Distribution by Scientific Domains
Distribution within Medical Sciences

Kinds of Lesions

  • DCI lesion
  • K lesion
  • abfraction lesion
  • ablation lesion
  • acid lesion
  • acne lesion
  • acneiform lesion
  • active inflammatory lesion
  • active lesion
  • acute gastric mucosal lesion
  • acute ischemic lesion
  • acute lesion
  • additional lesion
  • advanced lesion
  • airway lesion
  • amygdala lesion
  • and neck lesion
  • annular lesion
  • apical lesion
  • arterial lesion
  • artery lesion
  • asymptomatic lesion
  • atherosclerotic lesion
  • atrial lesion
  • atrophic lesion
  • atypical lesion
  • basal ganglia lesion
  • base lesion
  • benign lesion
  • bifurcation lesion
  • bilateral lesion
  • biliary lesion
  • bladder lesion
  • bleeding lesion
  • bone lesion
  • bone marrow lesion
  • borderline lesion
  • brain lesion
  • brainstem lesion
  • breast lesion
  • bullou lesion
  • c lesion
  • calcified lesion
  • cancer lesion
  • cancerous lesion
  • cardiac lesion
  • caries lesion
  • carious lesion
  • cartilage lesion
  • cell lesion
  • central nervous system lesion
  • cerebellar lesion
  • cerebral lesion
  • cerebral white matter lesion
  • cervical lesion
  • characteristic lesion
  • chronic lesion
  • classic lesion
  • clinical lesion
  • cns lesion
  • colonic lesion
  • colorectal lesion
  • common lesion
  • complete lesion
  • complex lesion
  • complex sclerosing lesion
  • congenital lesion
  • cord lesion
  • coronary artery lesion
  • coronary bifurcation lesion
  • coronary lesion
  • cortex lesion
  • cortical lesion
  • culprit lesion
  • cutaneous lesion
  • cystic lesion
  • cystic pancreatic lesion
  • de novo lesion
  • deep white matter lesion
  • demyelinated lesion
  • demyelinating lesion
  • depressed lesion
  • destructive lesion
  • discoid lesion
  • distal lesion
  • distinct lesion
  • dna lesion
  • duct lesion
  • duodenal lesion
  • dysplastic lesion
  • early lesion
  • electrolytic lesion
  • enamel lesion
  • endodontic lesion
  • endometrial lesion
  • endometriotic lesion
  • enhancing lesion
  • entorhinal cortex lesion
  • epidermal lesion
  • epithelial lesion
  • erosive lesion
  • erythematou lesion
  • esophageal lesion
  • excised lesion
  • excitotoxic lesion
  • extensive lesion
  • eyelid lesion
  • facial lesion
  • fibrotic lesion
  • fibrous lesion
  • finger lesion
  • focal brain lesion
  • focal lesion
  • focal liver lesion
  • folliculitis-like lesion
  • foot lesion
  • frequent lesion
  • frontal lesion
  • ganglia lesion
  • gastric lesion
  • gastric mucosal lesion
  • gastric precancerou lesion
  • gastrointestinal lesion
  • genetic lesion
  • genital lesion
  • giant cell lesion
  • gland lesion
  • glandular lesion
  • glomerular lesion
  • granulomatous lesion
  • gross lesion
  • growing lesion
  • haemorrhagic lesion
  • hallmark lesion
  • hcc lesion
  • head and neck lesion
  • heart lesion
  • hemorrhagic lesion
  • hepatic lesion
  • hepatocellular lesion
  • high-grade cervical lesion
  • high-grade lesion
  • high-grade squamous intraepithelial lesion
  • high-risk lesion
  • hippocampal lesion
  • histologic lesion
  • histological lesion
  • histopathological lesion
  • hyperintense lesion
  • hyperpigmented lesion
  • hypoechoic lesion
  • incipient lesion
  • individual lesion
  • infiltrative lesion
  • inflammatory lesion
  • initial lesion
  • interdigital lesion
  • intestinal lesion
  • intimal lesion
  • intra-epithelial lesion
  • intracranial lesion
  • intraepithelial lesion
  • intrauterine lesion
  • invasive lesion
  • ischaemic lesion
