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Kinds of Kids Selected AbstractsA rare connexin 26 mutation in a patient with a forme fruste of keratitis,ichthyosis,deafness (KID) syndromeINTERNATIONAL JOURNAL OF DERMATOLOGY, Issue 10 2009Ching Yin Neoh MBBS, MMed(Int Med) Background, Keratitis,ichthyosis,deafness (KID) syndrome is a rare ectodermal dysplasia characterized by generalized erythrokeratotic plaques, sensorineural hearing loss, and vascularizing keratitis. Cutaneous changes and hearing loss typically present in early childhood, whereas ocular symptoms present later. Mutations in the connexin (Cx) 26 gene, GJB2, are now established to underlie many of the affected cases, with the majority of patients harboring the p.D50N mutation. Methods, A rare patient demonstrating features of incomplete KID syndrome associated with an uncommon Cx26 gene mutation is described. Results, The patient presented late in adolescence with partial features of KID syndrome. There was limited cutaneous involvement and the rare association of cystic acne. Both hearing impairment and ophthalmic involvement were mild in severity. Genetic mutation analysis revealed a previously described, rare mutation in GJB2, resulting in a glycine to arginine change at codon 12 (p.G12R). Conclusions, This report describes a patient exhibiting characteristics suggestive of a late-onset, incomplete form of KID syndrome with the GJB2 mutation (p.G12R). The p.G12R mutation has only been described in one other patient with KID syndrome, whose clinical presentation was not characterized. [source] Keratitis-ichthyosis-deafness (KID) syndrome with squamous cell carcinomaINTERNATIONAL JOURNAL OF DERMATOLOGY, Issue 4 2007Luciana A. Conrado MD First page of article [source] A case of keratitis ichthyosis deafness (KID) syndrome associated with Dandy,WalkerJOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY & VENEREOLOGY, Issue 5 2007XB Zhang [source] A novel protein from Brassica napus has a putative KID domain and responds to low temperatureTHE PLANT JOURNAL, Issue 6 2003Ming-Jun Gao Summary To identify factors that interact with histone deacetylase (HDAC) in Brassica napus, a yeast two-hybrid library was screened using the Arabidopsis HDA19 as bait. A novel protein, bnKCP1, containing a putative kinase-inducible domain (KID) was found to interact with HDA19. Southern blot analysis indicated that the bnKCP1 gene belongs to a small gene family of at least three members. Northern blot analysis showed bnKCP1 to be strongly expressed in stems, flowers, roots, and immature siliques, but not in leaf blades of seedlings. The accumulation of bnKCP1 transcript in the leaf blades was induced significantly within 4 h of exposure of B. napus seedlings to cold stress, whereas treatment of leaf blades with inomycin, an ionophore of Ca2+, caused a rapid (30 min) but transient induction of bnKCP1 expression. In contrast to that observed in leaf blades, expression of bnKCP1 in the stems was repressed upon cold treatment. In vitro and in vivo protein-binding assays showed that bnKCP1 interacts with HDA19 via the KID domain, and that S188 is critical for bnKCP1,HDA19 interaction. BnKCP1 also exerted modest transactivation of the lacZ reporter gene in yeast through its N-terminal region. These assays suggest that bnKCP1 may function as a transcription factor, which regulates gene expression through interaction with HDA19. [source] The Impact of Injury Coding Schemes on Predicting Hospital Mortality After Pediatric InjuryACADEMIC EMERGENCY MEDICINE, Issue 7 2009Randall S. Burd MD Abstract Objectives:, Accurate adjustment for injury severity is needed to evaluate the effectiveness of trauma management. While the choice of injury coding scheme used for modeling affects performance, the impact of combining coding schemes on performance has not been evaluated. The purpose of this study was to use Bayesian logistic regression to develop models predicting hospital mortality in injured children and to compare the performance of models developed using different injury coding schemes. Methods:, Records of children (age < 15 years) admitted after injury were obtained from the National Trauma Data Bank (NTDB) and the National Pediatric Trauma Registry (NPTR) and used to train Bayesian logistic regression models predicting mortality using three injury coding schemes (International Classification