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Interesting Approach (interesting + approach)
Selected AbstractsImmunomodulation of atherosclerosis: myth and realityJOURNAL OF INTERNAL MEDICINE, Issue 3 2000A. Nicoletti Abstract. Nicoletti A, Caligiuri G & Hansson GK (Hōpital Broussais, Paris, and Karolinska Institute, Stockholm). Immunomodulation of atherosclerosis: myth and reality (Minisymposium). J Intern Med 2000; 247: 397,405. Atherosclerosis is an inflammatory disease which displays features of immune activation both locally and systemically. In the present review, we discuss the evidence for immune activation in human disease and experimental models, and survey candidate antigens associated with atherosclerosis. Studies of atherosclerosis in genetic models of immunodeficiency are analysed, as well as immunomodulating therapies and immunization protocols. Based on recent research, it is concluded that immunomodulation represents an interesting approach to the development of new prevention and treatment methods for atherosclerosis. [source] A General Misspecification Test for Spatial Regression Models: Dependence, Heterogeneity, and NonlinearityJOURNAL OF REGIONAL SCIENCE, Issue 2 2001Thomas De Graaff There is an increasing awareness of the potentials of nonlinear modeling in regional science. This can be explained partly by the recognition of the limitations of conventional equilibrium models in complex situations, and also by the easy availability and accessibility of sophisticated computational techniques. Among the class of nonlinear models, dynamic variants based on, for example, chaos theory stand out as an interesting approach. However, the operational significance of such approaches is still rather limited and a rigorous statistical-econometric treatment of nonlinear dynamic modeling experiments is lacking. Against this background this paper is concerned with a methodological and empirical analysis of a general misspecification test for spatial regression models that is expected to have power against nonlinearity, spatial dependence, and heteroskedasticity. The paper seeks to break new research ground by linking the classical diagnostic tools developed in spatial econometrics to a misspecification test derived directly from chaos theory,the BDS test, developed by Brock, Dechert, and Scheinkman (1987). A spatial variant of the BDS test is introduced and applied in the context of two examples of spatial process models, one of which is concerned with the spatial distribution of regional investments in The Netherlands, the other with spatial crime patterns in Columbus, Ohio. [source] APPLICATION OF TWO CONSUMER PROFILING TECHNIQUES TO COSMETIC EMULSIONSJOURNAL OF SENSORY STUDIES, Issue 5 2010MARĶA EMMA PARENTE ABSTRACT The sensory characteristics of cosmetic products are commonly used for attracting consumers' attention in advertising campaigns and packaging. Thus, in order to appropriately satisfy consumers' sensory expectations, it is important to gather information about their perception of the sensory characteristics. In this context, the aim of the present work was to apply two consumer methodologies (intensity scales and a check-all-that-apply [CATA] question) to gather information about the sensory profile of cosmetic emulsions. Six cosmetic emulsions with different formulation, widely differing in their sensory characteristics, were evaluated by two groups of 50 female consumers. One group used intensity scales to evaluate eight attributes of the emulsions and the other completed a CATA question comprising 20 terms related to sensory characteristics of the emulsions, cosmetic applications and effects on the skin. Both intensity scales and CATA question were able to detect differences in consumers' perception of the sensory characteristics of the evaluated emulsions. These differences could be explained considering the samples' formulation, which suggests their validity and indicates that they could consist on interesting alternatives to traditional sensory profiles obtained with trained assessors' panels. PRACTICAL APPLICATIONS The application of intensity scales or a CATA question consisted of an interesting approach to gather information about consumers' perception of cosmetic products. Despite both methodologies provided similar results, the application of CATA questions could be regarded as more natural for consumers and easier to use. Besides, CATA questions could enable the identification of consumers' perception of the sensory characteristics of cosmetic products, but also their effects on the skin and the cosmetic applications for which they are considered appropriate. An interesting application of this methodology could be the development of a line of cosmetic products with different applications