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Literature Reveals (literature + reveal)
Selected AbstractsDe Novo Malignant Eccrine Spiradenoma with an Interesting and Unusual LocationDERMATOLOGIC SURGERY, Issue 4 2001Serkan Yildirim MD Background. Reports in the literature reveal that malignant eccrine spiradenomas (MES) are exceedingly rare, and represent aggressive tumors arising in long-standing benign eccrine spiradenomas (ES). Objective. We present a de novo case of MES of the nose, in contrast to reports in the literature of progression from long-standing benign lesions. Methods. Case report and brief review of the literature. Results. Our case was accepted as de novo MES because there was no evidence of ES on pathologic examination. It was treated by surgical excision with 1 cm tumor-free margins. No recurrence or complications were observed for 2 months, but long-term follow-up could not be performed because the patient died of adenocarcinoma of the colon. Conclusion. Although previously reported lesions have arisen in long-standing benign ESs, usually on the trunk or extremities, this report shows that MES may occur as a primary malignant tumor and may occur in unusual locations such as the nose. [source] Targeting of the central histaminergic system for treatment of obesity and associated metabolic disordersDRUG DEVELOPMENT RESEARCH, Issue 8 2006Kjell Malmlöf Abstract There is currently a need for effective pharmacological therapies for treatment of obesity. In this communication, the involvement of the neurotransmitter histamine in the regulation of food intake is reviewed, together with results obtained in animals with pharmacologically increased brain histamine levels. A survey of the literature reveals that histaminergic circuits, arising from nerve cell bodies in the tuberomammillary nucleus and projecting into the paraventricular nucleus, the arcuate nucleus, and the ventromedial hypothalamus, are strongly involved in regulation of food intake and possibly also energy expenditure. Current literature also suggests the histaminergic circuits connect to other neuronal pathways involved in the regulation of energy balance and body weight. Studies performed in rodents demonstrate that H3 receptor antagonists increase hypothalamic histamine and decrease food intake, which result in decreased body weight. Lipid oxidation is increased and, at higher doses, body fat is also decreased. These changes are associated with lower circulating levels of insulin during an oral glucose challenge suggesting an increase in insulin sensitivity. The effects on food intake have also been confirmed in pigs and rhesus monkeys. It can thus be concluded that results obtained with H3 antagonist in animals warrant future clinical studies to evaluate whether this principle is effective in the treatment of human obesity. Drug Dev. Res. 67:651,665, 2006. © 2006 Wiley-Liss, Inc. [source] Neutrophil influx during non-typhoidal salmonellosis: who is in the driver's seat?FEMS IMMUNOLOGY & MEDICAL MICROBIOLOGY, Issue 3 2006Çagla Tükel Abstract A massive neutrophil influx in the intestine is the histopathological hallmark of Salmonella enterica serovar Typhimurium-induced enterocolitis in humans. Two major hypotheses on the mechanism leading to neutrophil infiltration in the intestinal mucosa have emerged. One hypothesis suggests that S. enterica serovar Typhimurium takes an active role in triggering this host response by injecting proteins, termed effectors, into the host cell cytosol which induce a proinflammatory gene expression profile in the intestinal epithelium. The second hypothesis suggests a more passive role for the pathogen by proposing that bacterial invasion stimulates the innate pathways of inflammation because the pathogen-associated molecular patterns of S. enterica serovar Typhimurium are recognized by pathogen recognition receptors on cells in the lamina propria. A review of the current literature reveals that, while pathogen recognition receptors are clearly involved in eliciting neutrophil influx during S. enterica serovar Typhimurium infection, a direct contribution of effectors in triggering proinflammatory host cell responses cannot currently be ruled out. [source] How Crisis Shapes Change: New Perspectives on China's Political Economy during the Sino-Japanese War, 1937,19451HISTORY COMPASS (ELECTRONIC), Issue 4 2007Morris L. Bian This article surveys the recent literature on China's political economy during the Sino-Japanese War (1937,45). This literature reveals that the war-triggered sustained systemic crisis brought about the most intensive Nationalist state-building efforts, the danwei designation of political, economic, and administrative organizations, the expansion of state-owned industries and the decline of the private sector, the creation of a state enterprise system, and the formation of an ideology of developmental state. This literature suggests that the elements of post-1949 institutional and structural arrangements and ideological systems developed well before 1949. Therefore, the critical issue is no longer that of establishing institutional, structural, and ideological continuity between the Nationalist and Communist eras; instead, it rests in understanding why and how the Chinese Communists kept intact, built on, and expanded existing institutions, structures, and ideologies in certain key areas of political, economic, and