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Little Doubt (little + doubt)
Selected AbstractsFamilial loading in specific language impairment: patterns of differences across proband characteristics, gender and relative typeGENES, BRAIN AND BEHAVIOR, Issue 3 2007G. Conti-Ramsden There is now little doubt that both environmental factors and genes are likely to make important contributions to the aetiology of specific language impairment (SLI). The most commonly proposed model for understanding these influences is the multifactorial model. In the present study we examine two expectations based on this model: that there will be a systematic relationship between the severity of proband language scores and the rate and severity of SLI in relatives and that relatives will be more strongly affected if they are relatives of a proband of the more rarely affected gender (female) because the latter require a higher genetic liability to become equally impaired. Ninety-three probands and their 300 first-degree relatives participated in this study. Results showed a relationship between proband severity at age 14 and an increased rate of SLI in relatives. This relationship was strong for child siblings and was significant with respect to both rate of SLI and severity over a range of language and literacy measures. In contrast, higher levels of SLI among relatives of female rather than male probands was entirely disproved. [source] Viscoelastic,afterslip concurrence: a possible mechanism in the early post-seismic deformation of the Mw 7.6, 1999 Chi-Chi (Taiwan) earthquakeGEOPHYSICAL JOURNAL INTERNATIONAL, Issue 3 2004Shyh-Yang Sheu SUMMARY Observed coseismic data as well as 97 days of post-seismic GPS data for the Chi-Chi earthquake are used as constraints in the modelling of crustal evolution using the 3-D finite-element method. First, the coseismic GPS data are used to justify the use of the elastic earth model and the source rupture model. Subsequently, the most likely rheological model is determined by analysing several modelled time-dependent displacements for various viscosity structures. The range of viscosities of the lower crust in central Taiwan is determined in advance from laboratory measurements and the long-term strain rate. The estimated viscosity of 5.0 × 1017 Pa s seems to be very low and a relaxation time of 116 days seems very short, but the latter approximates the GPS measurement of 86 days. Since earlier studies have indicated that both the viscoelastic response model and the afterslip model may affect post-seismic deformation, we compare theoretical surface displacements for each of the two models that we evaluate. The results reveal that there is little doubt that while neither of these models alone is able to predict the GPS measurements well in a 97-day period, the combination of the two models improves the predictions considerably. We conclude that the afterslip mainly dominated Chi-Chi post-seismic deformation in the rupture area while the viscoelastic model did so elsewhere. [source] Printing the Regicide of Charles IHISTORY, Issue 296 2004MOS TUBB The execution of Charles I by the English republic on 30 January 1649 was the most unpopular political act of the seventeenth century. Yet within three weeks of Charles's death the leaders of the new government were ,cheerful and well pleased'. This article explores one of the key reasons for their good mood: they had just managed a polemical triumph. In the weeks following the regicide, parliament and its supporters had justified the king's execution with a wide array of printed documents. Further, various government agents severely hampered the republic's opponents from printing their own missives, thereby creating a fairly clear space for the pro-regicide press. Although the long-term impact may have been limited, there can be little doubt that the English republic and its proponents asserted a potent case for regicide in early February 1649. [source] Racial discrimination in the Brazilian labour market: wage, employment and segregation effectsJOURNAL OF INTERNATIONAL DEVELOPMENT, Issue 8 2004Jean-Louis Arcand The social science literature has done much to document pervasive racial discrimination in Brazil and there is little doubt that a very dark colour is a handicap to social advancement. Nevertheless, very few empirical economic studies have attempted to quantify the impact of ethnic discrimination in Brazil. Using data culled from the Pesquisa National por Amostra de Domicílios (PNAD), this paper fills this void by analysing ethnic wage and employment gaps, as well as occupational segregation in Brazil, using the Oaxaca decomposition methodology. Copyright © 2004 John Wiley & Sons, Ltd. [source] Subtle, Pervasive, Harmful: Racist and Sexist Remarks in Public as Hate SpeechJOURNAL OF SOCIAL ISSUES, Issue 2 2002Laura Beth Nielsen Using field observations and 100 in-depth interviews with participants recruited from public places in Northern California, this article documents the experience of being the target of hate speech in public places. Focusing on racist and sexist hate speech (as participants define the phenomenon), I show that there is a range of experiences with hate speech and that it is often quite subtle, leaving all but intended victims unaware that it occurs. These data also show that such interactions occur with regularity and leave targets harmed in significant ways. There can be little doubt that members of traditionally disadvantaged groups face a strikingly different reality on the street than do members of privileged groups. Although the legal status of hate speech remains ambiguous, its harms are not. [source] Cardiovascular pharmacogenetics in the SNP eraJOURNAL OF THROMBOSIS AND HAEMOSTASIS, Issue 7 2003V. Mooser Summary., In the past pharmacological agents have contributed to a significant reduction in age-adjusted incidence of cardiovascular events. However, not all patients treated with these agents respond favorably, and some individuals may develop side-effects. With aging of the population and the growing prevalence of cardiovascular risk factors worldwide, it is expected that the demand for cardiovascular drugs will increase in the future. Accordingly, there is a growing need to identify the ,good' responders as well as the persons at