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Leucocytoclastic Vasculitis (leucocytoclastic + vasculitis)
Selected AbstractsWarfarin-induced allergic interstitial nephritis and leucocytoclastic vasculitisINTERNAL MEDICINE JOURNAL, Issue 4 2008K. G. Kapoor Abstract Warfarin sodium has been associated with leucocytoclastic vasculitis and has once been associated with allergic interstitial nephritis. Hypersensitivity to warfarin sodium simultaneously resulting in allergic interstitial nephritis and leucocytoclastic vasculitis has not yet been previously reported. We present a 48-year-old man who was on warfarin sodium for 2 months and presented with acute renal failure and reddish purplish macules on his hypogastric regions and lower extremities bilaterally. Kidney biopsy showed allergic interstitial nephritis and punch skin biopsy showed leucocytoclastic vasculitis. Both biopsies also showed high eosinophil count, highly suggestive of a drug-induced reaction. After a negative comprehensive work-up and the absence of other recent medication changes, our patient was determined to have allergic interstitial nephritis and leucocytoclastic vasculitis secondary to warfarin sodium. [source] Number VII Behçet's disease (Adamantiades syndrome)ORAL DISEASES, Issue 2 2006M Escudier Behçet's syndrome (BS; Adamantiades syndrome) is the association of the triple symptom complex of recurrent aphthous stomatitis (RAS) with genital ulceration, and eye disease (especially iridocyclitis) though a number of other systemic manifestations may also be seen. BS mainly affects young adult males, and there is an association with HLA-B5 and HLA-B51 (B5101). Features such as arthralgia and leucocytoclastic vasculitis suggest an immune-complex mediated basis, which is supported by finding circulating immune complexes and, although the antigen responsible is unidentified, heat shock proteins have been implicated. An inflammatory disorder, BS is now considered as a systemic vasculitis, characterised by a very wide spectrum of clinical features and by unpredictable exacerbations and remissions. [source] Polyangitis overlap syndrome: A fatal case combined with adult Henoch-Schönlein purpura and polyarteritis nodosaPATHOLOGY INTERNATIONAL, Issue 8 2003Kazuo Watanabe Henoch-Schönlein purpura (HSP) is a rather common disease characterized by systemic hypersensitivity vasculitis in the skin and other visceral organs. It has a favorable prognosis unless it is complicated by severe glomerular disease. We report a distinctive fatal case of systemic vasculitis combined with HSP and polyarteritis nodosa (PN) in a 56-year-old man who died of progressive renal failure one month after the onset of the disease. He complained of arthralgia, purpura of both lower extremities, nasal bleeding and tarry stool, and acute renal failure was noted at the time of admission to hospital. A skin biopsy from the purpura lesion exhibited leucocytoclastic vasculitis with IgA deposition, and HSP was considered. However, renal failure progressed rapidly and subsequently was complicated by acute myocardial infarction. Postmortem examination revealed PN type necrotizing vasculitis in the kidneys, heart and mesentery resulting in acute multiple infarctions of these organs. We think the current case was a polyangitis overlap syndrome. It is important to suspect the polyangitis overlap syndrome positively when progressive acute renal failure is seen in a patient with HSP and to begin appropriate therapy immediately. [source] Poster 1, Haemorrhagic bullae in a child with Henoch,Schönlein purpuraBRITISH JOURNAL OF DERMATOLOGY, Issue 6 2007S. Abdul-Ghaffar Henoch,Schönlein purpura (HSP) is one of the most common types of vasculitis in children. It usually presents with purpura, abdominal pain, arthralgia/arthritis and nephritis. The purpura seen in HSP is typically petechial or target-like and is the presenting sign in 50% of patients. Haemorrhagic bullae are rarely reported in children. We describe a 10-year-old boy who presented with a 1-week history of a petechial rash on his legs and buttocks, associated with abdominal pain and tender, swollen ankles and knees in May 2006. He had a history of a preceding upper respiratory tract infection. A clinical diagnosis of HSP was made at this stage. However, the rash became more extensive, involving his arms, shoulders and ears. Within 2 weeks, large tense haemorrhagic bullae developed on the lower legs, feet and hands. Urinalysis was positive for blood and protein but his blood pressure and renal function were normal. The rest of his investigations, including a full vasculitis screen, were normal. Because of the atypical bullae, a skin biopsy was performed. This showed leucocytoclastic vasculitis with IgA deposition consistent with HSP. The lesions improved with prednisolone, starting at 2 mg kg,1 daily, gradually reducing the dose over 3 months. Bullous HSP has been seen in up to 60% of adult patients but only in 2% of children. There have been only 11 reported cases of bullous HSP to date and the commonest sites were feet, ankles, legs and buttocks, suggesting that pressure is the most likely factor in its pathogenesis. This is an important observation as the presence of these atypical bullous lesions may pose a diagnostic challenge. [source] | ||||||||||