  • ischemic lesion
  • joint lesion
  • keratotic lesion
  • large lesion
  • larger lesion
  • left-sided lesion
  • lichenoid lesion
  • like lesion
  • linear lesion
  • liver lesion
  • local lesion
  • localized lesion
  • low-grade lesion
  • low-grade squamous intraepithelial lesion
  • lung lesion
  • lytic bone lesion
  • lytic lesion
  • macroscopic lesion
  • malignant breast lesion
  • malignant lesion
  • marrow lesion
  • mass lesion
  • matter lesion
  • melanocytic lesion
  • melanocytic skin lesion
  • metastatic lesion
  • microvascular lesion
  • missed lesion
  • mri lesion
  • mucosal lesion
  • mucous membrane lesion
  • multifocal lesion
  • multiple lesion
  • multiple sclerosis lesion
  • multiple skin lesion
  • neck lesion
  • necrotic lesion
  • neoplastic lesion
  • nerve lesion
  • nervous system lesion
  • neuropathological lesion
  • neurotoxic lesion
  • new lesion
  • nodular lesion
  • non-cariou cervical lesion
  • non-neoplastic lesion
  • nonneoplastic lesion
  • novo lesion
  • obstructive lesion
  • occult lesion
  • occupying lesion
  • olp lesion
  • one lesion
  • oral lesion
  • oral mucosal lesion
  • oral precancerou lesion
  • oral premalignant lesion
  • osseous lesion
  • osteolytic lesion
  • ostial lesion
  • other lesion
  • oxidative lesion
  • painful lesion
  • pancreatic cystic lesion
  • pancreatic lesion
  • papillary lesion
  • papular lesion
  • papulonodular lesion
  • parathyroid lesion
  • parenchymal lesion
  • pathological lesion
  • peri-implantitis lesion
  • perianal lesion
  • periapical lesion
  • periodontal lesion
  • periodontitis lesion
  • peripheral lesion
  • periradicular lesion
  • perirhinal cortex lesion
  • pigmented lesion
  • pigmented skin lesion
  • polypoid lesion
  • pre-cancerou lesion
  • precancerou lesion
  • precursor lesion
  • preinvasive lesion
  • premalignant lesion
  • preneoplastic lesion
  • primary lesion
  • progressive lesion
  • proliferative lesion
  • proximal lesion
  • psoriasis lesion
  • psoriatic lesion
  • psoriatic skin lesion
  • pulmonary lesion
  • purpuric lesion
  • radiofrequency lesion
  • rare lesion
  • reactive lesion
  • rectal lesion
  • recurrent lesion
  • relate lesion
  • renal lesion
  • representative lesion
  • residual lesion
  • resorptive lesion
  • retinal lesion
  • rf lesion
  • root caries lesion
  • salivary gland lesion
  • same lesion
  • satellite lesion
  • scab lesion
  • sclerosing lesion
  • sclerosis lesion
  • sclerotic lesion
  • selective lesion
  • severe lesion
  • significant lesion
  • similar lesion
  • single lesion
  • skin lesion
  • small lesion
  • smaller lesion
  • soft tissue lesion
  • solid lesion
  • solitary lesion
  • space occupying lesion
  • space-occupying lesion
  • specific lesion
  • spinal cord lesion
  • spinal lesion
  • spindle cell lesion
  • spot lesion
  • squamous intraepithelial lesion
  • stem lesion
  • stenotic lesion
  • striatal lesion
  • subcortical lesion
  • superficial lesion
  • surgical lesion
  • suspicious lesion
  • symmetrical lesion
  • system lesion
  • target lesion
  • tendon lesion
  • testicular lesion
  • thalamic lesion
  • thyroid lesion
  • tissue lesion
  • tongue lesion
  • tract lesion
  • traumatic lesion
  • treated lesion
  • true lesion
  • tumor lesion
  • tumorou lesion
  • ulcerative lesion
  • uncommon lesion
  • unilateral lesion
  • untreated lesion
  • v lesion
  • valve lesion
  • vascular lesion
  • verrucou lesion
  • vesicular lesion
  • visible lesion
  • vitiligo lesion
  • white matter lesion
  • white-matter lesion

