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Intramolecular Amidation (intramolecular + amidation)

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Chemistry100%

Selected Abstracts

First Copper-Catalyzed Intramolecular Amidation in Substituted 4-Iodopyrazoles Leading to the Synthesis of Pyrazolo[4,3- b]- pyridin-5-ones,

ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 16 2009
Somnath Nag
Abstract An unprecedented copper-catalyzed intramolecular amidation of substituted 4-iodopyrazoles generated either via Baylis,Hillman or Horner,Wadsworth,Emmons chemistry for the synthesis of pyrazolo[4,3- b]pyridine-5-ones is described. In addition, the effect of the stereochemistry of the acrylamide on the cross-coupling reaction has been investigated and it is demonstrated that only the Z-isomer is favoured to undergo the intramolecular cyclization. [source]

Microwave-Assisted Sequential Amide Bond Formation and Intramolecular Amidation: A Rapid Entry to Functionalized Oxindoles.

CHEMINFORM, Issue 30 2005
Rajamohan R. Poondra
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

Intramolecular Asymmetric Amidations of Sulfonamides and Sulfamates Catalyzed by Chiral Dirhodium(II) Complexes

HELVETICA CHIMICA ACTA, Issue 7 2004
Corinne Fruit
Enantioselective intramolecular amidation of aliphatic sulfonamides was achieved for the first time by means of chiral carboxylatodirhodium(II) catalysts in conjunction with PhI(OAc)2 and MgO in high yields and with enantioselectivities of up to 66% (Scheme,3, Table,1). The best results were obtained with [Rh2{(S)-nttl)4] and [Rh2{(R)-ntv)4] as catalysts ((S)-nttl=(,S)- , -(tert -butyl)-1,3-dioxo-2H -benz[de]isoquinoline-2-acetato, (R)-nto=(,R)- , -isopropyl-1,3-dioxo-2H -benz[de] isoquinoline-2-acetato). In addition, these carboxylatodirhodium(II) catalysts were also efficient in intramolecular amidations of aliphatic sulfamates esters, although the enantioselectivity of these latter reactions was significantly lower (Scheme,4, Table,3). [source]

First Copper-Catalyzed Intramolecular Amidation in Substituted 4-Iodopyrazoles Leading to the Synthesis of Pyrazolo[4,3- b]- pyridin-5-ones,

ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 16 2009
Somnath Nag
Abstract An unprecedented copper-catalyzed intramolecular amidation of substituted 4-iodopyrazoles generated either via Baylis,Hillman or Horner,Wadsworth,Emmons chemistry for the synthesis of pyrazolo[4,3- b]pyridine-5-ones is described. In addition, the effect of the stereochemistry of the acrylamide on the cross-coupling reaction has been investigated and it is demonstrated that only the Z-isomer is favoured to undergo the intramolecular cyclization. [source]

Intramolecular Asymmetric Amidations of Sulfonamides and Sulfamates Catalyzed by Chiral Dirhodium(II) Complexes

HELVETICA CHIMICA ACTA, Issue 7 2004
Corinne Fruit
Enantioselective intramolecular amidation of aliphatic sulfonamides was achieved for the first time by means of chiral carboxylatodirhodium(II) catalysts in conjunction with PhI(OAc)2 and MgO in high yields and with enantioselectivities of up to 66% (Scheme,3, Table,1). The best results were obtained with [Rh2{(S)-nttl)4] and [Rh2{(R)-ntv)4] as catalysts ((S)-nttl=(,S)- , -(tert -butyl)-1,3-dioxo-2H -benz[de]isoquinoline-2-acetato, (R)-nto=(,R)- , -isopropyl-1,3-dioxo-2H -benz[de] isoquinoline-2-acetato). In addition, these carboxylatodirhodium(II) catalysts were also efficient in intramolecular amidations of aliphatic sulfamates esters, although the enantioselectivity of these latter reactions was significantly lower (Scheme,4, Table,3). [source]