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Likely Consequences (likely + consequence)
Selected AbstractsEffects of dietary fatty acids on insulin sensitivity and secretionDIABETES OBESITY & METABOLISM, Issue 6 2004Melania Manco Globalization and global market have contributed to increased consumption of high-fat, energy-dense diets, particularly rich in saturated fatty acids( SFAs). Polyunsaturated fatty acids (PUFAs) regulate fuel partitioning within the cells by inducing their own oxidation through the reduction of lipogenic gene expression and the enhancement of the expression of those genes controlling lipid oxidation and thermogenesis. Moreover, PUFAs prevent insulin resistance by increasing membrane fluidity and GLUT4 transport. In contrast, SFAs are stored in non-adipocyte cells as triglycerides (TG) leading to cellular damage as a sequence of their lipotoxicity. Triglyceride accumulation in skeletal muscle cells (IMTG) derives from increased FA uptake coupled with deficient FA oxidation. High levels of circulating FAs enhance the expression of FA translocase the FA transport proteins within the myocites. The biochemical mechanisms responsible for lower fatty acid oxidation involve reduced carnitine palmitoyl transferase (CPT) activity, as a likely consequence of increased intracellular concentrations of malonyl-CoA; reduced glycogen synthase activity; and impairment of insulin signalling and glucose transport. The depletion of IMTG depots is strictly associated with an improvement of insulin sensitivity, via a reduced acetyl-CoA carboxylase (ACC) mRNA expression and an increased GLUT4 expression and pyruvate dehydrogenase (PDH) activity. In pancreatic islets, TG accumulation causes impairment of insulin secretion. In rat models, ,-cell dysfunction is related to increased triacylglycerol content in islets, increased production of nitric oxide, ceramide synthesis and ,-cell apoptosis. The decreased insulin gene promoter activity and binding of the pancreas-duodenum homeobox-1 (PDX-1) transcription factor to the insulin gene seem to mediate TG effect in islets. In humans, acute and prolonged effects of FAs on glucose-stimulated insulin secretion have been widely investigated as well as the effect of high-fat diets on insulin sensitivity and secretion and on the development of type 2 diabetes. [source] Tectonic and stratigraphic significance of the Middle Ordovician carbonate breccias in the Ogcheon Belt, South KoreaISLAND ARC, Issue 3 2002In-Chang Ryu Abstract Carbonate breccias occur sporadically in the Lower,Middle Ordovician Maggol Limestone exposed in the Taebacksan Basin in the northeastern part of the northeast,southwest-trending Ogcheon Belt, South Korea. These carbonate breccias have been previously interpreted as intraformational or fault-related breccias. Thus, little attention has been focused on tectonic and stratigraphic significance of these carbonate breccias. The present study, however, indicates that the majority of these carbonate breccias are solution,collapse breccias, which are causally linked to paleokarstification. Carbonate facies analysis in conjunction with conodont biostratigraphy suggests that an overall regression toward the top of the Maggol Limestone probably culminated in subaerial exposure of platform carbonates during the early Middle Ordovician (earliest Darriwilian). Extensive subaerial exposure of platform carbonates resulted in paleokarst-related solution,collapse breccias in the upper Maggol Limestone. This subaerial exposure event is manifested as a major paleokarst unconformity at the Sauk,Tippecanoe sequence boundary elsewhere beneath the Middle Ordovician succession and its equivalents, most notably North America and North China. Due to its global extent, this paleokarst unconformity has been viewed as a product of second- or third-order eustatic sealevel drop during the early Middle Ordovician. Although a paleokarst breccia zone is recognized beneath the Middle Ordovician succession in South Korea, the Sauk,Tippecanoe sequence boundary appears to be a conformable transgressive surface on the top of the paleokarst breccia zone in the upper Maggol Limestone. The paleokarst breccia zone beneath the conformable transgressive surface is represented by a thinning-upward stack of exposure-capped tidal flat-dominated cycles that are closely associated with multiple occurrences of paleokarst-related solution,collapse breccias. This paleokarst breccia zone was a likely consequence of repeated fourth- and fifth-order sealevel fluctuations. It suggests that second- and third-order eustatic sealevel drop may have been significantly tempered by substantial tectonic subsidence near the end of the Maggol deposition. The tectonic subsidence in the basin is also evidenced