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Maximum Accuracy (maximum + accuracy)

Distribution by Scientific Domains

Medical Sciences	50%

Selected Abstracts

Characteristics of image-detected solid renal masses: Implication for optimal treatment

INTERNATIONAL JOURNAL OF UROLOGY, Issue 2 2004
GUORONG LI
Abstract Background:, Solid renal masses are found increasingly. Further analysis of the characteristics of solid renal masses is useful for optimal treatment. Methods:, A retrospective analysis of all solid renal masses was conducted from December 1998 to May 2003 at the Urology Department, Central University Hospital of Saint-Etienne, France. A total of 162 solid renal masses were treated. The preoperative imaging diagnosis of ultrasound and computed tomography, and final pathological results were reviewed. Results:, One hundred and forty-five tumors were pathologically confirmed to be renal cell carcinomas (RCC); 17 tumors (10.5%) were benign. There were eight renal oncocytomas, eight renal angiomyolipomas and one benign mixed epithelial/stroma tumor. Three oncocytomas and five angiomyolipomas were strongly suspected before surgery. The majority of the benign tumors were ,4 cm. The percentage of small benign tumors (,4 cm) was significantly higher than large benign tumors (>4 cm). Although it is possible to use imaging to detect some benign tumors, the majority of benign tumors cannot be diagnosed definitively by imaging before surgery. Conclusions:, Malignancy in solid renal masses is tumor-size related. Benign solid renal tumors appear mainly as small-sized tumors. The preoperative differentiation between an RCC and a benign tumor can be difficult. Our data suggest that a biopsy is necessary in selected patients to achieve the maximum accuracy in order to provide optimal treatment. [source]

An amino acid "transmembrane tendency" scale that approaches the theoretical limit to accuracy for prediction of transmembrane helices: Relationship to biological hydrophobicity

PROTEIN SCIENCE, Issue 8 2006
Gang Zhao
Abstract Hydrophobicity analyses applied to databases of soluble and transmembrane (TM) proteins of known structure were used to resolve total genomic hydrophobicity profiles into (helical) TM sequences and mainly "subhydrophobic" soluble components. This information was used to define a refined "hydrophobicity"-type TM sequence prediction scale that should approach the theoretical limit of accuracy. The refinement procedure involved adjusting scale values to eliminate differences between the average amino acid composition of populations TM and soluble sequences of equal hydrophobicity, a required property of a scale having maximum accuracy. Application of this procedure to different hydrophobicity scales caused them to collapse to essentially a single TM tendency scale. As expected, when different scales were compared, the TM tendency scale was the most accurate at predicting TM sequences. It was especially highly correlated (r = 0.95) to the biological hydrophobicity scale, derived experimentally from the percent TM conformation formed by artificial sequences passing though the translocon. It was also found that resolution of total genomic sequence data into TM and soluble components could be used to define the percent probability that a sequence with a specific hydrophobicity value forms a TM segment. Application of the TM tendency scale to whole genomic data revealed an overlap of TM and soluble sequences in the "semihydrophobic" range. This raises the possibility that a significant number of proteins have sequences that can switch between TM and non-TM states. Such proteins may exist in moonlighting forms having properties very different from those of the predominant conformation. [source]

Anwendung von massiv paralleler Berechnung mit Grafikkarten (GPGPU) für CFD-Methoden im Brandschutz

BAUPHYSIK, Issue 4 2009
Hendrik C. Belaschk Dipl.-Ing.
Berechnungsverfahren; Brandschutz; calculation methods; fire protection engineering Abstract Der Einsatz von Brandsimulationsprogrammen, die auf den Methoden der Computational Fluid Dynamics (CFD) beruhen, wird in der Praxis immer breiter. Infolge der Zunahme von verfügbarer Rechenleistung in der Computertechnik können heute die Auswirkungen möglicher Brandszenarien nachgebildet und daraus nützliche Informationen für den Anwendungsfall gewonnen werden (z. B. Nachweis der Zuverlässigkeit von Brandschutzkonzepten). Trotz der erzielten Fortschritte reicht die Leistung von heute verfügbaren Computern bei weitem nicht aus, um einen Gebäudebrand mit allen beteiligten physikalischen und chemischen Prozessen mit der höchstmöglichen Genauigkeit zu simulieren. Die in den Computerprogrammen zur Berechnung der Brand- und Rauchausbreitung implementierten Modelle stellen daher immer einen Kompromiss zwischen der praktischen Recheneffizienz und dem Detailgrad der Modellierung dar. Im folgenden Aufsatz wird gezeigt, worin die Ursachen für den hohen Rechenbedarf der CFD-Methoden liegen und welche Problemstellungen und möglichen Fehlerquellen sich aus den getroffenen Modellvereinfachungen für den Ingenieur ergeben. Darüber hinaus wird ein neuer Technologieansatz vorgestellt, der die Rechenleistung eines Personalcomputers unter Verwendung spezieller Software und handelsüblicher 3D-Grafikkarten massiv erhöht. Hierzu wird am Beispiel des Fire Dynamics Simulator (FDS) demonstriert, dass sich die erforderliche Berechnungszeit für eine Brandsimulation auf einem Personalcomputer um den Faktor 20 und mehr verringern lässt. Application of general-purpose computing on graphics processing units (GPGPU) in CFD techniques for fire safety simulations. The use of fire simulation programs based on computational fluid dynamics (CFD) techniques is becoming more and more widespread in practice. The increase in available computing power enables the effects of possible fire scenarios to be modelled in order to derive useful information for practical applications (e.g. analysis of the reliability of fire protection concepts). However, despite the progress in computing power the performance of currently available computers is inadequate for simulating a building fire including all relevant physical and chemical processes with maximum accuracy. The models for calculating the spread of fire and smoke implemented in the computer programs therefore always represent a compromise between practical computing efficiency and level of modelling detail. This paper illustrates the reasons for the high computing power demand of CFD techniques and describes potential problems and sources of error resulting from simplifications applied in the models. In addition, the paper presents a new technology approach that significantly increases the computing power of a PC using special software and standard 3D graphics cards. The Fire Dynamics Simulator (FDS) is used as an example to demonstrate how the required calculation time for a fire simulation on a PC can be reduced by a factor of 20 and more. [source]

Image analysis to improve diagnosis of exfoliation

ACTA OPHTHALMOLOGICA, Issue 1 2000
Päivi Puska
ABSTRACT. Purpose: To improve visualization of exfoliation material in standard colour photographs by image analysis. Methods: Standard anterior segment colour photographs taken from 17 patients with known exfoliation were subjected to film scanning with a maximum accuracy of 3175 dpi. Results: Before image scanning, visualization of exfoliation was classified as barely visible in 10 (59%) patients and clearly visible in 7 (41%) patients. After the image scanning, exfoliation material became clearly visible in 13 (76%) patients and could easily be demonstrated. Conclusion: Diagnosis of exfoliation material can be improved by standard film scanning. [source]