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Intermediate Scale (intermediate + scale)
Selected AbstractsSystematic evaluation of rating scales for impairment and disability in Parkinson's diseaseMOVEMENT DISORDERS, Issue 5 2002Claudia Ramaker MD Abstract We assessed the clinometric characteristics of rating scales used for the evaluation of motor impairment and disability of patients with Parkinson's disease (PD), conducting a systematic review of PD rating scales published from 1960 to the present. Thirty studies describing clinometrics of 11 rating scales used for PD were identified. Outcome measures included validity (including factor structure), reliability (internal consistency, inter-rater, and intrarater) and responsiveness. We traced three impairment scales (Webster, Columbia University Rating Scale [CURS] and Parkinson's Disease Impairment Scale), four disability scales (Schwab and England, Northwestern University Disability Scale [NUDS], Intermediate Scale for Assessment of PD, and Extensive Disability Scale), and four scales evaluating both impairment and disability (New York University, University of California Los Angeles, Unified Parkinson's Disease Rating Scale [UPDRS], and Short Parkinson Evaluation Scale). The scales showed large differences in the extent of representation of items related to signs considered responsive to dopaminergic treatment or to those signs that appear late in the disease course and lack responsiveness to treatment. Regardless of the scale, there was a conspicuous lack of consistency concerning inter-rater reliability of bradykinesia, tremor, and rigidity. Overall disability items displayed moderate to good inter-rater reliability. The available evidence shows that CURS, NUDS, and UPDRS have moderate to good reliability and validity. In contrast to their widespread clinical use for assessment of impairment and disability in PD, the majority of the rating scales have either not been subjected to an extensive clinometric evaluation or have demonstrated clinometric shortcomings. The CURS, NUDS, and UPDRS are the most evaluated, valid, and reliable scales currently available. © 2002 Movement Disorder Society [source] Particles from fires,a screening of common materials found in buildingsFIRE AND MATERIALS, Issue 6 2003Tommy Hertzberg Abstract Small combustion generated particles are known to have a negative impact on human health and on the environment. In spite of the huge amount of particles generated locally in a fire accident, few investigations have been made on the particles from such fires. In this article, 24 different materials or products, typically found in buildings have been exposed to burning conditions in order to examine their particle generating capacity. In addition, a carbon fibre based composite material was tested in order to investigate if asbestos-resembling particles could be generated in a fire situation. The majority of the experiments were performed in the small-scale cone calorimeter, and some further data were collected in intermediate scale (SBI) and full scale (room-corner) tests. Additional testing of the composite material was made in a small-scale tubular reactor. The amount of particles and particle size distributions were measured by the use of a low-pressure impactor and particle aerodynamic diameter sizes from 30 nm to 10 ,m were measured. The results from the project show that the yield of particles generated varied significantly between materials but that the shape of mass and number size distributions were very similar for all the materials tested. The maximum amount of particles was obtained from materials that did not burn well (e.g. flame retarded materials). Well-burning materials, e.g. wood materials, tend to oxidize all available substances and thereby minimize the amount of particles in the smoke gas. It was found that asbestos-resembling particles could be produced from under-ventilated combustion of the composite material tested. Copyright © 2003 John Wiley & Sons, Ltd. [source] Rethinking the concept of community of practice in relation to schoolteachers' workplace learningINTERNATIONAL JOURNAL OF TRAINING AND DEVELOPMENT, Issue 1 2004Heather Hodkinson This paper explores two different ways of understanding communities of practice in relation to workplace learning. This is based upon a case study of secondary school teachers working and learning in four subject departments in two English schools. In spite of institutional similarities, the cultures and working practices of the departments were different, and influenced the learning of the workers significantly. In such contexts, a tight conceptualisation of community of practice can form a valuable intermediate scale of analysis, between the individual learner and wider organisational influences on learning. However, communities of practice can also have a valuable meaning in relation to the wider influences and in situations where close-knit groupings do not exist. [source] Partitioning nuclear and chloroplast variation at multiple spatial