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Selected AbstractsPriorities and paradigms: directions in threatened species recoveryCONSERVATION LETTERS, Issue 3 2009Sue V. Briggs Abstract Recovering threatened species is a key challenge for conservation managers, policy makers, and researchers. This article describes a practical framework for assigning priorities for recovery of threatened species according to cost-effectiveness of recovery strategies for species groups. The framework has the following steps: (1) determine the conservation goal,persistence in the wild of the largest number of threatened species with the funds available; (2) assign threatened species to species recovery groups according to their characteristics and threats,small-population species that require actions at sites and declining-population species that require actions across landscapes; (3) identify the recovery strategies and their component actions for the species groups; (4) cost the recovery strategies for the species groups; (5) determine the cost-effectiveness of the recovery strategies for the species groups,the number of species recovered divided by the cost of the strategies; (6) assign priorities to the recovery strategies according to their cost-effectiveness; (7) allocate funds to the recovery strategies that maximize the number of threatened species recovered for the funds available; and (8) undertake the funded recovery strategies and actions. The framework is illustrated with an example. [source] Funding and Publishing Trends of Original Research by Emergency Medicine Investigators over the Past DecadeACADEMIC EMERGENCY MEDICINE, Issue 1 2006Robert H. Birkhahn MD Abstract Objectives: To update the profile of author-reported funding of reports of original research published since 1994 in the four U.S. peer-reviewed general emergency medicine (EM) journals. Methods: For the primary analysis, articles published in Academic Emergency Medicine, American Journal of Emergency Medicine, Annals of Emergency Medicine, and Journal of Emergency Medicine between 1994 and 2003 were reviewed by two emergency physicians trained in abstracting from the literature. Original research was identified; case reports, case series, abstracts, and meta-analysis were excluded. Articles were classified by author report of extramural funding as government (public), private nonprofit (foundation), for profit (industry), or multiple. Data are reported as percent per year per journal. A secondary analysis of MEDLINE was performed to identify publishing trends by EM investigators outside of these four journals over the same period. Results: The primary analysis identified 5,728 articles; 3,278 (57%) were considered original research, with 32% of these reporting extramural funding. In 1994, there were 292 articles with 28% funded (28% public, 43% foundation, 17% industry, and 12% multiple). By 2003, there were 358 articles with 36% funded (42% public, 30% foundation, 18% industry, and 10% multiple). There was a trend toward increased extramural funding in all four journals (p = 0.007), with an estimated growth of 3.6% (95% confidence interval = 1.0% to 6.3%) per year over the past decade. The primary review identified 48% of all articles published by EM investigators. Conclusions: Author-reported extramural funding rates for original research have increased in the EM literature over the past decade. Foundations have funded the largest number of studies, with public (government) sources increasing in 2003. [source] Industry sponsorship and selection of comparators in randomized clinical trialsEUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Issue 2 2010D. N. Lathyris Eur J Clin Invest 2010; 40 (2): 172,182 Abstract Background, Most clinical trials on medical interventions are sponsored by the industry. The choice of comparators shapes the accumulated evidence. We aimed to assess how often major companies sponsor trials that involve only their own products. Methods, Studies were identified by searching ClinicalTrials.gov for trials registered in 2006. We focused on randomized trials involving the 15 companies that had sponsored the largest number of registered trials in ClinicalTrials.gov in that period. Results, Overall, 577 randomized trials were eligible for analysis and 82% had a single industry sponsor [89% (166/187) of the placebo-control trials, 87% (91/105) of trials comparing different doses or ways of administration of the same intervention, and 78% (221/285) of other active control trials]. The compared intervention(s) belonged to a single company in 67% of the trials (89%, 81% and 47% in the three categories respectively). All 15 companies strongly preferred to run trials where they were the only industry sponsor or even the only owner of the assessed interventions. Co-sponsorship typically reflected co-ownership of the same intervention by both companies. Head-to-head comparison of different active interventions developed by different companies occurred in only 18 trials with two or more industry sponsors. Conclusions, Each company generates a clinical research agenda that is strongly focused on its own products, while comparisons involving different interventions from different companies are uncommon. This diminishes the ability to understand the relative merits of different interventions for the same condition. [source] Selenium metabolism in zebrafish: multiplicity of selenoprotein genes and expression of a protein containing 17 selenocysteine residuesGENES TO CELLS, Issue 12 2000Gregory V. Kryukov Fish are an important source of selenium in human nutrition and the zebrafish is a potentially useful model organism for the study of selenium metabolism and its role in biology and medicine. Selenium is present in vertebrate proteins in the form of selenocysteine (Sec), the 21st natural amino acid in protein which is encoded by UGA. We report here the detection of 18 zebrafish genes for Sec-containing proteins. We found two zebrafish orthologs of human SelT, glutathione peroxidase 1 and glutathione peroxidase 4, and single orthologs of several other selenoproteins. In addition, new zebrafish selenoproteins were identified that were distant homologues of SelP, SelT and SelW, but their direct orthologs in other species are not known. This multiplicity of selenoprotein genes appeared to result from gene and genome duplications, followed by the retention of new selenoprotein genes. We found a zebrafish selenoprotein P gene (designated zSelPa) that contained two Sec insertion sequence (SECIS) elements and encoded a protein containing 17 Sec residues, the