Home About us Contact
|
Home About us Contact | ||
|
|
||
Lower Amplitude (lower + amplitude)
Selected AbstractsRoute of Administration Differentially Affects Fevers Induced by Gram-Negative and Gram-Positive Pyrogens in RabbitsEXPERIMENTAL PHYSIOLOGY, Issue 3 2002T. Cartmell We have investigated the febrile responses of New Zealand White rabbits to a Gram-negative pyrogen (bacterial lipopolysaccharide (LPS) from Salmonella typhosa), commonly associated with systemic infection, and a Gram-positive pyrogen (Staphylococcus aureus), more frequently associated with superficial soft tissue infection, each administered via one of four different routes (intravenous, intramuscular, subcutaneous or intraperitoneal) at each of three different doses (LPS: 0.1, 1 and 10 ,g kg,1; S. aureus: 1.5 × 107, 1.5 × 108 and 1.5 × 109 cell walls kg,1). Intravenous administration of LPS evoked rapid, dose-dependent biphasic fever. Injection of LPS by the other routes also evoked dose-dependent fever. However, these fevers were monophasic, had increased latency of onset, and were of lower amplitude. It is important to note that a dose of approximately 10 and 100 times that of the standard intravenous dose was required to produce a similar peak rise in temperature when administered subcutaneously and intraperitoneally, respectively. Intravenous injection of the highest dose of S. aureus evoked dose-dependent biphasic fever, with short latency of onset, which was very similar to that induced by intravenous LPS. At lower doses, intravenous S. aureus induced monophasic fever. No fever occurred when the same doses of S. aureus were administered by any other route. We conclude that any of the four routes may be used for the study of LPS-induced fever, provided that the doses are adjusted. However, studies of S. aureus -induced fever, and detection of contamination with either pyrogen, requires intravenous injection. [source] Subglacial modulation of the hydrograph from glacierized basinsHYDROLOGICAL PROCESSES, Issue 19 2008Gwenn E. Flowers Abstract The extent of basin glacierization has important implications for the hydrograph in part, because snow, firn and ice impart different delays in water transport through the system. Here, the significance of subglacial drainage morphology in modulating the hydrograph is examined with a one-dimensional physically based model. The conceptual model of subglacial drainage comprises both ,fast' and ,slow' elements, respectively associated with summer and winter drainage regimes. The additional possibility of a permeable glacier substrate is taken into account by allowing water transport in a subglacial aquifer. Forced by prescribed rates of melt-water delivery to the glacier bed, the model predicts glacier discharge by drainage system provenance. The effects of (1) ,hard' versus ,soft' glacier beds, (2) subsurface permeability and groundwater flow, and (3) glacier geometry are then investigated. Hydrograph character, in the form of peak timing and amplitude, symmetry with respect to the forcing, and the amplitude of diurnal fluctuations, is affected by the partitioning of water through the various flow elements. Hard beds and impermeable substrates maximize the discharge routed through the fast-drainage system in the simulations, generally resulting in higher seasonal discharge maxima and stronger diurnal variations in discharge. High hydraulic transmissivities, either at the glacier bed or in underlying strata, hinder the development of the fast-drainage system in the simulations, producing hydrographs of lower amplitude. Glacier geometry has a modest effect, with adverse bed slopes, very thick or very thin ice and short glacier lengths favouring prolonged drainage through the slow system. These results suggest that the morphology and evolution of the subglacial drainage system may play a significant role in determining the character of the hydrograph from glacierized basins. Copyright © 2008 John Wiley & Sons, Ltd. [source] Quantitative Electromyographic Examination in Myogenic Disorders of 6 HorsesJOURNAL OF VETERINARY INTERNAL MEDICINE, Issue 2 2003I.D. Wijnberg Electromyographic needle examination (EMG), including the semiautomatic quantitative analysis of motor unit action potential (MUAP), is an important diagnostic tool for myopathy in humans. The diagnostic possibilities of this technique have not been fully explored in horses; however, recent studies have shown that MUAP analysis can be performed in conscious horses. To determine the diagnostic possibilities