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Key Influence (key + influence)
Selected AbstractsGenetic Approaches to the Study of AgingJOURNAL OF AMERICAN GERIATRICS SOCIETY, Issue 9s 2005Richard A. Miller MD Can mouse genetics teach us enough about the biology of aging to guide the search for anti-aging medicines that can delay late-life illness? Recent progress gives reason for optimism, with new data showing that changes in single genes can extend average and maximal life span by 40%. Mice with these genetic variants remain healthy, active, and cognitively intact at average ages that correspond to 110,120 years of human life span. Multiple lines of evidence now point to a hormone, IGF-I, as a key influence on life span, with low IGF-I levels associated with extended longevity in multiple model systems. The goal of this research is not gene therapy,we have no idea of what genes to change, how to change them, or what harm such changes might do,but instead to use insights from the cell biology and endocrinology of genetically long-lived mice and other species to help develop drugs that manipulate aging and thus postpone the many diseases and disabilities that are typically troublesome in old age. The complete conquest of cancer or heart disease would each lead to an increase of a mere,3% in mean life span in humans, i.e. about a tenth of what can be accomplished, today, in laboratory animals of delayed aging. In this context the paltry commitment to research in biological gerontology (six cents per $100 of NIH funding, for example) seems worth reconsideration. [source] Nursing the clinic vs. nursing the patient: nurses' experience of a day hospital chemotherapy serviceJOURNAL OF CLINICAL NURSING, Issue 9 2006Sonja Mcilfatrick PhD Aims and objectives., This study sought to explore the nurses' experience of a day hospital chemotherapy service in an acute general hospital in Northern Ireland and how this compared with their experience of working in an inpatient setting. Background., Despite the many changes taking place in cancer care delivery, little research has been conducted on nurses' experience of working in more acute cancer treatment settings. Research conducted to date has tended to focus on the role of nurses in wards, hospices and palliative care settings. Design., This Heideggerian hermeneutic phenomenological study explored nurses' lived experience of day hospital chemotherapy service. Method., Face-to-face focused in-depth interviews were conducted with the total population of nurses who worked in the day hospital at the time of data collection (n = 10). Data analysis involved a two-staged approach, the analysis of narratives and narrative analysis, based on the work of Polkinghorne (1995). Conclusions., The nurses' viewed their experience of the chemotherapy day hospital as having both positive and negative dimensions. The positive dimensions included an increased sense of autonomy and the challenge of developing new skills, while the negative dimension included a perceived decrease in their caring role: (i),The individual characteristics of the nurse were seen to have a key influence on caring experience; (ii),Role changes led to a perceived dichotomy between their actual and aspired role and their caring and clinical role. Relevance to clinical practice., There is a need to achieve a balance between delivering a clinical role (administering chemotherapy) while maintaining the centrality of the nurse,patient relationship. This can be likened to achieving a balance between ,nursing the clinic' alongside ,nursing the patient'. These findings have implications for the discourse on caring within other outpatient type clinics and discourse on cancer nursing as therapy and the culture of the cancer clinic. [source] Does service failure influence customer loyalty?JOURNAL OF CONSUMER BEHAVIOUR, Issue 3 2002Francis Buttle Abstract There is a general consensus that customer loyalty to service providers is not solely dependent upon their level of satisfaction or dissatisfaction. However, the identified antecedents of loyalty remain, at best, highly speculative. The aim of this extensive literature review is to give some understanding of the nature of customer loyalty and the antecedent effects of service dissatisfaction. The research reviewed suggests that customer loyalty is an attitudinal state, reflecting value, trust and commitment within supplier,customer relationships. Satisfaction is one of several antecedents of loyalty. A key influence on loyalty is the offer of unique value-delivering advantages not provided by competitors. Thus firms need to develop positive value-based exit barriers to achieve loyalty. When service failures occur, the recovery process is likely to have a greater impact on loyalty than the original service failure. The key to successful recoveries was found to be the customer's perception of ,fairness'. Recovery programmes must get it right first time. Customers who remain dissatisfied after a complaint has been handled are more dissatisfied than if no recovery attempt had been made. Dissatisfaction and customer satiation are major causes of a customer's exit. The solution to customer satiation is dynamic value creation. Collection and monitoring of customer data is needed for success and two-way communication is vital. Copyright © 2002 Henry Stewart Publications. [source] Synchrony between growth and reproductive patterns in human females: Early investment in growth among Pumé foragersAMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, Issue 2 2010Karen L. Kramer Abstract Life history is an important framework for understanding many aspects of ontogeny and reproduction relative to fitness outcomes. Because growth is a key influence on the timing of reproductive maturity and age at first birth is a critical demographic variable predicting lifetime fertility, it raises questions about the synchrony of growth and reproductive strategies. Among the Pumé, a group of South American foragers, young women give birth to their first child on average at age 15.5. Previous research showed that this early age at first birth maximizes surviving fertility under conditions of high infant mortality. In this study we evaluate Pumé growth data to test the expectation that if early reproduction is advantageous, then girls should have a developmental trajectory that best prepares them for young childbearing. Analyses show that comparatively Pumé girls invest in skeletal growth early, enter puberty having achieved a greater proportion of adult body size and grow at low velocities during adolescence. For early reproducers growing up in a food-limited environment, a precocious investment in growth is advantageous because juveniles