or the selection of sensory and efficacy claims during the design of marketing strategies or labels of cosmetic products. [source] On the steady-state properties of actual flip angle imaging (AFI)MAGNETIC RESONANCE IN MEDICINE, Issue 1 2009Kay Nehrke Abstract AFI (actual flip angle imaging) represents an interesting approach to map the B1 transmit fields by measuring the spatial variations of the effective flip angle. However, the accuracy of the technique relies on the adequate spoiling of transverse magnetization. In the present work configuration theory was employed to develop a proper RF and gradient spoiling scheme for the AFI technique, making the sequence robust against off-resonance without the need of large spoiling gradients. Furthermore, numerical simulations were performed to predict the steady-state signals and, hence, the accuracy of the AFI technique as a function of the sequence and tissue parameters. It is shown that the spoiling properties of the sequence are mainly defined by the phase shift increment , of the RF pulses and the diffusion sensitivity resulting from the unbalanced gradients of the sequence. Adequate spoiling may be achieved for a reasonable range of tissue parameters and flip angles for moderate spoiling gradients if a favorable value for , is chosen. Phantom and in vivo head imaging experiments show an excellent agreement with the theoretical predictions, indicating that the proper operating range of the approach may be reliably predicted by the theory. Magn Reson Med 61:84,92, 2009. © 2008 Wiley-Liss, Inc. [source] The Effects of 5-Aminolevulinic Acid Esters on Protoporphyrin IX Production in Human Adenocarcinoma Cell Lines,PHOTOCHEMISTRY & PHOTOBIOLOGY, Issue 5 2001H. Brunner ABSTRACT Photodynamic diagnosis (PDD) and photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA),induced protoporphyrin IX (PPIX) is an interesting approach to detect and treat dysplasia and early cancers in the gastrointestinal tract. Because of low lipophilicity resulting in poor penetration across cell membranes, high doses of ALA should be administered in order to reach clinically relevant levels of PPIX. One way of increasing PPIX accumulation is derivatization of ALA into a more lipophilic molecule. In our in vitro study, different esterifications of ALA were investigated to analyze the effects on PPIX accumulation in human adenocarcinoma cell lines. For systematic analysis of cell type,specific PPIX accumulation, three human adenocarcinoma cell lines (SW480, HT29 and CaCo2) and a fibroblast cell line (CCD18) were tested. 3-(4,5-Dimethylthiazole-2-yl)-2,5-biphenyl tetrazolium bromide (MTT) assays were performed to ensure that the ALA esters showed no cellular dark toxicity. Different concentrations (ranging from 0.012 to 0.6 mmol/L, 3 h) and incubation times (5, 10, 30, 180 min; 0.12 mmol/L) were examined. PPIX accumulation was measured using flow cytometry. ALA esters, especially ALA-hexylester and ALA-benzylester, induced significant higher PPIX levels in adenocarcinoma cell lines when compared with ALA and may be promising candidates for PDT and PDD. [source] Autofluorescence spectroscopy for the diagnosis of cervical intraepithelial neoplasiaBJOG : AN INTERNATIONAL JOURNAL OF OBSTETRICS & GYNAECOLOGY, Issue 8 2002Helmut Weingandt Objective To assess the feasibility of autofluorescence spectroscopy in the diagnosis of cervical intraepithelial neoplasia (CIN) using broadband light excitation. Design Feasibility study. Setting Colposcopy clinic of an university hospital. Population Sixty-eight patients at risk for CIN. Methods After excitation with a broadband light between 375 and 440 nm, spectral distribution of native tissue fluorescence (autofluorescence) was acquired from 685 cervical sites for the localisation and differentiation of CIN, and compared with colposcopically directed biopsy and human papillomavirus (HPV) DNA testing. Main outcome measure Detection of CIN. Results The evaluation of spectral measurements revealed significantly lower autofluorescence values for CIN 3 lesions compared with normal tissue (P < 0.001), and compared with CIN 1 or CIN 2 (P < 0.002). High grade CIN lesions (CIN 2/3) presented with a significant reduced autofluorescence compared with CIN 1 (P < 0.002). Patients with a positive HPV DNA testing showed a significantly lower autofluorescence than patients tested negative for HPV DNA (P < 0.05). Severe inflammation such as chronic cervicitis may lead to false positive results. Conclusions Autofluorescence spectroscopy represents an interesting approach for the detection of cervical neoplasia. Using an excitation wavelength band between 375 and 440 nm, significant differences between normal and precancerous lesions of the cervix can be seen. [source] | ||||||||||