of EMG in horses, we compared the EMG results of the subclavian muscle, the triceps, and the lateral vastus muscle in 6 equine patients thought to have myogenic disorders with those in 7 normal control horses. The EMG results were compared with the results of the histopathologic examination of the lateral vastus muscle in patients and controls. Histopathologic examination showed muscle disease in 3 patients. In the patient group, several types of abnormal spontaneous activities were observed (mainly fibrillation potentials and positive sharp waves), and the MUAPs of the patient group had a markedly shorter duration and lower amplitude than those of the control group. In the subclavian muscle, triceps, and lateral vastus muscle of affected horses, the MUAP duration was 5.0 ± 0.4 (mean ± SD), 3.9 ± 0.3, and 4.7 ± 1.1 milliseconds, respectively. The MUAP amplitude was 217 ± 55, 150 ± 74, and 180 ± 54 MV; the number of phases was 2.4 ± 0.2, 2.5 ± 0.3, and 2.3 ± 0.1; and the number of turns was 2.6 ± 0.2, 2.4 ± 0.2, and 2.8 ± 0.5, respectively. In conclusion, it appears that the EMG may be a more sensitive method than other techniques for examining muscle biopsies for diagnosis of early-stage myopathy in horses. [source] Influence of chronic alcohol abuse and ensuing forced abstinence on static subjective accommodation function in humansOPHTHALMIC AND PHYSIOLOGICAL OPTICS, Issue 3 2001Hugh Campbell Summary Purpose. Acute alcohol ingestion can change accommodation, but the long term effects of sustained alcohol consumption on accommodative function have not been studied in detail. This study was thus undertaken on individuals with a history of alcohol abuse. Methods. Thirty-seven male individuals aged 25,56 years (average 40 years) from an alcohol rehabilitation centre in Inverness, Scotland, were assessed on admission and after a week of forced abstinence. The results were compared to a paired age-matched set of control male subjects. The static amplitude of accommodation was measured by an RAF rule, and the pupil size measured with a pupil gauge. Results. On admission, the group mean measured amplitude of accommodation was 4.7±2.2 D (mean±SD). These values for the alcoholics were lower than age-matched controls (of5.9±2.9 D). The slope of the age-dependent decline in RAF rule accommodation measures was significantly smaller for the alcoholics compared to controls (at 0.215±0.027 D/year versus0.332±0.015 D/year, respectively; p <0.001), with the younger alcoholics showing a greater impairment. Following abstinence, there was no measurable change in accommodation measured, indicating the lower amplitude in the alcoholics was not attributable to circulatory alcohol levels. The resting pupil diameter in the alcoholics was4.37±0.63 mm compared to the controls of3.97±0.75 mm, with a higher incidence of small pupils (,3 mm) in the controls. Conclusions. The results indicate that chronic alcohol use can adversely affect subjective static accommodation, especially in younger alcoholics, as well as cause slight mydriasis. [source] Magnetically evoked motor potentials in demyelinating and axonal polyneuropathy: a comparative studyEUROPEAN JOURNAL OF NEUROLOGY, Issue 1 2000H. Takada We investigated the value of magnetically evoked motor potentials (MEPs) for the differentiation of demyelinating and axonal polyneuropathies. The study population comprised 107 patients, with polyneuropathy verified by electromyography (EMG) and nerve conduction study (NCS), who had also been examined by means of MEP. MEPs were evoked by magnetic stimulation of the cortex and the spinal roots and were recorded from three upper limb muscles and two lower limb muscles bilaterally. From the EMG/NCS results 53 patients were characterized as having primary demyelination (demyelinating patients) and 54 as having axonal involvement (axonal patients). Demyelinating patients were classified as acute (acute inflammatory demyelinating polyradiculoneuropathy: AIDP ) or chronic (chronic inflammatory demyelinating polyradiculoneuropathy: CIDP ) according to the duration of illness. A series of indices were calculated from MEP results. One demyelinating patient and two axonal patients had normal MEPs. The MEPs of the demyelinating patients showed significantly longer peripheral conduction times, larger interside differences and lower amplitudes than the axonal patients. The central conduction index and the amplitudes upon cortical stimulation were significantly higher in patients with CIDP than in those with AIDP. Peripheral