largest number of Sec residues found in any known protein. In contrast, a second SelP gene (designated zSelPb) was also identified that contained one SECIS element and encoded a protein with a single Sec. We found that zSelPa could be expressed and secreted by mammalian cells. The occurrence of zSelPa and zSelPb suggested that the function of the N-terminal domain of mammalian SelP proteins may be separated from that of the C-terminal Sec-rich sequence: the N-terminal domain containing the UxxC motif is likely involved in oxidoreduction, whereas the C-terminal portion of the protein may function in selenium transport or storage. Our data also suggest that the utilization of Sec is more common in zebrafish than in previously characterized species, including mammals. [source] Reducing cell loss in banyan based ATM switching fabricsINTERNATIONAL JOURNAL OF COMMUNICATION SYSTEMS, Issue 1 2001M. Al-Mouhamed Abstract In this paper, we propose a new technique for reducing cell loss in multi-banyan-based ATM switching fabrics. We propose a switch architecture that uses incremental path reservation based on previously established connections. Path reservation is carried out sequentially within each banyan but multiple banyan planes can be concurrently reserved. We use a conflict resolution approach according to which banyans make concurrent reservation offers of conflict-free paths to head of the line cells waiting in input buffers. A reservation offer from a given banyan is allocated to the cell whose source-to-destination path uses the largest number of partially allocated switching elements which are shared with previously reserved paths. Paths are incrementally clustered within each banyan. This approach leaves the largest number of free switching elements for subsequent reservations which has the effect of reducing the potential of future conflicts and improves throughput. We present a pipelined switch architecture based on the above concept of path-clustering which we call path-clustering banyan switching fabric (PCBSF). An efficient hardware that implements PCBSF is presented together with its theoretical basis. The performance and robustness of PCBSF are evaluated under simulated uniform traffic and ATM traffic. We also compare the cell loss rate of PCBSF to that of other pipelined banyan switches by varying the switch size, input buffer size, and traffic pattern. Copyright © 2001 John Wiley & Sons, Ltd. [source] Reducing Irregular Migration from ChinaINTERNATIONAL MIGRATION, Issue 3 2003James K. Chin With the development of China's economy since 1979, a new type of Chinese migration has emerged, which is more diversified and quite distinct from previous migration patterns. Trafficking in human beings and other forms of irregular migration are one of the most pressing and complex human rights issues today, reaching across borders and affecting most of the countries in the world, with new and serious security implications. As part of the international irregular migration flows toward and into the European Union (EU), the Chinese, particularly from Fujian and Zhejiang provinces, have played a major role since the 1980s. To some extent, it could be said that China provides the largest number of East Asian irregular immigrants to Europe. Based on fieldwork conducted in southern China over the past seven years, this paper proposes to examine current Chinese irregular migration trends. It will further present the Government's response regarding the migratory modus operandi and policy implications with the aim of offering policy makers an empirical insight into the most active region of emigration in China. Because of the difficulty and sensitivity involved in collecting data on the topic, materials in this paper are mainly based on a content analysis of local Chinese newspapers and my interviews with various people involved in irregular migration activities, such as "snakeheads", illegal migrants and their family members, and police, local, and government officials at different levels. [source] Migration of Highly Skilled Chinese to Europe: Trends and PerspectiveINTERNATIONAL MIGRATION, Issue 3 2003Guochu Zhang Since China's economic opening and reforms in 1978, the country has broadened and deepened its exchanges and relations with other countries. This has contributed to the increase in the scale of international migration of highly skilled Chinese abroad. The impact of the migration of highly skilled Chinese on China and the relevant nations particularly deserve attention and study. Following the earlier migration flows mainly to the United States, Japan, Canada, Australia, and New Zealand, the migration of highly skilled Chinese to Europe has become a notable new trend. Currently, the flow of international migration of highly skilled Chinese personnel is mainly oriented toward Europe and the United States. While studying abroad has been the main form of migration of the skilled, this has now been joined by the migration of technical and professional staff, and the trend is increasing. The main country of destination for Chinese students is the United States, which absorbs more than half of the total, while Australia and Canada receive the largest number of skilled Chinese manpower. The United States also receives a large number of Chinese technical personnel, but its proportion has declined, while the flow to Europe has sharply increased. This development may be attributed to the global expansion of economic, scientific and technological, as well as cultural and educational exchanges and cooperation. But it is also the result of an increase in the educational investment made by the Chinese people following the continuous increase in China's economic strength and the population's personal income. Of greater importance are the gaps between China and Europe at the scientific, technological, and educational levels and the research and marketing environment. The intervening changes in labour market and immigration policies in European and American countries accelerate the trend further. For all of these and other reasons, the spatial distribution of Chinese students will become more balanced and play a positive role in the promotion of mutually beneficial exchanges between China and other countries. [source] The top 27 animal alien species introduced into Europe for aquaculture and related activitiesJOURNAL OF APPLIED ICHTHYOLOGY, Issue 2010D. Savini Summary The information extracted from IMPASSE, DAISIE, FishBase, and FAO-DIAS inventories of alien species were used to draw a list of the 27 most utilized animal alien species for aquaculture and