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Selected AbstractsNew occurrence of Ips duplicatus Sahlberg in Herstal (Liege, Belgium)EPPO BULLETIN, Issue 3 2006F. Piel The double-spined spruce engraver Ips duplicatus is not present in Belgium and France. In summer 2003, several adult Ips duplicatus beetles were caught near quays in Herstal (Liege) during a survey. Large volumes of spruce logs, from Russia and the Baltic countries, had been imported to the immediate locality where the beetles had been caught. Thus, it is most likely that the capture specimens were introduced with these consignments. [source] The National Minimum Wage: Coverage, Impact and Future,OXFORD BULLETIN OF ECONOMICS & STATISTICS, Issue 2002David Metcalf Abstract Since its establishment in 1997, the Low Pay Commission (LPC) , whose main task is to recommend the rate for the national minimum wage (NMW) to the Prime Minister and the Secretary of State for Trade and Industry , has operated in a very open manner. Commissioners and the (small) secretariat have visited all the corners of the UK and hundreds of workplaces. Large volumes of written evidence and much oral evidence inform successive reports (LPC, 1998, 2000, 2001a,b, 2003). The LPC also values and nurtures its links with the academic community, many of whom have undertaken research for the LPC which has greatly contributed to the debate on the merits or otherwise of the NMW. In addition the LPC have periodically held conferences where the latest research on low pay and the NMW is discussed and evaluated. Some of the papers in this volume were originally presented at just such a conference hosted by the Centre for Economic Performance at the London School of Economics (LSE) on 28 September 2001 and organized (beautifully) by Joanna Swaffield of York University. In what follows the conference papers, those published in this volume, and related research are put into context. Section I deals with the thorny matter of coverage and data. The impact of the NMW on the pay distribution, employment and incomes is set out in section II. Some thoughts on the future of the NMW follow in section III. [source] Acute Monoplegia After Lysis of Epidural Adhesions: A Case ReportPAIN PRACTICE, Issue 5 2008DAAPM, Kok-Yuen Ho MBBS, MMed (Anaes) Abstract Lysis of epidural adhesions is an interventional procedure performed to treat refractory low back pain or radicular pain due to epidural scarring. A 39-year-old female with a diagnosis of failed back surgery syndrome underwent lysis of epidural adhesions using a Racz catheter. She developed acute monoplegia of her right lower extremity immediately after the procedure. Radiographic imaging did not reveal an epidural hematoma. Motor and sensory function in the right lower limb returned after 5 days. Large volumes of fluid injected during neuroplasty could have caused transient nerve injury from compression within loculated epidural compartments. [source] Woody Debris in the Mangrove Forests of South Florida1BIOTROPICA, Issue 1 2005Ken W. Krauss ABSTRACT Woody debris is abundant in hurricane-impacted forests. With a major hurricane affecting South Florida mangroves approximately every 20 yr, carbon storage and nutrient retention may be influenced greatly by woody debris dynamics. In addition, woody debris can influence seedling regeneration in mangrove swamps by trapping propagules and enhancing seedling growth potential. Here, we report on line-intercept woody debris surveys conducted in mangrove wetlands of South Florida 9,10 yr after the passage of Hurricane Andrew. The total volume of woody debris for all sites combined was estimated at 67 m3/ha and varied from 13 to 181 m3/ha depending upon differences in forest height, proximity to the storm, and maximum estimated wind velocities. Large volumes of woody debris were found in the eyewall region of the hurricane, with a volume of 132 m3/ha and a projected woody debris biomass of approximately 36 t/ha. Approximately half of the woody debris biomass averaged across all sites was associated as small twigs and branches (fine woody debris), since coarse woody debris >7.5 cm felled during Hurricane Andrew was fairly well decomposed. Much of the small debris is likely to be associated with post-hurricane forest dynamics. Hurricanes are responsible for large amounts of damage to mangrove ecosystems, and components of associated downed wood may provide a relative index of disturbance for mangrove forests. Here, we suggest that a fine:coarse woody debris ratio ,0.5 is suggestive of a recent disturbance in mangrove wetlands, although additional research is needed to corroborate such findings. [source] Surgical Treatment of Ingrown Toenail without MatricectomyDERMATOLOGIC SURGERY, Issue 1 2008BERNARD NOËL MD BACKGROUND Partial excision of the nail matrix (matricectomy) is generally considered necessary in the surgical treatment of ingrown toenail. Recurrences may occur, however, and poor cosmetic results are frequently observed. OBJECTIVE The objective is to present a new surgical procedure for ingrown toenail with complete preservation of the nail matrix. METHODS Twenty-three patients with ingrown toenail were included in this study. The surgical excision was performed 1 week after the completion of treatment of the initial infection. A large volume of soft tissue surrounding the nail plate was removed under local anesthesia. No matrix excision was performed. RESULTS Short-term results were excellent. No recurrences or severe complications were observed during the minimum 12-months follow-up period. Cosmetic results were remarkable. CONCLUSIONS Ingrown toenail results from the compression of the lateral nail folds on the nail plate. This study shows that ingrown toenail can be surgically treated without matricectomy. A large volume of soft tissue surrounding the nail plate should be removed to decompress the nail and reduce inflammation. Cosmetic