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Selected AbstractsReport on Underwater Excavation at the Phoenician Harbour, Atlit, IsraelINTERNATIONAL JOURNAL OF NAUTICAL ARCHAEOLOGY, Issue 2 2010Arad Haggi Atlit is a small Phoenician settlement on the Carmel coast, with an artificial harbour, built during Iron Age II, before the Assyrian occupation, and used until the end of the Persian era. There are no remains of any later construction, in contrast to other Phoenician ports such as Sidon and Tyre. The study of Atlit harbour has therefore provided invaluable information on the positioning, planning and construction of Phoenician harbours in the Levant. This article is a summary of the most recent underwater excavation seasons at the harbour, and presents our conclusions on construction techniques and their historical implications. © 2009 The Author [source] Real time non-invasive imaging of receptor,ligand interactions in vivoJOURNAL OF CELLULAR BIOCHEMISTRY, Issue 3 2003Paul Winnard Abstract Non-invasive longitudinal detection and evaluation of gene expression in living animals can provide investigators with an understanding of the ontogeny of a gene's biological function(s). Currently, mouse model systems are used to optimize magnetic resonance imaging (MRI), positron emission tomography (PET), single-photon emission computed tomography (SPECT), and optical imaging modalities to detect gene expression and protein function. These molecular imaging strategies are being developed to assess tumor growth and the tumor microenvironment. In addition, pre-labeling of progenitor cells can provide invaluable information about the developmental lineage of stem cells both in organogenesis and tumorigenesis. The feasibility of this approach has been extensively tested by targeting of endogenous tumor cell receptors with labeled ligand (or ligand analog) reporters and targeting enzymes with labeled substrate (or substrate analog). We will primarily discuss MRI, PET, and SPECT imaging of cell surface receptors and the feasibility of non-invasive imaging of gene expression using the tumor microenvironment (e.g., hypoxia) as a conditional regulator of gene expression. © 2003 Wiley-Liss, Inc. [source] Toward the development of new medicinal leads with selectivity for protein kinase C isozymesTHE CHEMICAL RECORD, Issue 4 2005Kazuhiro Irie Abstract Tumor promoters such as phorbol esters bind strongly to protein kinase C (PKC) isozymes to induce their activation. Since each PKC isozyme is involved in diverse biological events in addition to tumor promotion, the isozymes serve as promising therapeutic targets. Tumor promoters bind to the C1A and/or C1B domain of conventional (,, ,I, ,II, and ,) and novel PKC isozymes (,, ,, ,, and ,). As these C1 domains play differential roles in PKC activation and their translocation in cells, the development of agents with binding selectivity for individual C1 domains is a pressing need. For this purpose, we established a synthetic C1 peptide library of all PKC isozymes. The library enabled us to identify indolactam-V (1) as a promising lead compound. Our diverse structure,activity studies on 1 indicated that the position of the hydrophobic substituent on the indole ring dominates the PKC isozyme- and C1 domain-selective binding rather than conformation of the nine-membered lactam. Moreover, we suggested that the indole ring of 1 could be involved in the CH/, interaction with Pro-11 of the C1B domain of PKC,. This invaluable information will lead to the structural optimization of the PKC, ligand as exemplified by the design and synthesis of naphtholactam-V8 (21). © 2005 The Japan Chemical Journal Forum and Wiley Periodicals, Inc. Chem Rec 5: 185,195; 2005: Published online in Wiley InterScience (www.interscience.wiley.com) DOI 10.1002/tcr.20044 [source] Fiberoptic Endoscopic Evaluation of SwallowingTHE LARYNGOSCOPE, Issue 8 2003CCC-SLP, Susan G. Hiss PhD Abstract Objectives/Hypothesis Approximately 8 million people in the United States report some degree of dysphagia annually; as the population continues to age, this will become a greater problem. A comprehensibly performed and interpreted fiberoptic endoscopic evaluation of swallowing provides invaluable information for the evaluation and management of individuals with dysphagia or aspiration, or both. Study Design Review. Methods The state-of-the-art technique, interpretation, predictive value, and safety of fiberoptic endoscopic evaluation of swallowing was reviewed. [source] Dissecting galaxies with quantitative spectroscopy of the brightest stars in the UniverseASTRONOMISCHE NACHRICHTEN, Issue 5 2010R.-P. KudritzkiArticle first published online: 20 MAY 2010 Abstract Measuring distances to galaxies, determining their chemical composition, investigating the nature of their stellar populations and the absorbing properties of their interstellar medium are fundamental activities in modern extragalactic astronomy helping to understand the evolution of galaxies and the expanding universe. The optically brightest stars in the universe, blue supergiants of spectral A and B, are unique tools for these purposes. With absolute visual magnitudes up to MV , -9.5 they are ideal to obtain accurate quantitative information about galaxies through the powerful modern methods of quantitative stellar spectroscopy. The spectral analysis of individual blue supergiant targets provides invaluable information about chemical abundances and abundance gradients, which is more comprehensive than the one obtained from HII regions, as it includes additional atomic species, and which is also more accurate, since it avoids the systematic uncertainties inherent in the strong line studies usually applied to the HII regions of spiral galaxies beyond the Local Group. Simultaneously, the spectral analysis yields stellar parameters and interstellar extinction for each individual supergiant target, which provides an alternative very accurate way to determine extragalactic distances through a newly developed method, called the Flux-weighted Gravity,Luminosity Relationship (FGLR). With the present generation of 10 m-class telescopes these spectroscopic studies can reach out to distances of 10 Mpc. The new generation of 30 m-class telescopes will allow to extend this work out to 30 Mpc, a substantial volume of the local universe (© 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) imaging in the staging and prognosis of inflammatory breast cancerCANCER, Issue 21 2009Jean-Louis Alberini MD Abstract BACKGROUND: To prospectively assess fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) staging and prognosis value in patients with suspected inflammatory breast cancer (IBC). METHODS: Sixty-two women (mean age 50.7 ± 11.4 years) presenting with unilateral inflammatory breast tumors (59 invasive carcinomas; 3 mastitis) underwent a PET/CT scan before biopsy. RESULTS: PET/CT scan was positive for the primary malignant tumor in 100% and false positive in 2 of 3 benign mastitis. In 59 IBC patients, FDG nodal foci were detected in axillary (90%; n = 53) and extra-axillary areas (56%; n = 33) ipsilateral to the cancer. Compared with clinical examination, the axillary lymph node status by PET/CT was upstaged and downstaged in 35 and 5 patients, respectively. In 7 of 9 N0 patients, the axillary lymph node positivity on PET/CT was correct, as revealed by pathological postsurgery assessment (not available in the 2 remaining patients). The nodal foci were compared with preoperative fine needle aspiration and/or pathological postchemotherapy findings available in 44 patients and corresponded to 38 true positive, 4 false-negative, and 2 false-positive cases. In 18 of 59 IBC patients (31%), distant lesions were found. On the basis of a univariate analysis of the first enrolled patients (n = 42), among 28 patients who showed intense tumoral uptake (standard uptake valuemax>5), the 11 patients with distant lesions had a worse prognosis than the 17 patients without distant lesions (P = .04). CONCLUSIONS: FDG-PET/CT imaging provides additional invaluable information regarding nodal status or distant metastases in IBC patients and should be considered in the initial staging. It seems also that some prognostic information can be derived from FDG uptake characteristics. Cancer 2009. © 2009 American Cancer Society. [source] | ||||||||||