  • Terms modified by Lesions

  • lesion area
  • lesion border
  • lesion characteristic
  • lesion clinic
  • lesion consistent
  • lesion count
  • lesion depth
  • lesion detection
  • lesion development
  • lesion diameter
  • lesion dimension
  • lesion distribution
  • lesion excision
  • lesion expansion
  • lesion formation
  • lesion greater
  • lesion groups
  • lesion growth
  • lesion length
  • lesion level
  • lesion localization
  • lesion location
  • lesion model
  • lesion pattern
  • lesion progression
  • lesion repair
  • lesion revascularization
  • lesion score
  • lesion set
  • lesion severity
  • lesion site
  • lesion size
  • lesion smaller
  • lesion subset
  • lesion suspicious
  • lesion type
  • lesion volume

  • Selected Abstracts


    Takashi Hisabe
    Background and Aim:, Ulcerative colitis (UC) is not only characterized by pathological lesions localized to colonic mucosa, but also to various complications involving other organs, including postoperative pouchitis. Among these complications, diffuse gastroduodenitis with lesions resembling colonic lesions has been reported, albeit rarely. The aim of the present study was to attempt to characterize the lesions of the upper gastrointestinal tract occurring as a complication of UC, and to assess the frequency and clinical course of these lesions. Methods:, A total of 322 UC patients who had undergone upper gastrointestinal endoscopy were retrospectively analyzed. We assessed the frequency of endoscopic findings, including diffuse gastroduodenal lesions resembling colonic lesions. Ulcerative gastroduodenal lesion (UGDL) associated with UC was diagnosed if lesions satisfied the following criteria: (i) improvement of the lesions with treatment of UC; and/or (ii) resemblance to UC in pathological findings. Results:, UGDL satisfying the aforementioned criteria was found in 15 (4.7%) of 322 patients. All the 15 patients had UGDL accompanied by pancolitis or after proctocolectomy. Frequency in 146 patients with pancolitis was 6.2% (nine patients) and that in 81 patients who had undergone proctocolectomy was 7.4% (six patients). Four patients with diffuse ulcerative upper-gastrointestinal mucosal inflammation (DUMI) had pouchitis. In all patients except one, the lesions resolved easily with medical treatment. Conclusions:, In more than half of the post-proctocolectomy patients, UGDL was related to the occurrence of pouchitis. The existence of characteristic UGDL must be taken into account in the diagnosis and treatment of UC, and UGDL is possibly related to the occurrence of pouchitis. [source]


    Shuichi Sano
    We report a case of ulcerative colitis complicating ileitis that endoscopically and histologically resembled a colonic lesion. Eight years prior to the time of writing, the patient had undergone proctosigmoidectomy and ileocecal resection because of severe hemorrhagic lesions of ulcerative colitis. A month prior to the time of writing, bleeding from the stoma occurred. Endoscopy revealed erosions on easy-bleeding mucosa in the ileum but no active inflammatory lesions in colonic mucosa except for small erosions in the descending colon beneath the stoma. Histologic findings of biopsy specimens from the ileal mucosa showed marked inflammation including neutrophile infiltration and crypt abscesses. This is a rare case of ulcerative colitis showing ileitis as a main recurrent lesion, suggesting that careful observation of the small intestine will be required after ileocecal resection in ulcerative colitis patients. [source]


    BJU INTERNATIONAL, Issue 4 2006
    Suresh K. Jariwala
    No abstract is available for this article. [source]


    Tomonori Yaguchi
    A 51-year-old man was referred to our hospital because of duodenal lesions of lymphoma. Endoscopy showed multiple tiny smooth whitish granules in the second portion of the duodenum including the papilla of Vater. Biopsy specimens showed medium-sized centrocyte-like cells forming lymphoid follicles, and immunohistology showed positive staining for bcl-2 and CD10. A small bowel series showed multiple granular lesions extending from the second portion of the duodenum to the proximal jejunum and the proximal ileum. On the basis of these findings, the tumor was diagnosed as stage I follicular lymphoma (FL). Although the patient was negative for Helicobacter pylori, he underwent antibiotic treatment. The lesions improved 3 months after antibiotic treatment, but biopsy specimens showed residual lymphoma cells. The patient therefore received combination chemotherapy with rituximab. Endoscopy 4 months later showed regression of FL, and there was no evidence of recurrence during 3 years of follow up. The partial regression of duodenal lesions of intestinal FL may be due to the effect of antibiotic treatment. [source]


    Edward P. Allen DDS


    Harvey J
    INTRODUCTION: Protocols for excision of mammographically detected lesions following core biopsy include all diagnoses of atypical ductal hyperplasia (ADH) or intraductal atypia of uncertain significance (AUS). The aims of this study were to look at: i) the prevalence of reporting ADH and AUS, ii) the proportion of cases where excision revealed breast carcinoma, iii) whether any cases could be downgraded to hyperplasia on review. METHODS: Breast core biopsy reports from the SCGH Breast Centre for the years 1999,2000 were retrieved. The results of excision biopsy were obtained and slides reviewed. RESULTS: There were 1048 core biopsies from 911 women. Breast carcinoma was diagnosed in 197 samples (18.8%) including 88 with invasive carcinoma (8.4%), 109 with ductal carcinoma in situ (10.4%) and 3 samples (2.9%) suspicious of invasive carcinoma. The suspicious cases all proved to be invasive carcinomas. There were 53 samples (5.1%) with a diagnosis of ADH or AUS. 46 were excised, showing 7 invasive carcinomas 15 DCIS, 11 ADH, 2 lobular carcinoma in situ (LCIS), 1 mucocoele-like lesion, 1 fibroadenoma and 9 fibrocystic change (FCC). The 22 malignancies represented 47.8% of the excised lesions. At review, 8 of the 53 original diagnoses were downgraded to benign hyperplasia; 5 underwent excision; 2 showed ,incidental' invasive carcinomas, 1 ,incidental' LCIS, 1 ADH and 1 FCC. CONCLUSIONS: There was a low prevalence of reporting of ADH and AUS in core biopsies (5.1%) and a high rate of carcinoma (47.8%) in subsequent excision biopsies. Very few diagnoses of ADH/AUS were downgraded at review. Current protocols for excision of lesions with a core biopsy diagnosis of ADH/AUS appear to be justified. [source]