results are excellent and superior to the classical Emmert plasty. Postoperative nail dystrophies and spicule formation are not observed. The main advantage of this surgical approach is the complete preservation of the anatomy and function of the nail to improve both therapeutic and cosmetic results. [source] CMP wastewater management using the concepts of design for environmentENVIRONMENTAL PROGRESS & SUSTAINABLE ENERGY, Issue 1 2002Gordon C. C. YangArticle first published online: 20 APR 200 Application of design for environment (DfE) concepts to management of wastewater from chemical mechanical polishing (CMP) processes are presented in this paper. Today, DfE is a prevailing concept and is widely adopted by advanced nations in lieu of the traditional "command and control" approach to control waste and toxic emissions. Designing environmentally-benign processes and products is a new and challenging frontier for engineering professionals, including those in the semiconductor industry. An insatiable need for water and subsequent wastewater treatment has imposed a chilling effect on semiconductor industry growth. It was estimated that semiconductor producers consumed more than 5.523 × 108 m3 of water in 2000. Of this amount, CMP processes accounted for 40% of the total. The CMP tool market and CMP slurry market are estimated to have 36% and 29% annual growth rates, respectively between 2000 and 2005. Inevitably, a tremendous amount of waste slurry and post-CMP rinse water will be generated and have to be managed properly. CMP wastewater is characterized by its high content of suspended solids having sub-micron particle sizes, high turbidity, and high conductivity. Traditional wastewater treatment technologies, such as chemical coagulation/precipitation, do not work well for CMP wastewater, because it would generate a large volume of sludge, which might cause disposal problems in many countries, such as Taiwan. Therefore, utilizing pollution prevention principles in the design of CMP tools, development of new CMP slurries, and improved plant operations are necessary to minimize environmental damage. Reclamation of process water is also a common requirement in the semiconductor industry. To this end, several alternatives for source reduction of CMP wastewater and water reclamation are presented in this paper. [source] Cough after inhalation of corticosteroids delivered from spacer devices in children with asthmaFUNDAMENTAL & CLINICAL PHARMACOLOGY, Issue 5 2003Jean-Christophe Dubus Abstract Children using a spacer device rather than another device for delivering inhaled corticosteroids (ICS) has been identified as a risk factor for cough immediately after inhalation. The aim of this study was to point out the different factors influencing the occurrence of such lateral side-effects. We studied this local side-effect in 402 asthmatic children (55.6 ± 34.9 months; 65.6% boys) treated for at least 1 month with beclomethasone dipropionate (n = 331), budesonide (n = 47) or fluticasone propionate (n = 24) delivered from pressurized metered-dose inhalers and small (75.1%) or large volume (24.8%) spacer devices mainly used with face mask (90.7%). A total of 219 patients (54.5%), treated with either high doses of ICS or ICS and long-acting ,2-agonist, were considered as having severe asthma. Cough was reported after each inhalation of corticosteroids in 216 patients (53.7%). Among them, about 30% also complained of cough with ,2-agonists. Despite different propellants and dispersants, all corticosteroids induced cough similarly. Cough was not linked with asthma severity, but was significantly related to therapy duration and use of long-acting ,2-agonist. Type and volume of the spacer device, use of a face mask or mouthpiece were not influencing factors. Cough after inhalation of corticosteroids delivered from spacer devices is a frequent local side-effect in children with asthma. This side effect can greatly alter compliance. A practitioner must be sought at each visit. [source] Real-time quadrupole mass spectrometer analysis of gas in borehole fluid samples acquired using the U-tube sampling methodologyGEOFLUIDS (ELECTRONIC), Issue 3 2006B. M. FREIFELD Abstract Sampling of fluids in deep boreholes is challenging because of the necessity of minimizing external contamination and maintaining sample integrity during recovery. The U-tube sampling methodology was developed to collect large volume, multiphase samples at in situ pressures. As a permanent or semi-permanent installation, the U-tube can be used for rapidly acquiring multiple samples or it may be installed for long-term monitoring applications. The U-tube was first deployed in Liberty County, TX to monitor crosswell CO2 injection as part of the Frio CO2 sequestration experiment. Analysis of gases (dissolved or separate phase) was performed in the field using a quadrupole mass spectrometer, which served as the basis for determining the arrival of the CO2 plume. The presence of oxygen and argon in elevated concentrations, along with reduced methane concentration, indicates sample alteration caused by the introduction of surface fluids during borehole completion. Despite producing the well to eliminate non-native fluids, measurements demonstrate that contamination persists until the immiscible CO2 injection swept formation fluid into the observation wellbore. [source] HYDROLOGY AND GEOMORPHIC EFFECTS OF A HIGH-MAGNITUDE FLOOD IN AN ALPINE RIVERGEOGRAFISKA ANNALER SERIES A: PHYSICAL GEOGRAPHY, Issue 1 2007DAVID MORCHE ABSTRACT. The catchment of the River Partnach, a torrent situated in a glacial valley in the Northern Calcareous Alps of Bavaria/Germany, was affected by a high-magnitude flood on 22/23 August 2005 with a peak discharge of more than 16 m3s -1 at the spring and about 50 m3s -1 at the catchment outlet. This flood was caused by a long period of intense rainfall with a maximum intensity of 230 mm per