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Antibacterial Activity (antibacterial + activity)
Kinds of Antibacterial Activity Selected AbstractsANTIBACTERIAL ACTIVITY AND CHEMICAL CONSTITUTIONS OF OLEA EUROPAEA L. LEAF EXTRACTSJOURNAL OF FOOD PROCESSING AND PRESERVATION, Issue 3 2010MIHRIBAN KORUKLUOGLU ABSTRACT The in vitro antimicrobial activity of aqueous, acetone, diethyl ether and ethyl alcohol extracts of olive leaves (Olea europaea L.) was studied. The aqueous extract of olive leaves had no antibacterial effect against the test microorganisms, whereas acetone extract showed inhibitory effect on Salmonella enteritidis, Bacillus cereus, Klebsiella pneumoniae, Escherichia coli, Enterococcus faecalis, Streptococcus thermophilus and Lactobacillus bulgaricus. Furthermore, the antimicrobial activities of some phenolic compounds against microorganisms were tested. The most effective compound was found to be oleuropein while syringic acid was found ineffective. The characterization of phenolic compounds in different extracts determined by high performance liquid chromatography-air pressure chemical ionization-mass spectrometry detector (HPLC-APCI-MSD GC-MS) gas chromatography-mass spectrometry (GC-MS). The acetone and the ethyl alcohol extracts had the most and the least oleuropein content, respectively. PRACTICAL APPLICATIONS In recent years the extracts of many plant species have become popular, and attempts to characterize their bioactive principles have gained speed for many pharmaceutical and food-processing applications. Especially, antimicrobial properties of plants have revived as a consequence of current problems associated with the use of chemical preservatives. Because of consumers' negative perspectives of synthetic preservatives, attention is shifting toward natural alternatives. The findings suggest that olive leaf extracts and their phenolic compounds have good potential as antibacterial substances in food preservation as they may be more acceptable to consumers and the regulatory agencies in comparison with synthetic chemical compounds. [source] ANTIBACTERIAL ACTIVITY AND BINDING ABILITY OF BOVINE LACTOFERRIN AGAINST PSEUDOMONAS SPP.JOURNAL OF FOOD SAFETY, Issue 1 2008WOAN-SUB KIM ABSTRACT The antibacterial activity of bovine lactoferrin was tested against Pseudomonas fluorescens and Pseudomonas syringae. The activity was studied by monitoring the growth of a Pseudomonas spp. in the presence or absence of bovine apo-lactoferrin, bovine holo-lactoferrin or native-lactoferrin in liquid media at different concentrations. Lactoferrin-binding proteins in the membrane fractions of Pseudomonas spp. were detected using far-Western blot analysis. The addition of bovine lactoferrin to the medium inhibited the growth of all tested strains. Furthermore, the growth of P. fluorescens and P. syringae was strongly inhibited by bovine apo-lactoferrin. The estimated molecular weights of lactoferrin-binding proteins in P. fluorescens were 70, 49, 47 and 25 kDa, and 70, 48 and 28 kDa in P. syringae. PRACTICAL APPLICATIONS Pseudomonas fluorescens is an important psychrotrophic bacterium responsible for undesirable flavors in milk and dairy products. Thus, flavor and texture defects, such as bitterness and running paste, were also reported. In addition, Pseudomonas syringae causes various diseases on many different susceptible plant species, generally producing chlorotic and necrotic lesions on leaves and fruits. The resultant bacterial spoilage causes considerable economic losses for the food and dairy industries. At present, antiseptics and agricultural chemicals are used for defense of foods and vegetables from these bacteria, but such substances are known to deleteriously affect the human body. The results of this study demonstrate that bovine lactoferrin significantly inhibits the growth of P. fluorescens and P. syringae. The results indicate that the incorporation of bovine lactoferrin is expected to protect dairy products, food and fruits from pathogenic bacteria. [source] Antibacterial Activities of Chitosans and