of Disease-9th revision [ICD-9] injury codes, the Abbreviated Injury Scale [AIS] severity scores, and the Barell matrix) and their combinations. Model performance was evaluated using independent data from the NTDB and the Kids' Inpatient Database 2003 (KID). Results:, Discrimination was optimal when modeling both ICD-9 and AIS severity codes (area under the receiver operating curve [AUC] = 0.921 [NTDB] and 0.967 [KID], Hosmer-Lemeshow [HL] h-statistic = 115 [NTDB] and 147 [KID]), while calibration was optimal when modeling coding based on the Barell matrix (AUC = 0.882 [NTDB] and 0.936 [KID], HL h-statistic = 19 [NTDB] and 69 [KID]). When compared to models based on ICD-9 codes alone, models that also included AIS severity scores and coding from the Barell matrix showed improved discrimination and calibration. Conclusions:, Mortality models that incorporate additional injury coding schemes perform better than those based on ICD-9 codes alone in the setting of pediatric trauma. Combining injury coding schemes may be an effective approach for improving the predictive performance of empirically derived estimates of injury mortality. [source] Molecular cloning and characterization of Bombyx mori CREB gene,ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY (ELECTRONIC), Issue 1 2009Hongsheng Song Abstract The cAMP response element binding protein (CREB), as one of the best characterized stimulus-induced transcription factors, plays critical roles in activating transcription of target genes in response to a variety of environmental stimuli. To characterize this important molecule in the silkworm, Bombyx mori, we cloned a full-length cDNA of CREB gene from B. mori brains by using RACE-PCR. The sequence of B. mori CREB (named BmCREB1) gene contains a 88,bp 5, UTR, a 783,bp open reading frame (ORF) encoding 261 amino acids and a 348,bp 3, UTR. The deduced BmCREB amino acid sequence has 56.7% and 37.2% homology with CREB from Apis mellifera carnica and Drosophila melanogaster, respectively. The primary structure of the deduced BmCREB1 protein contains a kinase-inducible domain (KID) and a basic region/leucine zipper (bZIP) dimerization domain which exisits in all CREB family members. Genomic analysis showed there are 9 exons and 5 introns in B. mori CREB genome sequences. We identified three different isoforms of BmCREB (BmCREB1, BmCREB2 and BmCREB3) through alternative splicing in C terminal. In addition, the expression of BmCREB in different developmental stages was investigated by using quantitative real-time PCR in both diapause and non-diapause type of B. mori bivoltine race (Dazao). BmCREB transcripts showed two peaks in embryonic stage and pupal stage in both types of bivoltine race. However, consistently higher expression of BmCREB was found throughout the developmental stages in the diapause type than in the non-diapause type. These results suggest that BmCREB is involved in the processs of diapause induced by environmental factors. © 2009 Wiley Periodicals, Inc. [source] Kinetic Study of Phosphorylation-Dependent Complex Formation between the Kinase-Inducible Domain (KID) of CREB and the KIX Domain of CBP on a Quartz Crystal MicrobalanceCHEMISTRY - A EUROPEAN JOURNAL, Issue 23 2004Hisao Matsuno Prof. Abstract We report quantitative analysis of peptide,peptide interactions on a 27 MHz quartz crystal microbalance (QCM) in aqueous solution. The KID (kinase-inducible domain) of transcription factor CREB (cyclic AMP response element binding protein) is known to interact with the KIX domain of coactivator CBP (CREB binding protein), facilitated by phosphorylation at Ser-133 of the KID. The KIX domain peptide (86,aa) was immobilized on the QCM gold electrode surface by means of a poly(ethylene glycol) spacer. Binding of the KID peptide (46,aa) to the KIX peptide was detected by frequency decreases (mass increases) of the QCM. Both maximum binding amount (,mmax) and association constants (Ka) obtained from the QCM measurements increased as a result of phosphorylation of Ser-133 of the KID peptide. The Ka values for KIX peptide to the phosphorylated (pKID) and unphosphorylated KID peptides were (93±2)×103 and (5±1)×103,M,1, respectively. This difference was explained by the dissociation rate constant (k,1) of the pKID being 20 times smaller than that of the KID, while association rate constants (k1) were independent of