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Light Chain Disease (light + chain_disease)

Distribution by Scientific Domains
Medical Sciences100%

Selected Abstracts

Coexistence of light chain disease and chronic lymphocytic leukaemia, a complex karyotype with a rapid fatal outcome

INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, Issue 2 2006
H. CASTRYCK
Summary We report on a 48-year-old man with concomitantly diagnosed kappa expressing chronic lymphocytic leukaemia (CLL) and lambda light chain disease with highly complex chromosomal aberrations. The clinical course of the disease was very aggressive with survival of only 1 month. We demonstrate the distinct clonal origin by cytogenetic data and immunoglobulin rearrangement studies. To our knowledge this is the first report of a light chain disease associated with CLL. [source]

Pulmonary manifestations of light chain deposition disease

RESPIROLOGY, Issue 5 2009
Lisa RHO
ABSTRACT Light chain deposition disease (LCDD) is a rare condition characterized by extracellular light chain deposition in tissues. Patients commonly have an underlying plasma cell dyscrasia, and produce excess levels of monoclonal light chains. Renal involvement is the most common clinical manifestation. Rarely, light chains are deposited in the lung. We present the pathologic and radiographic findings of three patients with biopsy-proven pulmonary light chain disease and a review of the literature. [source]