day. During this event, a landslide dam, which previously held a small lake, failed. The flood wave originating from the dam breach transported a large volume of sediment (more than 50 000 m3) derived from bank erosion and the massive undercutting of a talus cone. This caused a fundamental transformation of the downstream channel system including the redistribution of large woody debris and channel switching. Using terrestrial survey and aerial photography, erosional and depositional consequences of the event were mapped, pre- and post-event surfaces were compared and the sediment budget of the event calculated for ten consecutive channel reaches downstream of the former lake. According to the calculations more than 100 000 tonnes of sediment were eroded, 75% of which was redeposited within the channel and the proximal floodplain. A previous large flood which occurred a few weeks prior to the August 2005 event had a significant effect on controlling the impact of this event. [source] Financial Reporting for Private Companies: The Canadian Experience,ACCOUNTING PERSPECTIVES, Issue 1 2009Morina D. Rennie ABSTRACT The issue of whether small and/or private companies should be allowed to use simplified accounting standards in financial reports has concerned the accounting profession for decades. It has been argued that preparing financial reports in accordance with the large volume of promulgated standards contained in generally accepted accounting principles (GAAP), some of which are relatively complex, has put a significant strain on the resources of small/private business. Moreover, information produced and presented in accordance with at least some accounting standards within GAAP may not be relevant for the users of small/private companies' financial statements. In this paper we look at differential reporting in Canadian GAAP, which gives nonpublicly accountable enterprises the ability to opt out of certain CICA Handbook requirements with unanimous consent of the shareholders. We look at lobbying activity in response to the proposed differential reporting standard and at nonpublicly accountable company experience with the differential reporting opportunity in the period since the standard was promulgated. [source] Traffic flow continuum modeling by hypersingular boundary integral equationsINTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING, Issue 1 2010Luis M. Romero Abstract The quantity of data necessary in order to study traffic in dense urban areas through a traffic network, and the large volume of information that is provided as a result, causes managerial difficulties for the said model. A study of this kind is expensive and complex, with many sources of error connected to each step carried out. A simplification like the continuous medium is a reasonable approximation and, for certain dimensions of the actual problem, may be an alternative to be kept in mind. The hypotheses of the continuous model introduce errors comparable to those associated with geometric inaccuracies in the transport network, with the grouping of hundreds of streets in one same type of link and therefore having the same functional characteristics, with the centralization of all journey departure points and destinations in discrete centroids and with the uncertainty produced by a huge origin/destination matrix that is quickly phased out, etc. In the course of this work, a new model for characterizing traffic in dense network cities as a continuous medium, the diffusion,advection model, is put forward. The model is approached by means of the boundary element method, which has the fundamental characteristic of only requiring the contour of the problem to be discretized, thereby reducing the complexity and need for information into one order versus other more widespread methods, such as finite differences and the finite element method. On the other hand, the boundary elements method tends to give a more complex mathematical formulation. In order to validate the proposed technique, three examples in their fullest form are resolved with a known analytic solution. Copyright © 2009 John Wiley & Sons, Ltd. [source] Early Markers of Prolonged Hospital Stays in Older People: A Prospective, Multicenter Study of 908 Inpatients in French Acute HospitalsJOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 7 2006Pierre-Olivier Lang MD OBJECTIVES: To identify early markers of prolonged hospital stays in older people in acute hospitals. DESIGN: A prospective, multicenter study. SETTING: Nine hospitals in France. PARTICIPANTS: One thousand three hundred six patients aged 75 and older were hospitalized through an emergency department (Sujet Âgé Fragile: Évaluation et suivi (SAFEs) ,Frail Elderly Subjects: Evaluation and follow-up). MEASUREMENTS: Data used in a logistic regression were obtained through a gerontological evaluation of inpatients, conducted in the first week of hospitalization. The center effect was considered in two models as a random and fixed effect. Two limits were used to define a prolonged hospital stay. The first was fixed at 30 days. The second was adjusted for Diagnosis Related Groups according to the French classification (f-DRG). RESULTS: Nine hundred eight of the 1,306 hospital stays that made up the cohort were analyzed. Two centers (n=298) were excluded because of a large volume of missing f-DRGs. Two-thirds of subjects in the cohort analyzed were women (64%), with a mean age of 84. One hundred thirty-eight stays (15%) lasted more than 30 days; 46 (5%) were prolonged beyond the f-DRG-adjusted limit. No sociodemographic variables seemed to influence the length of stay, regardless of the limit used. For the 30-day limit, only cognitive impairment (odds ratio (OR)=2.2, 95% confidence interval (CI)=1.2,4.0) was identified as a marker for prolongation. f-DRG adjustment revealed other clinical markers. Walking difficulties (OR=2.6, 95% CI=1.2,16.7), fall risk (OR=2.5, 