Kg Heavier (kg + heavier)

Distribution by Scientific Domains

Selected Abstracts

Age distributions, birth weights, nephrogenic rests, and heterogeneity in the pathogenesis of Wilms tumor

Norman E. Breslow PhD
Abstract Background The National Wilms Tumor Study (NWTS) constitutes a unique resource for study of clinical, pathologic, and epidemiologic features of Wilms tumor (WT). Procedure Data from NWTS-3,4,5 were compiled for 7,455 patients with tumors of favorable (FH) or anaplastic (AH) histology. The associations of birth weight (BW) and age-at-onset with gender, intralobar (ILNR), and perilobar (PLNR) nephrogenic rests, tumor focality, congenital malformation syndromes, and tumor histology were analyzed using descriptive statistics and linear regression. Results Mean BWs for male and female patients without PLNR were 3.52 and 3.36 kg, respectively, and for those with PLNR were 0.12 kg and 0.15 kg heavier. Mean age was 45 months for males with no rests whose tumors were unifocal and of triphasic favorable histology. ILNR or multifocality decreased the mean age by 18 and 10 months, respectively, whereas female gender, blastemal/FH or AH increased it by 3, 10, and 16 months. Over 90% of multifocal tumors occurred in the presence of demonstrated ILNR or PLNR or both. The apparent bimodality of the age distributions and later mean ages-at-onset for females with both unifocal and multifocal tumors were explained in part by the relative deficit in females of ILNR versus PLNR-associated tumors. Conclusions These observations support the view that there are multiple pathways to Wilms tumorigenesis. They will facilitate selection of informative subgroups of patients for molecular analysis that may serve to identify the putative pathway for the majority of patients who cannot be classified provisionally on the basis of ILNR or PLNR. Pediatr Blood Cancer 2006;47:260,267. 2006 Wiley-Liss, Inc. [source]

Can the Broselow Tape Be Used to Estimate Weight and Endotracheal Tube Size in Korean Children?

Hye Young Jang MD
BackgroundThe Broselow pediatric emergency tape (BT) was developed to provide a length-based estimate of body weight and equipment size during resuscitation. ObjectivesTo conduct a validation study on the use of the BT in Korean children. MethodsAnesthesia records from children were retrospectively reviewed. The measured weights of the subjects were compared with the BT weight estimates by using Bland-Altman analysis. The accuracy of the BT and age-based formula in predicting the endotracheal tube (ETT) size were also compared. The authors drew a receiver operating characteristics (ROC) curve to evaluate the cutoff height that would be acceptable for the application of BT without error in Korean children. ResultsA total of 665 children (mean [ SD] age, 5.1 [ 3.3] years, 61.8% male) were enrolled. The average measured weight of the Korean children was 1.54 kg heavier than the BT estimates (95% CI = 1.24 to 1.85 kg). The BT estimates showed better agreement with the actually used ETT sizes than did the age-based formula estimates (86.9% vs. 34.9%, p < 0.001). The cutoff height of the ROC curve was 127.15 cm. When the BT was used in children who were shorter than the cutoff height, 98.8% of the enrolled children's estimated weights were within the limits of agreement. ConclusionsThe BT can be used in Korean children as a helpful adjunct during resuscitation to estimate the weight and ETT size. [source]

Efficacy of nifedipine or lisinopril in the treatment of hypertension after renal transplantation: a double-blind randomised comparative trial

Karsten Midtvedt
Calcium channel blockers and angiotensin converting enzyme-inhibitors are commonly used in the treatment of hypertensive renal transplant recipients. The purpose of this study was to investigate if the response rate to treatment differs with these drugs in this setting. A single centre, prospective, randomised, double-blinded, comparative study to address the efficacy of controlled release nifedipine or lisinopril in the treatment of hypertension (diastolic blood pressure ,95 mmHg) in cyclosporin (CsA)-treated renal transplant recipients was performed. Recipients were randomised to receive either lisinopril (10 mg once daily) or controlled release nifedipine (30 mg once daily). The dose was doubled on indication. The number of responders (diastolic blood pressure <90 mmHg on monotherapy) were addressed during the early post-transplant phase (first 3 months) and during a late post-transplant phase (from 3 to 12 months after renal transplantation) in the same patient population. One hundred and fifty-four patients (nifedipine=78, lisinopril=76) with untreated hypertension (diastolic blood pressure,95 mmHg) were randomised within 3 wk after renal transplantation. One hundred and twenty-tree patients (nifedipine=69, lisinopril=54) completed the study. Fourteen (20%) nifedipine-treated recipients responded during the early, and 26 (38%) during the late post-operative phase (months 4,12 after renal transplantation). Eleven (20%) lisinopril-treated recipients responded during the early, and 18 (33%) during the late post-transplant phase. Non-responders were, on average, 8.51.5 kg heavier both in the early phase and after 1 yr of treatment (p<0.01), and 6.10.9 yr older than responders (p<0.05). In conclusion, these results indicate that both controlled release nifedipine and lisinopril are equally efficient in the treatment of post-transplant hypertension. As monotherapy, both drugs show a ,response rate' of 20,38%, depending on time interval after transplantation. [source]

Swedish population-based longitudinal reference values from birth to 18 years of age for height, weight and head circumference

K Albertsson Wikland
This study aimed to update growth reference values for height, weight and head circumference in order to reflect the changes in body size in the Swedish population during the past two decades. The data came from a large longitudinal growth study on 3650 full-term healthy Swedish children who were born between 1973 and 1975. All of these 1801 girls and 1849 boys had longitudinal data for height and weight from birth to final height. Comparison with previous Swedish growth reference values based on children born between 1955 and 1958 revealed that there have been secular changes in body size. For instance, at 18 y of age, the updated height and weight reference values are 180.4 cm for males and 167.7 cm for females, i.e. 1.9 cm taller and 5.7 kg heavier for males and 2.3 cm taller and 3.4kg heavier for females compared with the previous reference values. Conclusion: These new growth reference values provide current national standards for growth monitoring and evaluation since the year 2000. [source]