phosphorylation. [source] Germline mosaicism in keratitis,ichthyosis,deafness syndrome: pre-natal diagnosis in a familial lethal formCLINICAL GENETICS, Issue 6 2010E Sbidian Sbidian E, Feldmann D, Bengoa J, Fraitag S, Abadie V, de Prost Y, Bodemer C, Hadj-Rabia S. Germline mosaicism in keratitis,ichthyosis,deafness syndrome: pre-natal diagnosis in a familial lethal form. Keratitis,ichthyosis,deafness (KID) syndrome is an autosomal dominant congenital ectodermal defect characterized by the association of skin lesions, hearing loss and keratitis. Most of the cases appear to be sporadic. KID syndrome is mostly related to mutations of GJB2 gene encoding connexin-26. Recently, a lethal form of the disease during the first year of life has been reported in two unrelated Caucasian patients. This rare lethal form is caused by the G45E mutation of GJB2 gene. We here report the first pre-natal molecular genetic diagnosis of the lethal form of KID syndrome relating to a G45E mutation. In the same family, the occurrence of this condition in three other siblings born to African non-consanguineous healthy parents lead to perform pre-natal diagnosis for this last pregnancy. Molecular analysis confirms the diagnosis of the lethal form of KID for the fetus. These results establish the role of germline mosaicism in KID syndrome and warrant careful genetic counseling. Furthermore, analysis of our cases and the literature allowed us to define a characteristic severe neonatal phenotype including facial dysmorphy, severe cornification with massive focal hyperkeratosis of the skin with erythroderma, dystrophic nails, complete atrichia and absence of foreskin. [source] A mutagenic analysis of the RNase mechanism of the bacterial Kid toxin by mass spectrometryFEBS JOURNAL, Issue 17 2009Elizabeth Diago-Navarro Kid, the toxin of the parD (kis, kid) maintenance system of plasmid R1, is an endoribonuclease that preferentially cleaves RNA at the 5, of A in the core sequence 5,-UA(A/C)-3,. A model of the Kid toxin interacting with the uncleavable mimetic 5,-AdUACA-3, is available. To evaluate this model, a significant collection of mutants in some of the key residues proposed to be involved in RNA binding (T46, A55, T69 and R85) or RNA cleavage (R73, D75 and H17) were analysed by mass spectrometry in RNA binding and cleavage assays. A pair of substrates, 5,-AUACA-3,, and its uncleavable mimetic 5,-AdUACA-3,, used to establish the model and structure of the Kid,RNA complex, were used in both the RNA cleavage and binding assays. A second RNA substrate, 5,-UUACU-3, efficiently cleaved by Kid both in vivo and in vitro, was also used in the cleavage assays. Compared with the wild-type protein, mutations in the residues of the catalytic site abolished RNA cleavage without substantially altering RNA binding. Mutations in residues proposed to be involved in RNA binding show reduced binding efficiency and a corresponding decrease in RNA cleavage efficiency. The cleavage profiles of the different mutants were similar with the two substrates used, but RNA cleavage required much lower protein concentrations when the 5,-UUACU-3, substrate was used. Protein synthesis and growth assays are consistent with there being a correlation between the RNase activity of Kid and its inhibitory potential. These results give important support to the available models of Kid RNase and the Kid,RNA complex. [source] Pediatric primary care to help prevent child maltreatment: the Safe Environment for Every Kid (SEEK) modelCHILD: CARE, HEALTH AND DEVELOPMENT, Issue 4 2009Richard Reading Pediatric primary care to help prevent child maltreatment: the Safe Environment for Every Kid (SEEK) model . DubowitzH., FeigelmanS., LaneW. & KimJ. ( 2009 ) Pediatrics , 123 , 858 , 864 . DOI: 10.1542/peds.2008-1376 . Context Effective strategies for preventing child maltreatment are needed. Few primary care-based programmes have been developed, and most have not been well evaluated. Objective Our goal was to evaluate the efficacy of the Safe Environment for Every Kid (SEEK) model of pediatric primary care in reducing the occurrence of child maltreatment. Methods A randomized trial was conducted from June 2002 to November 2005 in a university-based resident continuity clinic in Baltimore, Maryland. The study population consisted of English-speaking parents of children (0,5 years) brought in for child health supervision. Of