    J. Y. Yang
    Purpose To evaluate safety of laparoscopic resection of submucosal gastric lesions performed in Whangarei Based Hospital. Methodology From November 2002 to December 2006, 8 consecutive patients underwent the above mention surgery. (M : F = 5 : 3; Average age 63 [range, 43,83]). All patients underwent pre-operative gastroscopy. Wedge resections were performed for anterior wall lesions. (n = 3). Posterior wall lesions were resected via transgastric approach. (n = 4). Retroperitoneal resection was performed for the foregut duplication cyst. (n = 1). All except one lesion were resected using endoscopic GIA stapler. The medical records of the patients were reviewed retrospectively. Results All patients were successfully treated laparoscopically. No conversion to open surgery. Pathology included: Gastrointestinal-stromal tumor (GIST) (n = 5), Malignant leiomyosarcoma (n = 1), Ectopic pancreas (n = 1), and Foregut duplication cysts (n = 1). All achieved adequate negative surgical margin. Average operation time was 106.14 minutes. [Range, 75,150]. Average length of hospital stay was 3.42 days [range, 1,5]. Complication included one wound infection, and one pyloric stenosis. Average length of follow up was 10.96 months [range, 0.46,31.73]. No recurrence detected and all are still alive till date. Conclusion Laparoscopic resection of submucosal gastric lesions is a safe and appropriate alternative to open surgery. Its main advantage over open technique includes shorter length of hospital stay, lower recurrence rate and lower mortality rates. Surgical technique depends very much on tumor size and location. Outcome of the patients described from our centre is comparable to the others published till date. [source]

    Dermoscopy Identifies Histopathologically Indiscernible Malignant Lesion of Atypical Melanosis of the Foot, an Early Lesion of Acral Lentiginous Melanoma In Situ

    First page of article [source]

    Tophaceous Lesion of the Middle Third of the Nose

    No abstract is available for this article. [source]

    Patients Spend More Time With the Physician for Excision of a Malignant Skin Lesion Than for Excision of a Benign Skin Lesion

    Steven R. Feldman MD
    Background. Currently, there is a difference in reimbursement between excision of malignant and benign lesions. There is concern that there is not sufficient rationale for differential reimbursement for these two procedures. Objective. To assess whether there is a difference in physician work involved with excision of benign versus malignant skin tumors. Method. We searched National Ambulatory Medical Care Survey data for visits at which excision of benign and malignant skin lesions was performed. We compared the time spent with the physician at these two types of visits. To exclude confounding issues unrelated to the excision that would affect the time of visit, we excluded visits at which multiple diagnoses were addressed. Results. The mean time spent with the physician at visits for excision of benign lesions was 22.9±1.0 minutes. The mean time spent with the physician at visits for excision of malignant lesions was 30.0±1.7, 30% longer (p < 0.001). The longer time for excision of malignant lesions remained significant after controlling for age, gender, and race. Conclusion. Excision of malignant lesions involves more physician work than does excision of benign lesions. Elimination of differential compensation for benign versus malignant skin lesion procedures would not enhance the accuracy of reimbursement. In the absence of any compelling rationale to change the existing differential reimbursement, the proposals to do so are not warranted. [source]

    Atrial Endocarditis,The Importance of the Regurgitant Jet Lesion

    ECHOCARDIOGRAPHY, Issue 5 2005
    Shawn A. Gregory M.D.
    The jet lesions of valvular regurgitation or intracardiac shunts have been hypothesized to play an important role in the pathogenesis of endocarditis for many years. We describe a case of mitral valve endocarditis that involved the left atrium along the path of a jet lesion. This resulted in atrial endocarditis and pericarditis, both of which complicated her presentation and hospital course. Using transesophageal echocardiography, we were able to directly visualize the path and full extent of infection prior to surgery. Special attention should be focused upon the path of eccentric jets in order to fully define the extent of endocarditis. [source]

    Lesion of the anterior branch of axillary nerve in a patient with hereditary neuropathy with liability to pressure palsies

