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Literature Analysis (literature + analysis)
Selected AbstractsOsteoporosis management: a perspective based on bisphosphonate data from randomised clinical trials and observational databasesINTERNATIONAL JOURNAL OF CLINICAL PRACTICE, Issue 12 2009S. Boonen Summary Aims:, The efficacy of treatments for osteoporosis can be evaluated using a variety of study designs. This article aims to comprehensively review the evidence for bisphosphonate anti-fracture efficacy in postmenopausal women, discussing the strengths and limitations associated with each study method. Methods:, Literature analysis included English-language publications reporting results of randomised controlled trials (RCTs), post hoc analyses, meta analyses and observational studies evaluating the efficacy of alendronate (ALN), ibandronate (IBN), risedronate (RIS) and zoledronate (ZOL), with an initial sample size , 100 patients, and follow-up data for at least 1 year. Results:, Primary and secondary analyses of RCT data suggest differences among bisphosphonates with regard to site-specific anti-fracture efficacy and onset of fracture risk reduction. While some observational studies indicate differences in clinical outcomes among these agents, others report similar effectiveness. ALN and RIS data demonstrate sustained fracture protection for up to 10 and 7 years of treatment respectively. The efficacy of IBN and ZOL has been evaluated for up to 3 and 5 years respectively. Conclusions:, Understanding of the benefits of bisphosphonate treatment can be maximised by evaluating complementary data from RCTs and observational database studies. Fracture risk reduction with bisphosphonates is shown in RCTs and in real-world clinical settings. [source] EFNS guidelines on management of neurological problems in liver transplantationEUROPEAN JOURNAL OF NEUROLOGY, Issue 1 2006M. Guarino Neurological impairment after orthotopic liver transplantation (OLT) is common and represents a major source of morbidity and mortality. The diagnosis and management of neurological problems occurring after OLT are difficult and evidence-based guidelines for this task are currently lacking. A Task Force was set up under the auspices of the European Federation of Neurological Societies to devise guidelines to prevent and manage neurological problems in OLT. We selected six major neurological problems and approached them combining an evidence-based scientific literature analysis with a search of consensus by means of a Delphi process. Search results were translated into a series of recommendations constituting a basis for better care of patients with neurological complications after OLT. [source] Stable ,Floating' Air Diffusion Biocathode Based on Direct Electron Transfer Reactions Between Carbon Particles and High Redox Potential LaccaseFUEL CELLS, Issue 4 2010S. Shleev Abstract We report on the assembly and characterisation of a high potential, stable, mediator-less and cofactor free biocathode based on a fungal laccase (Lc), adsorbed on highly dispersed carbonaceous materials. First, the stability and activity of Trametes hirsuta Lc immobilised on different carbon particles were studied and compared to the solubilised enzyme. Based on the experimental results and a literature analysis, the carbonaceous material BM-4 was chosen to design efficient and stable biocatalysts for the production of a ,floating' air diffusion Lc-based biocathode. Voltammetric characteristics and operational stability of the biocathode were investigated. The current density of oxygen reduction at the motionless biocathode in a quiet, air saturated citrate buffer (100,mM, pH 4.5, 23,°C) reached values as high as 0.3,mA,cm,2 already at 0.7,V versus NHE. The operational stability of the biocathode depended on the current density of the device. For example, at low current density (20,,A,cm,2), the biocathode lost only 5× of its initial power after 1 month of continuous operation. However, when the device was polarised at 150,mV it lost more than 32× of its initial power in just 10,min. We also found that co-immobilisation of Lc and peroxidase on highly dispersed carbon materials could protect the biocatalyst from rapid inactivation by hydrogen peroxide produced during electrocatalytic reactions at high-current densities. [source] Patient characteristics as predictors of primary health care preferences: a systematic literature analysisHEALTH EXPECTATIONS, Issue 2 2003Hans Peter Jung MD PhD GP Abstract Objective To identify associations between various cultural and demographic factors and patients' primary health care preferences. Search strategy Searches were performed in MEDLINE (1966,December 2000), PsycINFO (1977,May 2001) and Sociological Abstracts (1963,December 2000). Identified papers were checked for more papers. Inclusion criteria Studies with a focus on primary health care or health care in general, asking patients about preferences with regard to health care, reporting quantitative results and examining the relations between specific patient characteristics and patient preferences. Data extraction and synthesis Data were extracted from studies using a scoring form to register what methods were used, which patient characteristics were analysed and which patient characteristics significantly influenced patients' preferences with regard to different aspects of health care (P < 0.05). Main