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Antifungal Activity (antifungal + activity)
Kinds of Antifungal Activity Selected AbstractsCHEMICAL CHARACTERIZATION AND ANTIFUNGAL ACTIVITY OF ORIGANUM ONITES L. ESSENTIAL OILS AND EXTRACTSJOURNAL OF FOOD SAFETY, Issue 1 2009MIHRIBAN KORUKLUOGLU ABSTRACT Essential oils (EOs) and extracts (methanol, acetone and diethyl ether) of fresh and dried oregano (Origanum onites L.) were used to determine the antifungal effect on Alternaria alternata, Aspergillus flavus (two strains), Aspergillus niger (two strains), Aspergillus parasiticus, Fusarium semitectum, Fusarium oxysporum, Mucor racemosus and Penicillium roqueforti by disk diffusion methods. Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of all samples were determined. The antifungal activity of the fresh herb was greater than that of the dried herb. MIC values for fresh and dried methanol extracts were 150,950 µg/mL and 750,950 µg/mL, respectively. MFC values for methanol extracts were determined between 300 and 1200 µg/mL for fresh oregano and between 750 and 1100 µg/mL for dried oregano. The EOs of fresh and dried oregano totally inhibited test fungi. EOs produced the lowest MIC and MFC values: 8.5 µg/mL and 9.0 µg/mL, respectively (P < 0.005). The highest extract activity was exhibited by fresh oregano against A. alternata (24 mm) followed by P. roqueforti (20 mm). The greatest total antifungal effect was observed from methanol extracts. The chemical composition of fresh oregano EO and extracts was examined using gas chromatography-mass spectrometry (GC-MS). Over 80 volatiles were detected, of which 42 were positively identified by matching both MS fragmentation patterns with standardized retention characteristics. p-Cymene, thymol and carvacrol were the most prominent, followed by ,-pinene, camphor and borneol. PRACTICAL APPLICATIONS In the past decade interest in natural antimicrobial plant extracts has been growing. Various plants have historically been used for the purposes of food preservation and flavor enhancement as well as medicinal purposes. An example is oregano, the leafy part of the plant belonging to the Labiatae family. It has been used to improve the flavor and the organoleptic properties of many foods from numerous cultures. It has also been used to prolong the storage life of foods probably because of antifungal properties. The preservative nature of fresh oregano has been employed in many food applications, including meat and fish products, as well as in pharmaceuticals, alternative medicines and natural therapies. [source] Synthesis, Antibacterial and Antifungal Activities of Novel 1,2,4-Triazolium DerivativesARCHIV DER PHARMAZIE, Issue 7 2009Yan Luo Abstract A series of novel 1,2,4-triazolium derivatives was synthesized starting from commercially available 1H -1,2,4-triazole, 2,4-dichlorobenzyl chloride, or 2,4-difluorobenzyl bromide. Their antibacterial and antifungal activities were evaluated against Staphylococcus aureus ATCC 29213, Escherichia coli ATCC 25922, Bacillus proteus, Bacillus subtilis, Pseudomonas aeruginosa, Candida albicans ATCC 76615, and Aspergillus fumigatus. All structures of the new compounds were confirmed by NMR, IR, and MS spectra, and elemental analyses. The antimicrobial tests showed that most of synthesized triazolium derivatives exhibit significant antibacterial and antifungal activities in vitro. 