    S. Simonetti
    We report the case of a 30-year-old woman affected by hereditary neuropathy with liability to pressure palsies (HNPP), who developed a painless left axillary neuropathy after sleeping on her left side, on a firm orthopaedic mattress, in her eighth month of pregnancy. Electromyography (EMG) showing neurogenic signs in the left anterior and middle deltoid, and normal findings in the left teres minor, posterior deltoid and other proximal upper limb muscles, demonstrated that the lesion was at the level of the axillary anterior branch. A direct compression of this branch against the surgical neck of the humerus seems the most likely pathogenic mechanism. This is the first documented description of an axillary neuropathy in HNPP. Knowledge of its possible occurrence may be important for prevention purposes. [source]

    The Kölliker-Fuse nucleus gates the postinspiratory phase of the respiratory cycle to control inspiratory off-switch and upper airway resistance in rat

    Mathias Dutschmann
    Abstract Lesion or pharmacological manipulation of the dorsolateral pons can transform the breathing pattern to apneusis (pathological prolonged inspiration). Apneusis reflects a disturbed inspiratory off-switch mechanism (IOS) leading to a delayed phase transition from inspiration to expiration. Under intact conditions the IOS is irreversibly mediated via activation of postinspiratory (PI) neurons within the respiratory network. In parallel, populations of laryngeal premotoneurons manifest the IOS by a brief glottal constriction during the PI phase. We investigated effects of pontine excitation (glutamate injection) or temporary lesion after injection of a GABA-receptor agonist (isoguvacine) on the strength of PI-pool activity determined from respiratory motor outputs or kinesiological measurements of laryngeal resistance in a perfused brainstem preparation. Glutamate microinjections into distinct parts of the pontine Kölliker-Fuse nucleus (KF) evoked a tonic excitation of PI-motor activity or sustained laryngeal constriction accompanied by prolongation of the expiratory phase. Subsequent isoguvacine microinjections at the same loci abolished PI-motor or laryngeal constrictor activity, triggered apneusis and established a variable and decreased breathing frequency. In summary, we revealed that excitation or inhibition of defined areas within the KF activated and blocked PI activity and, consequently, IOS. Therefore, we conclude, first, that descending KF inputs are essential to gate PI activity required for a proper pattern formation and phase control within the respiratory network, at least during absence of pulmonary stretch receptor activity and, secondly, that the KF contains large numbers of laryngeal PI premotor neurons that might have a key role in the regulation of upper airway resistance during reflex control and vocalization. [source]

    Susceptibility to Heterobasidion parviporum in Picea abies clones grown in different environments

    FOREST PATHOLOGY, Issue 2 2008
    B. Karlsson
    Summary Thirty-five Norway spruce, Picea abies, clones from Sweden were tested for resistance to Heterobasidion parviporum. Rooted cuttings of the clones were planted in Italy and Greece and cultivated for two growing seasons before inoculation with H. parviporum. Extent of infection was determined 6 weeks later. The results were compared to those of earlier inoculations in Sweden. Plant growth traits were under strong genetic control in all locations with broad sense heritability estimates between 0.14 and 0.54. Lesion and fungal extension heritabilities were moderate, H2 ranged from 0.09 to 0.20, and exhibited rather large genetic variation. There was significant genotypic correlation between Italy and Greece with respect to both lesions and fungal extension. No such correlations were found between Sweden and the two other countries. The lack of repeatability in testing susceptibility is unsatisfactory. It could be explained by C-effects associated with propagation of the host plants. Height growth correlated significantly and positively among all countries. [source]

    Hemicrania Continua Secondary to an Ipsilateral Brainstem Lesion

    HEADACHE, Issue 3 2007
    Marcelo M. Valença MD
    We describe a 47-year-old woman with a 3-year history of a continuum mild-moderate right-side headache, with exacerbations, associated with stabbing volleys of pain on right orbit-temporal region (10/10) and right eye ptosis and lacrimation with conjunctival injection. The pain was completely abolished with indomethacin (100 mg per day). The diagnosis of hemicrania continua was made according to the International Headache Society (IHS) criteria. The headache presentation was precipitated by a stroke and a right-side brainstem lesion was present at magnetic resonance imaging. This case report shows anatomoclinical evidence of the involvement of brainstem structures on the pathophysiology of hemicrania continua. [source]

    A voxel-based morphometry study of frontal gray matter correlates of impulsivity,