Chitosan Oligomers with Different Molecular Weights on Spoilage Bacteria Isolated from TofuJOURNAL OF FOOD SCIENCE, Issue 4 2002H.K. No ABSTRACT Seven bacteria were isolated from spoiled tofu and identified as Bacillus sp. (S08), B. megaterium (S10), B. cereus (S17, S27, S28, S32), and Enterobacter sakazakii (S35). In a paper disc test with 6 chitosans and 6 chitosan oligomers of different molecular weights, chitosans showed higher antimicrobial activity than did chitosan oligomers at a 0.1% concentration. Results of inhibitory effects of 6 chitosans on growth of Bacillus sp. (S08) failed to detect viable cells after incubation for 24 hrs at 37 C, even at 0.02% concentration. With B. megaterium (S10) and B. cereus (S27), a 3 to 4 log cycle reduction was found in the chitosan-treated group. The growth of Enterobacter sakazakii (S35) was completely suppressed in the presence of 0.04% chitosan except for 1 chitosan product. The minimum inhibitory concentration of chitosan differed with products and isolates, ranging from 0.005% to above 0.1%. [source] Synthesis and Antibacterial Activities of Eperezolid Analogs with Glycinyl SubstitutionsARCHIV DER PHARMAZIE, Issue 7 2009Xiao-Jun Wang Abstract A series of eperezolid analogs with glycinyl substitutions were prepared and their antibacterial activities were studied against a panel of susceptible and resistant Gram-positive bacteria. The compounds with N -arylacyl or N -heteroarylacyl glycinyl structural units showed good antibacterial activities. The compounds 11b, 11c, and 11e were twofold more active than linezolid against Staphylococcus epidermidis and Enterococcus faecalis. Several pyridine analogs were also prepared and found to have poor antibacterial activity against most of the tested Gram-positive bacteria, however, one of the compounds 12e showed very high activity against Enterococcus faecalis. [source] ChemInform Abstract: Synthesis and Antibacterial Activities of Novel Oxazolidinones Having Cyclic Sulfonamide Moieties.CHEMINFORM, Issue 10 2009Seoung Jong Kim Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] 2-Piperidin-4-yl-benzimidazoles with Broad Spectrum Antibacterial Activities.CHEMINFORM, Issue 51 2003Yun He Abstract For Abstract see ChemInform Abstract in Full Text. [source] Synthesis and Antibacterial Activities of 1-(p-Chlorophenyl)-2-amino/hydrazino-4- (p-nitrophenyl/p-chlorophenyl)-1,6-dihydro-1,3,5-triazine-6-thiones and Related Thiocarbamides, Thiosemicarbazides and Schiff Bases.CHEMINFORM, Issue 39 2002Sangeeta Mehrotra No abstract is available for this article. [source] In vitro Study of the Antibacterial Activity of Bioactive Glass-ceramic Scaffolds,ADVANCED ENGINEERING MATERIALS, Issue 7 2009Marta F. Gorriti Staphylococcus aureus is an opportunistic pathogen of major clinical interest for its high prevalence in biomaterial-related infections. This experimental study provides the first evidence in vitro that bioactive glass-ceramic scaffolds made from both 45S5 Bioglass® and from boron containing bioactive glass (45S5.2B) as well as their ionic dissolution products do no exhibit antibacterial effect against several strains of S. aureus. [source] Enhanced Antibacterial Activity of Nanocrystalline ZnO Due to Increased ROS-Mediated Cell InjuryADVANCED FUNCTIONAL MATERIALS, Issue 6 2009Guy Applerot Abstract An innovative study aimed at understanding the influence of the particle size of ZnO (from the microscale down to the nanoscale) on its antibacterial effect is reported herein. The antibacterial activity of ZnO has been found to be due to a reaction of the ZnO surface with water. Electron-spin resonance measurements reveal that aqueous suspensions of small nanoparticles of ZnO produce increased levels of reactive oxygen species, namely hydroxyl radicals. Interestingly, a remarkable enhancement of the oxidative stress, beyond the level yielded by the ZnO itself, is detected following the antibacterial treatment. Likewise, an exposure of bacteria to the small ZnO nanoparticles results in an increased cellular internalization of the nanoparticles and bacterial