1-(2,4-Difluorobenzyl)-4-dodecyl-1H -1,2,4-triazol-4-ium bromide and 1-(2,4-Dichlorobenzyl)-4-dodecyl-1H -1,2,4- triazol-4-ium bromide were the most potent compounds against all tested strains with the MIC values ranging from 1.05 to 8.38 ,M. They exhibited much stronger activities than the standard drugs chloramphenicol and fluconazole which are in clinical use. The results also showed that the antimicrobial activities of triazolium derivatives depend upon the type of substituent, the length of the alkyl chain, and the number of triazolium rings. [source] ChemInform Abstract: [4 + 2] Cycloaddition Reaction: Synthesis and Antifungal Activities of 5-Substituted-4-phenyl-1,3-thiazolo[3,2-a]pyrimidin-6-one Derivatives.CHEMINFORM, Issue 33 2008Babul C. Dutta Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Synthesis and Antifungal Activities of ,-(5-Aryl-1,2,4-triazol-3-thio)-,-(1H-1,2,4-triazol-1-yl) Acetophenones.CHEMINFORM, Issue 17 2001Chang-Hu Chu Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Synthesis of Allyl-cyclopropyl Alcohols and Allyl-1,5-hexadien-3-ols and Investigation of Their Antibacterial and Antifungal Activities.CHEMINFORM, Issue 4 2001S. Servi Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] High Antibacterial and Antifungal Activity of Silver Monodispersed Nanoparticles Embedded in a Glassy Matrix,ADVANCED ENGINEERING MATERIALS, Issue 7 2010Leticia Esteban-Tejeda Silver doped glass powders have been obtained starting from vitellinate/nAg and montmorillonite/nAg. These powders have shown a high biocide activity against the three different types of microorganisms studied: Escherichia coli (gram-negative bacteria), Micrococcus luteus (gram-positive-bacteria), and Issatchenkia orientalis (yeast). It was found that these glasses keep constant the silver concentration even below the cytotoxic limit. Therefore we interpret that silver doped glasses play the role of dosing devices. [source] Antifungal Activity of a Bowman,Birk-type Trypsin Inhibitor from Wheat KernelJOURNAL OF PHYTOPATHOLOGY, Issue 7-8 2000G. Chilosi A trypsin inhibitor from wheat kernel (WTI) was found to have a strong antifungal activity against a number of pathogenic fungi and to inhibit fungal trypsin-like activity. WTI inhibited in vitro spore germination and hyphal growth of pathogens, with protein concentration required for 50% growth inhibition (IC50) values ranging from 111.7 to above 500 ,g/ml. As observed by electron microscopy, WTI determined morphological alterations represented by hyphal growth inhibition and branching. One of the fungal species tested, Botrytis cinerea produced a trypsin-like protease, which was inhibited by the trypsin inhibitor. WTI, as well as other seed defence proteins, appear to be an important resistance factor in wheat kernels during rest and early germination when plants are particularly exposed to attack by potential soil-borne pathogens. Zusammenfassung Ein Trypsinhemmer aus Weizenkörnern (WTI) zeigte eine starke antifungale Aktivität gegenüber verschiedenen pathogenen Pilzen und hemmte deren trypsinähnliche Aktivität. WTI hemmte in vitro die Sporenkeimung und das Hyphenwachstum der Pathogene, wobei die IC50 -Werte zwischen 111,7 und mehr als 500 ,g/ml lagen. Elektronenmikroskopische Untersuchungen zeigten, dai WTI morphologische Veränderungen bewirkte, die aus einer Hemmung des Hyphenwachstums und einer veränderten Verzweigung bestanden. Eine der untersuchten Pilzarten, Botrytis cinerea, bildete eine trypsinähnliche Protease, die durch den Trypsininhibitor gehemmt wurde. Ebenso wie andere sameneigene Abwehrproteine scheint WTI während der Keimruhe und in den frühen Stadien der Keimung, wenn die Pflanzen gegenüber möglichen bodenbürtigen Pathogenen besonders exponiert sind, ein wichtiger Resistenzfaktor in Weizenkörnern zu sein. [source] Design and Synthesis of Novel Pyrazino[2,1- a]isoquinolin Derivatives with Potent Antifungal ActivityARCHIV DER PHARMAZIE, Issue 6 2010Hui Tang Abstract A series of novel pyrazino[2,1- a]isoquinolin compounds were designed, synthesized, and their antifungal activities in vitro were evaluated. The results showed that all of the title compounds exhibited antifungal activities. Most of them exhibited stronger antifungal activities than the lead compounds; compound 7c is more potent than fluconazole against two of the three tested fungal strains. The studies presented here provide a new structural type for the development of novel antifungal