related activities (e.g. stocking, sport fishing, ornamental purposes) in Europe. Three variables have been considered to assess their negative ecological impacts when these species escape from aquaculture facilities: (i) their distribution across Europe (including non-EU Member States); (ii) evidence of their environmental impact in the wild; and (iii) evidence of their being vectors of non-target alien species and other hitchhikers (e.g. pathogens). Drivers of use and mechanisms of dispersal in the wild have been also considered and reviewed. Twenty of the species are freshwater fishes: alien cyprinids and salmonids have been introduced into Europe mainly for food production, sport fishing and ornamental purposes. The most widespread species are the goldfish Carassius auratus and the rainbow trout Oncorhynchus mykiss, established in 29 and 28 European countries, respectively. Notwithstanding their successful distribution in Europe, only the Gibel carp Carassius gibelio and the peneid shrimp Marsupenaeus japonicus were found to have environmental impact in all the countries of establishment. Crayfish and predatory fishes (e.g. catfishes and salmonids) cause major environmental impacts in Europe by outcompeting native species and altering habitat structure. Alien crayfish, Procambarus clarkii and Pacifastacus leniusculus, are responsible for the largest range of impacts (i.e. crayfish plague dissemination, bioaccumulation of pollutants, community dominance, competition and predation on native species, habitat modifications, food web impairment, herbivory and macrophytes removal). Cyprinids (e.g. herbivorous carps) are vectors of diseases and parasites, while salmonids (e.g. Salvelinus fontinalis) often cause genetic impairment of native stocks by hybridization. The importation of alien farmed (target) species frequently leads to the introduction of associated non-target species. The cultures of the Pacific cupped oyster Crassostrea gigas and Manila clam Ruditapes philippinarum were responsible for the introduction of the largest number (60) of non-native invertebrates and algae, often attached to packaging material, fouling the shell or parasitizing bivalve tissues. [source] Structures and stability of lithium monosilicide clusters SiLin (n = 4,16): What is the maximum number, magic number, and core number for lithium coordination to silicon?JOURNAL OF COMPUTATIONAL CHEMISTRY, Issue 11 2008Ning He Abstract In the coordination, hypervalent and cluster chemistry, three important characteristic properties are the maximum coordination number, magic number, and core coordination number. Yet, few studies have considered these three numbers at the same time for an MLn cluster with n larger than 8. In this article, we systematically studied the three properties of SiLin (n = 4,16) clusters at the B3LYP/6-31G(d), B3LYP/6-311++G(2d), and CCSD(T)/6-311++G(3df)//B3LYP/6-311++G(2d) (for energy only) levels. Various isomeric forms with different symmetries were calculated. For each SiLin (n = 4,9), silicon cohesive energy (cE) from SiLin , Si + Lin reaction, vertical ionization potential (vIP), and vertical electron affinity (vEA) were obtained for the lowest-energy isomer. We found that the maximum Li-coordination number of Si is 9, which is the largest number among the known MLin clusters. All cE, vIP, and vEA values predicted that 6 is the magic Li-coordination number of Si. For small SiLin (n , 6) clusters, Li atoms favor direct coordination to Si, whereas for larger SiLin (n , 7) clusters, there is a core cluster that is surrounded by excessive Li atoms. The core Li-coordination number is 6 for SiLin (n = 7,8), 7 for SiLin (n = 9,10), 8 for SiLin (n = 11,15) and 9 for SiLin (n , 16). Through the calculations, we verified the relationship between the structure and stability of SiLin with the maximum coordination number, magic number, and core coordination number. © 2008 Wiley Periodicals, Inc. J Comput Chem, 2008 [source] Gaussian-type function set without prolapse for the Dirac,Fock,Roothaan equationJOURNAL OF COMPUTATIONAL CHEMISTRY, Issue 15 2003Hiroshi Tatewaki Abstract A Gaussian-type function (GTF) set without a prolapse (variation collapse) is generated for the Dirac,Fock,Roothaan (DFR) equation. The test atom was mercury. The number of primitive GTFs used is between 7and 62 (abbreviated as 7,62), 6,62, 6,62, 4,36, 4,36, 3,36, and 3,36 for s+, p,, p+, d,, d+, f,, and f+ symmetries. The respective exponent parameters were determined with even-tempered manner, which requires the minimum and maximum exponents for the respective symmetries. We prepared several sets of these. The total energy (TE) given by the numerical DF (NDF) is ,19648.849250 hartree; one of the present sets with largest number of expansion terms gave ,19648.849251 hartree. The error (,TE) relative to the NDR TE is quite small. We then applied this set to the inert gas atoms Ne (10), Ar (18), Kr (36), Xe (54), Rn (86), and No (102), and also to Es (99) as the representative of the open shell atoms. The absolute values of ,TE were at most 2.8 × 10,6 hartree, showing the potential of this set as a universal set. © 2003 Wiley Periodicals, Inc. J Comput Chem 24: 1823,1828, 2003 [source] Distribution, seasonal use, and predation of incubation mounds of Orange-footed Scrubfowl on Komodo Island, IndonesiaJOURNAL OF FIELD ORNITHOLOGY, Issue 2 2009M. Jeri Imansyah ABSTRACT Megapodes are unique in using only heat from the environment, rather than body heat, to incubate their eggs as well as the precocious independence of their chicks on hatching. Of 22 recognized species of megapodes, 9 are listed as threatened due to factors including habitat loss and fragmentation, and predation on eggs and chicks. Orange-footed Scrubfowl (Megapodius reinwardt) are conspicuous components of the Oriental/Austral avifauna that inhabit the monsoon forests of the Lesser Sunda chain of islands in Indonesia. We examined the abundance, patterns of distribution, physical characteristics, seasonal activity, and predation risk of incubation mounds of Orange-footed Scrubfowl on Komodo Island in eastern Indonesia. We surveyed 13 valleys on Komodo Island from April 2002 to January 2005 and located 113 tended and 107 untended incubation mounds. Densities of scrubfowl mounds in our study were similar to that reported by investigators during the 1970s, suggesting little change in the scrubfowl population since then. Most scrubfowl mounds were on sandy or loamy soils in open monsoon forest with little overhead shade, and placement of mounds in such areas may ensure adequate temperatures for egg incubation. Although