    HUMAN BRAIN MAPPING, Issue 4 2009
    Koji Matsuo
    Abstract Impulsivity is a personality trait exhibited by healthy individuals, but excessive impulsivity is associated with some mental disorders. Lesion and functional neuroimaging studies indicate that the ventromedial prefrontal region (VMPFC), including the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC) and medial prefrontal cortex, and the amygdala may modulate impulsivity and aggression. However, no morphometric study has examined the association between VMPFC and impulsivity. We hypothesized that healthy subjects with high impulsivity would have smaller volumes in these brain regions compared with those with low impulsivity. Sixty-two healthy subjects were studied (age 35.4 ± 12.1 years) using a 1.5-T MRI system. The Barratt impulsiveness scale (BIS) was used to assess impulsivity. Images were processed using an optimized voxel-based morphometry (VBM) protocol. We calculated the correlations between BIS scale scores and the gray matter (GM) and white matter (WM) volumes of VMPFC and amygdala. GM volumes of the left and right OFC were inversely correlated with the BIS total score (P = 0.04 and 0.02, respectively). Left ACC GM volumes had a tendency to be inversely correlated with the BIS total score (P = 0.05). Right OFC GM volumes were inversely correlated with BIS nonplanning impulsivity, and left OFC GM volumes were inversely correlated with motor impulsivity. There were no significant WM volume correlations with impulsivity. The results of this morphometry study indicate that small OFC volume relate to high impulsivity and extend the prior finding that the VMPFC is involved in the circuit modulating impulsivity. Hum Brain Mapp 2009. © 2008 Wiley-Liss, Inc. [source]

    Cranial fasciitis of childhood

    Margarita Larralde MD
    A 2-month-old boy was seen at our pediatric dermatology department with a history of a tumoral lesion of the scalp since his birth. On examination he had a single, ovoid, firm, 2 × 1.8-cm painless subcutaneous mass on the temporal left calvarium, covered by normal skin (Fig. 1). It had experienced explosive growth in the preceding 2 weeks. There was no history of previous trauma in the area. The remainder of the examination was normal. Roentgenographic studies of the skull revealed a soft-tissue mass without involvement of the underlying bone. Ultrasonography of the lesion showed it to be an echolucid tumor. With the presumed diagnosis of dermoid cyst we sent the patient for surgical removal. At surgery, the lesion did not have the typical surgical appearance of a cyst. The histopathologic exam of the specimen was interpreted as cranial fasciitis of childhood (Fig. 2). Immunohistochemistry showed diffuse positivity for vimentin and muscle actin. After 1 year the patient is free of lesions. Figure 1. Lesion at the temporal left calvarium Figure 2. Proliferation of loosely arranged spindle cells in a loose myxoid stroma (H&E stain, × 40) [source]

    Gold-Tip Electrodes,A New "Deep Lesion" Technology for Catheter Ablation?

    In Vitro Comparison of a Gold Alloy Versus Platinum, Iridium Tip Electrode Ablation Catheter
    Radiofrequency (RF) catheter ablation is widely used to induce focal myocardial necrosis using the effect of resistive heating through high-frequency current delivery. It is current standard to limit the target tissue,electrode interface temperature to a maximum of 60,70°C to avoid char formation. Gold (Au) exhibits a thermal conductivity of nearly four times greater than platinum (Pt,Ir) (3.17 W/cm Kelvin vs 0.716 W/cm Kelvin), it was therefore hypothesized that RF ablation using a gold electrode would create broader and deeper lesions as a result of a better heat conduction from the tissue,electrode interface and additional cooling of the gold electrode by "heat loss" to the intracardiac blood. Both mechanisms would allow applying more RF power to the tissue before the electrode,tissue interface temperature limit is reached. To test this hypothesis, we performed in vitro isolated liver and pig heart investigations comparing lesion depths of a new Au-alloy-tip electrode to standard Pt,Ir electrode material. Mean lesion depth in liver tissue for Pt,Ir was 4.33 ± 0.45 mm (n = 60) whereas Au electrode was able to achieve significantly deeper lesions (5.86 ± 0.37 mm [n = 60; P < 0.001]). The mean power delivered using Pt,Ir was 6.95 ± 2.41 W whereas Au tip electrode delivered 9.64 ± 3.78 W indicating a statistically significant difference (P < 0.05). In vitro pig heart tissue Au ablation (n = 20) increased significantly the lesion depth (Au: 4.85 ± 1.01 mm, Pt,Ir: 2.96 ± 0.81 mm, n = 20; P < 0.001). Au tip electrode again applied significantly more power (P < 0.001). Gold-tip electrode catheters were able to induce deeper lesions using RF ablation in vitro as compared to Pt,Ir tip electrode material. In liver and in pig heart tissue, the increase in lesion depth was associated with a significant increase in the average power applied with the gold electrode at the same level of electrode,tissue temperature as compared to platinum material. [source]