the 1118 participants approached, 729 agreed to participate, and 558 of them completed the study protocol. Resident continuity clinics were cluster randomized by day of the week to the model (intervention) or standard care (control) groups. Model care consisted of (1) residents who received special training; (2) the Parent Screening Questionnaire; and (3) a social worker. Risk factors for child maltreatment were identified and addressed by the resident physician and/or social worker. Standard care involved routine pediatric primary care. A subset of the clinic population was sampled for the evaluation. Child maltreatment was measured in three ways: (1) child protective services reports using state agency data; (2) medical chart documentation of possible abuse or neglect; and (3) parental report of harsh punishment via the Parent-Child Conflict Tactics scale. Results Model care resulted in significantly lower rates of child maltreatment in all the outcome measures: fewer child protective services reports, fewer instances of possible medical neglect documented as treatment non-adherence, fewer children with delayed immunizations and less harsh punishment reported by parents. One-tailed testing was conducted in accordance with the study hypothesis. Conclusions The SEEK model of pediatric primary care seems promising as a practical strategy for helping prevent child maltreatment. Replication and additional evaluation of the model are recommended. [source] Envisioning Fatherhood: A Social Psychological Perspective on Young Men without Kids,FAMILY RELATIONS, Issue 2 2000William Marsiglio Using in-depth interviews and a purposive sample of 32 men ages 16,30 who have not yet fathered a child, our grounded theory study examined how men envision aspects of fatherhood. Informed by symbolic interactionist and life course perspectives, our interpretive data analyses yielded two interrelated substantive dimensions: fatherhood readiness and fathering visions. We introduce five interrelated theoretical themes to sharpen our understanding of these dimensions, and discuss how these dimensions and themes inform interventions aimed at heightening young men's procreative responsibility. [source] Development and preliminary testing of a Paediatric Version of the Haemophilia Activities List (pedhal)HAEMOPHILIA, Issue 2 2010W. G. GROEN Summary., Worldwide, children with haemophilia suffer from limitations in performing activities of daily living. To measure such limitations in adults a disease-specific instrument, the Haemophilia Activities List (HAL), was created in 2004. The aim of this study was to adapt the HAL for children with haemophilia and to assess its psychometric properties. The structure and the main content were derived from the HAL. Additionally, items of the Childhood Health Assessment Questionnaire and the Activity Scale for Kids were considered for inclusion. This version was evaluated by health professionals (n = 6), patients (n = 4), and parents (n = 3). A pilot test in a sample of 32 Dutch children was performed to assess score distribution, construct validity (Spearman's rho) and reproducibility. Administration of the pedhal was feasible for children from the age of 4 years onwards. The pedhal scores of the Dutch children were in the high end of the scale, reflecting a good functional status. Most subscales showed moderate associations with the joint examination (rho = 0.42,0.63) and moderate-to-good associations with the physical function subscale of the CHQ-50 (rho = 0.48,0.74). No significant associations were found for the pedhal and the subscales mental health and behaviour, except for the subscales leisure and sport and mental health (rho = 0.47). Test,retest agreement was good. The pedhal is a promising tool, but further testing in populations with a higher level of disability is warranted to study the full range of its psychometric properties. [source] Goals and Social Relationships: Windows Into the Motivation and Well-Being of "Street Kids",JOURNAL OF APPLIED SOCIAL PSYCHOLOGY, Issue 5 2009Esther Usborne Research investigating homeless youth or, as they prefer, "street kids," has primarily described their dysfunction. In order to more thoroughly document their psychological reality and account for variability in their functioning, this study explored the close relationships and personal projects of 50 street