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Selected AbstractsMeasurement and data analysis methods for field-scale wind erosion studies and model validation,EARTH SURFACE PROCESSES AND LANDFORMS, Issue 11 2003Ted M. Zobeck Abstract Accurate and reliable methods of measuring windblown sediment are needed to con,rm, validate, and improve erosion models, assess the intensity of aeolian processes and related damage, determine the source of pollutants, and for other applications. This paper outlines important principles to consider in conducting ,eld-scale wind erosion studies and proposes strategies of ,eld data collection for use in model validation and development. Detailed discussions include consideration of ,eld characteristics, sediment sampling, and meteorological stations. The ,eld shape used in ,eld-scale wind erosion research is generally a matter of preference and in many studies may not have practical signi,cance. Maintaining a clear non-erodible boundary is necessary to accurately determine erosion fetch distance. A ,eld length of about 300 m may be needed in many situations to approach transport capacity for saltation ,ux in bare agricultural ,elds. Field surface conditions affect the wind pro,le and other processes such as sediment emission, transport, and deposition and soil erodibility. Knowledge of the temporal variation in surface conditions is necessary to understand aeolian processes. Temporal soil properties that impact aeolian processes include surface roughness, dry aggregate size distribution, dry aggregate stability, and crust characteristics. Use of a portable 2 tall anemometer tower should be considered to quantify variability of friction velocity and aerodynamic roughness caused by surface conditions in ,eld-scale studies. The types of samplers used for sampling aeolian sediment will vary depending upon the type of sediment to be measured. The Big Spring Number Eight (BSNE) and Modi,ed Wilson and Cooke (MWAC) samplers appear to be the most popular for ,eld studies of saltation. Suspension ,ux may be measured with commercially available instruments after modi,cations are made to ensure isokinetic conditions at high wind speeds. Meteorological measurements should include wind speed and direction, air temperature, solar radiation, relative humidity, rain amount, soil temperature and moisture. Careful consideration of the climatic, sediment, and soil surface characteristics observed in future ,eld-scale wind erosion studies will ensure maximum use of the data collected. Copyright © 2003 John Wiley & Sons, Ltd. [source] The UK National Cancer Research Institute (NCRI) Informatics Initiative: promoting partnership in cancer research,HUMAN MUTATION, Issue 12 2007Fiona Reddington Abstract The vast amount of information emerging from cancer research in recent years has presented a challenge for researchers worldwide. The opportunities for using this data to enhance understanding of the disease and advance the delivery of novel anticancer treatments are greater than ever, but will fail to be fully realized unless the necessary tools to collate and analyze the information are developed. This article describes the work of the National Cancer Research Institute (NCRI) Informatics Initiative which aims to maximize the impact of the results of research funded by NCRI Partner organizations for the benefit of cancer patients by ensuring that data generated through research is put to maximum use by the cancer research community. Hum Mutat 28(12), 1151,1155, 2007. © 2007 Wiley-Liss, Inc. [source] Network Resources for Internationalization: The Case of Taiwan's Electronics Firms*JOURNAL OF MANAGEMENT STUDIES, Issue 5 2003Tain-Jy Chen ABSTRACT This paper illustrates foreign direct investment (FDI) as the management of important network relations, using Taiwan's electronics firms as an example. Through FDI, seemingly small and weak firms propel the process of internationalization by making maximum use of external resources to which they have access. FDI often starts at a location close to the home base where support from the domestic networks can be drawn, subsequently moving on to more distant locations after investors have accumulated new network resources. The location chosen is usually an area rich in network resources or in close proximity to such rich networks. FDI enables the investors to construct a regional, or even global, sub-network under their control to supply a set of wide-ranging, differentiated and low-cost products in a flexible fashion, and sometimes within close proximity to the markets. With this capacity for versatility, investors become valuable partners for multinational firms that offer global services. [source] Areal PMP distribution of one-day to three-day duration over IndiaMETEOROLOGICAL APPLICATIONS, Issue 4 2002C P R Clark Rakhecha There is a need to assess the areal depth of the probable maximum precipitation (PMP) over specified catchment areas for the safe construction of dam spillways. The large number of dams in India, coupled with their risk of failure, makes this need imperative both for the maximum use of water resources and for public safety. On the basis of rainfall data for the heaviest storms that occurred in different parts of India during the period 1880,1983, improved estimates of one-, two-, and three-day point PMP for India have been made. In this paper the distribution of areal PMP over specified catchment sizes is