conduction time prolonged by more than 85% in at least one of the 10 muscles studied or a peripheral conduction index of above 9.4 were pathognomonic for demyelination . By combining all criteria 75% of the patients could be categorized as CIDP vs. AIDP in accordance with the EMG/NCS diagnosis. Likewise, 83% were categorized correctly as demyelinating versus axonal according to the EMG/NCS data. [source] Effect of size and pressure of surface recording electrodes on amplitude of sensory nerve action potentialsMUSCLE AND NERVE, Issue 2 2004Antoon A. Ven MSc Abstract The influence of electrode size on sensory nerve action potential (SNAP) amplitude of the lateral antebrachial cutaneous nerve (LACN) and sural nerve (SN) was studied in 63 healthy volunteers. The SNAP amplitudes were measured using surface recording electrodes of three different sizes, positioned across the nerve. Mean amplitudes using a 5-mm electrode were 9.0% (SN) and 15.3% (LACN) higher than with a 20-mm electrode and 19.4% (SN) and 25.8% (LACN) higher than using a 40-mm electrode. To study the influence of pressure on surface recording electrodes, studies were performed on the LACN in 31 healthy volunteers. Light pressure of the recording electrodes on the skin gave lower amplitudes (15.3%) than did greater pressure or pressure applied between active and reference electrodes. These studies demonstrate that standardized surface recording electrode size and pressure are imperative for obtaining valid and reliable results in experimental studies or in clinical follow-up of patients undergoing nerve conduction studies. Muscle Nerve 30: 234,238, 2004 [source] Investigating atmospheric predictability on Mars using breeding vectors in a general-circulation modelTHE QUARTERLY JOURNAL OF THE ROYAL METEOROLOGICAL SOCIETY, Issue 603 2004C. E. Newman Abstract A breeding vectors approach is used to investigate the hypothesis that the Martian atmosphere is predictable at certain times of year, by identifying the fastest-growing modes of instability at different times in a Mars general-circulation model. Results indicate that the period from northern mid-spring until mid-autumn is remarkably predictable, with negative global growth rates for a range of conditions, in contrast to the situation on the earth. From northern late autumn to early spring growing modes do occur, peaking in northern high latitudes and near winter solstice. Reducing the size of the initial perturbations increases global growth rates in most cases, supporting the idea that instabilities which saturate nonlinearly at lower amplitudes have generally faster growth rates. In late autumn/early winter the fastest-growing modes (,bred vectors') are around the north pole, increase with dust loading, and probably grow via barotropic as well as baroclinic energy conversion. In northern late winter/early spring the bred vectors are around the north pole and are strongly baroclinic in nature. As dust loading (and with it the global circulation strength) is increased their growth rates first decrease, as the baroclinic mode is suppressed, then increase again as the fastest-growing instabilities switch to being those which dominated earlier in the year. If dust levels are very low during late northern autumn (late southern spring) then baroclinic modes are also found around the spring pole in the south, though for a slight increase in dust loading the dominant modes shift back to northern high latitudes. The bred vectors are also used as perturbations to the initial conditions for ensemble simulations. One possible application within the Mars model is as a means of identifying regions and times when dust-lifting activity (related to surface wind stress) might show significant interannual variability for a given model configuration, without the need to perform long, computationally expensive multi-year model runs with each new set-up. This is tested for a time of year when previous multi-year experiments showed significant variability in dust storm onset in the region north of Chryse. Despite the model having no feedbacks between dust lifting and atmospheric state (unlike the original multi-year run), the ensemble members still show maximum divergence in this region in terms of near-surface wind stress, suggesting both that this application deserves further testing, and that the intrinsic atmospheric variability alone may be important in producing interannual variability in this storm type. Copyright © 2004 Royal Meteorological Society [source] | ||||||||||