    Reduction in Atrial Defibrillation Threshold by a Single Linear Ablation Lesion

    Single Lesion Lowers ADFT.Introduction: This study investigated a hybrid approach to reduce the atrial defibrillation threshold (ADFT) by determining the effect of a single linear radiofrequency ablation (RFA) lesion on both the ADFT and activation patterns during atrial fibrillation (AF). Methods and Results: In 18 open chest sheep (45 to 57 kg), coil defibrillation electrodes were placed in a superior vena cava/right ventricular configuration. AF was induced by burst pacing and maintained with acetyl ,-methylcholine (2 to 42 ,L/min). ADFTs were obtained before and after a linear RFA lesion was created in the left atrium (LAL; n = 6), right atrium (RAL; n = 6), or neither atrium as a control (n = 6). In animals receiving an LAL, a 504-unipolar-electrode plaque was sutured to the LA. For animals receiving an RAL, two 504-electrode plaques were placed, one each on the LA and RA. From each plaque, activations were recorded before and after ADFT shocks, and organizational characteristics of activations were analyzed using algorithms that track individual wavefronts. In sham-treated controls, the ADFT did not change. In contrast, LAL reduced ADFT energy 29%, from 4.5 ± 2.3 J to 3.2 ± 2.0 J (P < 0.05). RAL reduced ADFT energy 25%, from 2.0 ± 0.9 J to 1.5 ± 0.7 J (P < 0.05). AF activation was substantially more organized after RFA than before RFA for both the RAL- and LAL-treated animals. Conclusion: A single RFA lesion in either the RA or LA reduces the ADFT in this sheep model. This decrease is associated with an increase in fibrillatory organization. [source]

    Leiomyosarcoma of the Penis Presenting as a Cutaneous Lesion

    Thomas L. Cibull
    We report a case of a 68-year-old man with cutaneous leiomyosarcoma of the penis. Leiomyosarcoma of the penis is an extremely rare neoplasm that usually presents in middle to old age, and to our knowledge only approximately 30 cases have been reported in the literature to date. This is an important diagnosis in the differential diagnosis of cutaneous spindle cell neoplasms of the male genital tract. [source]

    "Backdoor" Alternative Approach to Stenting of a Post-Anastomotic Coronary Artery Lesion via a Chronically Obstructed Right Coronary Artery after Failure to Stent through a Tortuous Free Internal Mammary Graft

    We describe the case of a patient who previously had coronary artery bypass grafting including a free right internal mammary artery graft anastomosed to a chronic totally occluded right coronary artery (RCA) proximally and distally and who presented with a high-risk acute coronary syndrome. Coronary angiography revealed the graft to be patent with a distal post-anastomotic culprit lesion within the posterolateral branch of the native RCA. Because of technical challenges, PCI could not be performed through the graft and the lesion was stented via the chronically occluded RCA instead, in a "backdoor" approach with a good final result. [source]

    Regulation of SVZ-derived gliogenesis by inflammatory-demyelination

    A. Baron-Van Evercooren
    Identifying a source of cells with the capacity to generate oligodendrocytes in the adult CNS would help the development of strategies to promote myelin repair. During development of the neonate rodent forebrain, most oligodendrocytes derive from the subventricular zone (SVZ), a germinative area which also contributes to the genesis of astrocytes and neurons. While the SVZ persists in the adult brain, its size is largely reduced and its contribution to cell genesis is essentially restricted to the renewal of the granular and periglomerular neurons of the olfactory bulb. Lesion derived signals can have a profound impact on the behavior of the SVZ cells. While cortical trauma triggers their mobilization and differentiation in astrocytes in the lesioned cortex (Holmin et al. 1997), focaly-induced demyelination promotes their migration in the demyelinated white matter and differentiation in astrocytes and oligodendrocytes (Nait-Oumesmar et al. 1999). Using EAE, we will show that multifocal demyelination (i) promotes the proliferation of the SVZ precursors (ii) enhances their migration towards the olfactory bulb and triggers their mobilization to multiple sites of the diseased white matter, and (iii) induces their differentiation in neurons, astrocytes and oligodendrocytes in the olfactory bulb, and in oligodendrocytes and astrocytes in the demyelinated white matter. SVZ precursors could thus be a source of oligodendrocytes and contribute with oligodendrocyte progenitors to the replacement of lost oligodendrocytes in demyelinating diseases of the adult CNS. [source]

    Nodular Lesion of the Skin as Primary Cutaneous Tuberculosis

    Caterina Casalini
    No abstract is available for this article. [source]

    Vibrio cholerae O2 as a Cause of a Skin Lesion in a Tourist Returning from Tunisia

    Claudio Farina
    No abstract is available for this article. [source]

    Lesion of the dorsorostral midbrain sparing the nigrostriatal tract mimics axial rigidity seen in progressive supranuclear palsy

    MOVEMENT DISORDERS, Issue 8 2005
    Jan Lewerenz MD
    Abstract We report on a patient with a residual dorsorostral midbrain lesion after resection of a pineal gland tumor. In addition to severe vertical gaze palsy, this patient exhibited other neurological features closely resembling progressive supranuclear palsy. Normal dopamine transporter single-photon emission computed tomography imaging excluded significant dopamine deficiency. We suggest that dorsorostral midbrain pathology rather than dopamine deficiency due to degeneration of nigrostriatal dopaminergic neurons or basal ganglia nuclei might be responsible for axial rigidity in extension. © 2005 Movement Disorder Society [source]