results A total of 145 studies were included with 2276 comparisons between subgroups of patients. Of all the comparisons, 607 (27%) showed a significant association between patient characteristics and preferences with regard to primary health care. Age and economic status significantly related to patient preferences in 38 and 33% of the comparisons, respectively. Education, health status, family situation, sex, and utilization of health care related significantly to patient preferences in less than 25% of the comparisons. Conclusions This review of the literature showed patient characteristics to be an important determinant of preferences regarding many aspects of primary health care defined as general practice care or health care, in general. All of the patient characteristics examined here showed at least some significant associations with preferences for primary health care. [source] Towards a distinctive body of knowledge for Information Systems experts: coding ISD process knowledge in two IS journalsINFORMATION SYSTEMS JOURNAL, Issue 4 2004Juhani Iivari Abstract., This paper introduces the idea of coding a practically relevant body of knowledge (BoK) in Information Systems (IS) that could have major benefits for the field. In its main part, the paper focuses on the question if and how an underlying body of action-oriented knowledge for IS experts could be distilled from the IS research literature. For this purpose the paper identifies five knowledge areas as the most important parts for an IS expert's BoK. Two of these are claimed as distinct areas of competence for IS experts: IS application knowledge and IS development (ISD) process knowledge. The paper focuses particularly on ISD process knowledge because it allows the organizing of practically relevant IS knowledge in an action-oriented way. The paper presents some evidence for the claim that a considerable body of practically relevant IS process knowledge might, indeed, exist, but also notes that it is highly dispersed in the IS literature. It then argues that the IS research community should take stock of this knowledge and organize it in an action-oriented way. Based on results from prior work it proposes a four-level hierarchical coding scheme for this purpose. In order to test the idea of coding action-oriented knowledge for IS experts, the paper reports the results of a coded literature analysis of ISD research articles published from 1996 to 2000 in two leading IS journals , Information Systems Journal and MIS Quarterly. The results suggest that ISD approaches form a useful framework for organizing practically relevant IS knowledge. [source] The psychological contract: A critical reviewINTERNATIONAL JOURNAL OF MANAGEMENT REVIEWS, Issue 2 2006Niall Cullinane Literature on the psychological contract has blossomed progressively over the last ten years to the extent that it is now firmly located within the lexicon of the Human Resource Management (HRM) discipline. Yet as this review indicates, the theoretical assumptions that seem to pervade the psychological contract literature are not without major deficiencies, which in turn pose serious questions around the continued sustainability of the construct as currently constituted. This paper addresses some of the central problems presently confronting the theoretical side of the psychological contract literature. In seeking to advance knowledge and understanding, this review calls for an alternative approach to studying the psychological contract on the basis of a more critical and discursive literature analysis. From this, the authors unpick the construct of the psychological contract as portrayed in much of the extant literature and argue that, in its present form, it symbolizes an ideologically biased formula designed for a particular managerialist interpretation of contemporary work and employment. [source] The characteristics, qualities and skills of practice developersJOURNAL OF CLINICAL NURSING, Issue 3 2003Brendan Mccormack BSc, DPhil, PGCEA Summary ,,There is a growing interest in practice development as a systematic process for the development of quality patient care. ,,Whilst there is a range of accounts of practice development in the literature, little work has been undertaken to develop an understanding of the systems and processes involved and there is even less on the roles involved in practice development. ,,This paper explores in particular the characteristics, qualities and skills of practice developers, i.e. professionals who have formal responsibility for developing practice in organizations. ,,The paper represents part of a larger study exploring the conceptual basis of the term ,practice development'. ,,Data for this part of the project were collected through literature analysis, seven focus groups involving 60 practice developers and telephone interviews with 25 practising nurses with experience of working with practice developers. The data were analysed using cognitive mapping processes. ,,Four role functions are presented in the paper, as well as qualities and skills needed to operationalize the identified role functions. ,,A clear picture of the skills and qualities required by practice developers emerges from the data. [source] Peer evaluation in nurses' professional development: a pilot study to investigate the issuesJOURNAL OF CLINICAL NURSING, Issue 2 2000Riitta Vuorinen MNSc ,,Peer evaluation in