administrative life. [source] Observed changes in seasons: an overviewINTERNATIONAL JOURNAL OF CLIMATOLOGY, Issue 14 2002T. H. Sparks Abstract Within the last decade the study of phenology has taken on a new legitimacy in the area of climate change research. A growing literature reveals that a change in the timing of natural events is occurring in a wide range of locations and affecting a wide range of species. Changes in spring have been those most commonly reported, with the emphasis on an advance in spring linked to an increase in temperature. Detection of change in autumn is hampered by a smaller pool of available data, events that are harder to define (such as leaf coloration), and various influencing environmental factors triggering autumnal phases. Despite this, the general pattern may be towards a delay in autumn. Plant, animal and abiotic responses, especially in spring, are quite similar. Thus, it would appear that winter is being squeezed at both ends, and this effect, of increasing the growing season, should become more pronounced in the face of predicted global warming. Copyright © 2002 Royal Meteorological Society. [source] Enhancing occupational health and safety in young workers: the role of social marketingINTERNATIONAL JOURNAL OF NONPROFIT & VOLUNTARY SECTOR MARKETING, Issue 3 2008Anne M. Lavack Young workers (age 15,24) suffer work-related injury at a much higher rate than older workers, yet research on the role and effectiveness of social marketing to influence and improve workplace safety is limited. A review of the relevant literature reveals that significant gaps exist in terms of effectively using social marketing to reduce young worker injury rates. A comprehensive, multi-faceted social marketing approach is required to address young worker safety. Directing more attention toward the practice of social marketing can enhance the effectiveness of campaigns to reduce workplace injuries. Copyright © 2007 John Wiley & Sons, Ltd. [source] Personal Responsibility for Tornado Preparedness: Commitment or Choice?,JOURNAL OF APPLIED SOCIAL PSYCHOLOGY, Issue 8 2001JOHN-PAUL MULILIS A review of the literature reveals that personal responsibility assumed for one's behavior clearly affects behavioral outcomes for a variety of situations, and that personal responsibility is in turn affected by a wide variety of variables. However, limited research has been conducted to determine exactly what personal responsibility fundamentally entails. While duty, moral obligation, choice, and commitment have been suggested as being integral to the concept of responsibility, few investigations have systematically varied more than one of these variables in a single experiment. The present study was conducted to investigate the effects of both choice and commitment on personal responsibility assumed for and behavioral intentions to engage in tornado preparedness. Results indicate that both choice and commitment were required to generate personal responsibility for and subsequent intentions to engage in tornado preparedness. Implications of these results are discussed. [source] Pigmented extramammary Paget's disease of the axilla mimicking melanoma: case report and review of the literatureJOURNAL OF CUTANEOUS PATHOLOGY, Issue 9 2009Nicholaus J. Hilliard Pigmented Paget's disease is a rare variant that is often confused clinically and histologically with melanoma in situ. Herein, we describe a case of pigmented extramammary Paget's disease involving the axilla of a 79-year-old white male thought initially to represent malignant melanoma clinically and histologically. Review of the literature reveals that pigmented variant of Paget's disease, either mammary or extramammary, could be initially misdiagnosed as melanoma unless this entity is considered in the differential diagnosis, and additional confirmatory studies are performed. [source] Acute arthritis as an unusual complication of malignancyJOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY, Issue 4 2000Yvonne Zissiadis SUMMARY A 59-year-old man presented with an inability to weight-bear due to an acute, red, hot, swollen knee joint which was subsequently found to be due to a malignant joint effusion consequent to colonic carcinoma. Treatment with radiation therapy relieved his symptoms. A review of the literature reveals that malignant joint effusion is rare and this is only the third reported case secondary to colonic carcinoma. [source] Low-Income Parents and the Public SchoolsJOURNAL OF SOCIAL ISSUES, Issue 2 2001Bernice Lott This article addresses the responses likely to be received by low-income parents from teachers and staff in their children's public schools in the United States. A review of the relevant literature reveals that teachers and school administrators tend to subscribe to the dominant beliefs that low-income parents do not care about their children's schooling, are not competent to help with homework, do not encourage achievement, and do not place a high value on education. This article presents examples of such middle-class bias in the words and actions of individual teachers, and research findings that tend to contradict these stereotypes. The barriers that exist for low-income parents in interacting with the schools are discussed, and suggestions are offered for ways in which schools can recognize and respect the standpoint and potential contributions of these parents. [source] Skin