by the occurrence of coeval off-platform lowstand siliciclastic quartzite lenses as well as debris flow carbonate breccias (i.e. the Yemi Breccia). With the continued tectonic subsidence, subsequent rise in the eustatic cycle caused drowning and deep flooding of carbonate platform, forming a transgressive surface on the top of the paleokarst breccia zone. This tectonic implication contrasts notably with the slowly subsiding carbonate platform model for the basin as has been previously interpreted. Thus, it is proposed that the Taebacksan Basin in the northeastern part of the Ogcheon Belt evolved from a slowly subsiding carbonate platform to a rapidly subsiding intracontinental rift basin during the early Middle Ordovician. The proposed tectonic model in the basin gives much better insight to unravel the stratigraphic response to tectonic evolution of the Ogcheon Belt, which remains an enigmatic feature in formulating a tectonic framework of the Korean peninsula. The present study also provides a good example that the falling part of the eustatic sealevel cycle may not produce a significant event in a rapidly subsiding basin where the rate of eustatic fall always remained lower than the rate of subsidence. [source] Social bonds in birds are associated with brain size and contingent on the correlated evolution of life-history and increased parental investmentBIOLOGICAL JOURNAL OF THE LINNEAN SOCIETY, Issue 1 2010SUSANNE SHULTZ In birds, large brains are associated with a series of population-level phenomena, including invasion success, species richness, and resilience to population decline. Thus, they appear to open up adaptive opportunities through flexibility in foraging and anti-predator behaviour. The evolutionary pathway leading to large brain size has received less attention than behavioural and ecological correlates. Using a comparative approach, we show that, independent of previously recognized associations with developmental constraints, relative brain size in birds is strongly related to biparental care, pair-bonding, and stable social relationships. We also demonstrate correlated evolution between large relative brain size and altricial development, and that the evolution of both traits is contingent on biparental care. Thus, biparental care facilitates altricial development, which permits the evolution of large relative brain size. Finally, we show that large relative brain size is associated with pair-bond strength, itself a likely consequence of cooperation and negotiation between partners under high levels of parental investment. These analyses provide an evolutionary model for the evolution of and prevalence of biparental care, altricial development, and pair-bonding in birds. © 2010 The Linnean Society of London, Biological Journal of the Linnean Society, 2010, 100, 111,123. [source] Scaling the structure,function relationship for clinical perimetryACTA OPHTHALMOLOGICA, Issue 4 2005Ronald S. Harwerth Abstract. Purpose:,The full ranges of glaucomatous visual field defects and retinal ganglion cell losses extend over several orders of magnitude and therefore an interpretation of the structure,function relationship for clinical perimetry requires scaling of both variables. However, the most appropriate scale has not been determined. The present study was undertaken to compare linear and logarithmic transformations, which have been proposed for correlating the perimetric defects and neural losses of glaucoma. Methods:,Perimetry, by behavioural testing, and retinal histology data were obtained from rhesus monkeys with significant visual field defects caused by experimental glaucoma. Ganglion cell densities were measured in histologic sections of retina that corresponded to specific perimetry test locations for the treated and control eyes. The linear (percentage) and logarithmic (decibel) relationships for sensitivity loss as a function of ganglion cell loss were analysed. Results:,With decibel scaling, visual sensitivity losses and ganglion cell densities were linearly correlated with high coefficients of determination (r2), although the parameters of the functions varied with eccentricity. The structure,function relationships expressed as linear percentage-loss functions were less systematic in two respects. Firstly, the relationship exhibited considerable scatter in the data for small losses in visual sensitivity and, secondly, visual sensitivity losses became saturated with larger losses in ganglion cell density. The parameters of the percentage-loss functions also varied with eccentricity, but the variation was less than for the decibel-loss functions. Conclusions:,Linear scaling of perimetric defects and ganglion cell losses might potentially improve the structure,function relationship for visual