addresses such combinations. (Cancer Sci 2009; 00: 000,000) [source] Microreactor Technology: A Revolution for the Fine Chemical and Pharmaceutical Industries?CHEMICAL ENGINEERING & TECHNOLOGY (CET), Issue 3 2005D. M. Roberge Abstract 50,% of reactions in the fine chemical/pharmaceutical industry could benefit from a continuous process based mainly on microreactor technology. However, the frequent presence of a solid phase still hinders the widespread application of such a technology as a multi-purpose solution. For small scale and pilot productions, speed in process R&D, as well as the avoidance of scale-up issues, are the main drivers. On the other hand, for large scale productions, a gain in yield and safety are the main motivations for the use of micoreactor technology. The gain in yield must be significant in order to cope with the increase in capital expenditure associated with the development of a new technology. [source] | |||||||||||||||||||||||||