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Lung Cancer Incidence (lung + cancer_incidence)
Selected AbstractsCancer incidence in patients with schizophrenia and their first-degree relatives , a meta-analysisACTA PSYCHIATRICA SCANDINAVICA, Issue 5 2008V. S. Catts Objective:, Controversy concerning cancer incidence in schizophrenia exists because of heterogeneous study findings. Method:, A meta-analysis was performed on standardized incidence ratios (SIR) of cancer in patients with schizophrenia and first-degree relatives and compared with general population samples. Results:, The pooled overall cancer incidence in patients was not significantly increased (SIR = 1.05, CI 0.95,1.15). Lung cancer incidence was slightly increased (SIR = 1.31, CI 1.01,1.71), but was reduced after adjusting for smoking prevalence. The incidence of several cancers unrelated to smoking was reduced in patients. Breast cancer rates were significantly increased in female patients. The pooled overall cancer incidence in siblings (SIR = 0.89, CI 0.84,0.94) and parents (SIR = 0.90, CI 0.88,0.93) was significantly reduced. A meta-regression detected a significant relationship between cancer risk in the general population and relative risk in patients. Conclusion:, The meta-analysis aided exploration of inconsistent study findings. There is a discrepancy between cancer risk exposure and cancer incidence in schizophrenia consistent with a protective effect. [source] Fruit and vegetable consumption and lung cancer risk: Updated information from the European Prospective Investigation into Cancer and Nutrition (EPIC)INTERNATIONAL JOURNAL OF CANCER, Issue 5 2007Jakob Linseisen Abstract The association of fruit and vegetable consumption and lung cancer incidence was evaluated using the most recent data from the European Prospective Investigation into Cancer and Nutrition (EPIC), applying a refined statistical approach (calibration) to account for measurement error potentially introduced by using food frequency questionnaire data. Between 1992 and 2000, detailed information on diet and life-style of 478,590 individuals participating in EPIC was collected. During a median follow-up of 6.4 years, 1,126 lung cancer cases were observed. Multivariate Cox proportional hazard models were applied for statistical evaluation. In the whole study population, fruit consumption was significantly inversely associated with lung cancer risk while no association was found for vegetable consumption. In current smokers, however, lung cancer risk significantly decreased with higher vegetable consumption; this association became more pronounced after calibration, the hazard ratio (HR) being 0.78 (95% CI 0.62,0.98) per 100 g increase in daily vegetable consumption. In comparison, the HR per 100 g fruit was 0.92 (0.85,0.99) in the entire cohort and 0.90 (0.81,0.99) in smokers. Exclusion of cases diagnosed during the first 2 years of follow-up strengthened these associations, the HR being 0.71 (0.55,0.94) for vegetables (smokers) and 0.86 (0.78,0.95) for fruit (entire cohort). Cancer incidence decreased with higher consumption of apples and pears (entire cohort) as well as root vegetables (smokers). In addition to an overall inverse association with fruit intake, the results of this evaluation add evidence for a significant inverse association of vegetable consumption and lung cancer incidence in smokers. © 2007 Wiley-Liss, Inc. [source] Asbestos-related cancers among 28,300 military servicemen in the Royal Norwegian NavyAMERICAN JOURNAL OF INDUSTRIAL MEDICINE, Issue 1 2010Leif Aage Strand MSc Abstract Introduction This study focus on the incidence of asbestos-related cancers among 28,300 officers and enlisted servicemen in the Royal Norwegian Navy. Until 1987, asbestos aboard the vessels potentially caused exposure to 11,500 crew members. Methods Standardized incidence ratios (SIR) were calculated for malignant mesothelioma, lung cancer, and laryngeal, pharyngeal, stomach, and colorectal cancers according to service aboard between 1950 and 1987 and in other Navy personnel. Results Increased risk of mesothelioma was seen among engine room crews, with SIRs of 6.23 (95% CI,=,2.51,12.8) and 6.49 (95% CI,=,2.11,15.1) for personnel who served less than 2 years and those with longer service, respectively. Lung cancer was nearly 20% higher than expected among both engine crews and non-engine crews. An excess of colorectal cancer bordering on statistical significance was seen among non-engine crews (SIR,=,1.14; 95% CI,=,0.98,1.32). Land-based personnel and personnel who served aboard after 1987 had lower lung cancer incidence than expected (SIR,=,0.77; 95% CI,=,0.64,0.92). No elevated risk of laryngeal, pharyngeal, or stomach cancers was seen. Conclusion The overall increase (65%) in mesotheliomas among military Navy servicemen was confined to marine engine crews only. The mesothelioma incidence can be taken as an indicator of the presence or absence of asbestos exposure, but it offered no consistent explanation to the variation in incidence of other asbestos-related cancers. Am. J. Ind. Med. 