some mounds were tended during all months, mound use peaked during the late wet season in March. During the dry season (April,November), only a few mounds were tended. Komodo dragons (Varanus komodoensis) and wild pigs (Sus scrofa) were the primary predators of scrubfowl eggs, with no indication of egg predation by humans. The valley with the largest number of untended mounds in our study also had the largest number of active Komodo dragon nests. This suggests an effect of Komodo dragons on scrubfowl numbers, but additional study is needed. SINOPSIS Los Megadopodos son únicos al usar calor del ambiente, en vez de calor corporal, para incubar sus huevos, y que sus polluelos nidífugos son independientes después de la eclosión. De las 22 especies de Megapodos reconocidas, nueve están en la lista de especies amenazadas debido a factores como pérdida y fragmentación del hábitat y depredación de huevos y polluelos. Megapodius reinwardt es un componente conspicuo de la avifauna Oriental/Austral que vive en los bosques monzones en las islas de las Sundas Menores en Indonesia. Examinamos la abundancia, patrones de distribución, características físicas, actividades temporales y riesgo de depredación en los montículos incubadores de M. reinwardt en la isla de Komodo en el este de Indonesia. Examinamos 13 valles en la isla de Komodo entre Abril 2002 y Enero 2005 y localizamos 113 montículos incubadores atendidos y 107 que no estaban siendo atendidos. Las densidades de montículos de M. reinwardt en nuestro sitio de estudio fueron similares a los reportados por investigadores en la década de los ,70, lo cual siguiere pocos cambios en la población de M. reinwardt desde entonces. La mayoría de los montículos de M. reinwardt se encontraron en suelos arenosos o margosos en bosques monzones abiertos, con poca cobertura de vegetación, y la localización de los montículos en estas áreas posiblemente aseguran temperaturas adecuadas para la incubación de los huevos. A pesar de que algunos montículos estuvieron atendidos durante todos los meses, el pico de uso de los montículos ocurrió durante el final de la temporada de lluvias en Marzo, y durante la temporada seca (Abril,Noviembre) solo algunos montículos estuvieron atendidos. Los dragones de Komodo (Varanus komodoensis) y los cerdos salvajes (Sus scrofa) fueron los principales depredadores de los huevos de M. reinwardt, y no hubo indicio de depredación por humanos. En nuestro estudio el valle con los mayores números de montículos desatendidos tenía el mayor número de nidos activos de dragones de Komodo. Este resultado sugiere la posibilidad de algún efecto de los dragones de Komodo en los números de Megapodius reinwardt, pero estudios adicionales son requeridos. [source] CONSUMER-BASED OPTIMIZATION OF PEANUT-CHOCOLATE BAR USING RESPONSE SURFACE METHODOLOGYJOURNAL OF FOOD PROCESSING AND PRESERVATION, Issue 3-4 2005EDITH M. SAN JUAN ABSTRACT The acceptability of the sensory properties of a peanut-chocolate bar was optimized for consumer acceptance using response surface methodology. The factors studied included sugar, peanuts, cocoa powder and a process variable, degree of roast. Twenty-seven peanut-chocolate bar formulations with two replications were evaluated for consumer acceptance (n = 168) for overall liking and acceptance of color, appearance, flavor, sweetness and texture using 9-point hedonic scales. In terms of overall liking, the use of dark-roasted peanuts received the largest number of acceptable formulations when compared to the medium- and light-roasted peanuts. Sensory evaluation indicated that sweetness acceptance was the limiting factor for acceptability. An acceptable peanut-chocolate bar can be obtained by using formulations containing 44,54% dark-, medium- or light-roasted peanuts, 1,4% cocoa powder and 41,55% sugar. [source] Ability of stress-related volatiles to attract and induce attacks by Xylosandrus germanus and other ambrosia beetlesAGRICULTURAL AND FOREST ENTOMOLOGY, Issue 2 2010Christopher M. Ranger 1Xylosandrus germanus typically colonizes physiologically-stressed deciduous hosts but it is increasingly being recognized as a key pest of ornamental nursery stock. We tested the attractiveness of common plant stress-related volatiles to ambrosia beetles occupying the nursery agroecosystem, as well as their ability to induce attacks on selected trees. Experiments were conducted in Ohio, U.S.A. 2Stress volatile attractiveness was first assessed by positioning traps baited with acetaldehyde, acetone, ethanol and methanol in ornamental nurseries. Cumulative trap counts confirmed that ethanol was the most attractive stress-related volatile to X. germanus. Methanol-baited traps were slightly attractive to X. germanus, whereas traps baited with acetaldehyde and acetone were not attractive to any ambrosia beetle. 3A series of tree injection experiments were also conducted to determine the ability of these volatiles to induce attacks by ambrosia beetles under field conditions. Injection of ethanol into Magnolia virginiana induced the largest number of attacks, whereas injection of acetaldehyde induced more attacks than methanol or acetone. Xylosandrus germanus was the most predominant species emerging from M. virginiana injected with each of the stress-related volatiles. No attacks by wood-boring beetles were observed on water injected or uninjected control trees. 4Solid-phase microextraction,gas chromatography,mass spectrometry confirmed the emission of acetaldehyde, acetone, ethanol and methanol after their injection into M. virginiana. 5Xylosandrus germanus has an efficient olfactory-based mechanism for differentiating among host volatile cues. Injecting select trees with stress-related volatiles, particularly ethanol, shows promise as a trap tree strategy for X. germanus and other ambrosia beetles. [source] Light FCC gasoline olefin oligomerization over a magnetic NiSo4/,-Al2o3 catalyst in a magnetically stabilized bedAICHE JOURNAL, Issue 3 2009Ying Peng Abstract Magnetic NiSO4/,-Al2O3 catalysts were prepared by impregnating NiSO4 solutions onto the ,-Al2O3 support containing a magnetic material of Fe3O4. Characterization by XRD, NH3 -TPD, and thermal analysis showed that the magnetic NiSO4/,-Al2O3 catalyst with a nickel content of 7.0% by weight had a monolayer dispersion of NiSO4 and the largest number of moderate strength acid sites, and a high specific saturation magnetization. The magnetic catalyst was evaluated for light FCC gasoline olefin oligomerization in both fixed-bed and magnetically stabilized bed (MSB) reactors. Comparing with that in the fixed-bed reactor, the optimal