defects associated with small amounts of cell loss, but the usefulness of the relationship is limited because of the high variability in that range. With log,log co-ordinates, the structure,function relationship for clinical perimetry is relatively more accurate and precise for cell losses greater than about 3 dB. The comparatively greater accuracy and precision of decibel loss functions are a likely consequence of the logarithmic scale of stimulus intensities for perimetry measurements and because the relationship between visual sensitivity and the number of neural detectors is a form of probability summation. [source] Land-cover and land-use change and its contribution to the large-scale organization of Puerto Rico's bird assemblagesDIVERSITY AND DISTRIBUTIONS, Issue 1 2008Miguel A. Acevedo ABSTRACT Global biodiversity is changing rapidly driven by human alteration of habitat, and nowhere this is more dramatic than in insular habitats. Yet land-cover change is a complex phenomenon that not only involves habitat destruction but also forest recovery over different time scales. Therefore, we might expect species to respond in diverse ways with likely consequences for the reorganization of regional assemblages. These changes, however, may be different in tropical islands because of their low species richness, generalist habits and high proportion of endemics. Here, we focus on the island of Puerto Rico and ask how island-wide changes in land cover and land use has influenced the large-scale organization of bird assemblages. To address this question, we combined in a Geographical Information System (GIS) the first 6 years (1997,2002) of the Puerto Rican Breeding Bird Survey (PR-BBS) with land-cover and land-use data extracted from a published digital map derived from the classification of Landsat images. A Non-metric Multidimensional Scaling (NMS) ordination based on the composition and abundance of birds, and percentage land-use types showed that land use followed by climate could explain most of the variation observed among routes in terms of species composition and abundance. Moreover, endemic and exotic species were widely distributed throughout the island, but the proportion of endemic species is higher in closed forests while exotic species are more abundant in open habitats. However, historical accounts from the early 1900s indicate that endemic species were distributed across the entire island. Today, most of the land cover transformation in Puerto Rico occurs in the lowlands which may explain the high abundance of endemic species in cloud forests and the high abundance of exotic species in open habitats in the lowlands. [source] Women and Work in the Information AgeGENDER, WORK & ORGANISATION, Issue 1 2000Celia Stanworth Widespread social transformation and new class structures are predicted with the coming of the ,information age', but there is disagreement about the likely outcomes for work and em-ployment patterns. Mainstream writing on the information age, both from the functionalist and Marxist traditions, tends not to consider likely consequences for women, but recent feminist research on gender and technology, treating technology as masculine culture, offers a useful framework for further research. This article argues that the information age may lead to some areas of convergence between the sexes in their experience of future work, but men may continue to defend areas of competence and to dominate the high status and powerful occupational positions of the future. [source] A framework for assessing the biodiversity and fishery aspects of marine reservesJOURNAL OF APPLIED ECOLOGY, Issue 4 2009Phillip S. Levin Summary 1. ,Resource management agencies are often charged with managing natural resources for economic and social goals, while also protecting and conserving biodiversity and ecosystem function. However, this may not always be possible. Ecosystem-based management is frequently suggested as a way to achieve multiple objectives in resource management and requires that trade-offs among conflicting objectives be identified and an effective means to utilize these trade-offs developed. 2. ,We examine the relationship between area and species richness in a diverse assemblage of fishes along the US West Coast and then use parameters from this relationship as input for a model that considers trade-offs between fisheries yield and the number of species protected by different management strategies. 3. ,The species,area relationship (S = cAz) for fishes along the US Pacific coast is well described by the relationship S = 16·18A0·226. 4. ,There are nearly linear trade-offs between diversity and yield when fishing effort is low. However, the trade-offs become nonlinear as fishing effort increases and imposing MPAs increases both the conservation and fisheries value of the system when the system is overfished. 