kids. Self-determination theory provides a theoretical framework for hypotheses concerning the relationships that social networks and goals have with motivation and subjective well-being. The size of participants' social networks was positively related to internalization and positive well-being. Goal pursuit was also positively related to internalization and positive well-being. These findings,along with descriptive information documenting street kids' motivation, well-being, and family contact,afford us a view beyond their dysfunction, and elucidate factors associated with their optimal functioning. [source] Design criteria for children's Web portals: The users speak outJOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY, Issue 2 2002Andrew Large Four focus groups were held with young Web users (10 to 13 years of age) to explore design criteria for Web portals. The focus group participants commented upon four existing portals designed with young users in mind: Ask Jeeves for Kids, KidsClick, Lycos Zone, and Yahooligans! This article reports their first impressions on using these portals, their likes and dislikes, and their suggestions for improvements. Design criteria for children's Web portals are elaborated based upon these comments under four headings: portal goals, visual design, information architecture, and personalization. An ideal portal should cater for both educational and entertainment needs, use attractive screen designs based especially on effective use of color, graphics, and animation, provide both keyword search facilities and browsable subject categories, and allow individual user personalization in areas such as color and graphics. [source] Prevalence of post-thrombotic syndrome following asymptomatic thrombosis in survivors of acute lymphoblastic leukemiaJOURNAL OF THROMBOSIS AND HAEMOSTASIS, Issue 4 2008S. KUHLE Summary.,Background:,Deep vein thrombosis (DVT) is a complication of treatment of acute lymphoblastic leukemia (ALL) in children but little is known about the long-term outcomes of these DVT. Objective:,To determine the incidence of post-thrombotic syndrome (PTS) in (i) children with ALL diagnosed with asymptomatic DVT using radiographic testing and (ii) an unselected group of ALL survivors. Methods:,Cross-sectional study in two populations. Group I comprised children in the Prophylactic Antithrombin Replacement in Kids with ALL treated with L-Asparaginase (PARKAA) study diagnosed with DVT by radiographic tests. Group II consisted of non-selected childhood ALL survivors <21 years. PTS was assessed using a standardized scoring sheet. Results:,Group I: 13 PARKAA patients (median age 12 years) were assessed, and 7 had PTS (54%; 95% CI, 25,81). All patients had collaterals, three also had increased arm circumference. Group II: 41 patients (median age 13 years) with a history of ALL were enrolled, and 10 had PTS (24%; 95% CI, 11,38). All patients had collaterals; five also had increased arm circumference. Conclusion:,There is a high incidence of PTS in survivors of childhood ALL with radiographically diagnosed asymptomatic DVT. A significant proportion of ALL survivors develop PTS, indicating previously undiagnosed DVT. [source] Kids + Money by Lauren Greenfield Untouchable?AMERICAN ANTHROPOLOGIST, Issue 2 2010Bonded Labor Are Still Alive, The Caste System, Well in India by Poul Kjar No abstract is available for this article. [source] Kids steal the show at sixtieth All-America City awardsNATIONAL CIVIC REVIEW, Issue 1 2010Curtis Johnson No abstract is available for this article. [source] School Kids and Oil Rigs: Two More Pieces of the Post-Katrina Puzzle in New OrleansAMERICAN JOURNAL OF ECONOMICS AND SOCIOLOGY, Issue 2 2010Kelly Frailing Shortly after Hurricane Katrina's landfall in August 2005 and the reports of rampant looting of businesses in the city, we became curious about the extent of Katrina looting as compared to that after other major storms that hit New Orleans in 1947 and in 1965. Using burglary as a proxy variable for looting, we discovered that the burglary rates in the month before and the month after Katrina were significantly higher than those before and after the other two hurricanes. We then investigated the socioeconomic conditions in the city in an effort to explain these numbers. Population loss and high unemployment rates, coupled with a decline in high-paying manufacturing jobs and an