95% CI=1.7,5.3), cognitive impairment (OR=7.1, 95% CI=2.3,49.9), and malnutrition risk (OR=2.5, 95% CI=1.7,19.6) were found to be early markers for prolonged stays, although dependence level and its evolution, estimated using the Katz activity of daily living (ADL) index, were not identified as risk factors. CONCLUSION: When the generally recognized parameters of frailty are taken into account, a set of simple items (walking difficulties, risk of fall, risk of malnutrition, and cognitive impairment) enables a predictive approach to the length of stay of elderly patients hospitalized under emergency circumstances. Katz ADLs were not among the early markers identified. [source] Functional anatomy and muscle moment arms of the pelvic limb of an elite sprinting athlete: the racing greyhound (Canis familiaris)JOURNAL OF ANATOMY, Issue 4 2008S. B. Williams Abstract We provide quantitative anatomical data on the muscle,tendon architecture and geometry of the pelvic limb of an elite sprint athlete, the racing greyhound. Specifically, muscle masses, muscle lengths, fascicle lengths, pennation angles and muscle moment arms were measured. Maximum isometric force and power of muscles, the maximum muscle torque at joints and tendon stress and strain were estimated. We compare data with that published for a generalized breed of canid, and other cursorial mammals such as the horse and hare. The pelvic limb of the racing greyhound had a relatively large volume of hip extensor muscle, which is likely to be required for power production. Per unit body mass, some pelvic limb muscles were relatively larger than those in less specialized canines, and many hip extensor muscles had longer fascicle lengths. It was estimated that substantial extensor moments could be created about the tarsus and hip of the greyhound allowing high power output and potential for rapid acceleration. The racing greyhound hence possesses substantial specializations for enhanced sprint performance. [source] Treatment of low turbidity water by sweep coagulation using bentoniteJOURNAL OF CHEMICAL TECHNOLOGY & BIOTECHNOLOGY, Issue 5 2005Yun-Hwei Shen Abstract A novel strategy of sweep coagulation to treat low turbidity water is presented herein. Study findings demonstrated that an Na+ -saturated bentonite with medium cation exchange capacity (CEC) resulted in significant turbidity removal at a bentonite dosage of 30 mg dm,3. Bentonite dispersion with fully delaminated platelets tended to undergo a more porous type of coagulation with intense face-to-face interactions of platelets and effectively entrapped TiO2 particles in band-type structures. This type of coagulation usually results in a large volume of settled flocs with a fluffy structure and excellent turbidity removal efficiency for sweep coagulation. The sign and magnitude of electrical charge on TiO2 particles has a minor effect on the efficiency of sweep coagulation. Copyright © 2005 Society of Chemical Industry [source] Multiple myeloma patients receiving large volume leukapheresis efficiently yield enough CD34+ cells to allow double transplantsJOURNAL OF CLINICAL APHERESIS, Issue 1 2009A.C. Zubair Abstract Current protocols for myeloma patients require more than one autologous transplant. We performed a retrospective study to determine the cost-effectiveness of large volume leukapheresis (LVL) compared with standard volume leukapheresis (SVL) collection when two transplants are required. We evaluated 87 patients who underwent a cumulative total of 260 LVL and SVL collections. The median product volume per collection was 356 ml for LVL, and this was significantly higher than the median product volume per collection for SVL (median 149.5 ml, P < 0.001). The median total CD34+ cell yield/kg was 6.4 × 106 for LVL and 5.2 × 106 for SVL. This difference was statistically significant (P = 0.005). Because the target CD34+ cell dose for a single transplant was 3 × 106/kg at our institution, overall the LVL yields enough CD34+ cells that could allow for two transplants. Therefore, more patients in the LVL group were able to undergo a potential second transplant. Because of the reserved cells for a second transplant, LVL patients received significantly less CD34+ cell/kg per transplant than the patients in SVL group (P = <0.001). As a result, LVL group had statistically significant but clinically insignificant delay in neutrophil (P = <0.001) and platelet (P = 0.02) engraftments. Additionally, using LVL instead of SVL to collect ,6 × 106/kg CD34+ cells may potentially save $7,497 per patient. We therefore conclude that LVL is the method of choice for collection of multiple myeloma patients when two transplants are anticipated. J. Clin. Apheresis, 2009. © 2009 Wiley-Liss, Inc. [source] Continuous lumbar epidural infusion of levobupivacaine: effects of small-or large-volume regimen of infusionACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 4 2009G. DANELLI Background: The question of whether the dose, concentration or volume of a local anesthetic solution is the relevant determinant of the spread and quality of post-operative epidural analgesia is still open. In this prospective, randomized, double-blind study, we compared the effects of a large volume,low concentration with a small-volume,high-concentration lumbar epidural infusion of levobupivacaine. Methods: Seventy patients scheduled for total hip replacement were enrolled. After surgery, patients were randomly allocated to receive a continuous epidural infusion of levobupivacaine (10.5 mg/h) using either 0.125% levobupivacaine infused at 8.4 ml/h (low concentration group, n=35) or 0.75% levobupivacaine infused at 1.4 ml/h (high concentration group, n=35). We blindly recorded the degree of pain relief at rest and during movement every 8 h for the first two post-operative days, as well as hip flexion, motor block, rescue analgesic consumption and adverse events. Results: No difference in pain relief was observed between groups as estimated with the areas under the curve of the verbal Numerical Rating Scale for pain over time, both at rest and during movement. Similarly, there was no difference between groups in hip flexion degree, motor blockade and hemodynamic stability. Conclusions: Continuous lumbar epidural infusion of 0.75% levobupivacaine was as effective as continuous lumbar epidural infusion of 0.125% levobupivacaine, when administered at the same hourly dose of 10.5 mg, in achieving adequate analgesia both at rest and during movement, without differences in the incidence of hypotension and motor blockade. [source] A systematic review of the effect of diet in prostate cancer prevention and treatmentJOURNAL OF HUMAN NUTRITION & DIETETICS, Issue 3 2009R. W.