reaction temperature in the MSB lowered to 443 K, and its space velocity ranged broadly from 2.0 to 6.0 h,1. The sulfur-free diesel distillate produced by operation of the MSB for 100 h had higher cetane number and good low-temperature flow property, which illuminates a promising application of the MSB to manufacture clean diesel fuels with high productivity and flexibility. © 2009 American Institute of Chemical Engineers AIChE J, 2009 [source] An updated clinical and epidemiological profile of the adenomatoid odontogenic tumour: a collaborative retrospective studyJOURNAL OF ORAL PATHOLOGY & MEDICINE, Issue 7 2007Hans Peter Philipsen Background:, Adenomatoid odontogenic tumour (AOT) is a benign odontogenic jaw lesion. The aim of this study was to update the biological profile of AOT. Material and methods:, Cases published in the literature and cases in files of co-authors were included. Results:, 550 new cases were retrieved, and of a total of 1082 cases analysed, 87.2% were found in the second and third decades. The M:F ratio was 1:1.9. 70.8% were of the follicular variant (extrafollicular: 26.9%, peripheral: 2.3%). 64.3% occurred in the maxilla. 60% of follicular AOTs were associated with unerupted canines. Nineteen cases of AOT (2.8%, M:F ratio was 1:1.4) were associated with embedded third molars. Twenty-two peripheral AOTs (2.3%, M:F ratio was 1:5.3) were recorded. The relative frequency (RF) of AOT ranged between 0.6% and 38.5%, revealing a considerably wider AOT/RF range than hitherto reported (2.2,7.1%). Conclusions:, This updated review based on the largest number of AOT cases ever presented, confirms the distinctive, although not pathognomonic clinicopathological profile of the AOT, its worldwide occurrence, and its consistently benign behaviour. [source] An analysis of oral and maxillofacial pathology found in adults over a 30-year periodJOURNAL OF ORAL PATHOLOGY & MEDICINE, Issue 7 2006A. V. Jones Background:, The aim of this study was to determine the range of histologically diagnosed lesions in 44 000 oral and maxillofacial pathology specimens, from adults 17 years and older, submitted for diagnosis to our laboratory over a 30-year period (1973,2002). Materials:, All entries for specimens from the patients were retrieved and compiled into 12 diagnostic categories. Results:, During the period, 44 007 specimens comprised a male-to-female ratio of 0.9:1. The diagnostic category with the largest number of specimens was mucosal pathology (36.0%) followed by odontogenic cysts (13.8%). Malignant tumours accounted for 5.4% of all specimens and benign tumours 4.6%. Conclusion:, This survey showed that while the majority of diagnoses are benign, approximately one in 19 cases required major head and neck surgery for malignant disease. [source] The Interaction of Reward Genes With Environmental Factors in Contribution to Alcoholism in Mexican AmericansALCOHOLISM, Issue 12 2009Yanlei Du Background:, Alcoholism is a polygenic disorder resulting from reward deficiency; polymorphisms in reward genes including serotonin transporter (5-HTT)-linked polymorphic region (5-HTTLPR), A118G in opioid receptor mu1 (OPRM1), and ,141C Insertion/Deletion (Ins/Del) in dopamine receptor D2 (DRD2) as well as environmental factors (education and marital status) might affect the risk of alcoholism. Objective of the current study was to examine the main and interacting effect of these 3 polymorphisms and 2 environmental factors in contribution to alcoholism in Mexican Americans. Methods:, Genotyping of 5-HTTLPR, OPRM1 A118G, and DRD2-141C Ins/Del was performed in 365 alcoholics and 338 nonalcoholic controls of Mexican Americans who were gender- and age-matched. Alcoholics were stratified according to tertiles of MAXDRINKS, which denotes the largest number of drinks consumed in one 24-hour period. Data analysis was done in the entire data set and in each alcoholic stratum. Multinomial logistic regression was conducted to explore the main effect of 3 polymorphisms and 2 environmental factors (education and marital status); classification tree, generalized multifactor dimensionality reduction (GMDR) analysis, and polymorphism interaction analysis version 2.0 (PIA 2) program were used to study factor interaction. Results:, Main effect of education, OPRM1, and DRD2 was detected in alcoholic stratum of moderate and/or largest MAXDRINKS with education ,12 years, OPRM1 118 A/A, and DRD2 ,141C Ins/Ins being risk factors. Classification tree analysis, GMDR analysis, and PIA 2 program all supported education*OPRM1 interaction in alcoholics of largest MAXDRINKS with education ,12 years coupled with OPRM1 A/A being a high risk factor; dendrogram showed synergistic interaction between these 2 factors; dosage-effect response was also observed for education*OPRM1 interaction. No definite effect of marital status and 5-HTTLPR in pathogenesis of alcoholism was observed. Conclusions:, Our results suggest main effect of education background, OPRM1 A118G, and DRD2 ,141C Ins/Del as well as education*OPRM1 interaction in contribution to moderate and/or severe alcoholism in Mexican Americans. Functional relevance of these findings still needs to be explored. [source] A differential medium for lactic acid-producing bacteria in a mixed cultureLETTERS IN APPLIED MICROBIOLOGY, Issue 6 2008H.M. Lee Abstract Aims:, Modified deMan-Rogosa Sharpe agar containing bromophenol blue (mMRS-BPB) was tested as a medium for counting and differentiation of each lactic acid-producing bacterium (LAB), especially in a mixed culture. Methods and Results:, Type strains of 10 LAB species (Lactobacillus acidophilus, L. brevis, L. bulgaricus, L. gasseri, L. paracasei, L. plantarum, L. reuteri, Weissella confusa, Bifidobacterium bifidum and B. infantis) and five commercial yogurts were inoculated on plate count agar with bromocresol purple, mMRS, and mMRS-BPB. Each type strain showed more clearly formed colonies on the three media under anaerobic conditions than under aerobic conditions. Especially each type strain produced colonies with specific characteristics of each species on mMRS-BPB. Commercial yogurts produced the largest number of colonies with various shapes and colours on mMRS-BPB. Conclusions:, Modified deMan-Rogosa Sharpe agar containing bromophenol blue under anaerobic conditions is appropriate for counting and differentiating each LAB in a mixed culture. Significance and Impact of the Study:, Modified deMan-Rogosa Sharpe agar containing bromophenol blue will be useful in isolation and enumeration of each LAB from fermented foods as well as intestinal microflora. [source] Ex situ cultivation