bleaching: highlighting the misuse of cutaneous depigmenting agentsJOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY & VENEREOLOGY, Issue 7 2009OE Dadzie Abstract Hydroquinone and other cutaneous depigmenting agents are widely used by dermatologists to treat pigmentary disorders. On 29 August 2006, the US Food and Drug Administration (FDA) published a monograph in the US Federal Register proposing to ban all hydroquinone products that have not been approved via a New Drug Application process. Reports in the scientific literature on the occurrence of exogenous ochronosis, in relation to the use of hydroquinone, was one of the concerns expressed by the FDA in relation to this agent. However, a review of the English-language scientific literature reveals that most of the reported cases of hydroquinone-induced exogenous ochronosis occurs in Africa, where the cultural practice of skin bleaching is highly prevalent. Skin bleaching is the practice of applying hydroquinone and/or other depigmenting agents to specific or widespread areas of the body, the primary function being to lighten normally dark skin. This practice typically occurs in men and women with Fitzpatrick skin phototypes IV to VI. It is a dangerous practice associated with a diverse range of side-effects, including mercury poisoning. Thus, this current discussion within the dermatological community on the safety of hydroquinone provides a unique opportunity to raise awareness about skin bleaching. [source] Scalp psoriasis: a review of current topical treatment optionsJOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY & VENEREOLOGY, Issue 9 2007K Papp Abstract The scalp is the most common site of disease involvement at the onset and throughout the course of psoriasis. For many patients, psoriasis of the scalp is the most difficult aspect of their disease; yet, despite a wide range of therapy options and an extensive literature base, scalp psoriasis remains difficult to treat, highlighting a long-standing unmet need for the effective treatment of scalp psoriasis. A review of past and current medical literature reveals that a number of interesting therapeutic approaches have been used in the treatment of scalp psoriasis. The diverse and sometimes extreme therapeutic approaches, the marginal benefit of many topical agents, the paucity of controlled studies evaluating the efficacy of topical agents in the treatment of scalp psoriasis and the high level of patient dissatisfaction with currently available treatments for psoriasis all support the need for new, effective and well-tolerated treatment options for scalp psoriasis. [source] Nutritional comparison of fresh, frozen and canned fruits and vegetables.JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, Issue 6 2007Part 1. Abstract The first of a two-part review of the recent and classical literature reveals that loss of nutrients in fresh products during storage and cooking may be more substantial than commonly perceived. Depending on the commodity, freezing and canning processes may preserve nutrient value. The initial thermal treatment of processed products can cause loss of water-soluble and oxygen-labile nutrients such as vitamin C and the B vitamins. However, these nutrients are relatively stable during subsequent canned storage owing to the lack of oxygen. Frozen products lose fewer nutrients initially because of the short heating time in blanching, but they lose more nutrients during storage owing to oxidation. Phenolic compounds are also water-soluble and oxygen-labile, but changes during processing, storage and cooking appear to be highly variable by commodity. Further studies would facilitate the understanding of the changes in these phytochemicals. Changes in moisture content during storage, cooking and processing can misrepresent changes in nutrient content. These findings indicate that exclusive recommendations of fresh produce ignore the nutrient benefits of canned and frozen products. Nutritional comparison would be facilitated if future research would express nutrient data on a dry weight basis to account for changes in moisture. Copyright © 2007 Society of Chemical Industry [source] Institutional Performance And Social Capital: An Application To The Local Government LevelJOURNAL OF URBAN AFFAIRS, Issue 5 2005Hilde Coffé This literature reveals that societies characterized by higher levels of social capital tend to achieve superior performance. Still, enquiries to date predominantly concentrate on country-level data or large sub-national units. The primary purpose of this article is to extend the empirical work to the local government level, while retaining the use of objective data to gauge institutional performance. This use of local data has the advantage of increasing the data set available and provides a more stringent test of the effect of social capital because social capital is likely to vary less at lower levels of government. The results,based on an empirical analysis of 305 Flemish municipalities in 2000,support the view that social capital leads to government (out)performance also at the local level of government. [source] Corticobasal degeneration as a cognitive disorderMOVEMENT DISORDERS, Issue 11 2003Naida L. Graham PhD Abstract The presence of cognitive impairment in corticobasal degeneration (CBD) is now widely recognised. Our review of the literature reveals that, although the pattern and severity