-L. Abstract Dietary therapy has been proposed as a cost effective and noninvasive means of reducing the risk of prostate cancer (PC) and its progression. There is a large volume of published studies describing the role of diet in the prevention and treatment of PC. This article systematically reviews the data for dietary-based therapy in the prevention of PC, as well as in the management of patients with PC, aiming to provide clarity surrounding the role of diet in preventing and treating PC. Although conclusive evidence is limited, the current data are indicative that a diet low in fat, high in vegetables and fruits, and avoiding high energy intake, excessive meat, excessive dairy products and calcium intake, is possibly effective in preventing PC. However, caution must be taken to ensure that members of the public do not take excessive amounts of dietary supplements because there may be adverse affects associated with their over consumption. The dietary recommendations for patients diagnosed with PC are similar to those aiming to reduce their risk of PC. [source] The novel N -substituted benztropine analog GA2-50 possesses pharmacokinetic and pharmacodynamic profiles favorable for a candidate substitute medication for cocaine abuseJOURNAL OF PHARMACEUTICAL SCIENCES, Issue 12 2008Ahmed A. Othman Abstract GA2-50 is a novel N -substituted benztropine analog with improved potency and selectivity for the dopamine transporter. The pharmacokinetic and pharmacodynamic properties of GA2-50 were characterized as a part of its preclinical evaluation as a substitute medication for cocaine abuse. In vitro transport and metabolism studies as well as pharmacokinetic studies in rats were conducted. Effect of GA2-50 on the extracelluar nucleus accumbens (NAc) dopamine levels and on cocaine's induced dopamine elevation was evaluated using intracerebral microdialysis. GA2-50 showed high transcellular permeability despite being a P-glycoprotein substrate. GA2-50 was a substrate of human CYP2D6, CYP2C19, CYP2E1, rat CYP2C11, CYP2D1, CYP3A1, and CYP1A2; with low intrinsic clearance values. In vivo, GA2-50 showed high brain uptake (Ri,,,10), large volume of distribution (Vss,=,37 L/kg), and long elimination half-life (t½,=,19 h). GA2-50 resulted in 1.6- and 2.7-fold dopamine elevation at the 5 and 10 mg/kg i.v. doses. Dopamine elevation induced by GA2-50 was significantly reduced, slower and longer lasting than previously observed for cocaine. GA2-50 had no significant effect on cocaine's induced dopamine elevation upon simultaneous administration. Results from the present study indicate that GA2-50 possesses several attributes sought after for a substitute medication for cocaine abuse. © 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci [source] The importance of gel properties for mucoadhesion measurements: a multivariate data analysis approachJOURNAL OF PHARMACY AND PHARMACOLOGY: AN INTERNATI ONAL JOURNAL OF PHARMACEUTICAL SCIENCE, Issue 2 2004Helene Hägerström ABSTRACT In this study we used tensile strength measurements and a recently developed interpretation procedure to evaluate the mucoadhesive properties of a large set of gel preparations with diverse rheological properties. Multivariate data analysis in the form of principal component analysis (PCA) and partial least square projection to latent structures (PLS) was applied to extract useful information from the rather large quantities of data obtained. PCA showed that the selected series of gels was heterogeneous. Some groupings could be detected but none of the gels was identified as an outlier. By using PLS we investigated the relations between the rheological properties of a gel and the parameters defining the cohesiveness, as measured with the texture analyser used for the mucoadhesion measurements. The rheological properties proved to be important for the results of both the mucoadhesion and the cohesiveness measurements. Furthermore, by using PLS two different measurement configurations were evaluated and it was concluded that the combination of a relatively small volume of gel and two pieces of mucosa seems to be more appropriate than a large volume of gel in combination with one piece of mucosa. [source] Continuous mode of operation for large volume dosing in analytical carrier ampholyte-free isoelectric focusing of proteins applied to off-line detection of fractionsJOURNAL OF SEPARATION SCIENCE, JSS, Issue 11 2006Jana Budilová Abstract Mass spectrometry is being increasingly used for analysis of proteome complex samples. Sample preparation is often necessary to remove matrix interferences and to concentrate analytes prior to MS measurement. A useful method for this purpose is Carrier Ampholyte Free-Isoelectric Focusing (CAF-IEF). In this paper CAF-IEF of ampholytes was performed on a commercial apparatus EA101 (Villa Labeco, Slovakia) equipped with a specially made column for samples of large volume (up to 0.5 mL). A new continuous mode without voltage interruption or electrolyte replacement was developed. In this mode, a low molecular mass pI marker (PIM 7.4) and low concentrations of myoglobin and insulin (16 mg/L), respectively, were