increase in low-wage food and hotel service jobs generated severe economic inequality in the city that exacerbated the situation created by Katrina. Our current analysis of the impact of public school desegregation and the oil bust suggests that both events contributed to population loss and the increase in low-wage jobs prior to the storm. We believe that this type of research can assist in the recovery of New Orleans by providing an understanding of the city's pre-Katrina social and economic conditions and make clearer which post-Katrina changes are desirable. [source] Kids: How biology and culture shape the way we raise our childrenAMERICAN JOURNAL OF HUMAN BIOLOGY, Issue 3 2002Lee M. PachterArticle first published online: 26 APR 200 No abstract is available for this article. [source] It's All for the Kids: Gender, Families, and Youth SportsTHE JOURNAL OF POPULAR CULTURE, Issue 6 2009Mary Jane Philpy No abstract is available for this article. [source] Effects of crossbreeding indigenous Hair Goat with Saanen on carcass measurements and meat quality of kids under an intensive production systemANIMAL SCIENCE JOURNAL, Issue 4 2009Alper YILMAZ ABSTRACT The aim of study was to investigate the effect of genotype on carcass measurements and meat quality characteristics of purebred Hair Goat, Saanen × Hair Goat (F1 and B1) kids under an intensive production system. In total, 24 kids were slaughtered at the age of approximately 133 days. Kids were fattened for 56 days immediately after weaning. Hot carcass weights were 6.78, 7.61 and 7.02 kg and dressing percentages were 49.71, 49.27 and 48.78%, respectively (P > 0.05). Differences between genotypes for carcass measurements and indexes were not significant. Effect of genotype on pH measurements, drip loss, water holding capacity, cooking loss and Warner Bratzler shear force values were not significant. Meat lightness values at 0 h, 1 h and 1 day after cutting were higher in crossbred kids than Hair Goat kids (P < 0.05). Redness value was significantly higher in meat samples of Hair goat kids at 0 h, 1 h and 1 day measurements (P < 0.05). Kid genotype had no significant effect on meat sensory characteristics, except tenderness. Panelists gave lower scores for meat tenderness to F1 and B1 crosses compared to purebred Hair Goat kids. In conclusion, higher meat lightness values of crossbred kids, at particularly B1 level, might have a positive effect on the consumer choices. [source] Effect of weaning on behavior and serum parameters in dairy goat kidsANIMAL SCIENCE JOURNAL, Issue 4 2008Cengiz ATASOGLU ABSTRACT This study aimed at investigating the effects of weaning kids abruptly at an average of 55 ± 13 days of age on intake, behavioral and serum parameters and, lasted for a total of six weeks; two weeks pre-weaning and four weeks post-weaning. Sixteen single kids with equal gender were used. Kids were only allowed to stay with their mothers for suckling (45 min/period) both in the morning and in the evening period during pre-weaning. Grower concentrate and hay were offered ad libitum. The duration of the study was divided into three periods for the sampling of behavioral and serum parameters; (i) pre-weaning period lasting for two weeks (P-BW) (ii) early post-weaning period lasting for one week (P-AW1) and (iii) late post-weaning period lasting for three weeks (P-AW2). Daily weight gain of kids gradually decreased as the observation period progressed (P = 0.001). However concentrate feed intake increased from 0.154 kg/day in P-BW to 0.479 kg/day in P-AW1 and 0.499 kg/day in P-AW2. Water intake, rumination and standing behaviors decreased in P-AW2 (P < 0.001), whereas activity towards concentrate feed (CF) (P < 0.001) and roughage (P = 0.012) increased as compared to P-BW and P-AW1. Abnormal oral activity was not affected by the periods (P = 0.906). CF was significantly higher in females (P = 0.003), whereas males displayed higher lying behavior (P = 0.007). Glucose, total protein, urea, cholesterol, HDL-cholesterol, LDL-cholesterol concentrations (P = 0.001) and ALP activity (P = 0.003) were significantly affected by the periods. The results of the present study suggest that behavioral and serum parameters across the periods describe changes in the nutritional conditions as a result of the transition from milk to solid feed in association with weaning. [source] Book Review: Alphabet Kids: from ADD to Zellweger syndrome: a guide to developmental, neurobiological and psychological disorders for parents and professionals , By Robbie WoliverBRITISH JOURNAL OF SPECIAL EDUCATION, Issue 3 2009Margaret Cousins No abstract is available for this article. [source] Parents Influential in Discouraging Kids from SmokingCA: A CANCER JOURNAL FOR CLINICIANS, Issue 2 2002Article first published online: 31 DEC 200 No abstract is available for this article. [source] Tobacco Ads Still Aimed at Kids; Experts Advise Stronger ProtectionsCA: A CANCER JOURNAL FOR CLINICIANS, Issue 6 2001Article first published online: 31 DEC 200 No abstract is available for this article. [source] Cars before Kids: Automobility and the Illusion of School Traffic SafetyCANADIAN REVIEW OF SOCIOLOGY/REVUE CANADIENNE DE SOCIOLOGIE, Issue 2 2010SYLVIA PARUSEL La sécurité routière constitue une question d'intérêt public très discutée, et ses pratiques fortement débattues exigent une analyse sociologique et l'attention systématique des politiques publiques. Dans cette étude, les auteurs analysent les programmes de sécurité routière dans les écoles primaires de Vancouver, en Colombie-Britannique. Ils illustrent comment de tels programmes supposent une politique de la responsabilité visant grandement les enfants et les parents pour en faire des personnes sécuritaires sur la route dans un environnement institutionnel qui ne fournit pourtant aux programmes qu'un soutien et des fonds sporadiques pour administrer les risques de la circulation. Alors que ce contexte de programmes de sécurité routière à l'école aide à maintenir une certaine « illusion de sécurité», elle ne remet pas fondamentalement en question la structure dominante actuelle de la mobilité et les problèmes qui y sont inhérents. Traffic safety is a contested public issue and highly negotiated practice that requires sociological analysis and systematic public policy attention. In our case study, we examine elementary school traffic safety programs in Vancouver, British Columbia. We illustrate how such programs assume a politics of responsibility that largely targets children and parents for traffic safekeeping within an institutional environment that gives programs only sporadic support and funding to manage traffic risks. While this context of school traffic safety programs helps to maintain an "illusion of safety," it does not challenge the current auto-dominant mobility structure and its inherent problems. [source] A prospective cohort study determining the prevalence of thrombotic events in children with acute lymphoblastic leukemia and a central venous line who are treated with L-asparaginase,CANCER, Issue 2 2003Results of the Prophylactic Antithrombin Replacement in Kids with Acute Lymphoblastic Leukemia Treated with Asparaginase (PARKAA) Study Abstract BACKGROUND Thrombotic events (TEs) are serious secondary complications in children with acute lymphoblastic leukemia (ALL) who receive L-asparaginase (ASP) therapy; however, the prevalence of TEs has not been established. The primary objective of the Prophylactic Antithrombin Replacement in Kids with Acute Lymphoblastic Leukemia Treated with Asparaginase (PARKAA) Study was to determine the prevalence of TEs. The secondary objective was to detect any association of TEs with the presence of congenital or acquired prothrombotic disorders. METHODS Children with ALL were screened for TEs at the end of ASP treatment using bilateral venograms, ultrasound, magnetic resonance imaging, and echocardiography. Symptomatic TEs were confirmed by appropriate radiographic tests. All tests were read by a blinded central adjudication committee. RESULTS Twenty-two of 60 children had TEs, a prevalence of 36.7% (95% confidence interval, 24.4,48.8%). TEs were located in the sinovenous system of the brain in 1 patient, the right atrium in 3 patients, and the upper central venous system in 19 patients. TEs detected by venography resulted in 1) 25,100% occlusion, with 1 in 3 patients showing occlusion of > 75% of the greatest vessel dimension, and 2) the presence of collaterals in 60% of patients, with 40% categorized as major. No children with TEs were positive for factor V Leiden or prothrombin gene 20201A, and four of eight children with antiphospholipid antibodies had a TE. CONCLUSIONS The prevalence of TEs is exceedingly high in this population, and it is likely that the