cell damage. An examination of the antibacterial effect is performed on two bacterial species: Escherichia coli (Gram negative) and Staphylococcus aureus (Gram positive). The nanocrystalline particles of ZnO are synthesized using ultrasonic irradiation, and the particle sizes are controlled using different solvents during the sonication process. Taken as a whole, it is apparent that the unique properties (i.e., small size and corresponding large specific surface area) of small nanometer-scale ZnO particles impose several effects that govern its antibacterial action. These effects are size dependent and do not exist in the range of microscale particles. [source] Antibacterial Activity of an Atmospheric Pressure Plasma Jet Against Relevant Wound Pathogens in vitro on a Simulated Wound EnvironmentPLASMA PROCESSES AND POLYMERS, Issue 3-4 2010Georg Daeschlein Abstract The aim of the study was to test the efficacy of a hand-held atmospheric pressure plasma jet (APPJ) toward typical wound pathogens in vitro simulating antisepsis on wound surfaces. The plasma jet has been proved to be highly effective in vitro against the most commonly encountered pathogenic species of acute and chronic wounds reaching nearly the power of antiseptics. The following bacteria and fungi were treated on half rigid media (agar) imitating wound colonization: methicillin-sensitive Staphylococcus aureus ATCC 1924 (MSSA), Enterococcus faecium ATCC 6057 (EF), Pseudomonas aeruginosa ATCC 15442 (PA), Candida albicans ATCC 10231 (CA), and , -hemolyzing Streptococci of the Lancefield serogroup A (HSA). Highest reduction factor (RF) was obtained treating PA (RF 4.0) followed by HSA (3.2), MSSA (2.7), CA (2.0), and EF (1.9). Consequently, simulating wound surfaces with moist environment using semisolid agar media, the APPJ allowed bactericidal treatment of highly contaminated surfaces of 55,cm2 imitating skin and wound colonization within 6,min. This antibacterial reduction power together with its handsome flexibility of the APPJ could be a suited therapeutic option in the therapy of infected or colonized wounds. [source] Synthesis and Antibacterial Activity of Novel 4,- O -Carbamoyl Erythromycin-A DerivativesARCHIV DER PHARMAZIE, Issue 8 2010Yunkun Qi Abstract Novel 4,- O -carbamoyl erythromycin-A derivatives were designed, synthesized, and evaluated for their in-vitro antibacterial activities. All of the 4,- O -carbamoyl derivatives showed excellent activity against erythromycin-susceptible Staphylococcus aureus ATCC25923, Streptococcus pyogenes, and Streptococcus pneumoniae ATCC49619. Most of the 4,- O -arylalkylcarbamoyl derivatives displayed potent activity against erythromycin-resistant S. pneumoniae encoded by the mef gene and greatly improved activity against erythromycin-resistant S. pneumoniae encoded by the erm gene or the erm and mef genes. In particular, the 4,- O -arylalkyl derivatives 4c,4e and 4g were found to possess the most potent activity against all the tested erythromycin-susceptible strains, which were comparable to those of erythromycin, clarithromycin, or azithromycin. 4,- O -Arylalkyl derivatives 4e and 4g were the most effective against erythromycin-resistant S. pneumoniae encoded by the mef gene (0.25 and 0.25,µg/mL). 4,- O -Arylalkyl derivatives 4a and 4b exhibited significantly improved activity against erythromycin-resistant S. pneumoniae encoded by the erm gene. In contrast, the 4,- O -alkylcarbamoyl derivatives hardly showed improved activity against all the tested erythromycin-resistant strains. [source] Synthesis and Antibacterial Activity of a Novel Series of 2,3-Diaryl-substituted-imidazo(2,1- b)-benzothiazole DerivativesARCHIV DER PHARMAZIE, Issue 6 2010Mahesh Palkar Abstract Benzothiazole and imidazole compounds are extensively studied heterocyclics due to their wide spectrum of bioactivities. Among them, the imidazo(2,1- b)-benzothiazole derivatives are pharmacologically important because of their immunostimulant, anti-inflammatory, antifungal, antimicrobial, antitumor, and other activities. In the present research work, a