have no chance of pregnancy and it occurs before the onset of the competing metabolic demands of final reproductive maturation and childbearing. Documenting growth patterns under preindustrial energetic and demographic conditions expands the range of developmental variation not otherwise captured by normative growth standards and contributes to research on human phenotypic plasticity in diverse environments. Am J Phys Anthropol, 2010. © 2009 Wiley-Liss, Inc. [source] Influence of substituent groups at the 3-position on the mass spectral fragmentation pathways of cephalosporinsRAPID COMMUNICATIONS IN MASS SPECTROMETRY, Issue 14 2010Jin Li The structural fragment ions of nine cephalosporins were studied by electrospray ionization quadrapole trap mass spectrometry (Q-Trap MSn) in positive mode. The influence of substituent groups in the 3-position on fragmentation pathway B, an ,-cleavage between the C7C8 single bond, coupled with a [2,4]-trans-Diels-Alder cleavage simultaneously within the six-membered heterocyclic ring, was also investigated. It was found that when the substituent groups were methyl, chloride, vinyl, or propenyl, fragmentations belonging to pathway B were detected; however, when the substituents were heteroatoms such as O, N, or S, pathway B fragmentation was not detected. This suggested that the [M,R3]+ ion, which was produced by the bond cleavage within the substituent group at the 3-position, had a key influence on fragmentation pathway B. This could be attributed to the strong electronegativity of the heteroatoms (O, N, S) that favors the production of the [M,R3]+ ion. Moreover, having the positive charge of the [M,R3]+ ion localized on the nitrogen atom in the 1-position changed the electron density distribution of the heterocyclic structure, which prohibits a [2,4]-reverse-Diels-Alder fragmentation and as a result fragmentation pathway B could not occur. The influence of the substituent group in the 3-position was determined by the intensity ratio (e/d) of ions produced by fragmentation pathway A, a [2,2]-trans-Diels-Alder cleavage within the quaternary lactam ring, including the breaking of the amide bond and the C6C7 single bond (ion d), and fragmentation pathway B (ion e). The results indicate that the electronegativity of the substituent group was a key influencing factor of pathway B fragmentation intensity, because the intensity ratio (e/d) is higher for a chlorine atom, a vinyl, or a propenyl group than that of a methyl group. This study provided some theoretical basis for the identification of cephalosporin antibiotics and structural analysis of related substances in drugs. Copyright © 2010 John Wiley & Sons, Ltd. [source] The influences on women joining and participating in unionsINDUSTRIAL RELATIONS JOURNAL, Issue 5 2005Gill Kirton ABSTRACT This article brings gender to the centre of concepts used to explore union joining and participation, demonstrating that a gender-sensitive analysis adds to our understanding. Using qualitative data from a study of women in two large male-dominated UK trade unions, the article explores four key influences on women's union joining and participation,family, union, work and feminism. While prior beliefs and values played a role in promoting joining and participation, gendered experiences of unions and the workplace had a more profound influence. Feminism affected the nature of participation in that self-identified feminists were more critical of the masculine character of trade unionism. [source] Recent advances in computational fluid dynamics relevant to the modelling of pesticide flow on leaf surfacesPEST MANAGEMENT SCIENCE (FORMERLY: PESTICIDE SCIENCE), Issue 1 2010C Richard Glass Abstract Increasing societal and governmental concern about the worldwide use of chemical pesticides is now providing strong drivers towards maximising the efficiency of pesticide utilisation and the development of alternative control techniques. There is growing recognition that the ultimate goal of achieving efficient and sustainable pesticide usage will require greater understanding of the fluid mechanical mechanisms governing the delivery to, and spreading of, pesticide droplets on target surfaces such as leaves. This has led to increasing use of computational fluid dynamics (CFD) as an important component of efficient process design with regard to pesticide delivery to the leaf surface. This perspective highlights recent advances in CFD methods for droplet spreading and film flows, which have the potential to provide accurate, predictive models for pesticide flow on leaf surfaces, and which can take account of each of the key influences of surface topography and chemistry, initial spray deposition conditions, evaporation and multiple droplet spreading interactions. The mathematical framework of these CFD methods is described briefly, and a series of new flow simulation results relevant to pesticide flows over foliage is provided. The potential benefits of employing CFD for practical process design are also discussed briefly. © Crown copyright 2009. Reproduced with permission of Her Majesty's Stationery Office. Published by John Wiley & Sons, Ltd. [source] Influence of socioeconomic and cultural factors on rural healthAUSTRALIAN JOURNAL OF RURAL HEALTH, Issue 1 2009John R. Beard Abstract Objective:,To provide a framework for investigating the influence of socioeconomic and cultural factors on rural health. Design:,Discussion paper. Results:,Socioeconomic and cultural factors have long been thought to influence an individual's health. We suggest a framework for characterising these factors that comprises individual-level (e.g. individual socioeconomic status, sex, race) and neighbourhood-level dimensions (population composition, social environment, physical environment) operating both independently and through interaction. Recent spatial research suggests that in rural communities, socioeconomic disadvantage and indigenous status are two of the greatest underlying influences on health status. However, rural communities also face additional challenges associated with access to, and utilisation of, health care. The example is given of procedural angiography for individuals with an acute coronary event. Conclusions:,Socioeconomic and cultural factors specific to rural Australia are key influences on the health of residents. These range from individual-level factors, such as rural stoicism, poverty and substance use norms, to neighbourhood-level social characteristics, such as lack of services, migration out of rural areas of younger community members weakening traditionally high levels of social cohesion, and to environmental factors, such as climate change and access to services. [source] | ||||||||||||||||