5. ,Synthesis and applications. Solving conflicts between fisheries and conservation requires attention as to how conservation benefits accrue as fishing effort is reduced. However, scientists often lack quantitative information about the trade-offs inherent in human activities such as fisheries. The approach we develop here can begin to help frame the questions to be posed and evaluate the likely consequences of different management options. [source] CORPORATE CITIZENSHIP AND URBAN PROBLEM SOLVING: THE CHANGING CIVIC ROLE OF BUSINESS LEADERS IN AMERICAN CITIESJOURNAL OF URBAN AFFAIRS, Issue 1 2010ROYCE HANSON ABSTRACT:,Our concern in this article is corporate civic elite organizations and their role in social production and urban policy in the United States. Recent urban literature has suggested that the power and influence of CEO organizations has declined and that there has been some disengagement of corporate elites from civic efforts in many urban areas. Yet while these trends and their likely consequences are generally acknowledged, relatively little empirical research has been conducted on the nature and extent of the shifts in corporate civic leadership and on how these shifts have affected the civic agendas of central cities and metropolitan regions. In this study we obtain data from 19 large metropolitan areas in order to more systematically examine shifts in corporate civic leadership and their consequences. Our results suggest that the institutional autonomy, time, and personal connections to the central cities of many CEOs have diminished and that the civic organizations though which CEOs work appear to have experienced lowered capacity for sustained action. These trends suggest that while many CEOs and their firms will continue to commit their time and their firms' slack resources to civic enterprises, the problems they address will differ from those tackled in the past. We discuss the important implications these shifts have for the future of corporate civic engagement in urban problem solving and for the practice of urban governance. [source] The Terror that Failed: Public Opinion in the Aftermath of the Bombing in Oklahoma CityPUBLIC ADMINISTRATION REVIEW, Issue 3 2000Carol W. Lewis Did the bombing of the federal building in Oklahoma City affect the public's perception of terrorism as a political issue and their perceptions of individual risk and personal vulnerability? The author finds that the bombing in Oklahoma City altered neither the public's assessment of personal risk nor its reported behavior. Public opinion on terrorism and crime share three patterns: (1) perceived risk of victimization and the likely consequences affect public apprehension; (2) the voiced sense of personal security bears a direct relationship to the relative familiarity of the setting; and (3) the public shows resistance to the media's portrayal of risk. Opinion data indicate that domestic terrorism is likely to be seen as important in general and in the abstract, but with low personal risk, little impact on individuals' routine behavior, and, consequently, low political salience. In light of terrorism's purpose of inducing fear and the public's generally placid response on a personal level, the author concludes that the bombing failed as an act of domestic terrorism. [source] New Contractual Relationships in the Agency Worker Market: The Case of the UK's National Health ServiceBRITISH JOURNAL OF INDUSTRIAL RELATIONS, Issue 3 2008Kim Hoque In recent years, there has been a trend towards the negotiation of closer contractual relationships between employers and employment agencies. However, little is known about this change or its likely consequences. In theory, such relationships can benefit employers by lowering fees and also reducing many of the hidden costs associated with the use of agency staff by improving the effectiveness of placement matching. Against this is the suggestion that formal partnerships are unlikely to have a positive impact given the uncertainty of demand for temporary labour and broader tendencies for risk displacement in buyer,supplier networks. In this article, our aim is to explore this matter focusing on recent developments in the UK's National Health Service. We find that new contractual relationships such as framework agreements and master vendor contracts are having mixed effects. While they serve to reduce direct costs for employers in the short term, this has been at the expense of relationship building and improvements in placement matching. These developments are also found to have some potentially negative consequences for the agency workforce itself. [source] | |||||||||||||||||||