risk for developing adverse events. Evidence is accumulating to indicate that responses to drugs are at least partly under genetic control. As such, pharmacogenetics , the study of variability in drug responses attributed to hereditary factors in different populations , may significantly assist in providing answers toward meeting this challenge. Pharmacogenetics mostly relies on associations between a specific genetic marker like single nucleotide polymorphisms (SNPs), either alone or arranged in a specific linear order on a certain chromosomal region (haplotypes), and a particular response to drugs. Numerous associations have been reported between selected genotypes and specific responses to cardiovascular drugs. Recently, for instance, associations have been reported between specific alleles of the apoE gene and the lipid-lowering response to statins, or the lipid-elevating effect of isotretinoin. Thus far, these types of studies have been mostly limited to a priori selected candidate genes due to restricted genotyping and analytical capacities. Thanks to the large number of SNPs now available in the public domain through the SNP Consortium and the newly developed technologies (high throughput genotyping, bioinformatics software), it is now possible to interrogate more than 200 000 SNPs distributed over the entire human genome. One pharmacogenetic study using this approach has been launched by GlaxoSmithKline to identify the approximately 4% of patients who are predisposed to developing a hypersensitivity reaction to abacavir, an anti-HIV agent. Data collected thus far on the HLA locus on chromosome 6 indicate that this approach is feasible. Extended linkage disequilibrium can be detected readily, even across several haplotype blocks, thus potentially reducing the number of SNPs for future whole-genome scans. Finally, a modest number of cases and controls appears to be sufficient to detect genetic associations. There is little doubt that this type of approach will have an impact on the way cardiovascular drugs will be developed and prescribed in the future. [source] The effectiveness of a pre-operative home-based physiotherapy programme for chronic anterior cruciate ligament deficiencyPHYSIOTHERAPY RESEARCH INTERNATIONAL, Issue 4 2006SL Keays Abstract Background and Purpose.,Little evidence supports the prescription of pre-operative rehabilitation in the treatment of chronic anterior cruciate ligament-deficient (ACLD) subjects. The aim of the present study was to assess the effectiveness of a specific six-week pre-operative exercise programme on ACLD knees.,Method.,A single, masked, controlled study was designed. This comprised two matched groups of 12 chronically ACLD patients awaiting reconstruction and a group of 12 matched uninjured control subjects. Only one ACLD group received a home-based exercise and educational programme. Assessment before and after the exercise intervention included: knee joint stability (clinical and KT1000 evaluation); muscle strength (Cybex II); standing balance and functional performance (agility, hop and subjective tests).,Results.,At the time of initial assessment there were no statistically significant differences in any measures for the two ACLD groups but both ACLD groups were significantly different from the uninjured control group as regards quadriceps strength and function. Measures taken after six weeks showed no significant improvement in the untreated ACLD group or in the uninjured control group The treated ACLD group showed significant improvement in the following measures: quadriceps strength measured at 60° and 120° per second (p < 0.001); single leg standing balance with eyes closed (p < 0.001); instrumented passive stability at 20,lb (89N) force (p = 0.003); agility and subjective performance (p < 0.001). The incidence of unstable episodes had decreased in the treated ACLD group, reducing further damage to the joint.,Conclusion.,This study leaves little doubt that pre-operative physiotherapy had a positive effect on motor function in ACLD subjects and should be prescribed routinely to maximize muscle stabilizing potential prior to reconstruction. Patients report improved stability and, in certain cases, may avoid surgery. The finding that exercise increased the passive stability of the joint was unexpected and requires further investigation. Copyright © 2006 John Wiley & Sons, Ltd. [source] Measuring profitability impacts of information technology: Use of risk adjusted measuresPROCEEDINGS OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE & TECHNOLOGY (ELECTRONIC), Issue 1 2003Anil Singh This study focuses on understanding how investments in information technology are reflected in the income statements and balance sheets of firms. Today, little doubt exists that information technology is being used by organizations in a wide variety of settings and ways and that information technology is critical for the smooth operation of many organizations. Further, a strong body of research exists showing that information technology usage is positively correlated with organizational productivity. However, empirical evidence of information technology contributing to corporate profitability has not been forthcoming. Although the income statements, balance sheets, and cash-flow statements all together summarize the financial structure, health and profitability of firms but still much doubt and confusion exists over the impacts of information technology usage on a firm's "hard" numbers such as revenues, cost, profit margins, or financial ratios and structure. So far, only a few studies have found a significant positive relationship between information technology and some aspect of corporate profitability. The present research argues that the inability of earlier studies to identify the relationship between information technology investments and bottom-line performance is in part because of methodological reasons. This study first defines and develops risk-adjusted measures of corporate profitability. Then, it examines the income statements and balance sheets of more than 500 firms that are leading users of information technology for the period 1988-98. Finally, the study shows that the relationship between information technology investments and corporate profitability is much better explained