of neuropsychological impairments can be highly variable across patients, several general trends can be identified. The most characteristic impairments are limb apraxia (usually ideomotor), constructional and visuospatial difficulties, acalculia, frontal dysfunction, and nonfluent aphasia. The limb apraxia is associated with deficits in drawing, copying, and handwriting, but there is emerging evidence that the problems with handwriting are not due exclusively to the apraxia. The findings with respect to episodic memory are more variable, but when there is impairment in this area, it tends to be milder than that seen in Alzheimer's disease. Semantic memory functioning appears relatively preserved but has been poorly studied. Problems with speech are common, and may be due to dysarthria or buccofacial apraxia. Aphasia, although initially considered rare, is in fact a common accompaniment of CBD, may be the presenting feature, and is typically nonfluent in type. More systematic investigation of the clinical and neuropathological overlap between progressive nonfluent aphasia (generally considered to be a form of frontotemporal dementia) and CBD is needed.© 2003 Movement Disorder Society [source] The Myth of the Bureaucratic Paradigm: What Traditional Public Administration Really Stood ForPUBLIC ADMINISTRATION REVIEW, Issue 2 2001Laurence E. Lynn Jr. For a decade, public administration and management literature has featured a riveting story: the transformation of the field's orientation from an old paradigm to a new one. While many doubt claims concerning a new paradigm,a New Public Management,few question that there was an old one. An ingrained and narrowly focused pattern of thought, a "bureaucratic paradigm," is routinely attributed to public administration's traditional literature. A careful reading of that literature reveals, however, that the bureaucratic paradigm is, at best, a caricature and, at worst, a demonstrable distortion of traditional thought that exhibited far more respect for law, politics, citizens, and values than the new, customer-oriented managerialism and its variants. Public administration as a profession, having let lapse the moral and intellectual authority conferred by its own traditions, mounts an unduly weak challenge to the superficial thinking and easy answers of the many new paradigms of governance and public service. As a result, literature and discourse too often lack the recognition that reformers of institutions and civic philosophies must show how the capacity to effect public purposes and accountability to the polity will be enhanced in a manner that comports with our Constitution and our republican institutions. [source] The Impact of Product Innovativeness on the Link between Development Speed and New Product Profitability,THE JOURNAL OF PRODUCT INNOVATION MANAGEMENT, Issue 3 2006Fred Langerak A review of the literature reveals that the relationship between development speed and new product profitability is not as strong and straightforward as conventional wisdom suggests. A number of studies show positive results, others show mixed results, and some present no evidence of a relationship. In other words, the valence of the link between development speed and new product profitability is unclear at this time. Therefore, this study investigates whether or not speeding new products to market has positive or negative effects on new product profitability. Prior research shows that product innovativeness influences both development speed and new product profitability. This raises the question of whether increasing speed is equally successful in improving profitability across new products that differ in their degree of innovativeness. Therefore, this study also investigates the moderating effect of product innovativeness on the relationship between development speed and new product profitability. The results from a survey-based study of 233 manufacturers of industrial products in the Netherlands reveal an inverted U-shaped relationship between development speed and new product profitability. The findings also show that the optimal point is different for two new product types,product improvements and line additions,that vary in their innovativeness. These results provide an onset for the development of a decision tool that helps managers to determine how much to spend on accelerating the development of individual new products and how they should allocate that spending across products in their new product portfolio. [source] Laryngeal Abscess after Injection Laryngoplasty with Micronized AlloDerm,THE LARYNGOSCOPE, Issue 9 2004Philip E. Zapanta MD Objective: Patients with unilateral vocal cord paralysis usually present with dysphonia and occasionally with swallowing problems. Operative management includes thyroplasty type I, injection laryngoplasty, arytenoid adduction, and reinnervation. Recent publications have documented the safety of micronized AlloDerm (Cymetra, LifeCell Corporation, Branchburg, NJ) for injection laryngoplasty, but we report the first documented case of a laryngeal abscess after injection laryngoplasty with Cymetra. Study Design: Single case report of a laryngeal abscess after injection laryngoplasty with Cymetra. Methods: The patient's clinical course is presented and discussed, and the pertinent literature is reviewed. Results: Prompt hospital admission with intravenous antibiotics and steroids resolved