of Aplysinaaerophoba close to in situ conditions: ecological, biochemical and histological aspectsMARINE ECOLOGY, Issue 2 2008Anne Klöppel Abstract Sponges provide the largest number of biologically active natural products known from the marine environment and continue to be a very well studied phylum of marine fauna. The Mediterranean sponge Aplysina aerophoba accumulates brominated isoxazoline alkaloids such as Aplysinamisin-1, Aerophobin-2, Isofistularin-3 and the biotransformation product Aeroplysinin-1, which possesses, for example, antibiotic and cytotoxic properties. Until now, it is still being discussed which organisms , the sponge itself or associated microorganisms , are responsible for metabolite production. For cultivating Aplysina individuals under ex situ conditions, we surveyed relevant ecological factors in situ and controlled them in our aquarium system. We maintained A. aerophoba for more than 9 months and analysed changes of metabolite content and composition, microbial association as well as morphology in situ and ex situ under different light exposure. Although sponges showed slight reduction during maintenance, ex situ cultivation similar to in situ conditions provides a promising method to keep sponges and obtain their bioactive metabolites. [source] Delta Scuti Network observations of XX Pyx: detection of 22 pulsation modes and of short-term amplitude and frequency variationsMONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 2 2000G. Handler We report multisite observations devoted to the main-sequence , Scuti star XX Pyx, conducted as the 17th run of the Delta Scuti Network. Over 125 nights a total of 550 h of usable time-series photometric B - and V -filter data were acquired involving both photoelectric and CCD measurements at eight observatories spread around the world, which represents the most extensive single time-series for any pulsating star other than the Sun obtained so far. We describe our observations and reduction methods, and present the frequency analysis of our new data. First, we detect six new pulsation and five new combination frequencies in the star's light curves. We also discover evidence for amplitude and/or frequency variations of some of the modes during the observations. These can occur on time-scales as short as 20 d and show quite diverse behaviour. To take them into account in the frequency analysis, a so-called non-linear frequency analysis method was developed, allowing us to quantify the temporal variability of the modes and to compensate for it. Following that we continue the frequency search and we also incorporate published multisite observations. In this way, we reveal three more pulsation and two more combination frequencies. In the end, we report a total of 30 significant frequencies , 22 of which correspond to independent pulsation modes. This is the largest number of independent modes ever detected in the light curves of a , Scuti star. The frequencies of the modes show preferred separations as already suggested by previous work on this star; they are also arranged in clear patterns. These results lead to a refinement of the stellar mean density and to a new constraint on the rotation rate of XX Pyx (,rot=1.1±0.3 d,1). However, our attempts to identify the modes by pattern recognition failed. Moreover, mode identification from multicolour photometry failed as well because the high pulsation frequencies make this method unfavourable. The diverse behaviour of the amplitude and frequency variations of some of the modes leaves resonances as the only presently known possibility for their explanation. [source] Best practices in board governance: Evidence from South CarolinaNONPROFIT MANAGEMENT & LEADERSHIP, Issue 2 2008Jo An M. Zimmermann In June 2003, a large-scale survey was conducted among South Carolina nonprofit agencies to gather information on a range of board governance issues. Some of the survey questions dealt with how each agency's board contributes to the organization. More than 80 percent of the responding agencies were registered as 501(c)(3), with the largest number of respondents in the human services category. Statistical analysis reveals where actual roles differ from "best practices" as prescribed in the literature. Discussion then focuses on how these trends in governance affect management and operations. In particular, we look at best practice regarding the separation of board and staff duties. [source] Physiological risk factors, early warning scoring systems and organizational changesNURSING IN CRITICAL CARE, Issue 5 2007Carolyn C Johnstone Abstract Currently, medical and surgical wards tend to have a higher number of sicker and more dependent patients. There is also a growing recognition that several indicators of acute deterioration are being missed, leading to adverse consequences for the patients. As a result, many initiatives have been designed to try to reduce these consequences, including the development of early warning scoring or track and trigger systems and medical response and critical care outreach teams. This paper briefly discusses the risk factors associated with acute deterioration, the use of early warning scoring or track and trigger systems and the role of outreach teams. The aim of this paper is to discuss the development and subsequent implementation of early warning scoring systems (EWS) or track and trigger systems. It will also discuss the associated organizational changes; the main organizational change discussed will be the introduction outreach teams. For this paper, a pragmatic search strategy was implemented using the following terms: early warning score and scoring, track and trigger systems, decision-making tools, critical care outreach and medical emergency teams. The databases used included CINHAL (1997,2007), Medline, Blackwell Synergy and Science Direct, as these would enable the retrieval of relevant literature in the area of triggering of response to acute deterioration in clinical condition. A 10-year limit was initially set, although review of the literature identified resulted in a widening of this to include some of the relevant (and occasionally more dated) literature referred to in these papers. A total of 645 were accessed; of these 135 were retrieved as they appeared to meet the inclusion criteria, but only 35 have been included in this review. The term decision-making tools accounted for the largest number (500), but most of these were irrelevant. EWS are not always used to their full potential, raising the question of their impact. The impact of outreach teams and medical emergency teams has