agents. [source] Synthesis and Antifungal Activity of 1-Aryl-3-phenethylamino-1-propanone Hydrochlorides and 3-Aroyl-4-aryl-1-phenethyl-4-piperidinolsARCHIV DER PHARMAZIE, Issue 5 2010Ebru Mete Abstract Mono-Mannich bases, 1-aryl-3-phenethylamino-1-propanone hydrochlorides, 1a, 2a, 3a, 4a, 5a, 6a, 7a, 8a, 9a, and semi-cyclic mono-Mannich bases, 3-aroyl-4-aryl-1-phenethyl-4-piperidinols, 1b, 2b, 3b, 4b, 5b, 6b, 7b, 8b, 9b, were synthesized by a non-classical Mannich reaction. The aryl part was: C6H5 for 1a, 1b; 4-CH3C6H4 for 2a, 2b; 4-CH3OC6H4 for 3a, 3b; 4-ClC6H4 for 4a, 4b; 4-FC6H4 for 5a, 5b; 4-BrC6H4 for 6a, 6b; 2,4-(Cl)2C6H3 for 7a, 7b; 4-NO2C6H4 for 8a, 8b; and C4H3S(2-yl) i. e., 2-thienyl for 9a, 9b. Piperidinol compounds 2b, 3b, 4b, 5b, 7b, 8b, and 9b are reported here for the first time. The synthesized compounds were tested against seven types of plant pathogenic fungi and three types of human pathogenic fungi using the agar dilution assay. Itraconazole was tested against Candida parapsilosis as the reference compound, while Nystatin was tested as the reference compound against the other fungi. Compounds 1a, 1b, 2a, 4a, 4b, 5a, 5b, 6a, 7a, 8a, 9a, and 9b can be selected as model compounds to develop new antifungal agents against the human pathogen Microsporum canis. Compounds 8a and 8b, which had a similar antifungal activity compared with the reference compound Nystatin against the plant pathogen Aspergillus flavus, can serve as model compounds to develop new antifungal agents to solve agricultural problems. [source] Design, Synthesis, and Antifungal Activity of Novel Conformationally Restricted Triazole DerivativesARCHIV DER PHARMAZIE, Issue 12 2009Wenya Wang Abstract A series of new triazole derivatives were designed and synthesized on the basis of the active site of lanosterol 14,-demethylase from Candida albicans (CACYP51). 2-(2,4-Difluorophenyl)-3-(methyl-(3-phenoxyalkyl)amino)-1-(1H -1,2,4-triazol-1-yl)propan-2-ols show excellent in-vitro activity against most of the tested pathogenic fungi. The MIC80 value of compound 8a against Candida albicans is 0.01 ,M, which provides a good starting template for further structural optimization. The binding modes of the designed compounds were investigated by flexible molecular docking. The compounds interacted with CACYP51 through hydrophobic, van-der-Waals, and hydrogen-bonding interactions. [source] Synthesis, Cytotoxicity by Bioluminescence Inhibition, Antibacterial and Antifungal Activity of ([1,2,4]Triazolo[1,5- c]quinazolin-2-ylthio)carboxylic Acid AmidesARCHIV DER PHARMAZIE, Issue 11 2009Lyudmila N. Antipenko Abstract We report in this work the synthesis, cytotoxicity, and antimicrobial activity of ([1,2,4]triazolo[1,5- c]quinazolin-2-ylthio)carboxylic acid amides 4,7 in connection with our previous research in the preparation of triazoloquinazoline derivatives. Due to simplicity, general availability of starting materials, and high yields, the most reliable method of synthesis appeared to be the one with N,N -carbonyldiimidazole activation stage. The chemical structures of all obtained substances were deduced from FT-IR, 1H-NMR, EI-MS, and LC-MS spectral data. The results of cytotoxicity evaluated by bioluminescence inhibition of bacterium Photobacterium leiognathi, strain Sh1 showed that compounds 4.1, 4.6, and 6.1 were the most cytotoxic. Investigation of the antimicrobial and antifungal activity of amides 4,7 (concentration 5 mg/mL) was carried out by the stiff-plate agar-diffusion method. We found that the compounds possessed low (4.1, 4.7) antifungal activity against Candida tenuis and strong (4.21, 5.1, 5.9) or inefficient (4.7, 4.12, 4.16) activity against Aspergillus niger. Substances 5.1 and 5.9 slightly affected Mycobacterium luteum. Staphylococcus aureus was resistant to all obtained substances, and only the n -butyramide derivatives 7.1 and 7.5 inhibited the growth of Escherichia coli. Hence, there was no