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Lesional Cells (lesional + cell)
Selected AbstractsPapanicolaou tests associated with cervical mucosal endometriosis: An analysis of cellular features and comparison to endocervical adenocarcinoma in situDIAGNOSTIC CYTOPATHOLOGY, Issue 8 2010Charles V. Biscotti M.D. Abstract Endometrium directly sampled from endocervical mucosal endometriosis can mimic endocervical adenocarcinoma in situ (AIS) in Papanicolaou (Pap) tests. We analyzed a series of Pap tests to investigate the cellular features of mucosal endometriosis and to assess the utility of stroma and apoptotic bodies in the differential diagnosis with AIS. Pap test samples from patients known to have endocervical mucosal endometriosis were compared with samples containing AIS. Pap tests from patients with mucosal endometriosis had lesional cells in 13 (62%) cases which includes glandular and stromal cells (10 cases), stroma only (two cases), and glandular cells only (one case). Three (23%) cases had gland-stromal aggregates. Three (23%) cases had mitotic figures and two (15%) had apoptotic bodies. By comparison, only one (8%) AIS case had endometrial-type stroma. Seven (58%) AIS cases had apoptotic bodies and three (25%) had mitotic figures. We conclude that Pap tests from patients with mucosal endometriosis usually (62%) have lesional cells. These lesional cells almost always include stroma, which is useful in the differential diagnosis with AIS. We identified stroma significantly more often in endometriosis cases (92%) than in AIS cases (8%). Pathologists should look for endometrial stroma when considering an interpretation of directly sampled endometrium. In the absence of stroma, AIS should be considered. Diagn. Cytopathol. 2010;38:551,554. 2009 Wiley-Liss, Inc. [source] The role of lymphatic mapping and sentinel node biopsy in the management of atypical and anomalous melanocytic lesionsJOURNAL OF CUTANEOUS PATHOLOGY, Issue 2010Alistair J. Cochran Atypical and anomalous melanocytic lesions are tumors that cannot be determined by microscopy to be certainly benign or fully malignant. The malignant potential of these borderline lesions is unknown and logical determination of best therapy is challenging, in particular whether lymphatic mapping and sentinel node biopsy have a place in their management. Lesions that fall into this category include atypical Spitzoid lesions, atypical cellular blue nevi, combined nevi, deep penetrating nevi, ancient nevi, desmoplastic nevi, balloon cell nevi and proliferation nodules of congenital nevi. We report our experience managing patients with these problematic tumors and discuss our approaches to determining the true location of lesional cells in sentinel nodes. Cochran AJ, Binder S, Morton DL. The role of lymphatic mapping and sentinel node biopsy in the management of atypical and anomalous melanocytic lesions. [source] An infiltrative variant of non-neural granular cell tumor: a case reportJOURNAL OF CUTANEOUS PATHOLOGY, Issue 2009Iwei Yeh Dermal non-neural granular cell tumors are rare tumors of indeterminate lineage that typically present as well-circumscribed tumors with nuclear pleomorphism and mitotic activity. We describe a dermal non-neural granular cell tumor with a distinctive growth pattern with granular cells interspersed between collagen bundles. This asymptomatic papule arose on the scapula of a 46-year-old woman and consisted of a mixture of epithelioid and spindled granular cells. The immunohistochemical characteristics were similar to those of previously reported dermal non-neural granular cell tumors. Despite mild nuclear pleomorphism and dispersion of lesional cells among collagen bundles, mitoses were not present and Ki-67 staining indicated a low proliferative rate. In addition to being S-100 protein negative and NKI/C3 positive, our case was positive for PGP9.5 and weakly positive for neuron-specific enolase, a staining pattern similar to what has been observed for cellular neurothekeomas. Our case could represent a dermal non-neural granular cell tumor with unique architecture, a granular cellular neurothekeoma or a granular cell dermatofibroma. As both dermal non-neural granular cell tumor and cellular neurothekeoma are of indeterminate lineage, our case with features characteristic of both entities may suggest a common precursor or lineage for dermal non-neural granular cell tumor and cellular neurothekeoma. [source] Activation of P44/42 Map Kinases within Human Epidermal Neoplasia.JOURNAL OF CUTANEOUS PATHOLOGY, Issue 1 2005Bryon Jackson Squamous cell carcinoma (SCC) arises from a series of genetic changes that form a clone of keratinocytes with enhanced growth characteristics. The p44/42 Map kinase pathway is a highly conserved growth regulatory pathway that helps relay critical signals from the cell membrane to the nucleus. Evidence demonstrating activation of the p44/42 pathway in the human cutaneous SCC has not been established. This study examined if p44/42 MAP kinase is activated in lesions of keratinocytic neoplasia. Lesions from the defined stages of keratinocytic neoplasia, normal skin, actinic keratoses, squamous cell carcinoma in situ, and squamous cell carcinoma, were randomly selected from archived material and studied. Antibodies that detect human p44/42 (phosphorylated and unphosphorylated) and only phosphorylated, activated, human p44/42 were used. The intensity and prevalence of cytoplasmic and nuclear staining was evaluated in the lesional cells. The results suggest that there is a not a simple linear relationship between the amount of nuclear staining and the type of lesion. The results show that there was a significant increase in the level of nuclear phosphorylated p44/42 staining progressing from an actinic keratoses to a sqaumous cell carcinoma in situ. These findings suggest that p44/42 MAP kinases are activated in keratinocytic neoplasia. [source] The ectomesenchymal chondromyxoid tumor: a reviewORAL DISEASES, Issue 5 2008CM Allen The ectomesenchymal chondromyxoid tumor is a relatively recently described neoplasm that appears to involve uniquely the oral cavity, particularly the tongue. Thirty well-accepted cases have been reported since the initial description of this lesion in 1995. While a wide age range (9,78 years) has been documented, most of these tumors are diagnosed from the third to sixth decades of life. No sex predilection is seen. The size of the neoplasm is typically <2 cm, and most affect the anterior dorsal tongue. The duration of the lesion was difficult to gauge, probably due to the asymptomatic nature of the process. Some tumors, however, were well documented to have been present for as long as 10,20 years. Histopathologically, the ectomesenchymal chondromyxoid tumor is characterized by a well circumscribed, but unencapsulated, lobular growth pattern. Varying degrees of cellularity are noted, with the lesional cells often set in a myxoid, chondroid or hyalinized background. Immunohistochemical studies reveal positivity of the lesional cells for antibodies directed against glial fibrillary acidic protein, cytokeratins, S-100 protein and CD-57 in the majority of tumors. Treatment consists of conservative surgical excision, and while recurrence is possible, it has been noted in <10% of reported cases. [source] | ||||||||||