scales in the neotropical epiphytic orchid, Laelia rubescensMOLECULAR ECOLOGY, Issue 9 2004DORSET W. TRAPNELL Abstract Insights into processes that lead to the distribution of genetic variation within plant species require recognition of the importance of both pollen and seed movement. Here we investigate the contributions of pollen and seed movement to overall gene flow in the Central American epiphytic orchid, Laelia rubescens. Genetic diversity and structure were examined at multiple spatial scales in the tropical dry forest of Costa Rica using nuclear (allozymes) and chloroplast restriction fragment length polymorphism (RFLP) markers, which were found to be diverse (allozymes, P = 73.3%; HE = 0.174; cpDNA, HE = 0.741). Nuclear genetic structure (FSTn) was low at every spatial scale (0.005,0.091). Chloroplast markers displayed more structure (0.073,0.254) but relatively similar patterns. Neither genome displayed significant isolation-by-distance. Pollen and seed dispersal rates did not differ significantly from one another (mp/ms = 1.40) at the broadest geographical scale, among sites throughout Costa Rica. However, relative contributions of pollen and seeds to gene flow were scale-dependent, with different mechanisms determining the dominant mode of gene flow at different spatial scales. Much seed dispersal is highly localized within the maternal population, while some seeds enter the air column and are dispersed over considerable distances. At the intermediate scale (10s to 100s of metres) pollinators are responsible for substantial pollen flow. This species appears capable of distributing its genes across the anthropogenically altered landscape that now characterizes its Costa Rican dry forest habitat. [source] Field theory for biogeography: a spatially explicit model for predicting patterns of biodiversityECOLOGY LETTERS, Issue 1 2010James P. O'Dwyer Abstract Predicting the variation of biodiversity across the surface of the Earth is a fundamental issue in ecology, and in this article we focus on one of the most widely studied spatial biodiversity patterns: the species,area relationship (SAR). The SAR is a central tool in conservation, being used to predict species loss following global climate change, and is striking in its universality throughout different geographical regions and across the tree of life. In this article we draw upon the methods of quantum field theory and the foundation of neutral community ecology to derive the first spatially explicit neutral prediction for the SAR. We find that the SAR has three phases, with a power law increase at intermediate scales, consistent with decades of documented empirical patterns. Our model also provides a building block for incorporating non-neutral biological variation, with the potential to bridge the gap between neutral and niche-based approaches to community assembly. Ecology Letters (2010) 13: 87,95 [source] Large-scale cosmic homogeneity from a multifractal analysis of the PSCz catalogueMONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY, Issue 4 2000Jun Pan We investigate the behaviour of galaxy clustering on large scales using the PSCz catalogue. In particular, we ask whether there is any evidence of large-scale fractal behaviour in this catalogue. We find the correlation dimension in this survey varies with scale, consistent with other analyses. For example, our results on small and intermediate scales are consistent those obtained from the QDOT sample, but the larger PSCz sample allows us to extend the analysis out to much larger scales. We find firm evidence that the sample becomes homogeneous at large scales; the correlation dimension of the sample is D2=2.992±0.003 for r>30 h,1 Mpc. This provides strong evidence in favour of a universe that obeys the cosmological principle. [source] Fluid Mechanics, Cell Distribution, and Environment in Cell Cube BioreactorsBIOTECHNOLOGY PROGRESS, Issue 1 2003John G. Auni Cultivation of MRC-5 cells and attenuated hepatitis A virus (HAV) for the production of VAQTA, an inactivated HAV vaccine ( 1), is performed in the Cell Cube reactor, a laminar flow fixed-bed bioreactor with an unusual diamond-shaped, diverging-converging flow geometry. These disposable bioreactors have found some popularity for the production of cells and gene therapy vectors at intermediate scales of operation ( 2, 3). Early testing of the Cell Cube revealed that the fluid mechanical environment played a significant role in nonuniform cell distribution patterns generated during the cell growth phase. Specifically, the reactor geometry and manufacturing artifacts, in combination with certain inoculum practices and circulation flow rates, can create cell growth behavior that is not simply explained. Via experimentation and computational fluid dynamics simulations we can account for practically all of the observed cell growth behavior, which appears to be due to a complex mixture of flow distribution, particle deposition under gravity, fluid shear, and possibly nutritional microenvironment. [source] | ||||||||||