strong correlation between bioluminescence inhibition and antimicrobial activity of the investigated substances. [source] 3-Imidazolyl-Substituted Flavans as Potential Antifungal Agents: Synthesis, Stereochemical Properties, and Antifungal ActivityARCHIV DER PHARMAZIE, Issue 9 2009Saeed Emami Abstract A new series of 3-imidazolyl-substituted flavan derivatives being equipped with a N -(phenethyl)-azole scaffold as the common pharmacophore of azole antifungals, were synthesized. The stereochemical and conformational properties of compounds were also characterized by 1H-NMR data. The results of the antifungal evaluation of trans -3-imidazolyl-substituted flavan-4-ones and (Z) -trans -3-imidazolyl-substituted flavan-4-one oximes in comparison with the reference drug fluconazole indicated that most target compounds possessed significant in-vitro antifungal activities against the tested fungi, comparable or superior to fluconazole. [source] ChemInform Abstract: Synthesis and Antifungal Activity of Novel 2-Benzimidazolylimino-5-arylidene-4-thiazolidinones.CHEMINFORM, Issue 24 2010Akbar Mobinikhaledi Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Synthesis and Antifungal Activity of Novel 6-Fluoro-4-alkyl(aryl)thioquinazoline Derivatives.CHEMINFORM, Issue 37 2007Guang-Fang Xu Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Synthesis and Antifungal Activity of Novel 3-Anilino-6-ethylthio-4,5-dihydro-1,2,4,5-tetrazines.CHEMINFORM, Issue 34 2007J. R. Choudhari Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Synthesis and Evaluation of Antifungal Activity of Naphthoquinone Derivatives.CHEMINFORM, Issue 44 2006Giaccomo Errante Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Chemoselective Synthesis of Heterocyclic Derivatives of 18-nor Equilenine, 16-Substituted-12H-11-oxa-15-aza-17-thia-cyclopenta[a]phenanthrenene and Their in vitro Evaluation of Antibacterial and Antifungal Activity.CHEMINFORM, Issue 40 2006N. J. Malviya Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Synthesis and Antifungal Activity of N-(Alkyl/Aryl)-2-(3-oxo-1,4-benzothiazin-2-yl)acetamide.CHEMINFORM, Issue 26 2006G. Gupta Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Heterocyclic Synthesis: A Convenient Route to Some 2-Mercapto 1,3,4-Oxadiazole and Green Chemistry Microwave-Induced One-Pot Synthesis of 2-Aryl 1,3,4-Oxadiazole in Quinazolone and Their Antibacterial and Antifungal Activity.CHEMINFORM, Issue 49 2005A. R. Desai Abstract For Abstract see ChemInform Abstract in Full Text. [source] Synthesis of Novel Substituted Tetrazoles Having Antifungal Activity.CHEMINFORM, Issue 45 2004Ram Shankar Upadhayaya Abstract For Abstract see ChemInform Abstract in Full Text. [source] Synthesis of Isoxazolylpyrazolo[3,4-d]thiazoles and Isoxazolylthiazoles and Their Antibacterial and Antifungal Activity.CHEMINFORM, Issue 17 2004E. Rajanarendar Abstract For Abstract see ChemInform Abstract in Full Text. [source] ChemInform Abstract: A New Synthesis of 3,5-Dihydroxy-7-(1-pyrrolyl)-6-heptenoic Acids, a Family of HMGCoA Reductase Inhibitors with Antifungal Activity.CHEMINFORM, Issue 27 2002Julia Castro Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Synthesis and Antifungal Activity of Some New Quinazoline and Benzoxazinone Derivatives.CHEMINFORM, Issue 11 2001Alyaa A. Shalaby Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Synthesis and Antifungal Activity of Novel Chiral , -Aminophosphonates Containing Fluorine MoietyCHINESE JOURNAL OF CHEMISTRY, Issue 11 2006Song Yang Abstract Chiral , -aminophosphonates were synthesized using (R) or (S)-1-phenylethylamine in the presence of BF3·Et2O under microwave irradiation in moderate to good yields. The new compounds were identified by 1H NMR, 19F NMR, IR and elemental analysis. Their antifungal activities were evaluated and some compounds were found to exhibit excellent antifungal activities. To the best of our knowledge, this is the first report on antifungal