this airway emergency. Follow-up visits showed a significantly improved postoperative voice with an intact airway. Conclusion: A review of the literature reveals that this case of a laryngeal abscess after injection laryngoplasty with Cymetra is the first of its kind. Studies have shown that the use of AlloDerm in the head and neck region is safe, but otolaryngologists need to be cognizant of potential complications when working with this material. [source] Diagnosis and Management of Spontaneous Cerebrospinal Fluid-Middle Ear Effusion and Otorrhea,THE LARYNGOSCOPE, Issue 5 2004N. E. Brown MD Objectives/Hypothesis: Spontaneous leak of cerebrospinal fluid (CSF) into the middle ear can occur in adults without a history of temporal bone trauma or fracture, meningitis, or any obvious cause. Therefore, clues may be lacking that would alert the otolaryngologist that fluid medial to an intact eardrum, or fluid emanating from an eardrum perforation, is likely to be CSF fluid. A review of relevant medical literature reveals that herniation of the arachnoid membrane through a tegmen defect may be congenital, or CSF leak may occur when dynamic factors (i.e., brain pulsations or increases in intracranial pressure) produce a rent in the arachnoid membrane. Because tegmen defects may be multiple rather than single, identifying only one defect may not be sufficient for achieving definitive repair. Data on nine cases of spontaneous CSF leak to the ear in adult patients from four medical centers are presented and analyzed to provide collective information about a disorder that can be difficult to diagnose and manage. Study Design: Retrospective review of nine cases of spontaneous CSF middle ear effusion/otorrhea. Results: The majority of patients presented with symptoms of aural fullness and middle ear effusion. Many developed suspicious clear otorrhea only after insertion of a tympanostomy tube. Two patients had multiple defects in the tegmen and dura, and five patients had meningoencephaloceles confirmed intraoperatively. Five patients underwent combined middle cranial fossa/transmastoid repair. Materials used in repair included temporalis fascia, free muscle graft, Oxycel cotton, calvarial bone, pericranium, bone wax, and fibrin glue. Conclusions: CSF middle ear effusion/otorrhea can develop in adults without a prior history of meningitis or head trauma or any apparent proximate cause. Although presenting symptoms can be subtle, early suspicion and confirmatory imaging aid in establishing the diagnosis. Because surgical repair by way of a mastoid approach alone can be inadequate if there are multiple tegmen defects, a middle fossa approach alone, or in combination with a transmastoid approach, should be considered in most cases. [source] Nonsurgical Management of Parapharyngeal Space Infections: A Prospective StudyTHE LARYNGOSCOPE, Issue 5 2002Jean-Yves Sichel MD Abstract Objective/Hypothesis Parapharyngeal infections, which can potentially cause life-threatening complications, may, in certain cases, be treated conservatively with no need for surgical drainage. A review of the literature reveals that the most recommended treatment of parapharyngeal infection is surgical drainage combined with intravenous antibiotic therapy. Several retrospective reports recommend conservative treatment with no surgical drainage. Study Design Prospective, nonrandomized. Methods A prospective study was performed on all patients with an infection limited to the parapharyngeal space. Results Twelve patients presented with clinical and radiological diagnosis of parapharyngeal infection during a 5-year period. Five patients showed obvious presence of pus in other spaces and therefore were excluded. Seven patients with no gross extension into other spaces and with no respiratory distress or septic shock were treated with intravenous amoxicillin-clavulanic acid for 9 to 14 days (average period, 11 days). All patients except one were children. All were cured with conservative management, and no surgical drainage was needed. None had any complications. Conclusion Our results confirm the effectiveness of nonsurgical treatment of infections limited to the parapharyngeal space, at least in the pediatric population. [source] A glossary of DNA structures from A to ZACTA CRYSTALLOGRAPHICA SECTION D, Issue 4 2003Anirban Ghosh The right-handed double-helical Watson,Crick model for B-form DNA is the most commonly known DNA structure. In addition to this classic structure, several other forms of DNA have been observed and it is clear that the DNA molecule can assume different structures depending on the base sequence and environment. The various forms of DNA have been identified as A, B, C etc. In fact, a detailed inspection of the literature reveals that only the letters F, Q, U, V and Y are now available to describe any new DNA structure that may appear in the future. It is also apparent that it may be more relevant to talk about the A, B or C type dinucleotide steps, since several recent structures show mixtures of various different geometries and a careful analysis is essential before identifying it as a `new structure'. This review provides a glossary of currently identified DNA structures and is quite timely as it outlines the present understanding of DNA structure exactly 50,years after the original discovery of DNA structure by Watson and Crick. [source] | ||||||||||||||||||||||||||||||||||