concentrated, and then 5-,L fractions collected for off-line analyses. The total time of focusing was 66 minutes. The concentration of PIM 7.4 in the fractions was increased up to 75 times (determined by UV-VIS spectrometry). The concentration in the fractions was increased up to 30 times for myoglobin and 10 times for insulin. [source] The Cultural Paradigm of the Smaller FirmJOURNAL OF SMALL BUSINESS MANAGEMENT, Issue 4 2004Helen Haugh This paper presents the findings from an ethnographic study of organizational culture and shared values in four smaller firms, the outcome of which was the identification of the cultural values shared between owner,managers (OMs) and employees in each firm. The research employed Schein's conceptualization of culture as a three-layer phenomenon, consisting of surface artifacts, shared values and beliefs, and basic assumptions. The analytical technique of grounded theory was employed to process the large volume of data gathered during the extended research period. The data reveal a complex array of values in each firm, with only one firm exhibiting a homogenous culture where values are shared by all those working in the organization. In the remaining three firms, five values appear to be shared by all employees; however, this is overlaid by a pattern of subcultures differentiated by distinctive shared values. Interfirm analysis among the four firms found that the values of survival, independence, control, pragmatism, and financial prudence were shared by two or more firms. The research collectively defines these shared values as the cultural paradigm of the smaller firm. [source] Factors Associated with Outcome in Foals with Neonatal Isoerythrolysis (72 Cases, 1988,2003)JOURNAL OF VETERINARY INTERNAL MEDICINE, Issue 5 2008A.C. Polkes Background: Neonatal foals with isoerythrolysis (NI) often die, but the risk factors for death have not been identified. Objectives: To identify factors associated with outcome in foals with NI and to identify factors associated with death from liver failure or kernicterus in the same population. Animals: Seventy-two foals with NI examined at referral institutions. Methods: Retrospective case series. Information on signalment, clinical examination findings, laboratory testing, treatment, complications, outcome, and necropsy results were obtained. Results: The overall survival rate was 75% (54 of 72). Liver failure (n = 7), kernicterus (n = 6), and complications related to bacterial sepsis (n = 3) were the 3 most common reasons for death or euthanasia. The number of transfusions with blood products was the factor most strongly associated with nonsurvival in a multivariate logistic regression model. The odds of liver failure developing in foals receiving a total volume of blood products , 4.0 L were 19.5 (95% confidence intervals [CI]: 2.13,178) times higher than that of foals receiving a lower volume (P= .009). The odds of kernicterus developing in foals with a total bilirubin , 27.0 mg/dL were 17.0 (95% CI: 1.77,165) times higher than that of foals with a lower total bilirubin (P= .014). Conclusions and Clinical Importance: Development of liver failure, kernicterus, and complications related to bacterial sepsis are the most common causes of death in foals with NI. Foals administered a large volume of blood products are at greater risk for developing liver failure. [source] Pharmacokinetics of gamithromycin in cattle with comparison of plasma and lung tissue concentrations and plasma antibacterial activityJOURNAL OF VETERINARY PHARMACOLOGY & THERAPEUTICS, Issue 3 2010R. A. HUANG Huang, R. A., Letendre, L. T., Banav, N., Fischer, J., Somerville, B. Pharmacokinetics of gamithromycin in cattle with comparison of plasma and lung tissue concentrations and plasma antibacterial activity. J. vet. Pharmacol. Therap.33, 227,237. The pharmacokinetics (PK) and dose proportionality of gamithromycin (ZACTRAN®), a novel azalide, after a single intravenous (i.v.) dose of 3 mg/kg or subcutaneous (s.c.) injection at 3, 6 and 9 mg/kg body weight were studied in 13 male castrate and 13 female Angus cattle. Following i.v. administration, the mean area under the curve extrapolated to infinity (AUCinf) was 4.28 ± 0.536 ,g·h/mL, and mean elimination half-life (t1/2) was 44.9 ± 4.67 h, with a large volume of distribution (Vss) of 24.9 ± 2.99 L/kg and a high clearance rate (Clobs) of 712 ± 95.7 mL/h/kg. For cattle treated with s.c. injection of 3, 6 or 9 mg/kg, mean AUCinf values were 4.55 ± 0.690, 9.42 ± 1.11 and 12.2 ± 1.13 ,g·h/mL, respectively, and the mean elimination half-lives (t1/2) were 51.2 ± 6.10, 50.8 ± 3.80 and 58.5 ± 5.50 h. Gamithromycin was well absorbed and fully bioavailable (97.6,112%) after s.c. administration. No statistically significant (, = 0.05) gender differences in the AUCInf or elimination half-life values were observed. Dose proportionality was established based on AUCInf over the range of 0.5 to 1.5 times of the recommended dosage of 6 mg/kg of body weight. Further investigations were conducted to assess plasma PK, lung/plasma concentration ratios and plasma antibacterial activity using 36 cattle. The average maximum gamithromycin concentration measured in whole lung homogenate was 18 500 ng/g at first sampling time of 1 day (,24 h) after treatment. The ratios of lung to plasma concentration were 265, 410, 329 and 247 at 1, 5, 10 and 15 days postdose. The lung AUCinf was 194 times higher than the corresponding plasma AUCinf. The apparent elimination half-life for gamithromycin in lung was 90.4 h (,4 days). Antibacterial activity was observed with plasma collected at 6 h postdose with a corresponding average gamithromycin plasma concentration of 261 ng/mL. In vitro plasma protein binding in bovine plasma was determined to be 26.0 ± 0.60% bound over a range of 0.1,3.0 ,g/mL of gamithromycin. The dose proportionality of AUC, high bioavailability, rapid and extensive distribution to