by using risk-adjusted measures of corporate profitability than using the same measures of corporate profitability but unadjusted for risk. [source] Design and Analysis of Clinical Trials in Transplantation: Principles and PitfallsAMERICAN JOURNAL OF TRANSPLANTATION, Issue 9 2008J. D. Schold The contributions of prospective randomized controlled trials (RCTs) to the advancement of solid organ transplantation are well appreciated. However, some misconception exists that results deriving from RCTs uniformly provide clinically relevant, definitive and generalized evidence. While there is little doubt that RCTs are the gold standard to test cause-and-effect relationships, the quality and subsequent utility of trials carried out in this field vary substantially. As with all other disciplines, our ability to interpret and implement the findings of RCTs into practice is strongly dependent on the study design and statistical rigor of the analysis. Failure to conduct trials with appropriate standards or interpret trials with the appropriate limitations may place patients at risk or waste valuable healthcare resources. The purpose of this review is to delineate important principles of study design and analysis of RCTs that are commonly overlooked. This review will discuss possible limitations of trials with specific applications in the field of transplantation. Progress in the field of transplantation is highly dependent on critical examination of existing clinical trials and vigilance regarding the optimal development of future trials. [source] My favorite animal, Trichoplax adhaerensBIOESSAYS, Issue 12 2005Bernd Schierwater Trichoplax adhaerens is more simply organized than any other living metazoan. This tiny marine animal looks like a irregular "hairy plate" ("tricho plax") with a simple upper and lower epithelium and some loose cells in between. After its original description by F.E. Schulze 1883, it attracted particular attention as a potential candidate representing the basic and ancestral state of metazoan organization. The lack of any kind of symmetry, organs, nerve cells, muscle cells, basal lamina and extracellular matrix originally left little doubt about the basal position of T. adhaerens. Nevertheless, the interest of zoologists and evolutionary biologists suddenly vanished for more than half a century when Trichoplax was claimed to be an aberrant hydrozoan planula larva. Recently, Trichoplax has been rediscovered as a key species for unraveling early metazoan evolution. For example, research on regulatory genes and whole genome sequencing promise insights into the genetics underlying the origin and development of basal metazoan phyla. Trichoplax offers unique potential for understanding the minimal requirements of metazoan animal organization. BioEssays 27:1294,1302, 2005. © 2005 Wiley Periodicals, Inc. [source] Potential mechanisms of avian sex manipulationBIOLOGICAL REVIEWS, Issue 4 2003THOMAS W. PIKE ABSTRACT The aim of this review is to consider the potential mechanisms birds may use to manipulate the sex of their progeny, and the possible role played by maternal hormones. Over the past few years there has been a surge of reports documenting the ability of birds to overcome the rigid process of chromosomal sex determination. However, while many of these studies leave us in little doubt that mechanisms allowing birds to achieve this feat do exist, we are only left with tantalizing suggestions as to what the precise mechanism or mechanisms may be. The quest to elucidate them is made no easier by the fact that a variety of environmental conditions have been invoked in relation to sex manipulation, and there is no reason to assume that any particular mechanism is conserved among the vast diversity of species that can achieve it. In fact, a number of intriguing proposals have been put forward. We begin by briefly reviewing some of the most recent examples of this phenomenon before highlighting some of the more plausible mechanisms, drawing on recent work from a variety of taxa. In birds, females are the heterogametic sex and so non-Mendelian segregation of the sex chromosomes could conceivably be under maternal control. Another suggestion is that follicles that ultimately give rise to males and females grow at different rates. Alternatively, the female might selectively abort embryos or,dump lay'eggs of a particular sex, deny certain ova a chance of ovulation, fertilization or zygote formation, or selectively provision eggs so that there is sex-specific embryonic mortality. The ideas outlined in this review provide good starting points for testing the hypotheses both experimentally (behaviourally and physiologically) and theoretically. [source] Comprehensive Review of Patulin Control Methods in FoodsCOMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY, Issue 1 2005Matthew M. Moake ABSTRACT The mycotoxin, patulin (4-hydroxy-4H-furo [3, 2c] pyran-2[6H]-one), is produced by a number of fungi common to fruit- and vegetable-based products, most notably apples. Despite patulin's original discovery as an antibiotic, it has come under heavy scrutiny for its potential negative health effects. Studies investigating these health effects have proved inconclusive, but there is little doubt as to the potential danger inherent in the contamination of food products by patulin. The danger posed by patulin necessitates its control and removal from foods products, creating a demand for handling and processing techniques capable of doing so, preferably at low cost to industry. With this being the case, much research has been devoted to understanding the basic chemical and biological nature of patulin, as well as its interaction within foods and food production. While past resarch has elucidated a great deal, patulin contamination continues to be a challenge for athe food industry. Here, we review in depth the past research on patulin with an emphasis upon its influence within the food industry, including its regulation, health effects, biosynthesis, detection, quantification, distribution within foods, and control, during the various stages of apple juice production. Finally, key areas where future patulin research should focus to best control the patulin contamination problem within the food industry are addressed. [source] | ||||||||||||||||