activity of chiral , -aminophosphonates containing fluorine moiety. [source] Original article: Antifungal activities of cinnamon oil against Rhizopus nigricans, Aspergillus flavus and Penicillium expansum in vitro and in vivo fruit testINTERNATIONAL JOURNAL OF FOOD SCIENCE & TECHNOLOGY, Issue 9 2010Yage Xing Summary The postharvest pathogens such as R. nigricans, A. flavas and P. expansum are the causal agents of jujube or orange fruit, therefore, in vitro and in vivo antifungal activities of cinnamon oil to inactivate these fungi were investigated. Cinnamaldehyde is the main constituent of cinnamon oil. The minimum inhibitory concentrations of cinnamon oil against Rhizopus nigricans, Aspergillus flavus and Penicillium expansum were 0.64% (v/v), 0.16% (v/v) and 0.16% (v/v), respectively. The antifungal activity of cinnamon oil against A. flavus and P. expansum was stronger than that against R. nigricans and the activity was improved with increasing its concentration. In an in vivo study, cinnamon oil with concentrations of 2.0% (v/v) and 3.0% (v/v) showed complete control the growth of fungi in wound-inoculated Lingwu Long Jujube and Sand Sugar Orange fruits. These results revealed that cinnamon oil has a good potential to be as a natural antifungal agent for fruit applications. [source] Antifungal activity of the essential oil of Thymus capitellatus against Candida, Aspergillus and dermatophyte strainsFLAVOUR AND FRAGRANCE JOURNAL, Issue 5 2006Lígia Ribeiro Salgueiro Abstract The antifungal activity of Thymus capitellatus oils on Candida, Aspergillus and dermatophyte strains were studied. The essential oils were obtained from the aerial parts of the plants by water distillation and analysed by GC and GC,MS. Three chemotypes were characterized: 1,8-cineole (47.5%), 1,8-cineole/borneol (28.8% and 19.5%, respectively) and 1,8-cineole/linalyl acetate/linalool (27.5%, 20.0% and 17.0%, respectively). The minimal inhibitory concentration (MIC) determined according to the NCCLS protocols (M27-A and M38-P) and the minimal lethal concentration (MLC) were used to evaluate the antifungal activity of the oils against Candida (seven clinical isolates and three ATCC type strains), Aspergillus (five clinical isolates, two CECT and two ATCC type strains) and five dermatophyte clinical fungi strains. The oils exhibited antifungal activity for the dermatophyte strains, with MIC values of 0.32,1.25 µl/ml; the chemotype 1,8-cineole/linalyl acetate/linalool proved to be more active. The highest antifungal activity of this oil can be associated with the contribution of the linalyl acetate. In the other hand, all samples showed low activity against Candida and Aspergillus strains. Copyright © 2006 John Wiley & Sons, Ltd. [source] Antifungal activity of fatty acids and their monoglycerides against Fusarium spp. in a laboratory mediumINTERNATIONAL JOURNAL OF FOOD SCIENCE & TECHNOLOGY, Issue 2 2009Clelia Altieri Summary The antifungal activity of lauric, myristic and palmitic acids and their monoglycerides against fusaria was investigated. Data were modelled through a re-parameterized Gompertz equation and the Minimum Detection Time (MDT), i.e. the time (days) to attain 1 cm colony diameter, was evaluated. Lauric acid exerted a strong bioactivity against moulds; palmitic and myristic acids and their monoglycerides showed a moderate effectiveness and in a reversible manner. The results of this work could be considered quite promising; however, further investigations are proposed to validate these data in foods. [source] Antifungal activity of Thymus oils and their major compoundsJOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY & VENEREOLOGY, Issue 1 2004C Pina-Vaz ABSTRACT The increasing recognition and importance of fungal infections, the difficulties encountered in their treatment and the increase in resistance to antifungals have stimulated the search for therapeutic alternatives. Essential oils