53:64,71, 2010. © 2009 Wiley-Liss, Inc. [source] Association between respiratory symptom score and 30-year cause-specific mortality and lung cancer incidenceTHE CLINICAL RESPIRATORY JOURNAL, Issue 2008A. Frostad Abstract Introduction:, Respiratory symptoms are among the main reasons why patients make contact with healthcare professionals and they are associated with several diseases. Objective:, The aim of this study was to investigate the relationship between respiratory symptoms reported at one time and 30 years cause-specific mortality and incidence of lung cancer in an urban Norwegian population. Materials and Methods:, A total of 19 998 men and women, aged 15,70 years, were in 1972 selected from the general population of Oslo. They received a postal respiratory questionnaire (response rate 89%). All were followed for 30 years for end-point mortality and for lung cancer. The association between respiratory symptoms, given as a symptom load, and end point of interest were investigated separately for men and women by multivariable analyses, with adjustment for age, occupational exposure to air pollution and smoking habits. Results:, A total of 6710 individuals died during follow-up. Obstructive lung diseases (OLDs) and pneumonia accounted for 250 and 293 of the total deaths, respectively. Ischaemic heart disease (IHD) accounted for 1572; stroke accounted for 653 of all deaths. Lung cancer developed in 352 persons during follow-up. The adjusted hazard ratio for mortality from OLD and pneumonia, IHD and stroke increased in a dose,response manner with symptom score, more strongly for OLD and IHD than for pneumonia and stroke. Conclusions:, Respiratory symptoms were positively associated with mortality from OLD, pneumonia, IHD and stroke, and incidence of lung cancer. This association was significant for mortality from OLD and IHD. Please cite this paper as: Frostad A. Association between respiratory symptom score and 30-year cause-specific mortality and lung cancer incidence. The Clinical Respiratory Journal 2008; 2: 53,58. [source] Birth Cohort Effects on Incidence of Lung Cancers: A Population-based Study in Nagasaki, JapanCANCER SCIENCE, Issue 10 2000Hiroshi Soda Smoking prevalence remains high (around 60%) among Japanese males, but smoking initiation among males born in the 1930s decreased by approximately 10% due to economic difficulties following World War II. The present study was designed to examine whether this temporary decline in smoking initiation influenced the subsequent incidence of lung cancers, especially adenocarcinoma. Trends of lung cancer incidence by histological type in both sexes were investigated using data from the population-based cancer registry in Nagasaki, Japan, from 1986 through 1995. During this period, 5668 males and 2309 females were diagnosed as having lung cancer, and the overall incidence of lung cancers among both sexes remained stable. However, males aged 55,59 years showed a decrease in the age-specific incidence of adenocarcinoma and squamous-cell carcinoma (P < 0.05 and P < 0.01, respectively). In birth cohort analyses, the incidence of adenocarcinoma and squamous-cell carcinoma was lower in the 1935,1939 birth male cohort than in the successive cohorts. The incidence of lung cancers among females with low smoking prevalence did not change with birth cohort. The low smoking initiation among the 1935,1939 birth male cohort appeared to have resulted in a decreased incidence of adenocarcinoma and squamous cell carcinoma among middle-aged Japanese males. The present study suggests that smoking prevention has an effect in reducing the incidence of lung adenocarcinoma, as well as squamous-cell carcinoma, among smokers. [source] Reproducibility of Diagnosis and Its Influence on the Distribution of Lung Cancer by Histologic Type in Osaka, JapanCANCER SCIENCE, Issue 1 2000Seiichiro Yamamoto The histologic types of lung cancer cases diagnosed in 1979,1980 (n=799) and 1987 (n=587) were independently reviewed by two pathologists in order to investigate the reproducibility of the diagnosis of the histologic type when the WHO classification (1981) was used. The specimens from 354 surgical cases and biopsy or cytology specimens from 1032 non-surgical cases were reviewed. The inter-observer agreement was 87.9% (k=0.79) for surgical cases and 81.4% (k=0.72) for non-surgical cases. When compared to the original diagnosis, the agreement was 86.8% (k=0.78) for surgical and 86.4% (k=0.79) for non-surgical cases in 1979,1980 and the agreement was 92.8% (k=0.87) for surgical and 89.1% (k=0.83) for non-surgical cases in 1987. By histologic type, no difference in the agreement was observed except for large cell carcinoma. The distribution of histologic types after the review differed only slightly (less than 6%) from the original distribution. This suggests that in Osaka, Japan, the diagnosis based on the WHO classification (1981) had only a limited influence on the distribution of histologic types, and is not a major reason for the changing trends in lung cancer incidence by histologic type. [source] | ||||||||||