lung tissue and low level of plasma protein binding are beneficial PK parameters for an antimicrobial drug used for the treatment and prevention of bovine respiratory disease. [source] Pharmacokinetics of ibafloxacin following intravenous and oral administration to healthy Beagle dogsJOURNAL OF VETERINARY PHARMACOLOGY & THERAPEUTICS, Issue 2 2002M. COULET The pharmacokinetics of ibafloxacin, a new veterinary fluoroquinolone antimicrobial agent, was studied following intravenous (i.v.) and oral administration to healthy dogs. The mean absolute bioavailability of ibafloxacin after oral doses of 7.5, 15 and 30 mg/kg ranged from 69 to 81%, indicating that ibafloxacin was well absorbed by dogs. Ibafloxacin was also absorbed rapidly [time of maximum concentration (tmax) 1.5 h], reaching a mean maximum concentration (Cmax) of 6 ,g/mL at 15 mg/kg, well distributed in the body [large volume of distribution at steady state (Vss) and Varea of 1.1 L/kg and 4 L/kg, respectively], and exhibited an elimination half-life of 5.2 h and a low total body clearance (8.7 mL/min/kg). Both Cmax and area under the concentration,time curve (AUC) showed dose proportionality over the dose range tested (7.5,30 mg/kg). The pharmacokinetics of ibafloxacin was similar following single and repeated dosage regimens, implying no significant accumulation in plasma. Food promoted the absorption of ibafloxacin by increasing Cmax and AUC, but did not change tmax. High amounts of the metabolites, mainly 8-hydroxy- and, 7-hydroxy-ibafloxacin were excreted in urine and faeces, either unchanged or as glucuronide conjugates. Following oral administration of 15 mg ibafloxacin/kg, the total recovery of ibafloxacin, its metabolites and conjugates in urine and faeces was 61.9,99.9% of the dose within 48 h. [source] Spectral phase-corrected GRAPPA reconstruction of three-dimensional echo-planar spectroscopic imaging (3D-EPSI)MAGNETIC RESONANCE IN MEDICINE, Issue 5 2007Xiaoping Zhu Abstract MR spectroscopic (MRS) images from a large volume of brain can be obtained using a 3D echo-planar spectroscopic imaging (3D-EPSI) sequence. However, routine applications of 3D-EPSI are still limited by a long scan time. In this communication, a new approach termed "spectral phase-corrected generalized autocalibrating partially parallel acquisitions" (SPC-GRAPPA) is introduced for the reconstruction of 3D-EPSI data to accelerate data acquisition while preserving the accuracy of quantitation of brain metabolites. In SPC-GRAPPA, voxel-by-voxel spectral phase alignment between metabolite 3D-EPSI from individual coil elements is performed in the frequency domain, utilizing the whole spectrum from interleaved water reference 3D-EPSI for robust estimation of the zero-order phase correction. The performance of SPC-GRAPPA was compared with that of fully encoded 3D-EPSI and conventional GRAPPA. Analysis of whole-brain 3D-EPSI data reconstructed by SPC-GRAPPA demonstrates that SPC-GRAPPA with an acceleration factor of 1.5 yields results very similar to those obtained by fully encoded 3D-EPSI, and is more accurate than conventional GRAPPA. Magn Reson Med 57:815,820, 2007. © 2007 Wiley-Liss, Inc. [source] Dynamic imaging with multiple resolutions along phase-encode and slice-select dimensionsMAGNETIC RESONANCE IN MEDICINE, Issue 6 2001Lawrence P. Panych Abstract An implementation is reported of an imaging method to obtain MUltiple Resolutions along Phase-encode and Slice-select dimensions (MURPS), which enables dynamic imaging of focal changes using a graded, multiresolution approach. MURPS allows one to trade spatial resolution in part of the volume for improved temporal resolution in dynamic imaging applications. A unique method of Hadamard slice encoding is used, enabling the varying of the phase encode and slice resolution while maintaining a constant effective TR throughout the entire 3-D volume. MURPS was implemented using a gradient-recalled echo sequence, and its utility was demonstrated for MR temperature monitoring. In this preliminary work, it has been shown that changes throughout a large volume can be effectively monitored in times that would normally only permit dynamic imaging in one or a very few slices. Magn Reson Med 45:940,947, 2001. © 2001 Wiley-Liss, Inc. [source] Gaeumannomyces graminis, the take-all fungus and its relativesMOLECULAR PLANT PATHOLOGY, Issue 4 2004JACQUELINE FREEMAN SUMMARY Take-all, caused by the fungus Gaeumannomyces graminis var. tritici, is the most important root disease of wheat worldwide. Many years of intensive research, reflected by the large volume of literature on take-all, has led to a considerable degree of understanding of many aspects of the disease. However, effective and economic control of the disease remains difficult. The application of molecular techniques to study G. graminis and related fungi has resulted in some significant advances, particularly in the development of improved methods for identification and in elucidating the role of the enzyme avenacinase as a pathogenicity determinant in the closely related oat take-all fungus (G. graminis var. avenae). Some progress in identifying other factors that may be involved in determining host range and pathogenicity has been made, despite the difficulties of performing genetic analyses and the lack of a reliable transformation system. [source] Structures of the magnetoionic media around the Fanaroff,Riley Class I radio galaxies 3C 31 and Hydra AMONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 2 2008R. A. Laing ABSTRACT We use high-quality Very Large Array (VLA) images of the Fanaroff,Riley Class I radio galaxy 3C 31 at six frequencies in the range 1365,8440 MHz to explore the spatial scale and origin of the rotation measure (RM) fluctuations on the line of sight to the radio source. We analyse the distribution of the degree of polarization to show that the large depolarization asymmetry between the north and south