extent of occlusion is likely clinically significant. No trend was seen toward an association between TEs and the presence of congenital prothrombotic disorders. A trend was seen toward an association between TEs and antiphospholipid antibodies. Carefully designed clinical trials of primary prophylaxis for the prevention of TEs are required in this patient population. Cancer 2003;97:508,16. © 2003 American Cancer Society. DOI 10.1002/cncr.11042 [source] Kids and Violence: The Invisible School ExperienceCHILD AND ADOLESCENT MENTAL HEALTH, Issue 2 2007Alice Sluckin No abstract is available for this article. [source] Child or family assessed measures of activity performance and participation for children with cerebral palsy: a structured reviewCHILD: CARE, HEALTH AND DEVELOPMENT, Issue 4 2005C. Morris Abstract Background, There is a need to measure children's ,activity performance and participation' as defined in the World Health Organization's International Classification of Functioning, Disability and Health for Children and Youth (WHO ICF). The aim of this review is to identify instruments that are suitable for use in postal surveys with families of children with cerebral palsy. Methods, We conducted a structured review of instruments that use child or family self-assessment of ,activity performance and participation'. The review involved a systematic search for instruments using multiple published sources. Appraisal of the instruments used the predefined criteria of appropriateness, validity, reliability, responsiveness, precision, interpretability, acceptability and feasibility. Results, There are relatively few child or family assessed instruments appropriate for measuring children's activities and participation. Seven instruments were identified that could potentially be administered by mail. The Assessment of Life Habits for Children (LIFE-H) was the most appropriate instrument as assessed by its content but the reliability of child or family self-assessment is not known. If the LIFE-H were shown to be a reliable self-report measure then the LIFE-H would be the recommended choice. Currently, the Activities Scale for Kids and the condition-specific Lifestyle Assessment Questionnaire for cerebral palsy (LAQ-CP) provide the broadest description of what and how frequently children with cerebral palsy perform a range of activities and thereby indicate participation. The LAQ-CP also provides additional contextual information on the impact of any disability on the participation of the family unit. Conclusion, There remains much scope for developing valid and reliable self-assessed measures corresponding to the WHO ICF dimensions of activities and participation. [source] ,I'm Home for the Kids': Contradictory Implications for Work,Life Balance of Teleworking MothersGENDER, WORK & ORGANISATION, Issue 5 2008Margo Hilbrecht This study explores the experience of time flexibility and its relationship to work,life balance among married female teleworkers with school-aged children. Drawing from a larger study of teleworkers from a Canadian financial corporation, 18 mothers employed in professional positions discussed work, leisure and their perceptions of work,life balance in in-depth interviews. Telework was viewed positively because flexible scheduling facilitated optimal time management. A key factor was the pervasiveness of caregiving, which could result in ongoing tensions and contradictions between the ethic of care and their employment responsibilities. The ideology of ,intensive mothering' meant that work schedules were closely tied to the rhythms of children's school and leisure activities. The different temporal demands of motherhood and employment resulted in little opportunity for personal leisure. Time ,saved' from not having to commute to an office was reallocated to caregiving, housework or paid employment rather than to time for their self. The women also experienced a traditional gendered division of household labour and viewed telework as a helpful tool for combining their dual roles. Time flexibility enhanced their sense of balancing work and life and their perceived quality of life. At the same time, they did not question whether having the primary responsibility for caregiving while engaged in paid employment at home was fair or whether it was a form of exploitation. [source] | ||||||||||||||||||||||||||||||||||||||||