nursing is a method by which the nurse evaluates the work of a peer, according to set evaluation criteria. ,,The aim of the study was to clarify the potential significance of peer evaluation with regard to nurses' career development and relates to the introduction of a career development programme for nurses in a Finnish University Hospital. ,,The research concepts were created on the basis of literature analysis. The concepts served as a basis for data collection, and five open-ended questions were devised from them. Informants (n = 24) gave free-form essay-type answers to these questions. The material was analysed using qualitative content analysis. ,,The results indicate that self-evaluation constitutes the basis for peer evaluation. Peer evaluation allows nurses to give and receive professional and personal support promoting professional development. Professional support offers possibilities for change and alternative action. Personal support requires respect for the peer's equality and individuality. Personal peer support can decrease feelings of uncertainty and insecurity caused by work. ,,The conclusion is drawn that peer evaluation is a means of promoting nurses' professional development to further on-the-job learning in collaboration with peers. [source] Priorities for Nursing Research in KoreaJOURNAL OF NURSING SCHOLARSHIP, Issue 4 2002Mi Ja Kim Purpose: To identify priorities for nursing research in Korea. Methods: A national sample of nurses in academic and clinical settings, representing varied clinical specialties, participated in two rounds of a Delphi survey. Participants listed five most important nursing research problems rated on three dimensions: the degree of nurses' lead role, contribution to nursing profession, and nurses' contribution to health and welfare of patients and clients. A total of 29 research areas were derived from 1,013 research problems identified from the Delphi surveys, and 26 expert panel members who participated in a 1-day workshop to determine the priority of these areas. Key words of 706 research articles published in the major nursing research journals in Korea were analyzed to identify priorities. Results: In the two rounds of Delphi surveys 347 of 1,047 nurses participated (31%,33% response rates respectively). Top three research areas common to both Delphi survey and literature analysis were: clinical nursing practice, nursing education, and nursing research. Cultural nursing was rated the lowest in the Delphi survey but was rated third by the expert panel members. Conclusions: In the clinical practice area, research on the advanced practice nursing system was the first priority research problem followed by development of nursing interventions, clinical competency, quality and effectiveness of nursing care, and standardized nursing tasks. Research on home health care, nursing education, utilization of nursing research, and geriatric nursing were other areas of priority. Nurses around the world are encouraged to develop collaborative research projects based on common priority areas. [source] Pluralism and diversity: trends in the use and application of ordination methods 1990-2007JOURNAL OF VEGETATION SCIENCE, Issue 4 2009Henrik Von Wehrden Abstract Question: What are the trends and patterns in the application of ordination techniques in vegetation science since 1990? Location: Worldwide literature analysis. Methods: Evaluation of five major journals of vegetation science; search of all ISI-listed ecological journals. Data were analysed with ANCOVAs, Spearman rank correlations, GLMs, biodiversity indices and simple graphs. Results: The ISI search retrieved fewer papers that used ordinations than the manual evaluation of five selected journals. Both retrieval methods revealed a clear trend in increasing frequency of ordination applications from 1990 to the present. Canonical Correspondence Analysis was far more frequently detected by the ISI search than any other method. Applications such as Correspondence Analysis/Reciprocal Averaging and Detrended Correspondence Analysis have increasingly been used in studies published in "applied" journals, while Canonical Correspondence Analysis, Redundancy Analysis and Non-Metric Multidimensional Scaling were more frequently used in journals focusing on more "basic" research. Overall, Detrended Correspondence Analysis was the most commonly applied method within the five major journals, although the number of publications slightly decreased over time. Use of Non-Metric Multidimensional Scaling has increased over the last 10 years. Conclusion: The availability of suitable software packages has facilitated the application of certain techniques such as Non-Metric Multidimensional Scaling. However, choices of ordination techniques are currently less driven by the constraints imposed by the software; there is also limited evidence that the choice of methods follows social considerations such as the need to use fashionable methods. Methodological diversity has been maintained or has even increased over time and reflects the researcher's need for diverse analytical tools suitable to address a wide range of questions. [source] Central corneal thickness in European (white) individuals, especially children and the elderly, and assessment of its possible importance in clinical measures of intra-ocular pressureOPHTHALMIC AND PHYSIOLOGICAL OPTICS, Issue 6 2002Michael