novel series of 2,3-diaryl-substituted imidazo(2,1- b)-benzothiazoles 13a,o have been synthesized by reaction of substituted 2-aminobenzothiazoles 1,8 and an appropriately substituted ,-bromo-1-(4,,-substituted)-phenyl-2-(4,-substituted)-phenyl-1-ethanones 9,12 in the presence of anhydrous acetonitrile. They were characterized by physicochemical, elemental, and spectral (IR, 1H-NMR, and Mass) data. All the synthesized compounds were screened for their in-vitro antibacterial activity against Gram-positive, Gram-negative bacteria. The investigation of antibacterial screening data revealed that most of the compounds tested have demonstrated congruent activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa as compared with the standard ampicillin. Among the series, compounds 13d, 13h, and 13m exhibited excellent an antibacterial activity profile as compared with the standard. In summary, preliminary results indicate that some of the newly synthesized title compounds exhibited promising antibacterial activities and they warrant more consideration as prospective antimicrobials. [source] Synthesis and In Vitro Antibacterial Activity of 7-(3-Alkoxyimino-4-methyl-4-methylaminopiperidin-1-yl)-fluoroquinolone DerivativesARCHIV DER PHARMAZIE, Issue 3 2010Yi-Bin Zhang Abstract A series of novel 7-(3-alkoxyimino-4-methyl-4-methylaminopiperidin-1-yl)fluoroquinolone derivatives were designed, synthesized, and characterized by 1H-NMR, MS, and HRMS. These fluoroquinolones were evaluated for their in-vitro antibacterial activity against representative Gram-positive and Gram-negative strains. Generally, all of the target compounds have considerable antibacterial activity against the tested forty strains, and exhibit exceptional potency in inhibiting the growth of methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) ATCC33591 (MICs: 0.06 to 2 ,g/mL). In particular, compounds 14, 19, 28, and 29 are fourfold more potent than ciprofloxacin against MSSA 08-49. Compounds 23, 26, and 27 are twofold more potent than ciprofloxacin against MRSA ATCC33591 and MSSA ATCC29213. In addition, compound 14 exhibits excellent activity (MIC: 0.06 ,g/mL) against Acinetobactes calcoaceticus, which is two- to 16-fold more potent than the reference drugs gemifloxacin, levofloxacin, and ciprofloxacin. [source] Conformationally Constrained Analogs of N -Substituted Piperazinylquinolones: Synthesis and Antibacterial Activity of N -(2,3-Dihydro-4-hydroxyimino-4H -1-benzopyran-3-yl)-piperazinylquinolonesARCHIV DER PHARMAZIE, Issue 7 2009Saeed Emami Abstract A series of novel quinolone agents bearing a particular bulky and conformationally constrained bicyclic substituent (2,3-dihydro-4-hydroxyimino-4H -1-benzopyran-3-yl- moiety) on the piperazine ring of 7-piperazinyl quinolones (norfloxacin, enoxacin, ciprofloxacin, and levofloxacin) were synthesized and evaluated against a panel of Gram-positive and Gram-negative bacteria. Among these derivatives, ciprofloxacin counterpart 9c, highly inhibited the tested Gram-positive bacteria, superior to that of the reference drugs, and displayed antibacterial activity at non-cytotoxic concentrations. [source] Synthesis and Antibacterial Activity of a New Series of 3-[3-(Substituted Phenyl)-1-Isonicotinoyl-1H -Pyrazol-5-yl]-2H -Chromen-2-one DerivativesARCHIV DER PHARMAZIE, Issue 6 2009Prashant Aragade Abstract A novel series of 3-[3-(substituted phenyl)-1-isonicotinoyl-1H -pyrazol-5-yl]-2H -chromen-2-one derivatives 4a,k have been synthesized by the reaction of 3-[2,3-dibromo-3-(substituted phenyl) propanoyl]-2H -chromen-2-one 3a,k and isonicotinic acid hydrazide in the presence of triethylamine in absolute ethanol, characterized by spectral data and screened for their in-vitro antibacterial activity against Gram-positive and Gram-negative bacteria. Among the series, compounds 4e, 4i, and 4k displayed an encouraging antibacterial activity profile as compared to the reference drug ampicillin against tested bacterial strains. [source] Antifungal and Antibacterial Activity of the Newly Synthesized 2-Xanthone DerivativesARCHIV DER PHARMAZIE, Issue 1 2009Henryk Marona Abstract A series of 2-substituted xanthone derivatives 8,20 containing selected allyl, cinnamyl, morpholine, and imidazole moieties were synthesized and tested for their antifungal and antibacterial in-vitro properties. Of the newly synthesized derivatives, ten revealed antifungal activity especially against Trichophyton mentagrophytes (the biggest inhibition zones ranged 35 mm for 11 and 13). 