yet to be fully defined. For clinical practice, this means that care must be taken when developing and implementing these changes. The rigour of the development process needs to be considered along with reflection upon how to best meet local requirements. [source] Development and variability analysis of microsatellite markers in peachPLANT BREEDING, Issue 1 2002M. J. Aranzana Abstract A genomic DNA library enriched with AG/CT repeats has been developed from the peach cultivar ,Merrill O'Henry'. The enrichment method was efficient, with 61% of the clones obtained carrying a microsatellite sequence and a yield of one polymorphic microsatellite every 2.17 sequenced clones. From 35 microsatellites detected, 24 were polymorphic in a set of 25 cultivars including 14 peaches and 11 nectarines. A total of 82 alleles were found with the polymorphic microsatellites, with an average of a 37% of observed heterozygosity. Microsatellites with a high number of repeats were generally those having the largest number of alleles. All cultivars except two (,Spring Lady' and ,Queencrest') could be individually distinguished with the markers used. Just three selected microsatellites were enough for the discrimination of 24 out of the 25 possible genotypes. Cluster analysis grouped all nectarines in a single cluster. Peaches, with 75 of the 82 alleles found, were more variable than nectarines, with only 64. Microsatellites appear to be powerful and suitable markers for application in peach genetics and breeding. [source] Nonfatal work-related motor vehicle injuries treated in emergency departments in the United States, 1998,2002AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, Issue 9 2009Guang X. Chen MD Abstract Background Current data on nonfatal work-related motor vehicle injuries are limited and fragmented, often excluding government workers, self-employed workers, and workers on small farms. This study seeks to bridge the present data gap by providing a national profile of nonfatal work-related motor vehicle injuries across all industries and occupations. Methods Study subjects were people who suffered nonfatal work-related motor vehicle injuries and were treated in a hospital emergency department in the United States. Subjects were identified from a stratified probability sample of emergency departments. National estimates and rates were computed. Results From 1998 to 2002, the average annual rate of nonfatal work-related motor vehicle injuries was 7 injuries per 10,000 full-time equivalents. The rate was three times higher in men than in women. The rates were higher in workers 15,19 years of age and in workers 70 years or older. Justice, public order, and safety workers had the largest number of injuries, and taxicab service employees had the highest injury rate of all industries. Truck drivers had the largest number of injuries, and police and detectives, public service employees had the highest injury rate of all occupations. Conclusion Future efforts need to develop and enhance the use of surveillance information at the federal and state level for work-related nonfatal motor vehicle injuries. Prevention efforts need to address occupational motor vehicle safety for both commercial truck/bus drivers and workers who are not commercial drivers but who drive light motor vehicles on the job. Am. J. Ind. Med. 52:698,706, 2009. © 2009 Wiley-Liss, Inc. [source] On Integrating Immigrants in GermanyPOPULATION AND DEVELOPMENT REVIEW, Issue 3 2006Article first published online: 8 SEP 200 Immigration to Germany in the decades following World War II made the Federal Republic the host of the largest number of immigrants in Europe. The size of the population with an immigration background is on the order of 15 million, nearly one-fifth of the total population. (Many of these are ethnic German returnees.) Although restrictive policies and a less dynamic economy in recent years slowed the annual number of immigrants and asylum seekers, the interrelated demographic influences of very low fertility, negative natural population increase, and population aging make continuing future immigration likely and, judged by influential domestic interests, desirable. Anxieties about inadequate integration of immigrants in German society are, however, apparently strongly felt by large segments of the native population. The "Grand Coalition" government that took office in November 2005 considers the formation of an effective policy of integration a high priority. On 14 July 2006 an "Integration Summit" was convened in the Chancellery with the active participation of representatives of immigrant groups. Chancellor Angela Merkel called the Summit "an almost historical event." Reproduced below in full is a non-official English translation of a government statement (entitled "Good coexistence,Clear rules") presented to the participants at the opening of the meeting. Intended as a "start of the development of a national integration plan," the statement highlights existing deficiencies of integration, especially problems with second- and third-generation immigrants: lack of mastery of the German language, weaknesses in education and training, high unemployment, lack of acceptance of the basic rules of coexistence, and violation of the law. The importance of these issues is underlined by a demographic fact noted in the statement: by 2010 it is expected that in Germany's large cities 50 percent of the population under age 40 will have an immigrant background. The statement recognizes the government's responsibility to help immigrants learn German and become better informed about the country's laws, culture, history, and political system. In turn, it demands reciprocal efforts from migrants living permanently and lawfully in Germany. The original German text of the statement is available at the Bundeskanzleramt home page: «http://www.bundesregierung.d» [source] The digital divide: Who really benefits from the proposed solutions for closing the gapPROCEEDINGS OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE & TECHNOLOGY (ELECTRONIC), Issue 1 2002Roland D. Houston The authors conducted an exploratory content analysis of 269 English language articles about the digital divide to identify potential connections between proposed solutions and the strategic interests of the proposers, or stakeholders. Articles were coded by type of suggested solution and by type of stakeholder offering the solution. Educators predominated in the study literature, stressing the need for a change in Internet connectivity, educational content, and a change in user education, socioeconomic status (SES), and