provided for the first time. The areal reduction factors (ARF) were based on envelope curves of major storms to give the ARF for areas of 10,20,000 km2 . These factors were found to vary from 1.0 to 0.41, though there was no real difference between durations of rainfall. These values of ARF were then multiplied by values of one- to three-day PMP. The resulting maps allow a broad description of the spatial distribution of areal PMP and also provide a rapid and consistent estimate of the probable maximum flood (PMF) from the PMP. For 500 km2 the areal PMP varies from 40 to 120 cm for one-day duration; from 70 to 200 cm for twoday duration; and from 75 to 270 cm for three-day duration. The pattern of PMP is consistent with the geography and available moisture. Copyright © 2002 Royal Meteorological Society. [source] Systematic planning for Triad projectsREMEDIATION, Issue 1 2004Robert Howe This article examines specific systematic planning steps that can be used for designing and controlling Triad projects. Triad work strategies act to limit decision uncertainty, expedite schedules to meet project milestones, and reduce costs associated with cleanup activities. As a result, the Triad approach is rapidly increasing in popularity. Good project planning has always been seen as the cornerstone of successful Triad projects. However, the specific steps in the systematic planning process have not been extensively published. Demands of Triad projects, which attempt to make maximum use of innovative technologies and sequencing of activities in a learn- as-you-go framework, put new demands on regulators and project managers alike. Specific activities and relationships are identified to assist project managers with dynamic work strategies and real-time measurements to support improved decision making. These include: assembly of stakeholders, a core technical team, and key decisions; development and refinement of a site model; use of demonstrations of methods applicability; development of dynamic work strategies and project sequencing; real-time data management assessment and presentation; and unitized procurement of technologies and services. © 2004 Wiley Periodicals, Inc. [source] A new paradigm for operative dentistryAUSTRALIAN DENTAL JOURNAL, Issue 4 2007GJ Mount Abstract It is over 100 years since GV Black gathered together most of the knowledge then current on the caries process and set clear parameters for the discipline of operative dentistry. His four-volume treatise set standards that were relevant for the times and, in fact, were so well described that they remained dominant in this discipline until quite recently. However, over the last 50 years there has been great progress in scientific method and in knowledge of the common diseases of the oral environment, including the caries process, so maybe it is time for change. The term "paradigm" describes a philosophy of science, a generally accepted model of how ideas relate to one another, forming a conceptual framework within which scientific research is carried out. Black defined the paradigm within which further research was to be conducted during the following years and the profession accepted his lead. However, it is not expected that the parameters of a profession should remain unchanged over a substantial period so it is suggested that the dental profession should, at this time, recognize a new paradigm. Improvements in scientific method have led to a better understanding of the oral environment, resulting in extensive changes for this profession. It is suggested that the standards set by Black should be now consigned to history and an entirely new paradigm adopted. First, the profession must recognize that dental caries is a bacterial disease and its primary efforts should be directed towards identification and elimination of the disease prior to initiating repair of the damage that it has caused. Preservation of natural tooth structure is then the next responsibility. There should be maximum use made of preventive strategies, including remineralization, followed by minimal intervention cavity designs and the use of bioactive restorative materials to restore the lesions. The profession should be prepared to move on. [source] Simultaneous assay of sildenafil and desmethylsildenafil in neonatal plasma by ultra-performance liquid chromatography,tandem mass spectrometryBIOMEDICAL CHROMATOGRAPHY, Issue 2 2010Bregje C. Witjes Abstract Sildenafil is used to treat pulmonary hypertension in neonatal and pediatric patients. Pharmacokinetic studies in these patients are complicated by the limited sample volume. We present the validation results of an assay method to quantitate sildenafil and desmethylsildenafil simultaneously in 50,µL of plasma. Deuterated sildenafil was used as an internal standard. After liquid,liquid extraction, analytes were separated on an ultra-performance liquid chromatography (UPLC)-column and quantified via tandem mass spectrometry. The calibration range was linear, with acceptable accuracy and a precision of <15% for both compounds. The lower limits of quantification were 1,ng/mL. Matrix effects were present, but inter-plasma batch variability was under 12%. The method was successfully applied to samples from a pharmacokinetic study into sildenafil pharmacokinetics in neonates, making maximum use of the limited number and amount of plasma samples available. Copyright © 2009 John Wiley & Sons, Ltd. [source] | ||||||||||