    Mapping of Atrial Activation Patterns After Inducing Contiguous Radiofrequency Lesions: An Experimental Study

    CHORRO, F.J., et al.: Mapping of Atrial Activation Patterns After Inducing Contiguous Radiofrequency Lesions: An Experimental Study. High resolution mapping techniques are used to analyze the changes in atrial activation patterns produced by contiguous RF induced lesions. In 12 Langendorff-perfused rabbit hearts, left atrial activation maps were obtained before and after RF induction of epicardial lesions following a triple-phase sequential protocol: (phase 1) three separate lesions positioned vertically in the central zone of the left atrial wall; (phase 2) the addition of two lesions located between the central lesion and the upper and lower lesions; and (phase 3) the placement of four additional lesions between those induced in the previous phases. In six additional experiments a pathological analysis of the individual RF lesions was performed. In phase 1 (lesion diameter = 2.8 ± 0.2 mm, gap between lesions = 3 ± 0.8 mm), the activation process bordered the lesions line in two (2.0-ms cycles) and four experiments (1.0-ms cycles). In phase 2, activation bordered the lesions line in eight (2.0-ms cycles, P < 0.01 vs control) and nine experiments (1.0-ms cycles, P < 0.001), and in phase 3 this occurred in all experiments except one (both cycles, P < 0.001 vs control). In the experiments with conduction block, the increment of the interval between activation times proximal and distal to the lesions showed a significant correlation to the length of the lesions (r = 0.68, P < 0.05, 100-ms cycle). In two (17%) experiments, sustained regular tachycardias were induced with reentrant activation patterns around the lesions line. In conclusion, in this acute model, atrial RF lesions with intact tissue gaps of 3 mm between them interrupt conduction occasionally, and conduction block may be frequency dependent. Lesion overlap is required to achieve complete conduction block lines. Tachycardias with reentrant activation patterns around a lesions line may be induced. [source]

    Esophageal anthracosis: Lesion mimicking malignant melanoma

    Tetsuya Murata
    A case of anthracosis of the esophagus is reported. The patient was a previously healthy 69-year-old Japanese woman. A black and slightly elevated lesion was detected in her esophagus by upper gastroesophageal fiberoscopic examination. Endoscopically, the lesion looked like malignant melanoma. Thoracic esophagotomy was then performed. Histological examination revealed a pigmented lesion beneath the mucosal epithelial layer. The lesion consisted of an aggregation of histiocytes containing an abundance of tiny black pigments. A few mature lymphocytes and plasma cells were also evident in the periphery of the lesion. Histologically, these findings looked like lymph nodes in the pulmonary hilus; however, no lymph nodal structure was evident in the esophageal wall. Traction diverticula were also noted in the pigmented lesion. The patient has remained well without disease for 9 months since the surgery. Although anthracosis is a rare condition in the esophagus, the present case gave warning to pathologists and clinicians that it does indeed occur. Endoscopists and pathologists should differentiate anthracosis from malignant melanoma because the treatment and outcome are quite different for each. [source]

    Pedunculated Lesion of the Scalp with Surrounding Long, Dark Hair in a Newborn

    Almudena Hernández-Núńez M.D.
    No abstract is available for this article. [source]

    An Unusual Cutaneous Lesion as the Presenting Sign of Spinal Dysraphism in a Preterm Infant

    M. Mansur Tatli M.D.
    Our clinical diagnosis was probable twin nevus, with a blanched nevus adjacent to a telangiectatic nevus, later complicated by ulceration. Ultrasonography and magnetic resonance imaging of the lumbosacral region revealed that her conus medullaris level was at L4 and the spinal cord was tethered by an intraspinal lipoma, without evidence of a hemangioma. We could not find any literature reporting the association of twin nevus with spinal dysraphism. [source]

    A Newborn with Nodular Ulcerated Lesion on a Giant Congenital Nevus

    J. Borbujo M.D.
    It is usually small (less than 5 mm), sometimes multiple, with a slow growth rate, and has a black or dark brown, smooth, shiny surface. It usually involutes spontaneously. We report a newborn infant who, at birth, had a giant congenital nevus with a nodular, ulcerative, hemorrhagic lesion within it. Physical and neurologic examinations were normal. Radiologic studies at birth and subsequently were normal. A fragment of the lesion was biopsied and histologic findings were compatible with a diagnosis of proliferative nodule in a giant congenital nevus. The rest of the nodule regressed spontaneously after 4 months. [source]