culture. The digital industry provided the next largest number of articles, suggesting governmental policy changes to promote new equipment, increased Internet connectivity, the training of digital industry workers, and a change in content of the Internet. Articles from the nondigital business community suggested that no gap existed or that market dynamics (the status quo) would close it. [source] How many long-stay schizophrenia patients can be discharged in Japan?PSYCHIATRY AND CLINICAL NEUROSCIENCES, Issue 1 2007IWAO OSHIMA phd Abstract, The mental health-care system in Japan remains hospital-based, and has the largest number of psychiatric beds per capita in the world. However, serious discussion about deinstitutionalization has recently begun. This study attempts to determine the proportion of inpatients that would benefit from community-based programs, as judged by hospital psychiatrists, and to evaluate the need for community resources for their community placement. Inpatients with schizophrenia from 139 hospitals were randomly selected. Data on the psychiatrists' judgment of discharge and required resources for community placement were obtained for 2758 subjects. Among the subjects, 1097 (39.8%) were judged to have the possibility of being discharged using community resources (possible discharge group; PDG). Provided that the proportion of PDG was 40%, controlling for the hospital background variables, the number of schizophrenia inpatients with a hospital stay of ,1 year who could be discharged from psychiatric hospitals in Japan was estimated to be 66 000. For the PDG, the required community resources, including accommodation, daytime activity, and daily living support services, were calculated. The numbers of governmental targets for community resources, including community accommodation, daytime activities, and daily living support services may have been underestimated. [source] Litigation related to anaesthesia: an analysis of claims against the NHS in England 1995,2007ANAESTHESIA, Issue 7 2009T. M. Cook Summary The distribution of medico-legal claims in English anaesthetic practice is unreported. We studied National Health Service Litigation Authority claims related to anaesthesia since 1995. All claims were reviewed by three clinicians and variously categorised, including by type of incident, claimed outcome and cost. Anaesthesia-related claims account for 2.5% of all claims and 2.4% of the value of all claims. Of 841 relevant claims 366 (44%) were related to regional anaesthesia, 245 (29%) obstetric anaesthesia, 164 (20%) inadequate anaesthesia, 95 (11%) dental damage, 71 (8%) airway (excluding dental damage), 63 (7%) drug related (excluding allergy), 31 (4%) drug allergy related, 31 (4%) positioning, 29 (3%) respiratory, 26 (3%) consent, 21 (2%) central venous cannulation and 18 (2%) peripheral venous cannulation. Defining which cases are, from a medico-legal viewpoint, ,high risk' is uncertain, but the clinical categories with the largest number of claims were regional anaesthesia, obstetric anaesthesia, inadequate anaesthesia, dental damage and airway, those with the highest overall cost were regional anaesthesia, obstetric anaesthesia, and airway and those with the highest mean cost per closed claim were respiratory, central venous cannulation and drug error excluding allergy. The data currently available have limitations but offer useful information. A closed claims analysis similar to that in the USA would improve the clinical usefulness of analysis. [source] Effect of guard dogs on the behavior and reproduction of gazelles in cattle enclosures on the Golan HeightsANIMAL CONSERVATION, Issue 2 2009G. Gingold Abstract Cattle on the Golan Heights are kept in enclosures and some of these enclosures have guard dogs. We studied the effect of such dogs on the behavior and breeding success of mountain gazelles Gazella gazella living within enclosures. We found that guard dogs have both direct and indirect effects on gazelles. Gazelles living in enclosures with dogs spent more time in vigilance behavior and running, and less time resting and walking, in comparison with gazelles in dog-free enclosures. In the absence of dogs, gazelle female herds in enclosures tended to stay closer to the cattle, but shunned away from them in the presence of the dogs, which, in turn, remained near the cattle. The percentage of fawns per female was higher in enclosures without dogs in comparison with those with dogs, but the difference was not significant. However, the largest of the enclosures with dogs, which had the largest number of gazelles, had only an average number of dogs in it. Hence, the gazelles in this enclosure were better able to avoid the dogs in comparison with those in smaller enclosures. Removing this enclosure from the overall calculation revealed that guard dogs have a significant negative effect on gazelle reproductive success. In two of the four enclosures with dogs no fawn still survived 6 months after birth, while in each of the four enclosures without dogs some fawns did survive to that age and beyond, suggesting that the dogs themselves may predate the fawns. [source] Large Allele Frequency Differences between Human Continental Groups are more Likely to have Occurred by Drift During range Expansions than by SelectionANNALS OF HUMAN GENETICS, Issue 1 2009T. Hofer Summary Several studies have found strikingly different allele frequencies between continents. This has been mainly interpreted as being due to local adaptation. However, demographic factors can generate similar patterns. Namely, allelic surfing during a population range expansion may increase the frequency of alleles in newly colonised areas. In this study, we examined 772 STRs, 210 diallelic indels, and 2834 SNPs typed in 53 human populations worldwide under the HGDP-CEPH Diversity Panel to determine to which extent allele frequency differs among four regions (Africa, Eurasia, East Asia, and America). We find that large allele frequency differences between continents are surprisingly common, and that Africa and America show the largest number of loci with extreme frequency differences. Moreover, more STR alleles have increased rather than decreased in frequency outside Africa, as expected under allelic surfing. Finally, there is no relationship between the extent of allele frequency differences and proximity to genes, as would be expected under selection. We therefore conclude that most of the observed large allele frequency differences between continents result from demography rather than from positive selection. [source] | |||||||||||||||||||||||||