sides of the source seen in earlier work largely disappears as the resolution is increased. We show that the depolarization seen at low resolution results primarily from unresolved gradients in a Faraday screen in front of the synchrotron-emitting plasma. We establish that the residual degree of polarization in the short-wavelength limit should follow a Burn law and we fit such a law to our data to estimate the residual depolarization at high resolution. We discuss how to interpret the structure function of RM fluctuations in the presence of a finite observing beam and how to address the effects of incomplete sampling of RM distribution using a Monte Carlo approach. We infer that the observed RM variations over selected areas of 3C 31, and the small residual depolarization found at high resolution, are consistent with a power spectrum of magnetic fluctuations in front of 3C 31 whose power-law slope changes significantly on the scales sampled by our data. The power spectrum P(f) can only have the form expected for Kolmogorov turbulence [P(f) ,f,11/3] on scales ,5 kpc. On larger scales, we find . We briefly discuss the physical interpretation of these results. We also compare the global variations of RM across 3C 31 with the results of three-dimensional simulations of the magnetic-field fluctuations in the surrounding magnetoionic medium. We infer that the RM variation across 3C 31 is qualitatively as expected from relativistic-jet models of the brightness asymmetry wherein the apparently brighter jet is on the near side of the nucleus and is seen through less magnetoionic material than the fainter jet. We show that our data are inconsistent with observing 3C 31 through a spherically symmetric magnetoionic medium, but that they are consistent with a field distribution that favours the plane perpendicular to the jet axis , probably because the radio source has evacuated a large cavity in the surrounding medium. We also apply our analysis techniques to the case of Hydra A, where the shape and the size of the cavities produced by the source in the surrounding medium are known from X-ray data. We emphasize that it is essential to account for the potential exclusion of magnetoionic material from a large volume containing the radio source when using the RM variations to derive statistical properties of the fluctuations in the foreground magnetic field. [source] Original Article: Celiac disease prevalence in children and adolescents with type 1 diabetes from SerbiaPEDIATRICS INTERNATIONAL, Issue 4 2010Zlatko Djuri Abstract Background:, The association between celiac disease (CD) and type 1 diabetes mellitus (T1DM) is well known. Up to now, CD prevalence in children and adolescents with T1DM in Serbia has not been reported. The aim of the present study was to determine CD prevalence and its clinical manifestations in patients with T1DM. Methods:, One hundred and twenty-one patients (70 girls, 51 boys; mean age, 10.8 years) with T1DM (mean duration of diabetes, 3.4 years) and 125 control group participants (75 girls, 50 boys; mean age, 10.4 years) were tested for CD on tissue transglutaminase antibodies (tTG). In seven serologically positive T1DM patients endoscopic small bowel biopsies were taken and examined on histopathology. In all patients with CD and T1DM age, duration of T1DM, height for age, body mass index, glycosylated hemoglobin and clinical symptoms were noted. Results:, Nine patients with T1DM were positive on IgA tTG antibodies. In seven of them small bowel biopsy was performed, and all were proven to have CD on histopathology. The prevalence of biopsy-proven CD in children and adolescents with T1DM was significantly higher in the study group compared to controls (5.79%. vs 0.8%, P < 0.05). Conclusion:, The significantly higher prevalence of CD in children with type 1 diabetes, in accordance with the large volume of data published in the literature, underlines the need for yearly screening of CD in patients with diabetes in order to promptly start a gluten-free diet when appropriate. [source] The prescribed duration algorithm: utilising ,free text' from multiple primary care electronic systemsPHARMACOEPIDEMIOLOGY AND DRUG SAFETY, Issue 9 2010Caroline J. Brooks Abstract Purpose To develop and test an algorithm that translates total dose and daily regimen, inputted as ,free text' on a prescription, into numerical values to calculate the prescribed treatment duration. Method The algorithm was developed using antibiotic prescriptions (n,=,711,714) from multiple primary care computer systems. For validation, the prescribed treatment duration of an independent sample of antibiotic scripts was calculated in two ways: (a) computer algorithm, (b) manually reviewed by a researcher blinded to the results of (a). The outputs of the two methods were compared and the level of agreement assessed, using confidence intervals for differences in proportions. This was repeated on sample of antidepressant scripts to test generalisabilty of the algorithm. Results For the antibiotic prescriptions, the algorithm processed 98.5% with an accuracy of 99.8% and the manual review processed 98.5% with 98.9% accuracy. The differences between these proportions are 0.0% (95%CI of ,0.9, 0.9%) and 1.0% (95%CI of ,0.1, 2.3%), respectively. For the antidepressant prescriptions, the algorithm processed 91.5% with an accuracy of 96.6% compared to the manual review with 96.4% processed and 99.8% accuracy; difference between these proportions is 4.9% (95%CI of 2.0, 8.0%) and 3.2% (95%CI of 1.6, 5.3%), respectively. Conclusion The algorithm proved to be applicable and efficient for assessing prescribed duration, with sensitivity and specificity values close to the manual review, but with the added advantage that the computer can process large volume of scripts rapidly and automatically. Copyright © 2010 John Wiley & Sons, Ltd. [source] | ||||||||||||||||||||||||||||||||||||||||||||||||||||