J. Doughty Purpose:,To ascertain the impact of central corneal thickness (CCT, as assessed by pachometry) and central corneal curvature (as assessed by keratometry) on clinical measures of intra-ocular pressure (IOP, as assessed by tonometry), especially in the young and elderly. Methods:,Pachometry, keratometry and tonometry were carried out on three groups, namely children aged 5,15 years, adults aged 32,60 years, and elderly individuals aged between 61 and 82 years. For children, ultrasound pachometry was combined with non-contact tonometry (NCT), specular microscopy was used with Perkins tonometry in the adults, and ultrasound pachometry was used with Perkins tonometry for the elderly. Central corneal curvature was assessed by keratometry. Results:,The average CCT in children was 0.529 ± 0.034 mm (n=104, ±S.D.), averaged 0.533 ± 0.033 in adults (n=75) and 0.527 ± 0.034 mm (n=91) in the elderly. Tonometry values averaged 16.7 ± 2.9 mm in children, 13.0 ± 3.5 mmHg in adults and 13.6 ± 2.5 mm in the elderly group. Central corneal thickness values were not predictably different in relation to central corneal curvature values. Regression analyses indicated that the tonometry values were higher in both children and the elderly who had thicker corneas (and vice versa) (p , 0.003), with the measures increasing by 1.3 ± 0.4 and 2.6 ± 0.4 mmHg for a 10% difference in CCT in children and the elderly, respectively. For adults, no statistically significant difference in tonometry values could be demonstrated with respect to CCT (<1 mmHg for a 10% difference in CCT), and for no group were the CCT or tonometry values predictably different in relation to central corneal curvature values. Conclusions:,The results of these studies, albeit relatively small scale, indicate that in young or elderly individuals with essentially normal IOP and CCT measures, the tonometry values show only small differences with respect to CCT. The slope in the observed relationship was not that different from an average of 1.5 mmHg for a 10% different in CCT, as obtained from a literature analysis over a 30-year period. The magnitude of the effect does not provide evidence that pachometry needs to be routinely performed in glaucoma screening protocols based on tonometry. Notwithstanding, the finding of higher than expected tonometry values should be further investigated, by pachometry, especially in very young children and in the elderly. [source] Chinese R&D: naissance, renaissance, or mirage?R & D MANAGEMENT, Issue 4 2004William A. Fischer China's re-emergence has been treated mostly from economic and political standpoints. This article integrates these perspectives with a review of China's modern history of research and development (R&D). It starts with a brief retrospective of China's efforts in science and technology before the reforms of 1978. It then discusses China's principle R&D issues in the early 1980s and the most significant results of 20 years of rapid industrialization. Based on this historic review and a wide literature analysis, some observations are made about China's R&D capabilities in the first years of the new millennium as well as what challenges may still lie ahead for China before becoming a leading source of scientific and technological innovation. [source] Evaluating Oversight Systems for Emerging Technologies: A Case Study of Genetically Engineered OrganismsTHE JOURNAL OF LAW, MEDICINE & ETHICS, Issue 4 2009Jennifer Kuzma The U.S. oversight system for genetically engineered organisms (GEOs) was evaluated to develop hypotheses and derive lessons for oversight of other emerging technologies, such as nanotechnology. Evaluation was based upon quantitative expert elicitation, semi-standardized interviews, and historical literature analysis. Through an interdisciplinary policy analysis approach, blending legal, ethical, risk analysis, and policy sciences viewpoints, criteria were used to identify strengths and weaknesses of GEOs oversight and explore correlations among its attributes and outcomes. From the three sources of data, hypotheses and broader conclusions for oversight were developed. Our analysis suggests several lessons for oversight of emerging technologies: the importance of reducing complexity and uncertainty in oversight for minimizing financial burdens on small product developers; consolidating multi-agency jurisdictions to avoid gaps and redundancies in safety reviews; consumer benefits for advancing acceptance of GEO products; rigorous and independent pre- and post-market assessment for environmental safety; early public input and transparency for ensuring public confidence; and the positive role of public input in system development, informed consent, capacity, compliance, incentives, and data requirements and stringency in promoting health and environmental safety outcomes, as well as the equitable distribution of health impacts. Our integrated approach is instructive for more comprehensive analyses of oversight systems, developing hypotheses for how features of oversight systems affect outcomes, and formulating policy options for oversight of future technological products, especially nanotechnology products. [source] Apoptosis-Inducing High .CHEMMEDCHEM, Issue 10 2008NO Concentrations Are Not Sustained Either in Nascent or in Developed Cancers Abstract Nitric oxide (.NO) induces apoptosis at high concentrations by S-nitrosating proteins such