2-(3-(Allylamino)propoxy)-9H -xanthen-9-one hydrochloride 9 inhibited growth of all of the examined fungal species. Significant efficacy against evaluated yeasts and dermatophytes was also observed for 6-chloro-2-methyl-9H -xanthen-9-one derivatives 11,13 containing encyclic amine moieties. Additionally, compounds 9, 11, and 12 hindered development of bacteria species but in a lesser degree. They were efficacious against Staphylococcus aureus, Escherichia coli, and Enterococcus faecalis. [source] ChemInform Abstract: Synthesis and Antibacterial Activity of Isothiazolyl Oxazolidinones and Analogous 3(2H)-Isothiazolones.CHEMINFORM, Issue 19 2010Neda Adibpour Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Synthesis and Antibacterial Activity of 1,3-Diaryl-4-cyanopyrazoles.CHEMINFORM, Issue 32 2009Om Prakash Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Multi-Step, Microwave-Assisted, Solvent-Free Synthesis and Antibacterial Activity of 6-Substituted-2,3,4-trihydropyrimido[1,2-c]9,10,11,12-tetrahydrobenzo [b]thieno[3,2-e]pyrimidines.CHEMINFORM, Issue 44 2007Mailavaram Raghu Prasad Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Synthesis and Antibacterial Activity of New 7-Piperazinylquinolones Containing a Functionalized 2-(Furan-3-yl)ethyl Moiety.CHEMINFORM, Issue 18 2007Alireza Foroumadi Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Synthesis and Antibacterial Activity of Nitroaryl Thiadiazole-Levofloxacin Hybrids.CHEMINFORM, Issue 10 2007Alireza Foroumadi Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Antileishmanial and Antibacterial Activity of a New Pyrazole Derivative Designated 4-[2-(1-(Ethylamino)-2-methylpropyl)phenyl] -3-(4-methylphenyl)-1-phenylpyrazole (IV).CHEMINFORM, Issue 39 2006Zainaba Dardari Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Synthesis and Antibacterial Activity of New N-Acyl-N,-(3-chloro-4-fluorophenyl)thioureas.CHEMINFORM, Issue 11 2006I. M. Khazi Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Synthesis and Antibacterial Activity of Some Imidazole-5-(4H)one Derivatives.CHEMINFORM, Issue 7 2006Sampath Saravanan Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access the actual ChemInform Abstract, please click on HTML or PDF. [source] Synthesis and Antibacterial Activity of Some 5-(4-Biphenylyl)-7-aryl[3,4-d][1,2,3]-benzothiadiazoles.CHEMINFORM, Issue 46 2005T. Balasankar Abstract For Abstract see ChemInform Abstract in Full Text. [source] Synthesis of Pyrazole Imines and Azetidinone Compounds Using Conventional and Microwave Technique and Studies of Their Antibacterial Activity.CHEMINFORM, Issue 45 2005Ketan Mistry Abstract For Abstract see ChemInform Abstract in Full Text. [source] Syntheses and Antibacterial Activity of a Series of 3-(Pyridine-3-yl)-2-oxazolidinone.CHEMINFORM, Issue 26 2005Yingjie Cui Abstract For Abstract see ChemInform Abstract in Full Text. [source] Synthesis and Antibacterial Activity of Novel 6-Fluoro-1- [(1R,2S)-2-fluorocyclopropan-1-yl]-4-oxoquinoline-3-carboxylic Acids Bearing Cyclopropane-Fused 2-Amino-8-azabicyclo[4.3.0]nonan-8-yl Substituents at the C-7 Position.CHEMINFORM, Issue 4 2005Hiroaki Inagaki No abstract is available for this article. [source] Synthesis and Antibacterial Activity of N-Alkylpyridinium Podands.CHEMINFORM, Issue 15 2004I. G. Ovchinnikova Abstract For Abstract see ChemInform Abstract in Full Text. [source] Synthesis of Pyrazoline, Pyrimidine and 1,5-Benzodiazepine Derivatives of 1,8-Naphthyridine and Evaluation of Antibacterial Activity.CHEMINFORM, Issue 24 2003K. Mogilaiah Abstract For Abstract see ChemInform Abstract in Full Text. [source] | ||||||||||||||||||||||||||||||||||||||||