have been used empirically. The essential oils of Thymus (Thymus vulgaris, T. zygis subspecies zygis and T. mastichina subspecies mastichina) have often been used in folk medicine. The aim of the present study was to evaluate objectively the antifungal activity of Thymus oils according to classical bacteriological methodologies , determination of the minimal inhibitory concentration (MIC) and the minimal lethal concentration (MLC) , as well as flow cytometric evaluation. The effect of essential oils upon germ tube formation, an important virulence factor, was also studied. The mechanism of action was studied by flow cytometry, after staining with propidium iodide. The chemical composition of the essential oils was investigated by gas chromatography (GC) and gas chromatography/mass spectroscopy (GC/MS). The antifungal activity of the major components (carvacrol, thymol, p -cymene and 1,8-cineole) and also possible interactions between them were also investigated. The essential oils of T. vulgaris and T. zygis showed similar antifungal activity, which was greater than T. mastichina. MIC and MLC values were similar for all the compounds tested. At MIC values of the essential oils, propidium iodide rapidly penetrated the majority of the yeast cells, indicating that the fungicidal effect resulted primarily from an extensive lesion of the cell membrane. Concentrations below the MIC values significantly inhibited germ tube formation. This study describes the potent antifungal activity of the essential oils of Thymus on Candida spp., warranting future therapeutical trials on mucocutaneous candidosis. [source] In vitro fungitoxic activity of Larrea divaricata cav. extractsLETTERS IN APPLIED MICROBIOLOGY, Issue 1 2004E.N. Quiroga Abstract Aims:, To evaluate the fungitoxic activity of Larrea divaricata Cav. extract and one of its components against yeasts and fungi. This activity was compared with the action of ketoconazole, a known synthetic antimycotic. Methods and Results:, Antifungal activity of Larrea divaricata extract and of a fraction (Fr. B) purified by thin layer chromatography, was investigated using different methodologies. Both exhibited strong activity against the majority of the assayed fungi. Only Fusarium oxysporum and Schizophyllum commune growth was not affected with the assayed conditions. The fungitoxic and cytotoxic activity of the ethanolic extract and ketoconazole were compared. Conclusions:, Ethanolic extracts of L. divaricata Cav. produce growth inhibition of several fungi. One of its constituents with the same activity was purified and identified as a glycoside of a flavanone. A comparison with the action of ketoconazole, which is currently used as antimycotic and can cause adverse health effects was made. Significance and Impact of the Study:, Our data suggest that L. divaricata extract contains, at least, one compound of phenolic nature, with fungitoxic potency against yeasts and fungi. [source] Surface alteration of Saccharomyces cerevisiae induced by thymol and eugenolLETTERS IN APPLIED MICROBIOLOGY, Issue 6 2004S. Bennis Abstract Aims:, This study aims to bring some information about the mechanism of the fungicidal action of thymol and eugenol; phenolic major components of thyme and clove essential oils respectively. Saccharomyces cerevisiae was used as yeast model. Methods and Results:, Treatment of yeast cells with these components led to their lysis as shown by the release of substances absorbing at 260 nm. In addition, scanning electron microscope observations revealed that the surface of the treated cells was significantly damaged. Conclusions:, Antifungal activity of thymol and eugenol involve alteration of both membrane and cell wall of the yeast. Significance and Impact of the Study:, This work is a preliminary contribution aiming to develop a new generation of efficient and natural antifungal agents. [source] | |||||||||||||||||||||||||||||||||||||||||||