as glyceraldehyde-3-phosphate dehydrogenase. This literature analysis revealed that failure to sustain high . NO concentrations is common to all cancers. In cervical, gastric, colorectal, breast, and lung cancer, the cause of this failure is the inadequate expression of inducible nitric oxide synthase (iNOS), resulting from the inhibition of iNOS expression by TGF-,1 at the mRNA level. In bladder, renal, and prostate cancer, the reason for the insufficient . NO levels is the depletion of arginine, resulting from arginase overexpression. Arginase competes with iNOS for arginine, catalyzing its hydrolysis to ornithine and urea. In gliomas and ovarian sarcomas, low . NO levels are caused by inhibition of iNOS by N -chlorotaurine, produced by infiltrating neutrophils. Stimulated neutrophils express myeloperoxidase, catalyzing H2O2 oxidation of Cl, to HOCl, which N-chlorinates taurine at its concentration of 19,mM in neutrophils. In squamous cell carcinomas of the skin, ovarian cancers, lymphomas, Hodgkin's disease, and breast cancers, low . NO concentrations arise from the inhibition of iNOS by N -bromotaurine, produced by eosinophil-peroxidase-expressing infiltrating eosinophils. Eosinophil peroxidase catalyzes the H2O2 oxidation of Br, to HOBr, which N-brominates taurine to N -bromotaurine at its concentration of 15,mM in eosinophils. In microvascularized tumors, the . NO concentration is further depleted; . NO is rapidly consumed by red blood cells (RBCs) through S-nitrosation of RBC glutathione and hemoglobin, and by oxidation to nitrate by RBC oxyhemoglobin. Angiogenesis-inhibiting antibodies are currently used to treat cancers; their mode of action is not, as previously thought, reduction of the tumor O2 or nutrient supply. They actually decrease the loss of . NO to RBCs. [source] Australian Cancer Network Clinical Practice Guidelines for the Management of ocular and periocular Melanoma: an evidence-based literature analysisCLINICAL & EXPERIMENTAL OPHTHALMOLOGY, Issue 7 2008Simon E Skalicky MBBS Abstract Background:, With recent advances in the diagnosis and management of ocular and periocular melanoma, many of which are based on results from randomized control trials, there is an increasing need for an evidence-based review of the literature for the Australasian population. The Australian Cancer Network has recently redeveloped the evidence-based Clinical Practice Guidelines for the Management of Melanoma, including a chapter on ocular melanoma. These are the first evidence-based guidelines on ocular melanoma to be created by the Australian Cancer Network. Methods:, The primary research questions were formed and a detailed literature search was undertaken. Each relevant article was assessed and graded I,IV according to the level of evidence. Articles were grouped into bodies of evidence which were then assessed. Results:, A total of 107 relevant articles were identified and grouped into 12 bodies of evidence. Guidelines based on this analysis were formulated and graded. These are presented below. Conclusions:, The management of ocular melanoma has benefited from recent advances in imaging, molecular biology and cytogenetics, and tumours today are detected earlier and with greater accuracy than 25 years ago. With improved treatment ocular and periocular melanomas can be controlled locally, with good preservation of vision in many patients. However, there remains no cure for metastatic disease. [source] Tooth extraction decision model in periodontitis patientsCLINICAL ORAL IMPLANTS RESEARCH, Issue 1 2010A. Popelut Abstract Objective: The purpose of this study was to build, around several types of input data, a decision analysis model for dental extraction strategy in periodontitis patients. Materials and methods: The decision analysis was based on the following scenario: a fictitious adult chronic periodontitis patient with no chief complaint, being referred to make a decision of extraction on one single tooth presenting a periodontal defect that may affect the decision-making process. A decision tree was used to identify the treatment options within the next 5 years. Scientific evidences were based on probabilities given by a literature analysis using a systematic approach. Clinical expertize was based on subjective utilities (SUs) assigned by an experts' panel. Expected utilities (EUs) were used to rank the following options: no treatment (EU1) or periodontal treatment (EU2); extraction followed by a tooth-supported fixed partial denture , FPD , (EU3) or an implant-supported single crown , ISC , (EU4). Results: The robustness analysis calculation indicates that the probability of tooth survival needed to be equal to 0.78 in order that the passive option becomes optimal. However, EU1 was impossible to calculate due to the lack of available probabilities. The EU intervals were 79,96, 86,89 and 94,95 for EU2, EU3 and EU4, respectively. Consequently, the FPD option is dominated by the ISC option, and it is not possible to conclude to a difference between the periodontal and the ISC therapy. Conclusions: Within the limits of this model, tooth extraction followed by FPD is the worst strategy compared with ISC or periodontal therapies. To cite this article: Popelut A, Rousval B, Fromentin O, Feghali M, Mora F, Bouchard P. Tooth extraction decision model in periodontitis patients. Clin Oral Impl Res. 21, 2010; 80,89. [source] | ||||||||||||||||